Anti-oil and Anti-acne shower gel and production method therefor
By using azelaic acid, Frecher's leafy vegetable extract and other ingredients in shower gel, the problem of existing shower gel destroying skin moisture balance is solved, and the effect of removing acne and controlling oil is achieved, which significantly reduces skin oil secretion and acne Acne improves skin health.
Patent Information
- Application Number
- PCT/CN2023/102162
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-06-19
- Filing Date
- 2023-06-25
- Publication Date
- 2024-12-26
AI Technical Summary
Excessive chemical components in existing shower gels can easily destroy the balance of skin moisture and oil, resulting in dry skin, oily and acne problems, affecting skin health.
Develop an oil-controlled and acne-removing shower gel, containing azelaic acid, Frecher's leafy vegetable extract, caprylyglycine, Sophora ginseng extract, plant mite removal agent and other ingredients, which inhibit skin oil secretion, antibacterial and anti-inflammatory It works in concert with immune regulation to achieve the effect of removing acne and controlling oil.
Significantly reduces the secretion of skin oils, inhibits Propionibacterium acnes, relieves inflammation, prevents or relieves acne caused by mites, improves skin health, and is suitable for acne removal and daily cleaning of acne skin.
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Figure CN2023102162_26122024_PF_FP_ABST
Abstract
Description
Oil-controlling and acne-removing shower gel and preparation method thereof Technical Field
[0001] The present invention relates to the field of daily cosmetics, in particular to an oil-controlling and acne-removing shower gel and a preparation method thereof. Background Art
[0002] Shower gel has gradually become the most commonly used and consumed daily necessity in people's daily life. With the improvement of people's living standards, people's requirements for shower gel are getting higher and higher. At present, most of the common shower gels on the market contain more chemical ingredients. Frequent use will destroy the balance of moisture and oil in the skin, and easily cause dry skin, oily skin, and acne problems. Long-term use is not good for people's skin health.
[0003] Summary of the Invention
[0004] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides an oil-controlling and acne-removing shower gel and a preparation method thereof.
[0005] The technical solution adopted by one embodiment of the present invention to solve the technical problem is:
[0006] The invention discloses an oil-controlling and acne-removing shower gel, comprising the following raw materials in percentage by weight: 10-18% of a surfactant, 0.3-1% of a thickener, 0.5-2% of sodium chloride, 0.05-0.2% of a pH regulator, 0.1-0.6% of azelaic acid, 0.1-0.5% of capryloylglycine, 0.1-0.6% of a plant acaricide, 0.2-2% of a sophora flavescens extract, 0.01-0.1% of an epilobium fleischerii extract, 0.1-0.5% of a saccharide isomer mixture, 0.1-0.5% of sodium ascorbyl phosphate, 0.5-1.5% of a tremella fuciformis extract, 0.01-0.2% of a gentiana scabra extract, 0.6% of a preservative, and the balance of water.
[0007] Preferably, the surfactant is composed of sodium laureth sulfate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium lauroamphoacetate, and cocamidomethyl MEA.
[0008] Preferably, the plant acaricide is composed of thyme extract, rosemary water, 1,3-propylene glycol, dichlorobenzyl alcohol, and phenoxyethanol.
[0009] Preferably, the thickener consists of tocopherol and PEG-120 methyl glucose dioleate.
[0010] Preferably, the saccharide isomer mixture comprises saccharide isomers, water, citric acid and sodium citrate.
[0011] Preferably, the pH regulator is potassium hydroxide.
[0012] The preparation method of the above-mentioned oil-control and acne-removing shower gel comprises the following steps:
[0013] S1: Divide the water into two parts, put the first part of water into the production pot, heat it to 80-85℃, add surfactant and stir until it is evenly dissolved;
[0014] S2: Add thickener, azelaic acid, and capryloylglycine to the production pot and stir until dissolved evenly;
[0015] S3: Cooling to 45°C, adding plant acaricide, Sophora flavescens extract, pH regulator, saccharide isomer mixture, sodium ascorbyl phosphate, Tremella fuciformis extract, Gentiana scabra extract, and Epilobium fleischini extract, stirring to dissolve evenly;
[0016] S4: Sodium chloride is completely dissolved in the second part of water and then put into the production pot and stirred evenly, and the pH and viscosity are adjusted and the material is discharged.
