180 results about "Ethanesulfonic acid" patented technology

The invention relates to a betaine type double-tailed hydrophobic association polymer fracturing thickening agent and a preparation method thereof. The thickening agent is prepared by the following steps: copolymerizing four monomers, namely acrylamide, 2-allyl methylamino sodium ethanesulfonate, methyl diallyl hydroxypropyl sulfobetaine and double-tailed long-chain alkyl allyl sulfoethyl betaine to form gel, chopping, hydrolyzing, neutralizing and purifying. The preparation method comprises the following steps: firstly adding distilled water, adding acrylamide, 2-allylmethylamino sodium ethanesulfonate, methyldiallyl hydroxypropyl sulfobetaine and other remaining raw materials, adjusting the total concentration, introducing N2 to remove oxygen, adding an initiator, reacting to prepare gel, chopping the gel, and hydrolyzing to obtain the water-soluble polymer. The fracturing thickening agent has good water solubility and shows good salt resistance in mixed saline water with the mineralization degree larger than or equal to 30000 mg / L, a prepared linear solution and jelly formed after crosslinking have high viscosity retention capacity at the temperature of 150 DEG C and the shearing rate of 170 s <-1 >, and the actual construction requirement for fracturing yield increase with the on-site mineralization degree larger than or equal to 30000 mg / L is met.

The invention discloses a high-sensitivity cardiac troponin-T electrochemiluminescence detection kit. The kit comprises a magnetic microsphere reagent coated by a high-sensitivity cardiac troponin-T capture antibody and a high-sensitivity cardiac troponin-T detection antibody reagent labeled by an electrically neutral ruthenium compound, the structural general formula of the electrically neutral ruthenium compound is # imgabs0 # n = 0-9; the magnetic microsphere reagent coated with the high-sensitivity cardiac troponin-T capture antibody comprises a magnetic microsphere coated with the high-sensitivity cardiac troponin-T capture antibody and a diluent; the electrically neutral ruthenium compound labeled high-sensitivity cardiac troponin-T detection antibody reagent comprises an electrically neutral ruthenium compound labeled high-sensitivity cardiac troponin-T detection antibody and a diluent; the diluent is prepared from piperazine-1, 4-diethyl sulfonic acid or 3-(N-morpholinyl)-2-hydroxy propanesulfonic acid. When the high-sensitivity cardiac troponin-T electrochemiluminescence detection kit is used for detection, a reaction system does not contain streptavidin coated magnetic beads or biotinylated antibodies, so that interference of biotin in a sample is avoided.

The invention discloses a liquefying agent, application thereof and a nucleic acid detection system, the liquefying agent comprises strong base, acetylcysteine and 2-(N-morpholine) ethanesulfonic acid; in the liquefying agent, the concentration of the strong base is 0.2 mol / L to 1 mol / L; the concentration of the acetylcysteine is 3 to 300 mmol / L; the concentration of the 2-(N-morpholine) ethanesulfonic acid ranges from 2 mmol / L to 5 mmol / L. Through the synergistic effect of the strong base, the acetylcysteine and the 2-(N-morpholine) ethanesulfonic acid, the liquefaction time can be remarkably shortened, the viscous biological sample treatment efficiency and speed can be improved, and the viscous biological sample treated by the liquefier can be directly used for nucleic acid amplification; and the viscous biological sample treated by the liquefying agent can be stored for a long time, the accuracy and reliability of nucleic acid detection are ensured by long-time stability, and the credibility of a detection result is improved.

The invention relates to the technical field of oilfield chemistry, in particular to an aminoethanesulfonic acid type surfactant and a preparation method and application thereof.The preparation method of the aminoethanesulfonic acid type surfactant comprises the steps that firstly, fatty amine is dissolved in a first solvent, a sodium chloroethanesulfonate aqueous solution is added, and N-long-chain alkyl-2-sodium aminoethanesulfonate is obtained through a reaction; and 2, dissolving a required amount of N-long-chain alkyl-2-sodium aminoethanesulfonate in a second solvent, adding a required amount of methyl acrylate, and reacting to obtain the aminoethanesulfonic acid type surfactant. The aminoethanesulfonic acid type surfactant disclosed by the invention contains long-chain alkyl, amino, ester groups and sulfonic acid groups, so that the aminoethanesulfonic acid type surfactant has good surface activity and can meet the development requirements of oil and gas fields. The microemulsion cleanup additive prepared from the aminoethanesulfonic acid type surfactant can effectively reduce the surface tension and the interfacial tension of an aqueous solution, and the preparation method is easy and convenient to operate, mild in condition and suitable for industrial production.

The invention belongs to the technical field of cosmetics, and discloses a superconductive centella asiatica extract as well as a preparation method and application thereof. The superconductive centella asiatica extract has a core-shell structure, an inner core of the superconductive centella asiatica extract comprises centella asiatica extract, a shell of the superconductive centella asiatica extract comprises ionic liquid, and the ionic liquid comprises ethyoxyl diglycol, urea, betaine, N-ethyl pyrrolidone and hydroxyethyl piperazine ethanesulfonic acid. According to the invention, ethyoxyl diglycol, urea, betaine, N-ethyl pyrrolidone and hydroxyethyl piperazine ethanesulfonic acid are compounded to obtain the ionic liquid, and the centella asiatica extract is wrapped in the ionic liquid, so that the stability, transdermal absorption rate and bioavailability of the centella asiatica extract can be effectively improved.

