52 results about "Acute wound" patented technology

A bandage of the type used on acute wounds, minor wounds, burn wounds and irritations, includes a first layer for covering the wound site and an area around the wound site, with the first layer including a top surface and bottom surface; a second layer over the first layer bottom surface, for absorbing exudates from the wound site; the second layer including a poly(ethyleneoxide)-based compound and a chitosan-based compound. A third layer is situated over the second layer, the third layer being of a perforated film, and wherein, at least one antimicrobial agent is associated with the bandage in a position where the antimicrobial agent will come in contact with the wound site, and which is transferable from the bandage to the wound site, upon contact with the wound site.

A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.

A composition for repairing and cicatrization of cutaneous lesions of chronic or acute wounds including a hydrogel of chitosan, the degree of acetylation of which is no greater than about 40%.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and / or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.

Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating acute wounds, chronic wounds and / or a wound or epithelial tissue surface that contains bacterial biofilm, including unexpected synergy between bismuth-thiol (BT) compounds and certain antibiotics, to provide topical formulations including antiseptic formulations, for management and promotion of wound healing and in particular infected wounds. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating gram-negative bacterial infections.

The present invention provides novel compositions which comprise sodium hypochlorite, sodium, chloride, both organic and inorganic trace minerals in hypertonic condition presented in the forms of a clear aqueous solution (low or high concentrations for further reconstitution with purified water to obtain the final ready-to-use solution), gel or salve, lotion, wet pad, wet foam, ointment, stick, and dry mixture solution, for local application for the purposes of cleansing, disinfecting and inhibiting infection and promoting the natural healing of conditions such as fresh cuts, surgical stitches, chronic (diabetic gangrene) and acute wounds, herpes zoster, athlete's foot, and bed sores, without the necessity for covering up the wounds with gauzes / plasters nor any concurrent use of topical medication. These compositions are also suitable for the treatment of conditions such as unpleasant body odor, acne and mixed bacterial infection in the ear.

The invention relates to biological powder medical dressing and a preparation method thereof. The biological powder medical dressing is prepared by using main raw materials of chitosan, alginate, collagen peptide, epidermal growth factor (EGF), sodium carboxymethylcellulose (CMC) and pectin; the preparation method comprises the following steps: step 1, the chitosan, the collagen peptide and the epidermal growth factor are weighed in parts by weight, are fully stirred in a stirrer, and are mixed in solid powder to form a component A; step 2, the sodium carboxymethylcellulose, the pectin and the alginate are weighed in parts by weight at the normal temperature, and are mixed in solid powder; step 3, a mixed component B is slowly added in the component A for stirring; and step 4, biological powder is radiated for disinfecting to prepare the product. The method has the characteristics of reasonable technique process and high product yield; the biological powder medical dressing has simple preparation method and good stability, and is suitable for nursing acute wounds and chronic wounds in different periods.

The invention discloses ozonized borneol tea oil. The ozonized borneol tea oil comprises ozone, borneol and tea oil; the tea oil per 1L includes 30 to 50g of borneol; the total input of ozone in tea oil per 1L is controlled to be 13.5 to 20.0g under temperature of 25 to 30 DEG C and pressure of 0.5 to 1.5bar. According to the ozonized borneol tea oil, the raw materials are cheap and easy to be obtained, the antibacterial effect can be obviously improved, the effects of diminishing inflammation, relieving pain and sterilizing are great, the wound healing is effectively promoted, the recovery of patients is sped up, a patient can easily accept, the ozone can be stably and slowly released, escherichia coli, staphylococcus aureus, candida albicans and the like can be eliminated within a short time, and good effect is particularly shown on treating chronic wounds like diabetic foot and acute wounds.