[0017] Beneficial effects of the present invention:
[0018] 1. To address acne / pimples caused by abnormal androgen regulation of sebaceous glands and abnormal keratinization of sebaceous ducts, this application utilizes the synergistic effects of azelaic acid and Epilobium fleischerii extract to achieve acne and oil control. Azelaic acid, also known as azelaic acid, is currently used primarily to treat melanoma, melasma, rosacea, hyperpigmentation, and acne. Azelaic acid's mechanism of action: Inhibiting skin oil secretion. Androgen hormones, particularly dihydrotestosterone, stimulate sebaceous gland activity, which is one of the causes of acne. Azelaic acid competitively inhibits 5α-reductase in the sebaceous glands, which increases the bioconversion of testosterone to dihydrotestosterone. This enzyme, 5α-reductase, is a key enzyme in the conversion of testosterone to dihydrotestosterone, and azelaic acid competitively inhibits this enzyme, thereby reducing oil secretion. It also has an anti-keratinization effect on both normal and acne-affected skin, reducing the synthesis of filamentous keratin, preventing excessive keratinization of hair follicles, and unclogging pores. The inclusion of Epilobium fleischerii extract in the formula also has a strong inhibitory effect on 5α-reductase. By combining Epilobium schreibii extract with azelaic acid, the amount of azelaic acid used and skin irritation can be reduced, while achieving significant acne-removing and oil-control effects.
[0019] 2. Capryloylglycine has excellent skin compatibility and is gentle on the skin, targeting acne / pimples caused by overgrowth of Propionibacterium acnes. It also effectively inhibits P. acnes and Staphylococcus aureus in a short period of time (2-5 minutes), demonstrating significant effectiveness in the prevention and treatment of acne and pimples. Therefore, this formulation uses capryloylglycine as the active ingredient to inhibit P. acnes, taking into account its short duration of action and high efficacy, while also considering its gentleness on the skin.
[0020] 3. For acne / pimples caused by inflammatory immune responses, Sophora flavescens extract is primarily used. Sophora flavescens extract has broad-spectrum antimicrobial properties, not only inhibiting bacterial biosynthesis but also affecting bacterial biooxidation processes. The anti-inflammatory mechanism of Sophora flavescens extract is due to its stabilizing effect on red blood cell membranes. It also has a strong immunomodulatory effect, exerting its anti-inflammatory effects through changes in immune cells, cytokines, and other inflammatory regulatory factors. It has a strong therapeutic effect on eczema and dermatitis, relieving itchy skin caused by inflammation and accelerating the repair of acne-prone skin.
[0021] 4. To address acne / breakouts caused by skin mites, a plant-based mite remover is added to the formula. The main active ingredients of this mite remover are thyme extract, rosemary, water, and dichlorobenzyl alcohol. It has a strong killing and repelling effect on various types of mites, effectively preventing or alleviating breakouts caused by mites.
[0022] In summary, the compatibility mechanism of the acne-removing and oil-controlling ingredients in this formula covers various pathogenesis of acne / pimples, which can achieve more significant acne-removing and oil-control effects. At the same time, it also takes into account the mildness and safety of the overall formula, and is applicable to a wider range of groups. It can not only be used to remove acne on acne-prone skin, but also for daily cleansing and acne prevention. BRIEF DESCRIPTION OF THE DRAWINGS
[0023] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments with reference to the accompanying drawings, in which:
[0024] Figure 1 is a schematic diagram of the effects of use by subject 1;
[0025] Figure 2 is a schematic diagram of the effects of use by subject 2;
[0026] Figure 3 shows the comparison of ISGA scores at different time points (x±s, n=30);
[0027] Figure 4 shows the average volume change of acne (mm, x ± s, n = 30);
[0028] Figure 5 shows the changes in skin oil content (μg / cm, x±s, n=30). DETAILED DESCRIPTION
[0029] Detailed descriptions of implementation methods are crucial for fully disclosing, understanding, and reproducing the invention, and for supporting and explaining the claims. The description of the implementation methods should be consistent with the technical solution employed to solve the technical problem. For simple technical solutions, only one embodiment may be provided. For technical solutions with a broader scope of protection, more than one embodiment should be provided to support the scope of the claimed protection.
