160results about How to "Anticoagulant" patented technology

The invention relates to a medicinal mixture for treating cardiovascular diseases, which comprises (by weight portions) ginger extract 100 and dried orange peel extract 1-100 mainly containing ginger volatile oil, gingerol and dried orange peel volatile oil.

The invention discloses a blood occlusion device for a hepatic operation. The device comprises a tube body capable of being planted into a blood vessel. A displacement prevention device is arranged on the outer surface of one end of the tube body. A cavity is arranged inside the tube body. A blood occlusion device body is arranged inside the cavity. The displacement prevention device comprises an expander. The expander comprises a plurality of step protrusions evenly arranged on the outer surface of one end of the tube body. The step protrusions are in a wedge shape. An adjusting groove is formed in the surface, matched with the outer surface of the tube body, of each step protrusion. A groove is formed in the position, matched with each adjusting groove, of the tube body. According to the technical scheme, the displacement prevention device and the blood occlusion device are indispensable; if the displacement prevention device is omitted, the fixed position cannot be ensured, and the operation progress is affected; if the blood occlusion device is omitted, the predetermined effect cannot be achieved. The displacement prevention device and the blood occlusion device are operated in the operation process, so that the operation time is greatly shortened, and the survival probability of a patient is increased.

The invention relates to a heparin-phenylalanine adsorption material for a blood purification method for removing endotoxin. The preparation method of the heparin-phenylalanine adsorption material disclosed by the invention comprises the following steps: carrying out amination on chloromethylated polystyrene-diethylbenzene ene resin (merrifield resin) serving as a base material by using ethylenediamine to prepare the amino-methyl chloride resin, then utilizing 1-(3-dimethyl ami-nopropyl)-3-ethyl carbodiimide/N-hydroxysuccinimide (EDC/NHS) as a catalyst to connect spacer heparin, so as to prepare heparinized methyl chloride resin; and finally with the EDC/NHS as a catalyst, connecting phenylalanine to heparin, so as to prepare the heparin-phenylalanine adsorption material. The heparin-phenylalanine adsorption material disclosed by the invention can be effectively applied to the blood purification method for removing endotoxin, and is good in blood compatibility, and safe and nontoxic to a human body.

The invention discloses a process for producing low molecular sodium heparin by using raw sodium heparin as a raw material, which comprises the steps of: producing a sodium heparin solution; degradingthe solution; neutralizing the solution; collecting a precipitation; producing low molecular raw sodium heparin; producing low molecular fine sodium heparin and the like. The low molecular sodium heparin has the characteristics of rich sources of the raw material, high yield, stable and reliable quality, high purity, low cost, long curative effect, no toxic or side effect, simple process, convenient operation and no 'three wastes' discharge, has the effects of coagulation resistance, thrombosis resistance, tumor resistance, inflammation resistance, allergy resistance and the like and the efficiency of regulating blood lipid, has significant curative effect and wide application range, can be produced into injections, capsules, ointments and the like, is convenient for massive production, and is widely used for producing coagulation resistant low molecular sodium heparin.

The invention belongs to the technical field of fucoidan extraction and provides a method for extracting fucoidan through a biological enzymolysis process. The method comprises the following steps: grinding kelp into slurry; soaking; adding acidic cellulase and hemicellulase; adding alkaline pectinase; adding protease; adding sodium chloride and water and reacting, thereby acquiring sodium alginate jelly; adding modified attapulgite; centrifuging by using a centrifugal machine; and adding ethyl alcohol and dewatering, thereby acquiring solid-phase fucoidan. According to the method for extracting fucoidan provided by the invention, the biological enzymolysis process is adopted; on the basis of the structure and ingredients of kelp cytoderm, a defined amount of related enzyme is added in stages, so that the cytoderm is thoroughly split; the fucoidan therein is fully released, so that the extraction rate of the fucoidan is increased; the modified attapulgite is added for decolorizing and removing fishy smell in an extraction process, so that the appearance of the product is cleaner; and besides, the extraction steps are simplified, the use of the chemical raw materials is reduced and the purpose of environmental protection is achieved.

The invention provides a high-calcium seafood flavor soup base and a preparation method thereof. The preparation method comprises the following steps: firstly smashing and grinding fishbones until the granularity is 400-600 meshes, so as to obtain ultramicro fishbone powder, and then performing enzymolysis on blue clam meat by using papain and flavourzyme so as to obtain blue clam extractive; performing enzymolysis on shrimp leftovers by using the flavourzyme and a compound enzyme which consists of a compound protease and a neutral protease so as to obtain shrimp leftover extractive; uniformly mixing the blue clam extractive, the shrimp leftover extractive, the ultramicro fishbone powder, edible salt, monosodium glutamate, corn starch, disodium 5'-ribonucleotide, ascorbic acid, spring onion powder and garlic powder, adding dehydrated broccoli and dehydrated carrots and preparing the seafood flavor soup base. The high-calcium seafood flavor soup base has the advantages of being delicious in taste, convenient to eat, nutritive and healthy; the preparation method provided by the invention has the advantages that the additional value of the blue clam and leftovers such as fishbones, shrimp heads and shrimp shells, which are from aquatic product processing, is improved, and the environmental pollution is avoided.

The invention discloses a preparation method of Xinhui dried tangerine peel enzyme beverage. By adopting four industrial advanced unique processes such as natural fermentation and chelating process, low-high-pressure bidirectional homogenizing, high-temperature instantaneous sterilization and low-high-temperature canning, the specific nutritional ingredients of Xinhui orange, dried tangerine peel,rhizoma polygonati, fructus lycii, fructus crataegi and the like can be maximally reserved; and in the prepared Xinhui dried tangerine peel enzyme beverage, the content of crude polysaccharide and total flavonoids is increased, the extraction rate is high, the taste is good, and the tissue state stability is good.

The invention relates to a double-layer temperature-sensitive gel microsphere and a preparing method thereof. The double-layer temperature-sensitive gel microsphere and the preparing method are characterized in that: the double-layer temperature-sensitive gel microsphere adopts medicinal sodium hyaluronate and chitosan as gel raw materials, and comprises a chitosan gel core and a sodium hyaluronate gel shell. The inner layer of the gel microsphere contains the chitosan, so that the gel is compression-resistant and degradation-resistant. The outer layer of the gel microsphere is covered with the sodium hyaluronate gel shell, so that the gel microsphere is liable to inject. The particle size of the gel microsphere is small and uniform, so that the gel microsphere is liable to dialyze. The gel microsphere has synergistic effects of the sodium hyaluronate and the chitosan, so that the repairing time for an injection part is prolonged and the gel microsphere is more liable to inject. The gel microsphere is characterized by being antibacterial, anti-coagulation and good in formability in organisms.

The invention discloses a cationic angelica polysaccharide nanoparticle gene delivery system. The system is a gene delivery system of angelica polysaccharide combined DNA (Deoxyribonucleic Acid) plasmids modified by amine compounds, wherein molecular weight distribution of angelica polysaccharides is 30 to 50KD and 80 to 100KD; the mass ratio of the cationic angelica polysaccharide to the DNA plasmids is (1-200):1; and the particle diameter of the cationic angelica polysaccharide-DNA plasmid nancomposite is 21 to 77nm. The system has the characteristics that: 1, the angelica polysaccharide has various biological activities such as immune regulation activity, anti-aging activity, anticoagulation activity and the like, is safe and biologically degradable, does not have immunogenicity and isprepared with a simple, economic and convenient process; and 2, all the three cationic angelica polysaccharides have good DNA plasmid combination effect and gene delivery expression effect. Positive charges carried by primary amine, secondary amine and tertiary amine groups combined with saccharide chains can be effectively combined with the DNA plasmids with negative charges through an electrostatic effect, so that the plasmids are protected from being degraded by various enzymes inside and outside cells.

The invention pertains to a skin wound healing material and a manufacturing method thereof. The skin wound healing material comprises a fluorinated hydrophobic film and at least one biocompatible macromolecule, wherein the fluorinated hydrophobic film is provided with a first surface and a second surface which are opposite to each other, the fluorinated hydrophobic film has air permeability and liquid impermeability, the at least one biocompatible macromolecule is formed at part of the first surface of the hydrophobic film by covalent bonding, and the water contact angle of the first surface where the biocompatible macromolecule is formed is below 40 DEG.

The invention discloses a preparation method of a Xinhui pericarpium citri reticulatae enzyme beverage having anti-tumor and immunity enhancing functions. The preparation method includes steps of: 1)crushing a national geographical indication protection product, Xinhui pericarpium citri reticulatae and Xinhui tangerine whole fruits (including peel, pulp, segment membrane, and seeds) in a crushingsystem; 2) fermenting the crushed raw material through combination of natural fermentation and modern fermentation technology; 3) after the fermentation is completed, performing solid liquid separation and delivering the materials to a blending and homogenizing system for performing low- and high-pressure homogenization respectively; 4) after the homogenization, sterilizing and fill-packaging theproduct. In the invention, through double-direction fermentation, solid liquid separation, blending, low- and high-pressure homogenization, sterilization and medium/high-temperature fill-packaging, adifficult problem of food safety in the industry is completely solved, and the total flavones, crude polysaccharides, probiotics, probiotic active factors, and Xinhui tangerine metabolite, which arehigh in content in the Xinhui pericarpium citri reticulatae and Xinhui tangerine, are maintained as most as possible.

