Medical dressing having copper-containing coating and preparation method thereof

A copper coating and medical technology, applied in the field of copper-containing medical dressings, can solve problems such as threats to human health and cytotoxicity, reduce the risk of thrombus and tissue adhesion, prolong the service cycle, and avoid bacterial drug resistance.

Active Publication Date: 2018-09-04
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of clinical results have confirmed the effectiveness of silver-containing dressings in antibacterial aspects, but many studies have proved that the antibacterial performance of pure silver ions is stronger than that of silver complexes, and the complexes are more likely to produce cytotoxicity. The nano-silver dressings developed later There are also nano-scale silver particles that can penetrate the cell wall and enter the blood, enter the blood circulation and deposit in certain organs, posing a risk of threatening human health

Method used

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  • Medical dressing having copper-containing coating and preparation method thereof
  • Medical dressing having copper-containing coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of coatings with gradient copper-loaded particles on medical dressings by layer-by-layer chemical grafting:

[0041] Copper-loaded microspheres with active functional groups such as hydroxyl and carboxyl groups were immobilized on natural degradable chitosan polymers with amino and hydroxyl groups by layer-by-layer chemical grafting, and the amount of copper loaded in each layer was gradient. Copper ions are released through layer gradient, and the biofunctionalization of copper-containing coatings can be adjusted.

[0042] (1) Preparation of copper-loaded microspheres

[0043] ① Weigh 0.05g, 0.2g and 0.5g CuCl 2 , and were dissolved in 5mL distilled water to prepare three homogeneous solutions;

[0044]② Dissolve 1.0 g of PACA in a mixed solution of chloroform and acetone (wherein the volume ratio of chloroform: acetone is 3:2), and prepare a PACA organic solution with a mass volume concentration of 100 mg / mL;

[0045] ③Weigh 1.0g of PVA, dissolve it in ...

Embodiment 2

[0061] Preparation of coatings with gradient copper-loaded microspheres on medical dressings by layer-by-layer electrostatic adsorption method:

[0062] (1) Prepare an aqueous solution of negatively charged sodium hyaluronate (concentration 1-5%), and prepare a hyaluronic acid coating on the inner / outer surface of the medical dressing by extraction;

[0063] (2) Preparation of copper-loaded microspheres

[0064] ①Weigh 0.20g of chitosan in a 250mL single-necked round bottom flask, add 250mL of 2% (mass fraction) acetic acid solution, turn on the electric stirring device and stir slowly until the chitosan is completely dissolved.

[0065] ② Add Span-80 0.4mL and Tween-80 0.6mL while stirring, and continue stirring for 30min to form a uniform, transparent and stable microemulsion. Then add 0.05g copper sulfate powder, stir at high speed to make it spread evenly;

[0066] ③ Then, slowly drop 1mol·L -1 NaOH solution, while stirring at a constant speed, use the PHS-3B precision ...

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Abstract

The invention discloses medical dressing having a copper-containing coating. Different concentrations of copper-loaded microspheres are fixed / dispersed in a gradient manner in a polymer carrier on thesurface of the medical dressing, thereby realizing bio-functionalization of the medical dressing. The fixing method of the functionalized copper-loaded microspheres includes chemical grafting, physical blending, electrostatic action and the like. The medical dressing with the bio-functionalized copper-containing coating is applied to the wound to prevent bacterial proliferation, promote wound healing, promote neovascularization and resist tissue adhesion, thereby preventing infection or difficulty in healing caused by the dressing after attachment to the wound.

Description

technical field [0001] The invention relates to the field of dressing medical devices, in particular to a medical dressing applied to difficult-to-heal wounds, which can isolate and prevent bacteria from invading and multiplying, promote wound healing speed, promote neovascularization and prevent adhesion. Background technique [0002] Dressing, even if it is used as a covering outside the wound, can replace the damaged skin to play a temporary protective role during the wound healing process, avoid or control wound infection, and provide a suitable healing environment for the wounded body surface. Traditional dressings can play a role in monitoring and covering wounds, but cannot be used for infected wounds, have no effect on wound healing, have limited ability to manage exudate, adhere to wounds, damage new epithelial tissue and cause bleeding, and cause pain after dressing changes . In order to provide a good environment for wound healing, reduce scars, and improve user ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/42A61L15/46A61L15/62
CPCA61L15/18A61L15/20A61L15/42A61L15/46A61L15/62A61L2300/102A61L2300/404A61L2300/412A61L2300/42
Inventor 陈姗姗杨柯张炳春杨辉
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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