The invention relates to the field of the formula of the traditional Chinese medicine, in particular to Chinese ephedra and perilla fruit decoction used for chronic bronchitis. The preparation method comprises the following steps: grinding aquilaria wood into fine medicinal powder for standby, soaking Chinese ephedra, wild ginger, white paeony root, cassia twig, licorice, pinellia ternata, schisandra fruit, almond, baikal skullcap root, dandelion, isatis leaf, orange twig, ginger and perilla seed by water, decocting, removing residues to obtain filtrate, then adding the fine powder of the lignum aquilariae resinatrm into the filtrate, and boiling off. The decoction comprises the following raw materials, by weight percent: 12-15% of Chinese ephedra, 3-4% of wild ginger, 6-8% of white peony root, 6-9% of cassia twig, 4-5% of licorice, 5-7% of pinellia ternata, 4-6% of schisandra fruit, 3-5% of almond, 4-7% of baikal skullcap root, 5-7% of dandelion, 6-8% of isatis leaf, 9-12% of radix platycodi, 5-7% of ginger, 3-5% of lignum aquilariae resinatrm and 9-12% of perilla fruit. The invention has high curative effect for treating the chronic bronchitis and no toxic or side effect and has the functions of diminishing inflammation, resisting infection, relieving bronchial spasm, clearing away the lung-heat, resolving phlegm, resolving drinks, stopping asthma, promoting the dispersing function of the lung and relieving asthma.