10 results about "Acute wound" patented technology

This invention belongs to the field of traditional Chinese medicine adhesive bandage technology, specifically relating to a Shengji Yuhong Ointment, its preparation method, and a medicated film adhesive bandage. The Shengji Yuhong Ointment has a hydrogel structure, comprising raw materials, a gel matrix, and nano-zinc oxide or silver sulfadiazine nanoparticles. The raw materials include the following components by weight: 13-17 parts Angelica dahurica, 34-38 parts Glycyrrhiza uralensis, 58-62 parts Angelica sinensis root, 10-14 parts Dragon's Blood, 4-8 parts Lithospermum erythrorhizon, and 0.2-0.25 parts Musk-β-cyclodextrin inclusion complex powder or Musk nanoliposome powder. The matrix comprises the following components by weight: 245-255 parts sesame oil, 57-63 parts beeswax, 93-103 parts polymer material, 37-43 parts plasticizer, 3-8 parts penetration enhancer, and 0.8-1.2 parts preservative. The Shengji Yuhong Ointment of this invention is used in medicated film adhesive bandages, is convenient to use, and is particularly suitable for chronic, difficult-to-heal ulcers and acute wounds requiring accelerated healing.

The technology presented herein, in general, relates to the use of biosurfactants, such as rhamnolipids, for treating and / or accelerating the healing of wounds. More particularly, the present technology relates to a method for treating chronic and acute wounds, by applying a composition comprising a mixture of rhamnolipids to the wound, wherein application of the composition facilitates coordinated gene expression associated with wound healing.

The invention belongs to the field of biomedical materials, and particularly relates to a composite nanofiber capable of stopping bleeding, resisting bacteria and promoting vascular wound repair as well as a preparation method and application of the composite nanofiber. The composite nanofiber comprises a fiber matrix and copper tannic acid nanoparticles, wherein the fiber matrix is composed of a hydrophilic polymer and zein, and the copper tannic acid nanoparticles are loaded on the fiber matrix. The composite nanofiber can generate active oxygen and release copper ions for synergistic sterilization, angiogenesis is facilitated, wound healing is promoted, excellent biocompatibility is shown, the composite nanofiber is suitable for wounds of different sizes and depths, safe, hemostatic, antibacterial and wound repair customized management promotion can be achieved, and the application prospect is wide. A solution is provided for rapid hemostasis, antibiosis and wound healing of acute wounds.

This application discloses a method for preparing a novel topical Tiger Yellow Healing Traditional Chinese Medicine (TCM) preparation for treating wounds, comprising the following steps: S1, preparation of medicinal materials: Seven medicinal materials powders are obtained by grinding or pulverizing Bauhinia bark, Astragalus membranaceus, Angelica pubescens, Saxifraga stolonifera, Paeonia lactiflora, Acorus tatarinowii, and Angelica dahurica; S2, preparation of homologous carbon quantum dots; S3, preparation of a TCM compound; S4, mixing the homologous carbon quantum dots obtained in step S2 with the TCM compound obtained in step S3, dialysis the mixture with distilled water to remove unloaded small molecules of the TCM compound, and then drying to obtain the Tiger Yellow Healing TCM preparation. This application also provides an application of this novel topical Tiger Yellow Healing TCM preparation for treating wounds. This application is the first to propose a method for preparing a TCM compound loaded with homologous carbon quantum dots, increasing the efficacy of the TCM compound itself. It can be used to treat various acute wounds and chronic, difficult-to-heal wounds, promote rapid wound healing, and has good antibacterial, antioxidant, and wound angiogenesis effects.

The invention discloses a composite bacterial cellulose dressing as well as a preparation method and application thereof, and belongs to the technical field of medical dressings. The preparation method of the composite bacterial cellulose dressing comprises the following steps: S1, treating a bacterial cellulose membrane with an alkaline solution and an acidic solution in sequence, and then cleaning until the pH value is nearly neutral to obtain a purified bacterial cellulose membrane; s2, placing the purified bacterial cellulose membrane between two layers of support materials, and dehydrating to obtain a primary dressing; s3, the primary dressing is soaked in a solution containing cationic polysaccharide, sterilization is conducted, and the composite bacterial cellulose dressing is prepared. The composite bacterial cellulose dressing can effectively maintain the physical and chemical stability of cationic polysaccharide, can effectively promote the healing of wounds, especially acute wounds and chronic refractory wounds, and shortens the wound healing time.