[0030] Example of recipe of embodiment
[0031] The preparation method is as follows:
[0032] 1. Accurately weigh the ingredients in the formula and clean the production equipment;
[0033] 2. Add raw material No. 1 (reserve 5% water) to the stirring pot, heat to 80-85℃, add raw materials No. 2 and 3, and stir until completely dissolved;
[0034] 3. Add raw materials 4, 5, and 6 in sequence and stir for 20 minutes until evenly dissolved;
[0035] 4. Add raw materials 7, 8, and 9 in sequence, stir until completely dissolved, and then cool down;
[0036] 5. Cool down to 45℃, add raw materials 10, 11, 12, 13, 14, 15, 16, 17 and 18, and stir each raw material evenly before adding the next one;
[0037] 6. Add the remaining water-dissolved raw material No. 19, adjust the pH and viscosity, and then conduct sampling inspection;
[0038] 7. After passing the inspection, the semi-finished products are discharged and stored;
[0039] 8. Filling, packaging and coding;
[0040] 9. Goods will be put into storage after passing random inspection.
[0041] The plant-based mite remover used in this application is produced and provided by Guangdong Dimei New Material Technology Co., Ltd.
[0042] Skin occlusive patch test Skin reaction test
[0043] 1. Materials and Methods
[0044] 1. Test substance: Cosmetic final product (diluted to 1% aqueous solution).
[0045] 2. Control: blank filter paper control.
[0046] 3. Subjects: A total of 30 subjects, including 1 male and 29 females, aged 21 to 59 years old, with an average age of 39.77±12.14 years old, met the voluntary inclusion criteria.
[0047] 4. Test Method: Select qualified patch test equipment and use the closed patch test method. Place approximately 0.020mL-0.025mL (liquid) of the diluted test substance in the patch tester and apply it to the subject's back with hypoallergenic tape. Remove the test substance after 24 hours and observe the skin reaction 0.5, 24, and 48 hours after removal. Record the results according to the skin reaction grading standards in the "Technical Specifications for Safety of Cosmetics" (2015 edition).
[0048] Skin reaction grading standard for occlusive patch test
[0049] 2. Test results
[0050] Summary of cosmetics human skin patch test results
[0051] The results showed that: the results of human skin patch test showed that 6 cases of grade 1 adverse skin reactions occurred among 30 people.
[0052] Acne removal and oil control effect experiment
[0053] 1. Materials and Methods
[0054] 1. Test substance: original cosmetic final product
[0055] 2. Comparison: Compare yourself before and after
[0056] 3. Subjects: A total of 30 subjects (33 subjects were enrolled and 3 subjects dropped out), including 14 females and 16 males, aged 18 to 40 years, with an average age of 29.50±6.31 years, who met the subject inclusion criteria.
[0057] 4. Instrument measurement parameters and related equipment:
[0058] 5. Test environment: temperature: 20℃~22℃, humidity: 40%~60%, and real-time dynamic monitoring.
[0059] 6. Test methods:
[0060] 6.1 Test Purpose and Principle
[0061] At least 30 subjects were recruited to use the test sample for 28 consecutive days. The improvement level of acne lesions was evaluated subjectively and by doctors. Antera 3D was used to collect and analyze the corresponding parameters of acne on the subjects' backs. The oil content on the skin surface was measured using the test probe SM815. The changes in various indicators before and after use were compared to determine the product's acne-removing and oil-control effects.
[0062] 6.2 Experimental Design Principles
[0063] Double-blind, randomized, self-controlled
[0064] 6.3 Subject Screening
[0065] 6.3.1 Number of subjects: Minimum valid number of subjects: 30
[0066] 6.3.2 Subject conditions:
[0067] 6.3.2.1 Inclusion criteria:
[0068] (1) Applicants should be healthy male or female and aged between 18 and 45 years.
