Preparation of polysiloxane supermolecule elastomer wound dressing containing PEG (polyethylene glycol) block

A technology of supramolecular elastomer and polysiloxane, which is applied in the field of synthetic polymer biomaterials, can solve the problem of low infection probability of patients, achieve good water absorption and air permeability, facilitate growth and regeneration, and biophase good capacitive effect

Inactive Publication Date: 2016-04-06
SOUTH CHINA UNIV OF TECH
View PDF2 Cites 15 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What's more, a warm, moist healing environment did not increase the chance of wound

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation of polysiloxane supermolecule elastomer wound dressing containing PEG (polyethylene glycol) block
  • Preparation of polysiloxane supermolecule elastomer wound dressing containing PEG (polyethylene glycol) block
  • Preparation of polysiloxane supermolecule elastomer wound dressing containing PEG (polyethylene glycol) block

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: polysiloxane supramolecular elastomer wound dressing (ESESi) containing PEG block 1 / 9 ) preparation

[0056] (1) Synthesis of allyl-terminated polyethylene glycol (APEG): in a reactor equipped with mechanical stirring, condenser, dropping funnel, the molar ratio of raw materials is PEG: allyl chloride=1: 1.5, the amount of TBAB is 5% of the amount of PEG material for feeding, and the reaction is carried out at 60° C. for 5 hours. After the reaction, the product was dissolved in ethyl acetate and washed 5 times with saturated sodium chloride solution. The organic layer was taken out and evaporated under reduced pressure to remove ethyl acetate and water to obtain APEG.

[0057] (2) Synthesis of terminal hydrogen polysiloxane (PHMS): at room temperature, add D 4 and HMM, HMM and D 4 The molar ratio of feeding is 1:4.5, then adding concentration is the sulfuric acid solution of 86wt%, and the consumption of sulfuric acid solution is D 4 3% of the mass, s...

Embodiment 2

[0063] Embodiment 2: polysiloxane supramolecular elastomer wound dressing containing PEG block (ESESi 1 / 11 ) preparation

[0064] Except HMM and D in step (2) 4 The molar ratio of feeding is 1:5.5, and all the other are identical with embodiment 1. The resulting product is ESESi 1 / 11 Film dressing.

Embodiment 3

[0065] Embodiment 3: polysiloxane supramolecular elastomer wound dressing containing PEG block (ESESi 1 / 15 ) preparation

[0066] Except HMM and D in step (2) 4 The molar ratio of feeding is 1:7.5, and all the other are identical with embodiment 1. The resulting product is ESESi 1 / 15 Film dressing.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of synthetic macromolecule biological materials, and discloses a preparation method of polysiloxane supermolecule elastomer wound dressing containing a PEG (polyethylene glycol) block. The preparation method comprises the following steps: firstly, synthesizing a carboxyl-terminated triblock copolymer containing a polysiloxane block and the PEG block; then, synthesizing the triblock copolymer into a hydrogen-bond cross-linking type supermolecule elastomer based on a PDMS-b-PEG-b-PDMS triblock copolymer through a two-step reaction with diethylenetriamine and urea; a thin film prepared by performing hot press molding on the elastomer has good water absorptivity and breathability, and by using the thin film as acute wound dressing, the growth and regeneration of wounded tissues are facilitated and the healing of a wound can be accelerated. According to the preparation method, polysiloxane and PEG are taken as raw materials, cytotoxicity and skin irritation are avoided and the biocompatibility is good.

Description

technical field [0001] The invention belongs to the technical field of synthetic macromolecule biomaterials, in particular to the preparation of a polysiloxane supramolecular elastic body wound dressing containing PEG blocks. Background technique [0002] The skin is the largest organ of the living body, an important guarantee for maintaining the balance and stability of the human body environment, and plays an important role in the physiological activities of the human body. For example: the skin can resist the invasion of bacteria, which is conducive to maintaining the balance of fluids and electrolytes in the body. In addition, the skin also has the function of regulating body temperature, protecting blood vessels and other human organs. [0003] When the skin is damaged, it usually causes a large amount of exudate, and is susceptible to infection by bacteria and viruses, leading to inflammation and even tissue necrosis, which seriously affects the normal operation of th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L15/26A61L15/42A61L15/44C08G81/00C08G65/337C08G77/12
CPCA61L15/26A61L15/42A61L15/44C08G65/337C08G77/12C08G81/00A61L2300/412C08L87/00
Inventor 张安强雷雨风邓文文犹阳黄炜妍
Owner SOUTH CHINA UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap