324 results about "Antiseptic Agent" patented technology

The invention relates to the technical field of biological medicine, and particularly discloses an atopic dermatitis treatment medicine and a preparation method and application thereof.The preparation method comprises the steps that sodium alginate, sodium polyacrylate and water are mixed and then subjected to a swelling reaction, and a colloidal solution with the viscosity larger than or equal to 5000 cP is formed; mixing upatinib, a preservative, glycerol and azone to obtain a raw material phase; and mixing the colloidal solution with the raw materials, and homogenizing to obtain the atopic dermatitis treatment medicine. Through swelling reaction of sodium alginate and sodium polyacrylate, the viscosity of a colloidal solution is remarkably improved through molecular chain entanglement, charge repulsion and water absorption synergistic effects of sodium alginate and sodium polyacrylate; through compounding of all the components, the transdermal efficiency of the medicine is improved, the irritation of the medicine is reduced, and meanwhile, the inhibition efficiency on atopic dermatitis inflammatory factors is also improved.

The invention belongs to the technical field of pesticide suspending agents, and particularly discloses a micro-capsule suspension-suspending agent containing chlorine fluorine and clothianidin and a preparation method of the micro-capsule suspension-suspending agent. The microcapsule suspension-suspending agent is prepared from the following raw materials: 11 to 13 percent of lambda-cyhalothrin, 12 to 14 percent of clothianidin, 9.20 to 9.60 percent of a solvent, 3.25 to 3.45 percent of a wall material I, 0.35 to 0.50 percent of protective glue, 2.13 to 2.33 percent of an emulsifier, 1.24 to 1.45 percent of a dispersing agent I, 0.24 to 0.45 percent of a wall material II, 3.90 to 4.10 percent of a dispersing agent II, 2.92 to 3.12 percent of an anti-freezing agent, 0.03 to 0.07 percent of a thickening agent I, 0.45 to 0.55 percent of a thickening agent II, 0.46 to 0.52 percent of a preservative and the balance of water. The microcapsule suspension-suspending agent prepared in the invention has good stability in the storage process, the slow release of effective components is controlled, and the lasting period is prolonged.

The invention provides an eye drop composition as well as a preparation method and application thereof, and belongs to the technical field of ophthalmic preparations. The eye drop composition adopted by the invention is prepared from the following components: brimonidine tartrate, hyaluronic acid, collagen, trehalose and injection water. By compounding the components, the eye drops which can realize slow release of brimonidine tartrate and prolong the antihypertensive action time and have the characteristics of relieving blink discomfort, long-acting moisturizing, anti-inflammatory soothing, mildness, corrosion prevention and the like are prepared; the eye drops are beneficial to people suffering from glaucoma, intraocular hypertension, xerophthalmia, postoperative inflammation or allergy and preservative sensitivity or preservative allergy, the life quality is improved, and diseases are relieved.

The invention relates to the technical field of cosmetics, and particularly discloses emulsion type foaming cleaning scrub cream with a skin care effect and a preparation method of the emulsion type foaming cleaning scrub cream. The scrub cream is prepared from the following raw material components in percentage by mass: 8 to 15 percent of glycerol, 0.2 to 0.9 percent of sodium hydroxide, 0.3 to 0.8 percent of citric acid, 0.03 to 0.2 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.5 to 1.5 percent of an auxiliary agent, 1.5 to 3.0 percent of a thickening agent A, 1.5 to 3.0 percent of a thickening agent B, 5.86 to 1457 percent of an emollient, 12 to 22 percent of a surface active foaming agent, 0.8 to 3.0 percent of an emulsifying agent, 2.5 to 13 percent of a cutin stripping agent, 0.7 to 1.3 percent of a preservative, 0.32 to 0.92 percent of a skin conditioning agent and the balance of water, the skin conditioner is a mixture prepared from sodium hyaluronate, tocopherol, papain, nicotinamide, carnosine, panthenol and phytosterol oleate.

