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Preparation method for composite micro-sphere for stopping bleeding in clinical operation

A technology of composite microspheres and microspheres, applied in bandages, absorbent pads, medical science, etc., can solve the problems of affecting the hemostatic effect, low water absorption, and insufficient water absorption, and achieve good biodegradability and acid and alkali resistance , No harmful substances are produced, and the preparation steps are simple

Inactive Publication Date: 2015-08-05
杨子中
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The disadvantages of this type of material are high cost, possible infection of human or animal blood-borne diseases, inconvenient use, slow hemostasis, and poor hemostatic effect on large blood vessels
However, there are still deficiencies in the hemostatic effect of this effective hemostatic material, its water absorption is not strong enough, and the water absorption multiple is low, thus affecting the hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A method for preparing composite microspheres for hemostasis in clinical operations specifically comprises the following steps:

[0051] (1) Prepare chitosan solution:

[0052] Chitosan powder with a molecular weight of 40,000 Da and a degree of deacetylation of 85% was dissolved in dilute hydrochloric acid under stirring conditions to prepare a solution with a chitosan mass fraction of 0.5%;

[0053] (2) Preparation of chitosan microspheres:

[0054] In the chitosan solution that step (1) makes, add particle diameter and be the solid chlorinated paraffin powder of 20 microns, the solid chlorinated paraffin powder quality and chitosan mass fraction are the solution volume ratio of 0.5% be 1g: 2ml , after stirring evenly, pump it into a spray centrifuge, control the speed of the centrifuge to 4000r / min for spraying, then slowly stir with an electric mixer for 10 minutes, then filter, and the collected filter residue is chitosan microspheres;

[0055] (3) Preparation of...

Embodiment 2

[0072] A method for preparing composite microspheres for hemostasis in clinical operations specifically comprises the following steps:

[0073] (1) Prepare chitosan solution:

[0074] Chitosan powder with a molecular weight of 120,000 Da and a degree of deacetylation of 95% was dissolved in dilute hydrochloric acid under stirring conditions to prepare a solution with a chitosan mass fraction of 5.0%;

[0075] (2) Preparation of chitosan microspheres:

[0076] In the chitosan solution that step (1) makes, add particle diameter and be the solid chlorinated paraffin powder of 60 microns, the solid chlorinated paraffin powder quality and chitosan mass fraction are the solution volume ratio of 5.0% be 1g: 5ml , after stirring evenly, pump it into a spray centrifuge, control the speed of the centrifuge to 8000r / min for spraying, then slowly stir with an electric mixer for 30 minutes, then filter, and the collected filter residue is chitosan microspheres;

[0077] (3) Preparation o...

Embodiment 3

[0094] A method for preparing composite microspheres for hemostasis in clinical operations specifically comprises the following steps:

[0095] (1) Prepare chitosan solution:

[0096] Chitosan powder with a molecular weight of 80,000 Da and a degree of deacetylation of 90% was dissolved in dilute hydrochloric acid under stirring conditions to prepare a solution with a chitosan mass fraction of 3.0%;

[0097] (2) Preparation of chitosan microspheres:

[0098] In the chitosan solution that step (1) makes, add particle diameter and be the solid chlorinated paraffin powder of 40 microns, the solid chlorinated paraffin powder quality and the mass fraction of chitosan are that the solution volume ratio of 3.0% is 1g: 4ml , after stirring evenly, pump it into a spray centrifuge, control the speed of the centrifuge to 6000r / min for spraying, then slowly stir with an electric mixer for 20 minutes, then filter, and the collected filter residue is chitosan microspheres;

[0099] (3) Pr...

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Abstract

The invention discloses a preparation method for a composite micro-sphere for stopping bleeding in clinical operation. The preparation method for the composite micro-sphere for stopping bleeding in the clinical operation mainly includes that adding water to a crosslinked chitosan wet micro-sphere to prepare into crosslinked chitosan wet micro-sphere solution with concentration 1.5-2.5% (W / V), adding water to a crosslinked starch micro-sphere to prepare into crosslinked starch micro-sphere solution with concentration 10-20% (W / V), mixing according to the volume ratio of 5: 5, 6: 4, 7: 3 or 8: 2, using ultrasonic wave to enable the solution to mix uniformly, using a high-speed centrifugal machine to centrifuge for 30 minutes, defoaming, solidifying in NaOH solution with mass concentration 0.5% under aseptic condition, using alcohol to dehydrate, using injection water to wash, drying at 30 to 40 degrees centigrade to realize a semi-dry state, dehydrating, washing, solidifying, spraying and drying, and packaging and sterilizing through cobalt 60 to obtain the composite micro-sphere for stopping bleeding. The average diameter of the composite micro-sphere for stopping bleeding is 600 to 900 micrometers, the average pore size is 50 to 100 micrometers, and the specific surface area arrives at 720.8-810.2 m2.g -1; the composite micro-sphere for stopping bleeding is capable of absorbing and degrading biological material and stopping the bleeding of various wound and the acute wound bleeding regions of fresh operation tissues.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a method for preparing composite microspheres for hemostasis in clinical operations. Background technique [0002] Surgical hemostasis is one of the cores of surgical techniques, and a good hemostasis technique is the key to a successful operation. With the improvement of the effectiveness and safety requirements of the medical circles in various countries, it is imperative to find excellent biological materials in nature and develop hemostatic materials with better hemostatic effect, no toxic side effects, no irritation, and easy to process. Row. Absorbable hemostatic materials currently used in surgical and traumatic wounds mainly include: [0003] 1. Fibrin glue [0004] Fibrin glue, also known as fibrin adhesive, is a biological product extracted from human plasma, mainly composed of thrombin and fibrinogen, and has been widely used clinically for many years a...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/42A61L15/64
Inventor 杨子中
Owner 杨子中
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