Preparation method for multifunctional hydrogel used for 3D printing

Abstract

The invention provides a preparation method for multifunctional hydrogel used for 3D printing.Raw herbal materials of radix angelica sinensis and radix astragali are mixed and smashed, and then a water-extraction and alcohol-precipitation method is used for extracting radix angelica sinensis and radix astragali polysaccharides; radix angelica sinensis and radix astragali polysaccharide powder is added into a dry reaction kettle, then ethyl alcohol is added, NaIO4 with the mass 0.4-0.6 time that of the radix angelica sinensis and radix astragali polysaccharides is dissolved in 200 ml of water, and the solution is added into a reaction system for reacting for 8 h in a lucifugal state; glycol is added, absolute ethyl alcohol with the volume about 2 times that of the reaction system is added into the reaction system, stirring is carried out for 10 min before suction filtration, then a dialysis bag with the molecular cut-off of 3,500 is used for dialysis for 72 h, drying is carried out for 12 hours at the temperature of 50 DEG C, and oxidized radix angelica sinensis and radix astragali polysaccharides are obtained; the oxidized radix angelica sinensis and radix astragali polysaccharides are weighed and dissolved in distilled water according to the mass-to-volume ratio of 1:20, N,O-carboxymethyl chitosan with the mass 1-3 times that of the oxidized radix angelica sinensis and radix astragali polysaccharides is weighed and dissolved in distilled water according to the mass-to-volume ratio of 1:10, the two solutions are mixed in an isovolumetric mode, standing is carried out for 10 min at room temperature, and the multifunctional radix angelica sinensis and radix astragali polysaccharide gel is obtained.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a preparation method of a multifunctional polysaccharide hydrogel. Background technique [0002] Hydrogel is a kind of multi-component system with a three-dimensional cross-linked network structure, which can be constructed by hydrophilic polymer chains, and a polymer that can be swelled by water but insoluble in water and a medium. It absorbs a large amount of water in water, and can swell rapidly, and after swelling, it can continue to maintain the original structure of the hydrogel without being dissolved, and can respond quickly to subtle changes in the environment, and it has excellent biocompatibility Sex, and similar in nature to the extracellular matrix part, so it is closer to living tissue than many other synthetic biomaterials. Currently commonly used hydrogel materials mainly include polyglycolide, polylactide, polycaprolactone, glycolide-lactide copol...

AI Technical Summary

Problems solved by technology

Currently commonly used hydrogel materials mainly include polyglycolide, polylactide, polycaprolactone, glycolide-lactide copolymer, chitosan, sodium alginate, etc. These gels or histocompatibility Poor, or a single life form, can not meet the requirements of new tissue engineering gel materials, so the development of new, new multifunctional hydrogels with multiple activities is an inevitable demand for the development of gel materials

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