22 results about "Acute wound" patented technology

The invention discloses a pseudo-ginseng exosome-like nano vesicle loaded with an epidermal growth factor / application of the pseudo-ginseng exosome-like nano vesicle in wound healing. The research shows that not all exosome-like nano-vesicles from Chinese herbal medicines capable of promoting wound healing have the effect of promoting wound healing, the action mechanism of the pseudo-ginseng exosome-like nano-vesicles in wound healing is further explored, and the research shows that PNVs can promote the proliferation and migration of an epidermal keratinocyte line, so that the PNVs can be used for promoting the healing of the wound. The treatment can be realized by regulating and controlling the activity of immune cells to promote cell proliferation and migration, and the wound healing effect of the EGF-loaded EGF-coated PNVs is remarkably enhanced, so that the EGF-loaded EGF-coated PNVs have a synergistic effect. The invention not only provides a theoretical basis for deeply researching PELNVs, but also provides a new method and a new idea for treating acute wounds.

The invention relates to a device that enables and accelerates wound healing by generating a controlled vacuum used in the healing of chronic and acute wounds and protects the wound area from external effects, and a method for operating said device.

This invention belongs to the field of traditional Chinese medicine adhesive bandage technology, specifically relating to a Shengji Yuhong Ointment, its preparation method, and a medicated film adhesive bandage. The Shengji Yuhong Ointment has a hydrogel structure, comprising raw materials, a gel matrix, and nano-zinc oxide or silver sulfadiazine nanoparticles. The raw materials include the following components by weight: 13-17 parts Angelica dahurica, 34-38 parts Glycyrrhiza uralensis, 58-62 parts Angelica sinensis root, 10-14 parts Dragon's Blood, 4-8 parts Lithospermum erythrorhizon, and 0.2-0.25 parts Musk-β-cyclodextrin inclusion complex powder or Musk nanoliposome powder. The matrix comprises the following components by weight: 245-255 parts sesame oil, 57-63 parts beeswax, 93-103 parts polymer material, 37-43 parts plasticizer, 3-8 parts penetration enhancer, and 0.8-1.2 parts preservative. The Shengji Yuhong Ointment of this invention is used in medicated film adhesive bandages, is convenient to use, and is particularly suitable for chronic, difficult-to-heal ulcers and acute wounds requiring accelerated healing.

The present invention discloses a recombinant human FGF4 protein, which is an amino acid sequence as shown in SEQ ID NO: 1, 2, 3 or 4, or a protein derived from the above amino acid sequence by substitution, deletion or addition of one or several amino acids and having the activity of a recombinant human FGF4 protein; the activity of the protein provides a function capable of promoting keratinocyte migration. The present invention also discloses the use of the recombinant human FGF4 protein or a composition thereof in the preparation of a drug or kit capable of promoting keratinocyte migration and promoting skin wound recovery. The present invention discovered through in vivo and in vitro pharmacological experiments that the recombinant human FGF4 protein (rFGF4) can promote keratinocyte migration, significantly promote the healing of acute wounds and chronic diabetic wounds, and improve the quality of wound healing. Therefore, FGF4 can be prepared for use in skin wounds, especially chronic, refractory wounds.

The invention discloses a method for scar-free healing in treatment of wounds / wounds by miR-185-5p, relates to the field of biological medicine and plastic surgery and beauty repair, and comprises application of scar-free healing in acute / subacute / chronic wounds related to any skin injury (including burn, laceration, bruise, operation, perforation and vaccination) of deep dermis. Wound healing is a series of complex and elaborately-planned overlapping stages arranged according to a time sequence, wherein the stages comprise four stages of hemostasis, inflammation, proliferation and remodeling. No matter at any stage, the skin stability after wound healing and whether scars are formed or not can be directly influenced. The miR-185-5p is used in an animal skin model caused by an acute wound, so that the wound healing time is integrally shortened, the reepithelization formation of the wound is promoted, the number of skin appendages is increased, and the regeneration of hair follicles is promoted. The secretion amount of the collagen I is reduced, and the formation of the collagen III is improved.

The utility model relates to a table-type negative pressure wound therapeutic apparatus, which comprises a front cover, a back cover and a drainage box which are connected in sequence, and a control panel, a diaphragm pump, a fixed support, a pressure relief valve, a battery pack and a negative pressure tube which are arranged between the front cover and the back cover, and a key panel electrically connected with the control panel is arranged on the outer side of the front cover; through the combined action of the diaphragm pump and the pressure relief valve, the air pressure sensor detects the internal air pressure and feeds back the internal air pressure in real time, the air pressure value is controlled within a specified range, a continuous or intermittent negative pressure mode is met, and the negative pressure type negative pressure negative pressure device is suitable for various treatment modes such as acute wounds, non-acute wounds, diabetic feet, chronic ulcers and burn wounds.

