Lactobacillus plantarum with functions of losing weight and reducing lipid and application thereof

A technology of Lactobacillus plantarum and lipid-lowering, which is applied in the field of microorganisms and can solve problems such as endocrine disorders

Active Publication Date: 2020-10-20
江苏新申奥生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to suppress obesity, currently available weight loss drugs on the market are lipid absorption inhibitors or diuretics, but their side effects can cause endocrine disorders

Method used

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  • Lactobacillus plantarum with functions of losing weight and reducing lipid and application thereof
  • Lactobacillus plantarum with functions of losing weight and reducing lipid and application thereof
  • Lactobacillus plantarum with functions of losing weight and reducing lipid and application thereof

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Experimental program
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Effect test

Embodiment 1

[0033] 1. Materials and Methods

[0034] 1.1 Experimental strain

[0035] Lactobacillus plantarum HFY15 was isolated from yak yogurt in Sichuan Province, China. It was identified as lactic acid bacteria, LAB by 16S rDNA sequence. Center (CGMCC for short, address: Institute of Microbiology, Chinese Academy of Sciences, No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing), and the deposit registration number is CGMCC No.16648.

[0036] The Lactobacillus plantarum HFY15 isolated and purified from yak yoghurt samples showed positive Gram staining; the color of the colonies was mostly white or milky white, round in shape, with neat edges, and a moist and smooth surface. There are long rods, short rods, and spherical shapes, and there is no budding.

[0037] The 16S rDNA base sequence of the bacterial strain HFY15 of the present invention is shown in SEQ ID No.1; the sequencing results are compared on the NCBI website (http: / / blast.ncbi.nlm.nih.gov / Blast.cgi) . Same as ...

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Abstract

The invention discloses lactobacillus plantarum with functions of losing weight and reducing lipid and an application thereof, and belongs to the technical field of microorganisms; the lactobacillus plantarum LP-KFY04 is lactic acid bacteria (LAB), and the preservation number is CGMCC No. 15651; lactobacillus plantarum KFY04 is separated from yoghourt and is used for mice maintaining 45% fat diet;then liver and serum samples are obtained, and gene expression related to the TG level, oxidation, inflammation and PPAR pathway is detected to evaluate the influence of LP-KFY04 on obesity, oxidation and inflammation; and results show that the LP-KFY04 can be used for relieving obesity of mice induced by high fat diet, and the LP-KFY04 can effectively reduce liver injury and fat accumulation caused by obesity.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a lactobacillus plantarum with the function of reducing weight and fat and its application. Background technique [0002] Probiotic microorganisms, including Lactobacillus, Bifidobacterium, Lactococcus, Enterococcus and other lactic acid bacteria, mainly colonize the human intestinal tract and can improve the intestinal microbial balance and exert beneficial effects. In food, lactic acid bacteria are used for fermentation and have received much attention in recent years due to their functional roles. In addition, when lactic acid bacteria are used for the fermentation of raw milk, antibacterial substances such as organic acids, hydrogen peroxide, and diacetyl are produced to prevent the deterioration of dairy products by preventing the growth of pathogenic bacteria. In addition, many studies have shown that lactic acid bacteria can improve intestinal function and enhance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61P3/04A23L33/135C12R1/25
CPCA61K35/747A61P3/04A23L33/135A23V2002/00C12R2001/25C12N1/205A23V2400/169A23V2200/332
Inventor 赵欣
Owner 江苏新申奥生物科技有限公司
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