[0069] (2) The patient is in good general health and has no major systemic diseases.
[0070] (3) There are more than two acne spots on the back.
[0071] (4) Able to strictly follow the requirements and time schedule of the research plan and sign the informed consent form and confidentiality agreement.
[0072] 6.3.2.2 Exclusion criteria:
[0073] (1) Women who are currently pregnant, breastfeeding, or planning to become pregnant in the next two months.
[0074] (2) Acute inflammation or other skin diseases on the back (such as eczema, lupus erythematosus, seborrheic dermatitis, psoriasis, severe epidermal exfoliation, etc.).
[0075] (3) Those with a highly sensitive constitution or allergic reaction to cosmetics.
[0076] (4) Those with obvious sunburn, scars, excessive hair growth on the back or other conditions that may affect the test results.
[0077] (5) Any medications taken orally or topically in the past month that may affect skin condition or reaction, such as antihistamines, antibiotics, insulin, anti-inflammatory drugs, vitamin A, steroids, aspirin, thyroid drugs, etc.
[0078] (6) Those who have used hormone drugs and immunosuppressants in the past month.
[0079] (7) Those who are currently or have participated in other clinical trials within the past month.
[0080] (8) The patient has received cosmetic treatments such as chemical peel (acid treatment), microdermabrasion, laser resurfacing, etc. on the back within the past three months.
[0081] (9) Acne classified as grade IV according to the modified international acne grading system and Pillsbury classification.
[0082] 6.3.2.3 Exclusion criteria: serious adverse reactions during the trial and non-compliance with the R&D plan (such as use of other cosmetics, drugs during the trial, or requesting to withdraw for other reasons)
[0083] Table 1 International Modified Acne Grading System
[0084] 6.4 Preparation before the test
[0085] No products can be used on the test site on the day of the test. Before the test, the subjects need to be in the human efficacy evaluation room (temperature: 20℃~22℃,
[0086] (Humidity: 40%-60%) Sit quietly for 30 minutes without drinking water or other beverages. Maintain a relaxed posture and avoid touching the back.
[0087] Before the trial, the subjects were given an explanation of the experiment and signed an informed consent form.
[0088] The test area was the back.
[0089] 6.5 Product Usage
[0090] When bathing, apply an appropriate amount of the test product in place of your usual bath product, gently massage all over your body, and then rinse. Use once daily for 28 consecutive days. During the trial, participants were prohibited from using acne-removing, oil-control, or anti-inflammatory / antibacterial medications. Participants were also prohibited from using intravenous drips, injections, oral administration, or other forms of ingestion that could affect acne-removing or oil-control testing. Participants were primarily indoors and avoided prolonged exposure to outdoor sunlight.
[0091] 6.6 Subjective Evaluation
[0092] During a follow-up visit 28 days after using the product (D28), participants completed a questionnaire to evaluate their back condition and recorded their scores in the human efficacy laboratory. Using a 7-point scale, the product was rated based on four aspects: skin feel, effectiveness, mildness, and user satisfaction. This was then evaluated and recorded at each follow-up visit.
[0093] 6.7 Semi-quantitative evaluation (doctor assessment)
[0094] Dermatologists evaluated the acne lesions on the subjects' backs (photographed) before product use (D0) and 28 days after use (D28). The improvement in lesion symptoms before and after use was scored using the ISGA scale (Table 2), and the percentage reduction in lesions was calculated.
[0095] Table 2 ISGA scale
[0096] 6.8 Objective Quantitative Evaluation
[0097] After a 30-minute rest in the human efficacy evaluation room, subjects were photographed using an Antera 3D Skin Image Analyzer at the acne site on their backs. Software analysis determined the average volume of acne within the test area. An SM815 was then used to measure skin oil content at the test site. This measurement served as the baseline (D0). The product was then distributed and instruction on how to use the product was provided. Subjects were revisited 28 days after using the product (D28) for the same indicators to be measured.
[0098] The same tester should use the same instrument to test the same subject. The test site should be consistent between the two test time points.