The technology presented herein, in general, relates to the use of biosurfactants, such as rhamnolipids, for treating and / or accelerating the healing of wounds. More particularly, the present technology relates to a method for treating chronic and acute wounds, by applying a composition comprising a mixture of rhamnolipids to the wound, wherein application of the composition facilitates coordinated gene expression associated with wound healing.

The invention belongs to the field of biomedical materials, and particularly relates to a composite nanofiber capable of stopping bleeding, resisting bacteria and promoting vascular wound repair as well as a preparation method and application of the composite nanofiber. The composite nanofiber comprises a fiber matrix and copper tannic acid nanoparticles, wherein the fiber matrix is composed of a hydrophilic polymer and zein, and the copper tannic acid nanoparticles are loaded on the fiber matrix. The composite nanofiber can generate active oxygen and release copper ions for synergistic sterilization, angiogenesis is facilitated, wound healing is promoted, excellent biocompatibility is shown, the composite nanofiber is suitable for wounds of different sizes and depths, safe, hemostatic, antibacterial and wound repair customized management promotion can be achieved, and the application prospect is wide. A solution is provided for rapid hemostasis, antibiosis and wound healing of acute wounds.

The invention discloses a hydrogel film loaded with an antibacterial agent as well as a preparation method and application of the hydrogel film. Specifically, the hydrogel film disclosed by the invention is prepared from the following raw materials: two or more polyethylene glycol monomers with different end groups, polyphenol substances and an antibacterial agent. The hydrogel film loaded with the antibacterial agent has good hemostatic performance in acute wound nursing, has good anti-infection, anti-oxidation and wound healing promoting performance in chronic infection wound nursing, and has good biocompatibility in the environments of wounds, blood and the like.

This application discloses a method for preparing a novel topical Tiger Yellow Healing Traditional Chinese Medicine (TCM) preparation for treating wounds, comprising the following steps: S1, preparation of medicinal materials: Seven medicinal materials powders are obtained by grinding or pulverizing Bauhinia bark, Astragalus membranaceus, Angelica pubescens, Saxifraga stolonifera, Paeonia lactiflora, Acorus tatarinowii, and Angelica dahurica; S2, preparation of homologous carbon quantum dots; S3, preparation of a TCM compound; S4, mixing the homologous carbon quantum dots obtained in step S2 with the TCM compound obtained in step S3, dialysis the mixture with distilled water to remove unloaded small molecules of the TCM compound, and then drying to obtain the Tiger Yellow Healing TCM preparation. This application also provides an application of this novel topical Tiger Yellow Healing TCM preparation for treating wounds. This application is the first to propose a method for preparing a TCM compound loaded with homologous carbon quantum dots, increasing the efficacy of the TCM compound itself. It can be used to treat various acute wounds and chronic, difficult-to-heal wounds, promote rapid wound healing, and has good antibacterial, antioxidant, and wound angiogenesis effects.

The invention discloses a composite bacterial cellulose dressing as well as a preparation method and application thereof, and belongs to the technical field of medical dressings. The preparation method of the composite bacterial cellulose dressing comprises the following steps: S1, treating a bacterial cellulose membrane with an alkaline solution and an acidic solution in sequence, and then cleaning until the pH value is nearly neutral to obtain a purified bacterial cellulose membrane; s2, placing the purified bacterial cellulose membrane between two layers of support materials, and dehydrating to obtain a primary dressing; s3, the primary dressing is soaked in a solution containing cationic polysaccharide, sterilization is conducted, and the composite bacterial cellulose dressing is prepared. The composite bacterial cellulose dressing can effectively maintain the physical and chemical stability of cationic polysaccharide, can effectively promote the healing of wounds, especially acute wounds and chronic refractory wounds, and shortens the wound healing time.