The invention relates to the technical field of seed treatment suspending agents. The invention discloses a seed treatment suspending agent containing clothianidin, prothioconazole and fludioxonil as well as a preparation method and application of the seed treatment suspending agent. The seed treatment suspending agent is prepared from the following raw materials: clothianidin, prothioconazole, fludioxonil, a bactericidal synergist, a dispersing agent, a wetting dispersing agent, a thickening agent, a preservative, an anti-freezing agent, a film-forming agent, warning coloration, a de-foaming agent and de-ionized water. The seed treatment suspending agent containing clothianidin, prothioconazole and fludioxonil prepared by the invention is good in suspending performance, low-temperature stability and heat storage stability. The application amount and the harm to the environment are reduced. The invention also relates to application of the seed treatment suspending agent in prevention and treatment of diseases and insect pests.

The invention relates to an application of D-camphor and cymenin in preparation of an anti-inflammatory soothing preparation for sensitive skin. The invention discloses an application of D-camphor and cymenin as only two effective components in preparation of an anti-inflammatory soothing preparation for sensitive skin. The invention further discloses an anti-inflammatory soothing preparation for sensitive skin, only two effective components of the anti-inflammatory soothing preparation for sensitive skin are D-camphor and cystin, and the anti-inflammatory soothing preparation for sensitive skin can reduce the reaction of IL-6, IL-8 and NO related microinflammation in a keratinocyte inflammation model. The invention has the following beneficial effects: 1, in a high proportion window (5-10: 1) of D-camphor and polycymenin, the inhibition of the compound system of D-camphor and polycymenin on IL-6, IL-8 and NO is superior to that of any monomer; 2, stable dispersion and good use experience can be realized through the micro-emulsion type emulsifying essence or the face cream carrier, and meanwhile, the face cream still has feasibility under the conditions of no essence and no conventional preservative.

The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial / antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

The invention relates to the technical field of daily chemicals, in particular to an anti-hair-loss composition containing hexapeptide-11 and application of the anti-hair-loss composition. The composition comprises a foaming agent, a suspending agent, a hair conditioner, a foaming agent, a thickening agent, an emollient, a preservative, a PH regulator, a chelating agent, hexapeptide-11 and a solvent. The hexapeptide-11 can promote metabolism and proliferation of hair papilla cells; the ginseng and black bean hydrolysate provides plant hormone-like components; the radix scutellariae extract effectively inhibits scalp inflammation, and the three components have a remarkable synergistic effect in the aspects of regulating and controlling the hair follicle cycle and prolonging the growth period. Through synergistic fermentation conversion of probiotics, the molecular structure and skin absorption capacity of original components are improved, meanwhile, various active substances such as small molecular peptides, organic acids and B vitamins are released, and the scalp microenvironment can be improved. The hexapeptide-11 is not obviously degraded in the fermentation process, and forms a composite stable system together with the plant extract, so that the hexapeptide-11 has good pH adaptability and storage stability, and is suitable for daily scalp care.

Deionized water, glycerin, an antioxidant and a preservative are fully mixed to prepare a mixed solution, and hydrophobic silane modified silicon dioxide and the mixed solution are fully mixed in a high-speed powder stirring homogenizer to prepare mixed powder A; adding fluorophlogopite and a coloring agent into a high-speed powder stirring homogenizer, and fully mixing to obtain mixed powder B; then the mixed powder A and the mixed powder B are fully mixed to prepare the make-up powder with the particle size not exceeding 500 meshes, the make-up powder is fine and light in particle size, and the make-up skin is soft and fine in touch. The makeup powder has high fluidity and can be contained in the bottle body, the makeup powder is sprayed out through the spray head by utilizing the pressure difference inside and outside the bottle body, and the makeup applying mode is novel and convenient; in addition, the powder has the characteristic of high covering power, and after the sprayed powder is simply smeared for multiple times for makeup, the color difference of the part covered by the makeup powder is small, so that the makeup effect with a good covering effect is formed.