[0099] 6.9 Statistical Analysis
[0100] The measured values of each test area were statistically analyzed, including quantity, mean, standard deviation, standard error, minimum value, median, maximum value, etc. If the test data was normally distributed, the paired t-test method was used for statistical analysis; if the test data was non-normally distributed, the rank sum test method was used for statistical analysis. The statistical method used was a two-tailed test, with a test level of α = 0.05. SPSS 25.0 software was used for statistical analysis. When the results showed significant differences, *p < 0.05 and **p < 0.01 were used to indicate them, respectively. *p < 0.05 indicates a significant difference, and **p < 0.01 indicates an extremely significant difference. If there is a significant difference in the numerical values of the various indicators in the test area, it means that the product has acne-removing and oil-control effects.
[0101] 2. Test results
[0102] During the trial, 33 subjects were enrolled, 3 dropped out (withdrawn automatically due to personal reasons), and finally 30 subjects met the protocol and were considered valid cases. Among them, there were 14 females and 16 males with an average age of 29.50±6.31 years. This study used this population for statistical analysis.
[0103] 1. Safety and adverse reaction evaluation
[0104] During the trial, professional dermatologists asked the subjects whether they experienced dryness, oiliness, scaling, redness, or stinging while using the test product. They also observed and recorded any rash, redness, swelling, or scaling on their backs. The subjects were then scored according to the scoring criteria in Table 3. The scores were recorded on the event report form and evaluated for relevance according to the criteria listed in Table 4. No subjects experienced adverse reactions during the trial. Table 3: Scoring criteria for adverse reactions
[0105] Table 4 Evaluation of the tested products
[0106] 2. Subjective evaluation of subjects
[0107] Using a 7-point scale (Table 5), participants completed the questionnaire regarding product effectiveness, mildness, and satisfaction with the product four weeks after trial use (D28). This scale was used to analyze participants' evaluations of product experience, efficacy, and satisfaction with the product.
[0108] Table 5 Self-assessment scoring standards (7-level scoring method)
[0109] The following are statistical charts based on the questionnaires filled out by the subjects, and conclusions are drawn from the data in the tables and charts.
[0110] 2.1 Product skin feel evaluation
[0111] Table 6 Product skin feel evaluation results (n=30)
[0112] The product's skin feel received an average score of over 6.1, with statistically over 50% of participants giving it a positive rating. On D28, the average score for "feeling no tightness on the back skin after use" was 6.17, with 96.67% of participants agreeing. On D28, the average score for "gentle and non-irritating" was 6.30, with 100% of participants agreeing.
[0113] 2.2 Product usage evaluation
[0114] After 4 weeks of use (D28), the subjects evaluated the product's acne-removing and oil-control effects. The questionnaire data are as follows:
[0115] 2.2.1 Acne-removing effect
[0116] Table 7 Evaluation results of product anti-acne effect (n=30)
[0117] In terms of acne treatment, after 28 days of use (D28), all mean scores were above 5.8, with statistically over 50% of participants giving positive feedback on the product's acne-removing effects. 93.33% of participants agreed with the statements "redness and swelling in the acne area are soothed after use" and "skin feels smoother after use." 96.67% agreed with the statement "protruding acne on the back feels smaller after use." 90.00% agreed with the statement "acne-prone skin feels improved and the number of acne spots has decreased after use."
[0118] 2.2.2 Oil control effect
[0119] Table 8 Evaluation results of product oil control effect (n=30)
[0120] In terms of oil control, after 28 days of use (D28), all average ratings were above 5.9, with over 50% of participants giving the product positive reviews. 100% of participants agreed with the statement "I feel less oil on my back after use," and 90% agreed with the statement "My back skin feels refreshed after use."
[0121] 2.3 Product Satisfaction Evaluation
[0122] Table 9 Product satisfaction evaluation results (n=30)
[0123] In terms of overall product satisfaction, after 28 days of use (D28), more than 50% of the subjects gave positive comments on the product satisfaction survey results. At D28, 93.33% of the subjects expressed satisfaction with the product.
[0124] 3. Semi-quantitative evaluation (doctor evaluation)
[0125] Dermatologists evaluated the acne lesions on the subjects' backs before and after use of the product. The improvement in lesion symptoms was scored using the ISGA scale, and the percentage reduction in lesions was calculated. The percentage reduction in lesions was calculated using Formula 1. Comparing the ISGA scores before and after use can reflect the product's acne-removing efficacy.
[0126] Percentage of skin lesion reduction = (ISGA score before using the product - ISGA score after using the product) / ISGA score before using the product × 100%
[0127] Table 10 Comparison of ISGA scores before and after use (x±s, n=30)
[0128] The evaluation results are shown in Table 10 and Figure 3 (the baseline values and the follow-up time point values of the ISGA score were analyzed using the rank sum test. Significant differences are marked with *p<0.05 and **p<0.01):
[0129] Compared with the baseline value before use (D0), the ISGA skin lesion score showed a downward trend after using the product. After 28 days of use (D28), the percentage of skin lesion reduction was 36.51%, and the difference between the two was extremely significant (p<0.01).
[0130] 4. Analysis of average acne volume
[0131] Antera3D captures acne area images and uses software analysis to measure the average volume change of acne within the selected AOI at different time points. Comparing the average volume change before and after use can reflect the product's acne-removing efficacy.
[0132] The greater the decrease in the average acne volume at different time points compared to the baseline value before use (D0), the better the improvement of acne lesions, indicating that the product is more effective in removing acne. Average acne volume reduction rate = (average acne volume before product use - average acne volume after product use) / average acne volume before product use × 100%
[0133] Table 11 Descriptive statistics of average volume of acne (mm, n=30)
[0134] Table 12 Analysis of differences in average volume of acne (mm, x±s, n=30)
[0135] The test results are shown in Table 12 and Figure 4 (paired t-test was used to analyze the differences between the baseline and follow-up time points of the average acne volume. Significant differences are indicated by *p<0.05 and **p<0.01):
[0136] Compared with the baseline value before use (D0), the average volume of acne showed a downward trend after using the product, and decreased by 74.17% after 28 days of use (D28), which was extremely significantly different from the baseline value (p<0.01). The average volume of acne after using the product was lower than the baseline value.
[0137] 5. Analysis of skin surface oil content
[0138] A higher value for the sebum content measured by the Sebumeter SM815 indicates a higher surface oil content. Comparing the changes in oil content within a specific area of the skin before and after use can reflect the product's oil-control effectiveness. The greater the decrease in sebum content at different follow-up time points compared to the pre-use baseline (D0), the greater the improvement in surface oil content within the tested area, indicating a more effective product in reducing surface oil content.
[0139] Skin oil content reduction rate = (oil content before using the product - oil content after using the product) / oil content before using the product × 100%
[0140] Table 13 Descriptive statistics of skin oil content (μg / cm, n=30)
[0141] Table 14 Analysis of differences in skin oil content (μg / cm, x±s, n=30)
[0142] The test results are shown in Table 14 and Figure 5 (the baseline values and the values at the follow-up time points of skin oil content were analyzed using the rank sum test. Significant differences are marked with *p<0.05 and **p<0.01):
[0143] Compared with the baseline value before use (DO), the oil content on the skin surface showed a downward trend after using the product. After 28 days of use (D28), it decreased by 45.39%, which was extremely significantly different from the baseline value (p<0.01). The oil content on the skin surface was lower than the baseline value after using the product.
[0144] 3. Test Conclusion
[0145] The efficacy of cosmetics in acne treatment and oil control was evaluated by repeated use of the Beti Oil Control Anti-Acne Shower Gel provided by Zhongshan Changxing Industrial Co., Ltd. on 30 subjects. The results showed that:
[0146] 1. No adverse reactions occurred in this trial, and the trial product has a high safety profile.
[0147] 2. Subjective evaluations showed that after 28 days of use (D28), the average score was above 5 points. Statistically, over 50% of subjects gave positive comments on the product's skin feel, acne removal, oil control, mildness, and satisfaction. On D28, 100% of subjects agreed with the statements "I felt less oil on my back skin after use" and "The product was mild and non-irritating." Over 90% of subjects agreed with the statements "It soothed redness and swelling in acne-prone areas," "I felt my back pimples were smaller," "My skin felt smoother after use," "I felt my acne-prone skin improved and the number of pimples decreased," "My back skin felt refreshed after use," and "My back skin felt less tight after use." Over 90% of subjects also gave positive feedback on product satisfaction.
[0148] 3. Semi-quantitative evaluation (doctor's evaluation) showed that after the subjects used the product, the ISGA score showed a downward trend at the follow-up time point D28, which was significantly different from the baseline value.
[0149] 4. Analysis of the average volume of acne showed that after the subjects used the product, the average volume of acne showed a downward trend at the follow-up time point D28, which was significantly different from the baseline value.
[0150] 5. Analysis of the oil content on the skin surface showed that after the subjects used the product, the oil content on the skin surface showed a downward trend at the follow-up time point D28, which was significantly different from the baseline value.
[0151] In summary, 28 days of use of the Beauté Oil-Control Anti-Acne Body Wash reduced ISGA scores, improved overall back acne lesions, decreased the average volume of back acne, and reduced back oil content, achieving both acne and oil control effects. Furthermore, in the subjective evaluation, statistically over 50% of participants gave positive comments on the product's skin feel, acne removal, oil control effects, mildness, and satisfaction, demonstrating its acne-removing and oil-control properties.
[0152] Although the present invention has been described in detail with reference to the above embodiments, it will be apparent to those skilled in the art from this disclosure that various changes or modifications may be made to the present invention without departing from the principles and spirit of the invention as defined in the claims. Therefore, the detailed description of the disclosed embodiments is intended to be illustrative only and not to limit the present invention, which is to be defined by the claims.
Claims
1. An oil-controlling and acne-removing shower gel, characterized in that: The invention comprises the following raw materials in percentage by weight: 10-18% surfactant, 0.3-1% thickener, 0.5-2% sodium chloride, 0.05-0.2% pH regulator, 0.1-0.6% azelaic acid, 0.1-0.5% capryloyl glycine, 0.1-0.6% plant acaricide, 0.2-2% sophora flavescens extract, 0.01-0.1% epilobium fleischer extract, 0.1-0.5% carbohydrate isomer mixture, 0.1-0.5% sodium ascorbyl phosphate, 0.5-1.5% tremella extract, 0.01-0.2% gentian extract, 0.3-0.7% preservative and balance water.
2. The oil-controlling and acne-removing shower gel according to claim 1, characterized in that: The surfactant consists of sodium laureth sulfate, sodium methyl cocoyl taurate, cocamidopropyl betaine, sodium lauroylamphoacetate and cocamidomethyl MEA.
3. The oil-controlling and acne-removing shower gel according to claim 1, characterized in that: The plant acaricide consists of thyme extract, rosemary water, 1,3-propylene glycol, dichlorobenzyl alcohol and phenoxyethanol.
4. The oil-controlling and acne-removing shower gel according to claim 1, characterized in that: The thickener consists of tocopherol and PEG-120 methyl glucose dioleate.
5. The oil-controlling and acne-removing shower gel according to claim 1, characterized in that: The sugar isomer mixture includes sugar isomers, water, citric acid and sodium citrate.
6. The oil-controlling and acne-removing shower gel according to claim 1, characterized in that: The pH regulator is potassium hydroxide.
7. Prepare an oil-controlling and anti-acne shower gel as claimed in claim 1, characterized in that: The preparation method comprises the following steps: S1: Divide the water into two parts, put the first part of water into the production pot, heat it to 80-85℃, add surfactant and stir until it is evenly dissolved; S2: Continue to add thickener, azelaic acid, and capryloyl glycine into the production pot and stir until they are evenly dissolved; S3: Cool down to 45°C, add plant acaricide, Sophora flavescens extract, pH adjuster, sugar isomer mixture, sodium ascorbyl phosphate, Tremella fuciformis extract, Gentiana scabra extract, and Epilobium freiherb extract, and stir to dissolve evenly; S4: Sodium chloride is first completely dissolved with the second part of water and then put into the production pot and stirred evenly, and the pH and viscosity are adjusted and the material is discharged.
Citation Information
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