The present application belongs to the field of pharmaceutical preparations, and particularly relates to a gel of Duiyiwai and application thereof. The gel of Duiyiwai is an external preparation prepared from raw and auxiliary materials including the following parts: Duiyiwai extract 1.25-5 parts by weight, carbomer 940 0.5-1 part by weight, hydroxyphenyl ethyl ester 0.01-0.05 part by weight, triethanolamine 0.5-1 volume part, glycerol 1-2 volume parts, 1,2-propylene glycol 1.5-2 volume parts. The gel of Duiyiwai has the same curative effect as the Duiyiwai extract of the same dosage in repairing acute wounds; but has a significantly better curative effect than the Duiyiwai extract of the same dosage in repairing infected wounds, and is also better than the commonly used fuscide acid cream and compound Huangbai liquid in the clinic, and has practical popularization and application value.

The invention belongs to the technical field of medical supplies, and discloses a scar repair patch with an immune microenvironment adjusting function and application thereof.The scar repair patch comprises a backing layer, a silica gel layer and a protective film layer, the silica gel layer is connected with the backing layer, the backing layer is connected with elastic cloth, and the elastic cloth is connected with a pasting layer; the silica gel layer is prepared from a first silica gel component, a second silica gel component and an immune regulation component, and the immune regulation component is prepared from the following raw materials in parts by mass: 2 to 8 parts of arginine hydrochloride, 0 to 10 parts of chondroitin sulfate, 20 to 35 parts of polyethylene glycol 400, 20 to 35 parts of polydimethylsiloxane, 20 to 35 parts of glycerol, 3 to 10 parts of cetyl PEG / PPG-10 / 1 polydimethylsiloxane and 4 to 10 parts of purified water; meanwhile, the preparation method is optimized, according to the technical scheme, immune cell phenotypes can be actively regulated and controlled, repairing and healing of skin wounds are synergistically promoted, closing of chronic wounds is accelerated, skin regeneration of acute wounds is promoted, scar growth is inhibited, the curative effect of the scar patch is improved, and long-term use of the scar patch is facilitated.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to lamiophlomis rotata gel and application thereof. The lamiophlomis rotata gel is an external preparation prepared from the following raw and auxiliary materials in parts by weight: 1.25 to 5 parts of lamiophlomis rotata extract, 0.5 to 1 part of carbomer 940, 0.01 to 0.05 part of ethylparaben, 0.5 to 1 part of triethanolamine, 1 to 2 parts of glycerol and 1.5 to 2 parts of 1, 2-propylene glycol. The curative effect of the lamiophlomis rotata gel is equivalent to that of the lamiophlomis rotata extract with the same dosage when the lamiophlomis rotata gel is used for repairing acute wounds; however, when the composition is used for repairing infectious wounds, the curative effect of the composition is obviously superior to that of the same dosage of lamiophlomis rotata extract, and is also superior to that of fusidic acid cream and compound cortex phellodendri liquid which are commonly used clinically at present, so that the composition has practical popularization and application values.

A preparation method of a pH response cotton swab for wound infection monitoring, first, natural cotton fibers are soaked in a bromocresol green solution for dyeing, and the color of the bromocresol green solution is blue during the dyeing process; the soaked natural cotton fibers are rinsed with a buffer solution; then, the excess buffer solution is squeezed out, the natural cotton fibers are dried, and orange-yellow natural cotton fibers are obtained; finally, the dried natural cotton fibers are fixed on the top end of a thin rod, and the pH response cotton swab is obtained. The color change of the pH response cotton swab after wiping the wound is used to quickly judge the type of wound infection of the patient, the pH value of 4.0-6.0 corresponds to acute wounds, the pH value of 7.0-10.0 corresponds to chronic wounds, corresponding treatment strategies are adopted based on the type of wound, which helps to improve the work efficiency of medical staff; at the same time, compared with the traditional form of dressing, the cotton swab avoids the secondary infection risk caused by multiple times of uncovering the dressing.

The invention provides a wound cover, which contains, in the following order: - a first layer of polyester fabric, - a first layer of petroleum jelly, - a layer of deactivated non-viable amniotic tissue (DNAT), - a second layer of petroleum jelly, - a removable second layer of polyester fabric, which is configured to be removed before applying the wound cover to a wound. The wound cover is suitable for healing acute as well as chronic wounds. It provides a suitable environment supporting the healing of the wound. The invention further provides a method of manufacturing the wound cover.