The invention discloses a PDRNamp and a method for preparing the PDRNamp. The invention discloses EGT eye wash as well as a preparation method and application thereof, and belongs to the technical field of eye care products. The eye wash is prepared from the following active components in percentage by mass: 0.001 to 0.01 percent of PDRN, 0.03 to 0.1 percent of EGT (Ergothioneine), sodium hyaluronate, sodium chloride, taurine and the like, wherein the mass percent of the PDRN is 0.001 to 0.01 percent, and the mass percent of the EGT is 0.03 to 0.1 percent. Through the synergistic effect of PDRN and EGT, the product has excellent cornea repairing capacity and a powerful anti-oxidation function at the same time, and the moisturizing and soothing effects are enhanced by compounding sodium hyaluronate and taurine. The obtained eye washing liquid is an isotonic solution with neutral pH, is mild and non-irritating, does not contain preservatives, can effectively achieve multiple nursing effects of eye cleaning, moisturizing, repairing, anti-inflammatory and anti-oxidation, and is suitable for relieving xerophthalmia, assisting cornea repair and daily anti-oxidation nursing of eyes.

Hinged antiseptic delivery devices and methods are disclosed comprising a fluid applicator device. The fluid applicator device has a handle having a first end, a second end, and a length therebetween, wherein two fingers extend from the second end and define an opening between the two fingers. The fluid applicator device further has a base plate rotatably coupled with the handle, the base plate having a top surface and a bottom surface. The top surface includes a first support and a second support disposed thereon, and a rod disposed between the first support and the second support. The fluid applicator device further has a foam applicator coupled to the base plate to absorb and distribute an antiseptic solution, wherein the top surface of the base plate is proximate the handle in a delivery condition and is disposed at an angle to the handle in the use condition.

The invention discloses a feed for feeding cordyceps sinensis host hepialus larvae as well as a preparation method and application of the feed, and relates to the technical field of artificial feeds. The feed comprises the following components in parts by weight: 5-20 parts of beer yeast powder and / or casein, 30-80 parts of wheat germ powder, 20-40 parts of carrot powder, 0.2-5 parts of a modified preservative, 0.05-0.2 part of antibiotics, 0.2-5 parts of vitamins, 0.01-1 part of edible oil, 6-15 parts of agar and 200-400 parts of water. The modified preservative is composed of a chitosan oligosaccharide-natamycin compound subjected to plasma activation treatment and potassium sorbate according to the ratio of 1: 3-1: 5; a modified preservative composed of a chitosan oligosaccharide-natamycin compound subjected to plasma activation treatment and potassium sorbate is adopted, a porous microsphere structure is formed through a specific preparation process, and the contact area of the preservative and the feed is greatly increased. Agar and water form a gel matrix at a specific temperature, and nutritional ingredients and the like are injected into a coaxial micro-fluidic device, so that the preservative effect of the feed is remarkably enhanced.

The invention relates to the technical field of cosmetics, and particularly discloses bright non-stick cup lip glaze and a preparation method thereof. The raw materials of the lip glaze comprise the following components in parts by weight: 15 to 40 parts of a solvent, 5 to 15 parts of an emollient, 30 to 70 parts of a film-forming agent, 2 to 20 parts of a brightener, 0.1 to 10 parts of a thickening agent, 3 to 10 parts of a coloring agent, 0.5 to 1.0 part of a preservative, 0.1 to 1.0 part of an antioxidant, 0.1 to 1.0 part of a cool feeling agent, 0.01 to 1.0 part of an active component and 0.01 to 1.0 part of an aromatic, wherein the film forming agent is prepared from an acrylic acid (ester) / polydimethylsiloxane copolymer, polymethyl silsesquioxane, trimethylsiloxy silicate ester and polypropyl silsesquioxane. The lip glaze provided by the invention is not easy to stick to a cup, is lasting, and also has a relatively good light effect.