The invention discloses a method for preparing oligopeptide of snake meat, which comprises the following steps of: selecting a healthy and live adult snake from zaocys dhumnade, hagworm, gloydius saxatilis, dinodon rufozonatum, cobra, coral snakes, agkistrodon acutus, elaphe schrenckii, elaphe anomala, enhydris chinensis, and the like, slaughtering, removing the head, tail, skin and viscera of the snake, cleaning a carcass part with clear water, and performing processes such as grinding, jordaning, enzymolysis, filtration, enzyme deactivating, salt and arsenic removal, nanofiltration and concentration, spray drying and the like to obtain dry oligopeptide powder of the snake meat. The obtained product has the molecular weight of over 85 percent and the molecular weight distribution of 200-5,000Dalt; and bioactive substances have the effects of resisting tumors, coagulation, oxidation and fatigue, improving immunity, preventing heart cerebrovascular disease, preventing and treating rheumatic arthritis and the like.

The invention belongs to the field of cosmetics, discloses cream containing plant composition with oil control and anti-acne efficacies and aims to provide cream which is capable of effectively inhibiting excessive oil excretion and minimizing pores to prevent acnes and free of toxic and side effects and skin irritation. The cream is technically characterized by being mainly prepared from, by mass, 1-6% of the plant composition, 0.05-0.1% of o-cymene-5-ol, 2-6% of babassu seed oil glyceryl polyether-8 esters, 1-5% of macadamia seed oil, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.01-0.1% of sodium hyaluronate and 82.5-95.84% of matrix. The plant composition is prepared by compounding of alchemilla japonica extract liquor, basil leaf extract liquor and peanut seed coat extract liquor.

The invention relates to a process for preparing lubricating agent which is used on high-speed conveyer belt production line such as PET bottles, glass bottles, tins and the like, which belongs to the preparation filed of chemical lubricating agent. The components and quality percentages of lubricating agent which are prepared by the process for preparation are that triethanolamine oleate 3-8%, triethanolamine 4-9%, LF-131 2-5%, isothiazolone 1-3%, polymaleic acid 0.5-2%, glucuronidase 4-9%, EDTA-2Na 4-10%, benzotriazole 0.5-2%, sodium dimethyl benzene sulfonate 0.5-2%, H2O 65-75%, the water-base chain lubricating agent has high lubricating property and excellent solubility, which has multinomial excellent properties such as hard water resisting, sterilization, low foaming, non corrosiveness, crack resistance, coagulability resistance and the like, when the lubricating agent is used in lubricating systems, the lubricating system can effectively reduce bottle inversing rate, improve workplace environment and prolong service span of chain mats.

The invention relates to a preparation method of a heart and brain intravascular stent.The heart and brain intravascular stent prepared through the preparation method can solve the problems that in existing intravascular stents, relative displacement occurs between the intravascular stents and vessels, corrosion resistance is poor, vascular functions are deteriorated, and cells are damaged easily to cause vascular sclerosis; the heart and brain intravascular stent is moderate in strength and good in processing plasticity, mechanical strength and the volume can meet the clinic requirements, the surface of the stent is treated, and accordingly the stent can serve as a medicine carrier and position slow-release medicine in a targeted mode.Meanwhile, the preparation method is relatively low in cost, high in manufacturing precision and high in formation efficiency.

The invention discloses a cellulose acetate/polyethylene glycol blood dialysis membrane and a preparation method thereof, and relates to the field of biological materials. The dialysis membrane is a hollow fiber membrane, wherein hollow fiber has a diameter of 0.8 to 4.5 [mu]m, a pore size of 1.4 to 4.8 [mu]m and a wall thickness of 55 to 90 [mu]m. The dialysis membrane is prepared from the following components: cellulose acetate, polyethylene glycol, polymethyl methacrylate, polycaprolactone, tetrahydrofuran and acetone. The preparation method for the cellulose acetate/polyethylene glycol blood dialysis membrane comprises the following preparation steps: (1) preparation of a spinning solution; and (2) electrostatic spinning. The cellulose acetate/polyethylene glycol blood dialysis membrane provided by the invention has excellent biocompatibility and certain anticoagulant and surface adsorptive effects, can improve retention rate of macromolecular protein and is an ideal dialysis membrane material.

The invention belongs to the technical field of oral cavity nursing liquid, and relates to natural active bacterium restraining mouthwash by using marine oligosaccharides as a core component. The mouthwash comprises the components of the marine oligosaccharides, composite vitamins, semen sterculiae lychnophorae, a sweetening agent, a flavoring agent, potassium sorbate and water, wherein the marineoligosaccharides are small-molecular-weight carbohydrate substances extracted from marine animals and plants, and the sweetening agent is stevioside, licorice roots, disodium glycyrrhizinate or tripotassium glycyrrhizinate. The mouthwash disclosed by the invention is wide in application range and convenient to use, has the effects of cleaning teeth, restraining bacteria, resisting viruses, preventing tooth decay and promoting repairing of oral mucosa and does not have any toxic or side effects.

The invention provides an agaric-kelp ferment solution capable of reducing blood lipid and a preparation method thereof. The agaric-kelp ferment solution capable of reducing blood lipid is mainly prepared from, by mass, 50-80% of black agaric and 20-50% of kelp. According to the agaric-kelp ferment solution capable of reducing blood lipid, since the black agaric and kelp can have a synergistic effect, after scientific treatment and reasonable blending, the ferment solution has the advantages of being excellent in taste, suitable for daily drinking and capable of reducing the blood lipid level of a human body, reinforcing the immunity of organisms and promoting the health of a man.

The invention discloses a method for producing nanometer functional sugar. The method comprises the following steps of crushing and processing raw materials in a crushing tube for 60 to 180 minutes; meanwhile, controlling the rotating speed of a stirring rod to be 2000 to 6000 r/min; in addition, controlling the ultrasonic frequency to be about 30k to 90 k Hz; finally, performing refining for 30 to 120 minutes in an airflow crushing machine; finally, obtaining the nanometer functional sugar with the particle diameter being 20 to 40 nm; controlling the molecular weight distribution of the nanometer functional sugar within 10,000 to 20,000 Da. When the nanometer functional sugar is applied to a hyperglycemic product, after the eating, the blood sugar can be obviously reduced; in the dosage range of 0.5g/kg to 2.0g/kg, the hyperglycemic effect is improved along with the dosage; in addition, the nanometer functional sugar is subjected to sulfuric acid esterification modification; the sulfuric acid esterification derivatives with good water solubility are obtained; the sulfuric acid esterification derivatives have the anticoagulation and antithrombus effects.

The invention discloses a preparation method of a sea cucumber egg fermentation product with functions of lowering blood pressure and resisting blood coagulation. The preparation method of the sea cucumber egg fermentation product with the functions of lowering blood pressure and resisting blood coagulation comprises the following steps: washing sea cucumber eggs, and freeze-drying the washed sea cucumber eggs, so that freeze-dried sea cucumber egg powder is prepared for later use; mixing the freeze-dried sea cucumber egg powder with water, adding glucose, and adjusting the initial pH, so that a sea cucumber egg basic culture medium is prepared; sterilizing the basic culture medium; adding a bacillus natto bacterial suspension, and carrying out shaking culturing, so that a sea cucumber egg fermentation broth is prepared; centrifuging the sea cucumber egg fermentation broth, and collecting the obtained supernatant; and then, concentrating the supernatant, and freeze-drying the concentrate, so that the sea cucumber egg fermentation product freeze-dried powder with the functions of lowering blood pressure and resisting blood coagulation is prepared. The sea cucumber eggs are fermented with the bacillus natto according to the preparation method, so that fibrinolytic enzymes with the effect of dissolving thrombus are produced; moreover, polypeptides which are easy to absorb and have the functions of resisting blood coagulation and lowering blood pressure are also produced. The sea cucumber egg fermentation product can be directly eaten as a food, or prepared into health-care functional products after further developments, including concentrating, separating and so on.

The invention discloses a processing method of traditional Chinese medicine Salvia miltiorrhiza Bunge, which comprises the following steps: adding auxiliary material yellow wine to crude Salvia miltiorrhiza Bunge, placing in a closed container, smoldering until the Salvia miltiorrhiza Bunge is moistened, then frying in a pan at 100-110 DEG C for 5 minutes, taking out when the Salvia miltiorrhiza Bunge slices are fried to yellow and have slight wine flavor, and airing to obtain the wine-prepared Salvia miltiorrhiza Bunge slices. Compared with the wine-prepared Salvia miltiorrhiza Bunge slices processed by the traditional method, the wine-prepared Salvia miltiorrhiza Bunge slices processed by the method minimize the loss of active components, can effectively meet the clinical requirements for traditional Chinese medicine Salvia miltiorrhiza Bunge slices, and improve the medicine action and the clinical curative effect.

The invention discloses a halogen coumarins derivative. The derivative is characterized by having a structural formula as follows. The name of the derivative is 4-methyl-7-[6-bromohexyloxy] coumarin. Meanwhile, the invention also discloses a preparation method of the halogen coumarins derivative, specific application of the derivative, and a preparation method of harpacticoida insecticide which contains the derivative serving as a main effective component.