The invention discloses a collagen chitosan composite scaffold and its preparation method and application. The present invention obtains glycidyl methacrylate collagen by reacting collagen with glycidyl methacrylate; chitosan solution and methacrylic anhydride are reacted to obtain methacrylic chitosan; methacrylic anhydride and dopamine are reacted to obtain methacrylic dopamine; glycidyl methacrylate collagen, methacrylic chitosan, methacrylic dopamine and copper ion are mixed, and light curing reaction is carried out under the initiation of phenyl (2,4,6-trimethylbenzoyl) lithium phosphate to obtain collagen chitosan composite scaffold. The scaffold has certain mechanical strength, toughness, fatigue resistance and viscoelasticity, and also has good biocompatibility, adhesion, antibacterial and antioxidant properties, and has outstanding application prospects in terms of acute wound healing.

The invention discloses mussel mucoprotein water and a preparation process thereof, and the mussel mucoprotein water comprises the following components in parts by mass: 5-12 parts of mussel mucoprotein; 3 to 8 parts of a hydroxylated chitosan-polyethylene glycol grafted copolymer; 4 to 9 parts of modified sodium alginate; 2 to 6 parts of beta-cyclodextrin embedded theabrownin; 1 to 4 parts of nano hydroxyapatite; 1-3 parts of glycerol; 60 to 85 parts of deionized water; through the synergistic effect of the four innovative components and the mussel mucoprotein, the dressing has excellent biological adhesion, mechanical properties, antibacterial and anti-inflammatory properties and healing promotion effects, and the problems that an existing dressing is single in function and insufficient in performance are solved; the adopted raw materials are natural high polymer materials or modified products with excellent biocompatibility, and after purification treatment, the impurity content is low, the biological safety is high, and no obvious toxic or side effect exists; the prepared hydrogel dressing is good in moisture retention and air permeability, can meet the healing requirements of various acute wounds and chronic wounds, and has wide clinical application prospects.

The present invention relates to the therapeutic use of a composition for the treatment of cutaneous wounds such as acute wounds, chronic wounds or epidermolysis bullosa wounds. The composition according to the invention is based on ABA-type triblock copolymers, comprising two thermoplastic styrene end blocks A and an elastomeric central block B which is a saturated olefin, comprising at least one resin selected from aromatic resins usable in particular for producing an interface dressing with a framework or support or self-supporting.

The invention provides a wound dressing based on COGS hydrogel, which is mainly composed of carboxymethyl chitosan and oxidized gellan gum, forms a double-crosslinking structure through ionic crosslinking and Schiff base crosslinking technologies, and has excellent mechanical properties and biocompatibility. The hydrogel also contains gentamicin sulfate with the concentration range of 0.7%-1.3%, so that the hydrogel can effectively provide an antibacterial effect; the hydrogel is widely applicable to treatment of chronic or acute wounds such as burns, incision wounds, ulcers, diabetic feet, postoperative wounds and the like. The application can effectively promote wound healing and relieve pain, and has the effects of resisting bacteria, preventing infection and promoting tissue regeneration. Therefore, the wound dressing has important application value in clinical treatment.

The invention provides a hemostatic hydrogel for wound hemorrhage. The hemostatic hydrogel is prepared from the following components in parts by mass: 15 to 18 parts of cationic cassava starch, 9 to 15 parts of polyvinyl alcohol, 5 to 8 parts of oxidized konjac glucomannan, 0.1 to 0.2 part of cannabidiol, 1.5 to 2.5 parts of polydopamine nanoparticles, 0.5 to 0.8 part of panax notoginseng saponins and 2 to 4 parts of polyethylene glycol diacrylate. The hydrogel has the advantages of being rapid in gelling and high in blood coagulation efficiency, is suitable for scenes with massive hemorrhage of wounds, such as acute wound surfaces of accidental incisions, scratches and the like, and environments with limited medical resources, such as fields, battlefields, severe accident and disaster sites, can be used as a first-line first-aid material, rapidly realizes hemostasis and infection resistance, relieves pain of the wounded, and has a good application prospect. The injury condition is stabilized.

The application discloses two peptide segments derived from Cervus elaphus Linnaeus and application of the two peptide segments in promoting wound healing. Amino acid sequences of the two peptide segments are Gly-Ser-Phe-Pro-Trp-Gln-Ala-Lys (SEQ ID NO:1) and His-Ser-Trp-Ala-Val-Pro-Ser-Leu (SEQ ID NO:2) respectively. In-vitro experiments show that the two peptide segments can significantly promote proliferation and migration of human umbilical vein endothelial cells and mouse skin fibroblasts; in-vivo mouse acute wound model experiments prove that the two peptide segments can effectively accelerate the healing process of mouse acute wounds, have excellent biological activity of promoting acute skin wound healing, and have a good application prospect in development of drugs and functional products related to wound repair.