Cosmetic method for improving skin characteristics, in which the cleansed skin surface is sprayed with water containing four-atom oxygen, known in itself as activated stabilized oxygen, and then, after the skin has absorbed the spray, the surface is coated with a preparation containing at least 0.040% by weight of hydrolyzed beta-glucan, preferably 0.1% by weight, wherein the preparation also contains at least 0.04% by weight, preferably 0.1 w% acetyl tetrapeptide-40, in the form of a gel or cream, and then the pretreated skin surface is irradiated with soft laser light emitting scattered rays with a wavelength of 700-900 nm and a power density of 40-200 mW cm2 power density, where the irradiation time is at least 30 seconds, depending on the power density. The composition contains at least 0.040% by weight of hydrolyzed beta-glucan, 1-5% by weight of a moisturizing agent, 15-20% by weight of a skin conditioning agent, 1-5% by weight of a preservative, and at least 0.04% by weight of acetyl tetrapeptide-40.

The invention discloses a preparation method and application of an isoxaflutole suspending agent, and belongs to the field of pesticide preparations. The isoxaflutole is 1-50%, the wetting dispersant is 1-12%, the thickening agent is 0.5-2%, the anti-freezing agent is 1-10%, the defoaming agent is 0.1-0.2%, the preservative is 0.1-0.3%, the safener is 1-5%, and the balance is water. The wetting dispersant is composed of Agnique CP 72L, Agnique ANSC 1NP B and Lutensol A9N, and the wetting dispersant is composed of Agnique CP 72L, Agnique ANSC 1NP B and Lutensol A9N. The prepared isoxaflutole suspending agent is reasonable in preparation component system, has the advantages of being high in suspension rate, simple in processing technology, stable in performance, high in safety and the like, and has good social and ecological benefits.

The present application belongs to the field of daily chemicals, and particularly relates to a skin care composition containing Physocarpus fruit extract, which comprises the following components calculated by weight percentage: Physocarpus fruit extract 0.01-6.0%; humectant 0.1-15.0%; oil 5.0-30.0%; emulsifier 1.0-10.0%; thickening agent 0.1-5.0%; preservative 0.5-2.0%; and the balance of pure water. The skin care composition of the present application not only can improve the symptom of excessive secretion of sebaceous glands, dredge the blocked pores, effectively reduce the generation of comedones and inflammatory acne, but also has excellent soothing and redness fading ability, can quickly calm the existing red and swollen acne skin, and reduce the stinging and uncomfortable feeling caused by acne. In addition, after using the composition of the present application, the secretion of sweat and oil can be reduced, so as to achieve the effect of reducing body odor.

The invention relates to the technical field of cosmetics, in particular to a moisturizing mask with a repairing effect and a preparation method of the moisturizing mask, and mask liquid comprises a sensitive skin repairing composition, an auxiliary effect system, a thickening system, a moisturizing system, a grease system, a buffer system and purified water. The sensitive skin repairing composition is prepared from chamomile oil, tea tree oil, a radix gentianae extract, a herba centellae extract, 4-tert-butyl cyclohexanol, butanediol, phosphatidyl ethanolamine and cardiolipin, phosphatidyl ethanolamine is modified, and the weight ratio of all the components is adjusted, so that the sensitive skin repairing composition is prepared. The traditional Chinese medicine composition has the advantages that various components in the composition are coordinated to play the optimal anti-inflammatory, anti-allergy, analgesic and repairing functions, exogenous stimulation, nerve stress response and inflammatory response are reduced, the self-protection mechanism is strengthened, the skin barrier is repaired, the oxidative stress capability is further strengthened, and the composition has more excellent high-temperature and low-temperature stability; the traditional Chinese medicine composition is natural and safe, and does not generate side effects such as dependence and drug resistance after long-term use.

The utility model belongs to the technical field of bolt processing, and particularly relates to a preservative smearing device applied to an iron tower torsional shear bolt, which comprises a bottom plate, the bottom plate is connected with a support frame in a clamping manner, the inner wall of the support frame is rotatably connected with two symmetrical rotating plates, and a limiting plate is fixedly connected between the two rotating plates. An upper frame plate and a lower frame plate are arranged above and below the limiting plate respectively, a plurality of receding holes used for receding the bolt rods are formed in the limiting plate, and a clamping plate is connected to the inner wall of the upper frame plate in a clamped mode; a rotating plate rotates in a supporting frame, the distance between an upper frame plate and a lower frame plate can be adjusted, a matched supporting groove is in a conical shape, bolts of different sizes can be clamped, fixed and sprayed, meanwhile, the distance between the upper frame plate and a limiting plate and the distance between the lower frame plate and a limiting plate can be independently adjusted, the rotating plate can be matched to rotate, and the bolts can rotate; and the screw rod and the nut are located at the top open positions correspondingly, and the spraying device can conduct spraying on the whole bolt.

The invention relates to the technical field of suspending agents, in particular to a suspending agent containing oxine-copper and benziothiazolinone as well as a preparation method and application of the suspending agent. The invention relates to a suspending agent containing oxine-copper and benziothiazolinone, which is prepared from the following raw materials in percentage by mass: 28 to 32 percent of oxine-copper, 4 to 8 percent of benziothiazolinone, 1 to 6 percent of dispersing agent, 1 to 6 percent of wetting dispersant, 1 to 1.5 percent of suspending thixotropic agent, 4 to 8 percent of antifreezing agent, 0.05 to 0.5 percent of preservative, 0.05 to 0.5 percent of thickening agent, 0.1 to 0.5 percent of defoaming agent and the balance of water. The dispersing agent comprises polycarboxylic acid ammonium salt; the invention provides the suspending agent containing oxine-copper and benziothiazolinone, which has the advantages of favorable dispersity, favorable stability and favorable control effect. The suspending agent containing oxine-copper and benziothiazolinone provided by the invention has a good control effect on citrus tree canker and cucumber bacterial angular leaf spot.

The invention relates to the technical field of metal heat treatment, and discloses a water-based quenching agent and a production method thereof.The method comprises the steps that water, triethanolamine, a preservative and a bactericide are mixed into a first mixed solution; adding a dispersing agent into the first mixed solution to obtain a second mixed solution; finally, the water-soluble polyurethane solution is slowly added into the second mixed solution in a stirring state, through specific process setting, especially pre-adding of triethanolamine and slow adding of the water-soluble polyurethane solution, intermolecular hydrogen bond association between triethanolamine and the water-soluble polyurethane solution is synergistically regulated, and the water-soluble polyurethane solution is prepared. The method is used for guiding components to spontaneously assemble to form an ordered liquid phase association structure, the structure has the objective attribute of gradual and uniform redissolution along with temperature reduction in the quenching low-temperature stage, and the technical problem that an existing quenching medium is prone to being irregularly stripped in a low-temperature area, so that cooling is out of control, and then workpiece cracking is caused can be solved.

The invention relates to an EPS targeted cleaning type medical nano-enzyme cleaning agent and a preparation method thereof. The cleaning agent comprises the following components in percentage by weight: 3%-5% of trehalose, 5%-10% of glycerol, 9%-11% of nano compound enzyme, 3%-5% of sodium xylene sulfonate, 0.5%-1.5% of a builder, 0.5%-1.5% of ethylenediamine tetraacetic acid, 0.3%-0.7% of benzotriazole, 0.1%-0.5% of a defoaming agent, 0.1%-0.5% of a preservative, 0.05%-0.15% of triethanolamine and the balance of pure water. Through strict verification, the EPS targeted removal type medical nano-enzyme cleaning agent can quickly remove EPS (extracellular polymer matrix) on medical instruments such as endoscopes and the like in an extremely short time, effectively prevents the formation of biological membranes, has the bacterium removal rate of 95% and the biological membrane removal rate of 90%, and has remarkable effects on reducing the infection rate of hospitals and improving the medical safety.

The invention relates to the technical field of medical coupling agents, and discloses a medical sterile ultrasonic coupling agent which comprises the following components: carbomer, a humectant, a quaternary ammonium salt disinfectant, a preservative, a pH regulator and purified water. A preparation method of the medical sterile ultrasonic coupling agent comprises the following steps: step 1, dispersing the carbomer in part of purified water, stirring until the carbomer is completely swelled, adding the preservative and the pH regulator, and continuously stirring for 20 minutes; step 2, dissolving a quaternary ammonium salt disinfectant and a humectant in the residual purified water, uniformly mixing, adding into the gel in the step 1, and vacuumizing and stirring for 10 minutes; and step 3, performing irradiation sterilization after filling to obtain a finished product. Compared with the prior art, the invention has the advantages that: the quaternary ammonium salt is used for replacing triclosan, so that skin irritation and environmental pollution are avoided, and the safety is high. A solubilizer is not needed, and the production process is simplified. According to the invention, the compatibility problem of quaternary ammonium salt and carbomer is solved through a special process, and the stability and viscosity of the product are ensured.

This invention relates to the field of cutting fluids, particularly to a biomimetic self-healing nanocomposite cutting fluid and its preparation method. The cutting fluid is composed of the following components by mass percentage: 5-10% lubricant, 2-5% extreme pressure anti-wear agent, 0.1-2% nanofunctional agent, 1-3% surfactant, 1-2% corrosion inhibitor, 0.5-1.5% pH stabilizer, 0.1-0.5% defoamer, 0.1-0.5% corrosion inhibitor, and the remainder being deionized water. This invention creatively introduces nanofunctional agents such as MXene and nanodiamond. These nanomaterials can form a high-strength, low-friction penetrating layer and repair film on the tool surface. During cutting, they actively fill the microscopic defects caused by tool wear, thereby achieving a "self-healing" effect. This characteristic can significantly reduce the coefficient of friction and cutting force between the tool and the workpiece, and tests have shown that it can extend tool life by more than 50%.

The invention relates to an antibacterial cleaning agent and a preparation method thereof, the antibacterial cleaning agent comprises the following components: 1%-5% of polyether, 1%-5% of fatty alcohol polyoxyethylene polyoxypropylene ether, 0.1%-1% of ethylene diamine tetraacetic acid tetrasodium salt, 0.1%-1% of ethylene diamine tetraacetic acid disodium salt, 0.1%-0.5% of zinc diricinoleate, 0.01%-0.05% of essence, 0.001%-0.003% of 1, 2-benzisothiazole-3-ketone, the balance of water, and 5-100 ppm of nano silver. Through compounding of the non-surfactant, the chelating agent, the buffering agent, the deodorant, the preservative, the enzyme and the nano-silver, bacteria and fungi can be effectively inhibited, it is guaranteed that the used diluent does not stink within 24 h, and meanwhile the good defoaming property and decontamination effect are achieved.

A non-abrasive oral care composition includes a fragrance for imparting aroma and an additive for imparting additional properties. The oral care composition forms a protective coating on an applied dental structure, the oral care composition further comprises a type of plant-derived anionic surfactant and a type of plant-derived non-ionic surfactant, wherein the type of plant-derived anionic surfactant is sodium cocoyl apple amino acid. Optionally, the oral care composition further comprises a type of plant-derived amphoteric surfactant for stabilizing the composition and enhancing coating and foaming. The composition further includes an essential oil for imparting flavour, a menthol for providing a cooling sensation, and a sweetener for imparting pleasant taste to the composition, and a preservative for preventing the growth of microorganisms.

The present invention relates to a soothing and moisturizing composition for sensitive skin and a preparation method thereof, belonging to the technical field of cosmetics. The present invention creatively physically blends a moisturizing component composed of ectoine, saccharide isomers, trehalose, squalane, and glycerol in a certain mass ratio; a soothing component composed of asparagus cochinchinensis extract and rheum palmatum extract in a certain mass ratio; cyclodextrin, an emulsifier, a thickener, a preservative, and a solvent to prepare a composition. When applied to the skin around the eyes, the composition not only exhibits excellent moisturizing and soothing effects but also exhibits minimal irritation, making it highly suitable for people with sensitive skin.