A preparation method of a pH response cotton swab for wound infection monitoring, first, natural cotton fibers are soaked in a bromocresol green solution for dyeing, and the color of the bromocresol green solution is blue during the dyeing process; the soaked natural cotton fibers are rinsed with a buffer solution; then, the excess buffer solution is squeezed out, the natural cotton fibers are dried, and orange-yellow natural cotton fibers are obtained; finally, the dried natural cotton fibers are fixed on the top end of a thin rod, and the pH response cotton swab is obtained. The color change of the pH response cotton swab after wiping the wound is used to quickly judge the type of wound infection of the patient, the pH value of 4.0-6.0 corresponds to acute wounds, the pH value of 7.0-10.0 corresponds to chronic wounds, corresponding treatment strategies are adopted based on the type of wound, which helps to improve the work efficiency of medical staff; at the same time, compared with the traditional form of dressing, the cotton swab avoids the secondary infection risk caused by multiple times of uncovering the dressing.

The invention discloses mussel mucoprotein water and a preparation process thereof, and the mussel mucoprotein water comprises the following components in parts by mass: 5-12 parts of mussel mucoprotein; 3 to 8 parts of a hydroxylated chitosan-polyethylene glycol grafted copolymer; 4 to 9 parts of modified sodium alginate; 2 to 6 parts of beta-cyclodextrin embedded theabrownin; 1 to 4 parts of nano hydroxyapatite; 1-3 parts of glycerol; 60 to 85 parts of deionized water; through the synergistic effect of the four innovative components and the mussel mucoprotein, the dressing has excellent biological adhesion, mechanical properties, antibacterial and anti-inflammatory properties and healing promotion effects, and the problems that an existing dressing is single in function and insufficient in performance are solved; the adopted raw materials are natural high polymer materials or modified products with excellent biocompatibility, and after purification treatment, the impurity content is low, the biological safety is high, and no obvious toxic or side effect exists; the prepared hydrogel dressing is good in moisture retention and air permeability, can meet the healing requirements of various acute wounds and chronic wounds, and has wide clinical application prospects.

The present invention relates to the therapeutic use of a composition for the treatment of cutaneous wounds such as acute wounds, chronic wounds or epidermolysis bullosa wounds. The composition according to the invention is based on ABA-type triblock copolymers, comprising two thermoplastic styrene end blocks A and an elastomeric central block B which is a saturated olefin, comprising at least one resin selected from aromatic resins usable in particular for producing an interface dressing with a framework or support or self-supporting.

The invention provides a hemostatic hydrogel for wound hemorrhage. The hemostatic hydrogel is prepared from the following components in parts by mass: 15 to 18 parts of cationic cassava starch, 9 to 15 parts of polyvinyl alcohol, 5 to 8 parts of oxidized konjac glucomannan, 0.1 to 0.2 part of cannabidiol, 1.5 to 2.5 parts of polydopamine nanoparticles, 0.5 to 0.8 part of panax notoginseng saponins and 2 to 4 parts of polyethylene glycol diacrylate. The hydrogel has the advantages of being rapid in gelling and high in blood coagulation efficiency, is suitable for scenes with massive hemorrhage of wounds, such as acute wound surfaces of accidental incisions, scratches and the like, and environments with limited medical resources, such as fields, battlefields, severe accident and disaster sites, can be used as a first-line first-aid material, rapidly realizes hemostasis and infection resistance, relieves pain of the wounded, and has a good application prospect. The injury condition is stabilized.

The application discloses two peptide segments derived from Cervus elaphus Linnaeus and application of the two peptide segments in promoting wound healing. Amino acid sequences of the two peptide segments are Gly-Ser-Phe-Pro-Trp-Gln-Ala-Lys (SEQ ID NO:1) and His-Ser-Trp-Ala-Val-Pro-Ser-Leu (SEQ ID NO:2) respectively. In-vitro experiments show that the two peptide segments can significantly promote proliferation and migration of human umbilical vein endothelial cells and mouse skin fibroblasts; in-vivo mouse acute wound model experiments prove that the two peptide segments can effectively accelerate the healing process of mouse acute wounds, have excellent biological activity of promoting acute skin wound healing, and have a good application prospect in development of drugs and functional products related to wound repair.