The invention belongs to the technical field of synthetic macromolecule biological materials, and discloses a preparation method of polysiloxane supermolecule elastomer wound dressing containing a PEG (polyethylene glycol) block. The preparation method comprises the following steps: firstly, synthesizing a carboxyl-terminated triblock copolymer containing a polysiloxane block and the PEG block; then, synthesizing the triblock copolymer into a hydrogen-bond cross-linking type supermolecule elastomer based on a PDMS-b-PEG-b-PDMS triblock copolymer through a two-step reaction with diethylenetriamine and urea; a thin film prepared by performing hot press molding on the elastomer has good water absorptivity and breathability, and by using the thin film as acute wound dressing, the growth and regeneration of wounded tissues are facilitated and the healing of a wound can be accelerated. According to the preparation method, polysiloxane and PEG are taken as raw materials, cytotoxicity and skin irritation are avoided and the biocompatibility is good.

A hemostatic tissue sealant sponge and a spray for acute wounds are disclosed. The sponge comprises hydrophobically modified polymers that anchor themselves within the membrane of cells in the vicinity of the wound. The seal is strong enough to substantially prevent the loss of blood inside the boundaries of the sponge, yet weak enough to substantially prevent damage to newly formed tissue upon recovery and subsequent removal of the sponge. In examples, the polymers inherently prevent microbial infections and are suitable for oxygen transfer required during normal wound metabolism. The spray comprises hydrophobically modified polymers that form solid gel networks with blood cells to create a physical clotting mechanism to prevent loss of blood. In an example, the spray further comprises at least one reagent that increases the mechanical integrity of the clot. In another example, the reagent prevents microbial infection of the wound.

A wound dressing is which has haemostatic, coagulation-promoting and biocidal properties and can therefore be utilized particularly for acute wound care. Typical areas of application for acute wound care are, for example, the treatment of gunshot wounds. The wound dressing features selected halloysites which, for example, are applied to textile fibers or non-woven materials.

The invention discloses a compound growth factor of blood platelet sources as well as a preparation method and application of the compound growth factor. According to the compound growth factor as well as the preparation method and the application of the compound growth factor, platelet-rich plasma as the raw material is firstly subjected to virus inactivation through an S / D (Solvent / Detergent) method to remove such reagents as organic solvents and eradicators in the platelet-rich plasma and then activated by adding calcium or / and thrombin, supernatant fluid after activation is extracted to obtain the compound growth factor fitting for the natural proportion of the human body; and the problems that single recombinant growth factors in clinic are high in price, and difficult to purify, is involved into gene recombination biological safety and on the like are overcome. The invention further discloses a compound growth factor gel obtained based on the compound growth factor by adding chitosan microspheres carriers, which can slowly release growth factors during use. The compound growth factor has remarkable treatment effects for acute wounds, burns, cosmetic treatment, and chronic hard-healing wounds, is convenient to use, and has high safety.

Disclosed are compositions and methods for wound care, especially for treatment of chronic wounds. Compositions are methods are described for inhibiting reconstitution of biofilm in a chronic wound or preventing expansion of a biofilm in a chronic or acute wound.

The invention discloses a skin wound repair peptide RL-RF10. An amino acid sequence contained in the repair peptide RL-RF10 is RFCFKGTPCG, and the invention also discloses a purification method and application of the repair peptide RL-RF10. The skin wound repair peptide RL-RF10 disclosed by the invention can be used for remarkably promoting healing of skin acute wounds and reducing scar generation, has the capacity of promoting dental ulcer repair and chronic wound healing, is one of the strongest active substances for promoting skin repair in the world, and has wide application prospects.

The invention relates to a supersonic wave device used for improving acute wound debridement efficiency. The supersonic wave device comprises a host computer (16), a pump (12), a supersonic wave probe (1), a probe front end face (2), a probe front end face side face (3) and an inner probe through hole (4). The supersonic wave device is characterized in that the probe front end face side face (3) is provided with multiple tooth type cones (5), and front side faces of the tooth type cones are processed to be front inclination angles. Compared with the prior art, the mechanical fragmentation effect of a debridement cutter is fully performed, and wound debridement efficiency is greatly improved.

