The invention relates to an anti-infection bio-derived
hernia and body wall
repair material, a preparation and an application thereof, the
repair material comprises a small intestinal submucosal
acellular matrix (SIS) with the thickness of 80mu m-100mu m and nano-
silver particles which are implanted in the SIS. The preparation method comprises the steps of preparing the nano-
silver particles into working solution with the concentration of 50ppm-500ppm, carrying out flat immersion into the SIS under the conditions that the volume ratio of working solution / SIS is 100-120:1, the temperature is 37 DEG C and the CO2 concentration is 5% and turning over the SIS at 1 time / 30 minutes, thereby obtaining the nano-silver SIS. The
repair material has the advantages of safety, no
toxicity, anti-infection property, high tissue affinity, absorbability, rapid tissue regeneration, light adhesion, low
hernia recurrence rate and the like, the anti-infection property is characterized by high efficiency, durability, broad antibacterial spectrum, no
drug resistance and the like, and the
composite material can be applied in repair of body wall wounds, fascial defects or
hernia accompanied with
contamination or infection.