The present invention relates to the field of cosmetic technology, and particularly, to a whitening and anti-aging composition, a method for preparing same, and use thereof. The whitening and anti-aging composition is prepared from the following ingredients in parts by weight: 0.1-2 parts of hydroxypropyl cyclodextrin; 0.1-2 parts of tocopherol; 1-5 parts of an emulsifier; 0.5-1 part of a preservative; 1-5 parts of a functional solvent; 0.1-0.9 part of retinol; 0.1-3 parts of an adjusting mixed acid agent; and 90-100 parts of deionized water. The adjusting mixed acid agent consists of lactobionic acid, inositol hexaphosphate, and ferulic acid, and the ratio of lactobionic acid to inositol hexaphosphate to ferulic acid is (5-7):(0.5-1):1. The method for preparing the whitening and anti-aging composition comprises: dissolving the adjusting mixed acid agent in a portion of deionized water; adding hydroxypropyl cyclodextrin, the emulsifier, and retinol into the remaining deionized water and heating for dissolution; and finally, mixing and stirring the two resulting solutions along with the addition of tocopherol and the preservative during the process to give the composition. The composition exhibits excellent whitening and anti-aging effects with low irritation, and is also suitable for populations having sensitive skin with damaged skin barriers.

The present invention relates to methods of reducing occurrence or severity of dermatologic adverse events (DAEs) in a subject treated with an anti-epidermal growth factor receptor (EGFR) / hepatocyte growth factor receptor (c-Met) antibody and EGFR tyrosine kinase inhibitor, comprising (a) administering an antibiotic(s); (b) administering an antiseptic(s); and (c) administering a non-comedogenic moisturizer to the subject.

This invention provides an exposed single-component waterproof coating with self-healing function, its preparation method, and its application. The exposed single-component waterproof coating, based on a total weight percentage of 100 wt%, comprises: 25-50 wt% fluorocarbon emulsion, 5-20 wt% microcapsule self-healing agent, 0.1-1 wt% water-resistant agent, 0.1-3 wt% film-forming aid, 0.1-1 wt% stabilizer, 0.1-1 wt% bactericide and preservative, with the balance being water. The fluorocarbon emulsion is a core-shell polymer emulsion. The outer shell is formed by emulsion polymerization of fluorinated acrylate monomers, furan-structured monomers, and maleimide-structured monomers, while the core is formed by emulsion polymerization of soft acrylate monomers and hard acrylate monomers. The emulsion polymerization is carried out in an aqueous solution containing emulsifiers and initiators. The microcapsule self-healing agent has a core-shell structure, including a urea-formaldehyde resin shell and a fluorooil core material encapsulated within the urea-formaldehyde resin shell.

The invention discloses a whitening and cleansing composition and a preparation method thereof. The whitening and cleansing composition is prepared from the following components: 15 to 23 parts of a surfactant, 3.5 to 6.5 parts of a whitening active agent, 1.3 to 3.8 parts of an antioxidant, 7.5 to 15.5 parts of a humectant, 0.15 to 0.65 part of a stabilizer, 0.01 to 0.05 part of a pH (Potential of Hydrogen) regulator and 0.8 to 1.2 parts of a preservative. The antioxidant contains a characteristic compound; through component compounding, the stability and efficiency of an anti-oxidation system in the cleansing composition are effectively improved, and the retention rate of active components is remarkably increased. Meanwhile, the compatibility of all the components in the system is optimized, so that the cleaning process and the skin care effect do not interfere with each other, the multiple effects of mild cleaning, deep whitening and barrier protection are synergistically achieved, and the balance of the cleaning power and the skin care effect is achieved.