The invention relates to a natural polymer liquid spray for wound protection, which aims to use non-toxic natural polymer material carboxymethyl chitosan as a raw material, supplemented by a low-concentration bifunctional siloxane coupling agent , the two solutions are sprayed onto the wound surface at the same time, and through the rapid cross-linking reaction of the two, a layer of polymer film is formed within 1 min. Promote wound healing to a great extent. This novel, efficient, safe and convenient drug for skin wounds has broad application prospects in acute wound treatment.

The present invention relates to absorbent dressings comprising sidebands coated with adhesive silicone, which are particularly suitable for surgical treatment of chronic wounds such as ulcers or eschars or acute wounds such as burns. care. The absorbent dressing comprises a breathable and impermeable backing (4) and an absorbent non-woven fabric (6). The backing is formed by assembling a continuous membrane (4a) and a grid-like reinforcement (4b), which is treated with an adhesive silicone gel in such a way that the pores in the reinforcement are not blocked. coated. The non-absorbent web (5) is fixed to the complementary non-woven fabric (7) so as to wrap the above-mentioned absorbent non-woven fabric (6) in such a way that it is not fixed to the absorbent non-woven fabric (6) at any point. The wrapped absorbent nonwoven was then assembled to the backing (4) along a portion of the silicone-coated backing surface.

The present invention relates to methods and compositions that control, i.e., antagonize / inhibit or agonize / stimulate, de novo glucocorticoid production in the skin. Such methods and compositions can be used for the prevention and / or treatment of a variety of skin conditions, including inflammation, acute wounds, chronic non-healing wounds, keloid, fibrotic or hypertrophic scars, and epithelial-derived cancer.

The invention discloses a preparation method for a composite micro-sphere for stopping bleeding in clinical operation. The preparation method for the composite micro-sphere for stopping bleeding in the clinical operation mainly includes that adding water to a crosslinked chitosan wet micro-sphere to prepare into crosslinked chitosan wet micro-sphere solution with concentration 1.5-2.5% (W / V), adding water to a crosslinked starch micro-sphere to prepare into crosslinked starch micro-sphere solution with concentration 10-20% (W / V), mixing according to the volume ratio of 5: 5, 6: 4, 7: 3 or 8: 2, using ultrasonic wave to enable the solution to mix uniformly, using a high-speed centrifugal machine to centrifuge for 30 minutes, defoaming, solidifying in NaOH solution with mass concentration 0.5% under aseptic condition, using alcohol to dehydrate, using injection water to wash, drying at 30 to 40 degrees centigrade to realize a semi-dry state, dehydrating, washing, solidifying, spraying and drying, and packaging and sterilizing through cobalt 60 to obtain the composite micro-sphere for stopping bleeding. The average diameter of the composite micro-sphere for stopping bleeding is 600 to 900 micrometers, the average pore size is 50 to 100 micrometers, and the specific surface area arrives at 720.8-810.2 m2.g -1; the composite micro-sphere for stopping bleeding is capable of absorbing and degrading biological material and stopping the bleeding of various wound and the acute wound bleeding regions of fresh operation tissues.

The present invention provides a method of making a wound treatment composition, wherein the method comprises; i) fractionating a whole blood sample into multiple samples including a platelet rich plasma (PRP) sample,a platelet poor plasma (PPP) sample and a erythrocyte sample, wherein the PRP sample has a haematocrit level of 1-10%, ii) processing a portion of the PPP and / or PRP sample to facilitate cleavage of autologous pro-thrombin present in the PPP and / or PRP to produce autologous thrombin, and iii) combining the PRP sample with a portion of the PPP sample and a portion of the thrombin produced in step (ii) to produce the wound treatment composition; wherein step ii) is performed at less than 15 DEG C. In preferred embodiments the PRP has a haematocrit level of 2% or 8%. Wound treatment compositions produced by the methods are also provided as are compositions for use in treating chronic and acute wounds.

The invention relates to a novel medical operation glue liquid and a preparation method thereof, and the novel medical operation glue liquid comprises the following components by weight: 100 parts of medical grade injection water, 1-10 parts of sodium carboxymethyl cellulose, 0.3-20 parts of calcium alginate and 2-40 parts of a medical polylactic acid modified polyether type waterborne polyurethane material. The novel medical operation glue liquid is packed by a sterile medical infusion bottle, is simple and easy to use, can be saved in the environment at room temperature for 24 months without losing efficacy, and has good flushing and hemostatic effects on surgical entocoele and acute wounds, the novel medical operation glue liquid is a human body-absorbable material without side effects and bio-risks, and after flushing, the novel medical operation glue liquid can form a tough protective film on the surface of the wounds, and has good anti infection, adhesion-preventing and wound healing accelerating effects.

The invention provides a transparent waterproof dressing. The waterproof dressing is composed of a wound contact layer, a porous foam pad and a breathable film. The breathable film can prevent liquidand bacteria from permeating and prevent the wound from being polluted by the outside; due to the net-shaped design of the porous foam pad, the wound part and the surrounding skin of the wound part can be directly checked under the condition that the dressing is not replaced; and the surface of the dressing in contact with the wound and the skin is coated with an adhesive. The dressing is used foracute wounds with seepage levels from low to medium, such as postoperative wounds, wounds, small incisions, abrasion, scratching or cutting, puncture wounds, tearing wounds and first-degree or shallow second-degree burns and scalds.

The invention relates to biological powder medical dressing and a preparation method thereof. The biological powder medical dressing is prepared by using main raw materials of chitosan, alginate, collagen peptide, epidermal growth factor (EGF), sodium carboxymethylcellulose (CMC) and pectin; the preparation method comprises the following steps: step 1, the chitosan, the collagen peptide and the epidermal growth factor are weighed in parts by weight, are fully stirred in a stirrer, and are mixed in solid powder to form a component A; step 2, the sodium carboxymethylcellulose, the pectin and the alginate are weighed in parts by weight at the normal temperature, and are mixed in solid powder; step 3, a mixed component B is slowly added in the component A for stirring; and step 4, biological powder is radiated for disinfecting to prepare the product. The method has the characteristics of reasonable technique process and high product yield; the biological powder medical dressing has simple preparation method and good stability, and is suitable for nursing acute wounds and chronic wounds in different periods.

A nutritional composition for promoting wound healing comprises a protein source, a lipid source and a carbohydrate source wherein no more than 1.8% of the total calories of the composition derive from arginine and wherein the protein source includes proline in an amount of at least 3% of the total calories of the composition. The composition may be administered orally and is particularly suitable for the amelioration of pressure ulcers although it may also be used with advantage in the nutritional management of acute wounds including pre and post surgery.

The invention discloses a high-affinity liquid dressing capable of taking effect quickly, and the formula of the high-affinity liquid dressing capable of taking effect quickly comprises the following components: 1.3-2.5% of a composite bacteriostatic agent, 0.2-1.5% of a film-forming agent, 0.02-0.1% of a pain-relieving agent, 8-10% of a calcium and silicon ion bioactive buffer solution, 0.5-20% of a modified bioactive glass loaded molecular sieve, 1.2-6% of a humectant, 0.2-1.5% of absolute ethyl alcohol, and the balance of water. And the balance of deionized water. The compound bacteriostatic agent is formed by compounding a plant extraction bacteriostatic agent which is one of NADOVEC or NADOVAC with at least one of octenidine hydrochloride, polyhexamethylene biguanide and polyhexamethylene biguanide. By means of the mode, the antibacterial wound dressing has good biocompatibility, an antibacterial protection layer can be formed on the surface of a wound surface, rapid liquid absorption and hemostasis of the wound are promoted, healing is accelerated, and the antibacterial wound dressing is especially suitable for collaborative nursing of various acute wounds and chronic wounds after debridement; finished products which can be manufactured by the method comprise but not limited to functional dressings of mechanical font sizes and disinfection articles for eliminating font sizes.