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Medical dressing with copper-containing coating and method for its preparation

A copper coating and coating technology, applied in medical science, absorbent pads, bandages, etc., can solve problems such as cytotoxicity and threats to human health, prolong the service life, reduce the risk of thrombus and tissue adhesion, and promote wound healing Effect

Active Publication Date: 2021-03-02
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of clinical results have confirmed the effectiveness of silver-containing dressings in antibacterial aspects, but many studies have proved that the antibacterial performance of pure silver ions is stronger than that of silver complexes, and the complexes are more likely to produce cytotoxicity. The nano-silver dressings developed later There are also nano-scale silver particles that can penetrate the cell wall and enter the blood, enter the blood circulation and deposit in certain organs, posing a risk of threatening human health

Method used

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  • Medical dressing with copper-containing coating and method for its preparation
  • Medical dressing with copper-containing coating and method for its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation of coatings with gradient copper-loaded particles on medical dressings by layer-by-layer chemical grafting:

[0041] Copper-loaded microspheres with active functional groups such as hydroxyl and carboxyl groups were immobilized on natural degradable chitosan polymers with amino and hydroxyl groups by layer-by-layer chemical grafting, and the amount of copper loaded in each layer was gradient. Copper ions are released through layer gradient, and the biofunctionalization of copper-containing coatings can be adjusted.

[0042] (1) Preparation of copper-loaded microspheres

[0043] ① Weigh 0.05g, 0.2g and 0.5g CuCl 2 , and were dissolved in 5mL distilled water to prepare three homogeneous solutions;

[0044]② Dissolve 1.0 g of PACA in a mixed solution of chloroform and acetone (wherein the volume ratio of chloroform: acetone is 3:2), and prepare a PACA organic solution with a mass volume concentration of 100 mg / mL;

[0045] ③Weigh 1.0g of PVA, dissolve it in ...

Embodiment 2

[0061] Preparation of coatings with gradient copper-loaded microspheres on medical dressings by layer-by-layer electrostatic adsorption method:

[0062] (1) Prepare an aqueous solution of negatively charged sodium hyaluronate (concentration 1-5%), and prepare a hyaluronic acid coating on the inner / outer surface of the medical dressing by extraction;

[0063] (2) Preparation of copper-loaded microspheres

[0064] ①Weigh 0.20g of chitosan in a 250mL single-necked round bottom flask, add 250mL of 2% (mass fraction) acetic acid solution, turn on the electric stirring device and stir slowly until the chitosan is completely dissolved.

[0065] ② Add Span-80 0.4mL and Tween-80 0.6mL while stirring, and continue stirring for 30min to form a uniform, transparent and stable microemulsion. Then add 0.05g copper sulfate powder, stir at high speed to make it spread evenly;

[0066] ③ Then, slowly drop 1mol·L -1 NaOH solution, while stirring at a constant speed, use the PHS-3B precision ...

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Abstract

The invention discloses a medical dressing with a copper-containing coating. The copper-loaded microspheres of different concentrations are gradiently fixed / dispersed in the polymer carrier on the surface of the medical dressing in a certain way, so as to realize the biofunctionalization of the medical dressing. Among them, the immobilization methods of functionalized copper-loaded microspheres include chemical grafting, physical blending, electrostatic interaction and the like. This dressing with a biofunctional copper-containing coating can resist bacterial proliferation, promote wound healing, promote neovascularization and resist tissue adhesion after the dressing is attached to the wound, so as to avoid infection after the dressing is attached to the wound Or problems such as difficulty healing.

Description

technical field [0001] The invention relates to the field of dressing medical devices, in particular to a medical dressing applied to difficult-to-heal wounds, which can isolate and prevent bacteria from invading and multiplying, promote wound healing speed, promote neovascularization and prevent adhesion. Background technique [0002] Dressing, even if it is used as a covering outside the wound, can replace the damaged skin to play a temporary protective role during the wound healing process, avoid or control wound infection, and provide a suitable healing environment for the wounded body surface. Traditional dressings can play a role in monitoring and covering wounds, but cannot be used for infected wounds, have no effect on wound healing, have limited ability to manage exudate, adhere to wounds, damage new epithelial tissue and cause bleeding, and cause pain after dressing changes . In order to provide a good environment for wound healing, reduce scars, and improve user ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/42A61L15/46A61L15/62
CPCA61L15/18A61L15/20A61L15/42A61L15/46A61L15/62A61L2300/102A61L2300/404A61L2300/412A61L2300/42
Inventor 陈姗姗杨柯张炳春杨辉
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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