The invention relates to a bisulfonate hydrophobic association polymer oil-displacing agent with a benzene ring structure and a preparation method thereof. The polymer oil-displacing agent is formed by copolymerization of three monomers, namely acrylamide, sodium 2-allyl methylamino ethanesulfonate and long-chain alkyl disulfoethyl (4-vinyl benzyl) betaine which is a hydrophobic monomer with the benzene ring structure. The preparation method comprises the following steps: firstly adding distilled water, sequentially adding acrylamide, 2-allylmethylamino sodium ethanesulfonate and long-chain alkyl disulfoethyl (4-vinyl benzyl) betaine, adding water to adjust the total concentration, introducing N2 to remove oxygen, adding an initiator, and reacting at a certain temperature to obtain the terpolymer. The polymer oil-displacing agent prepared by the invention has good water solubility and good temperature resistance and shear resistance, shows good salt resistance in saline water with the degree of mineralization being greater than or equal to 30000 mg / L, shows a good oil-displacing effect in heterogeneous rock cores, and can improve the crude oil recovery rate by 10% or above.

A method for preparing exosomes is provided. The method includes preparing a human platelet, treating the human platelet with a buffer to obtain a platelet solution, centrifuging the platelet solution, and collecting supernatant of the centrifuged platelet solution to obtain an exosome solution. The buffer is calcium ion buffer, phosphate buffered saline (PBS), tris(hydroxymethyl)aminomethane hydrochloride (Tris-HCl) buffer, or 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES) buffer.

The invention discloses a whitening and freckle-removing essence which comprises the following components: a calendula extract, pure water, 1, 2-pentanediol, methylpropanediol, carbomer, arginine, nicotinamide, a freckle-removing essence, a natural plant penetration enhancer, hydroxyethyl piperazine ethanesulfonic acid, small-molecule ellagic acid, dipropylene glycol, 1, 2-propylene glycol, ethanol and water. The composition is prepared from 1, 2-hexanediol, caprylyl glycol, ethylhexylglycerin, raspberry ketone glucoside and a PEG / PPG-17 / 6 copolymer. The invention further discloses a production process of the whitening and freckle-removing essence water. The invention has the following advantages: with pure natural plants as a main product, the skin has obvious change after being used for a week, specifically, pregnancy spots, sunburn, chloasma, pigmentation after inflammation and other color spots on the face can be reduced and faded, the face skin can be whitened, the face is mild and non-irritating, and the effects of improving uneven skin color, brightening skin color and the like can be achieved.

To provide an electrolytic silver germanium alloy plating solution capable of codepositing a sufficient amount of germanium in a film, having good liquid stability, and hardly causing foaming.SOLUTION: The problem is solved by an electrolytic silver germanium alloy plating solution containing a silver source and a germanium source characterized by containing a nitrogen-containing coordination compound having a molecular weight of 500 or less. Specific examples of the nitrogen-containing coordination compound include N,N-di(2-hydroxyethyl)glycine, diethanolamine, N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid, triethylenetetramine, glycine, tris(hydroxymethyl) aminomethane, N-methylglucamine, bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane, tricin, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, and salts of these compounds.SELECTED DRAWING: None

The invention discloses a preserving fluid for stably preserving sample DNA at normal temperature and a preparation method thereof, and belongs to the technical field of biological sample preservation. The preserving fluid comprises a lysis system, a nucleic acid protection system and a buffering and stabilizing system, the cracking system comprises a composite surfactant and an enzymolysis auxiliary agent; the composite surface active agent is prepared from polyether polyol fatty acid ester and cocamidopropyl hydroxy sulfobetaine; the enzymolysis auxiliary agent comprises lysozyme Lyso-V and protease K; the nucleic acid protection system comprises a nitrogen heterocyclic polyamine-carboxylic acid derivative and dextran sulfate; the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N' ', N ''tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N''-triacetic acid, disodium ethylene diamine tetraacetate-nitrogen heterocyclic derivative, and diethylenetriamine pentaacetic acid-piperazine derivative, and the nitrogen heterocyclic polyamine-carboxylic acid derivative comprises 1, 4, 7, 10-tetraazacyclododecane-N, N ', N '', N'' tetraacetic acid, 1, 4, 7-triazacyclononane-N, N', N ''-triacetic acid. The buffering and stabilizing system comprises an amphoteric buffering agent and a polymer stabilizer; the amphoteric buffering agent comprises 2-(N-morpholino) ethanesulfonic acid and N-tri (hydroxymethyl) methylglycine.

The invention belongs to the field of oilfield chemistry, and relates to self-thickening polyacrylamide as well as a preparation method and application thereof. The preparation method of the self-thickening polyacrylamide comprises the following steps: dissolving acrylamide, 2-acrylamide-2-phenyl ethanesulfonic acid, hydroxyl-N-allylaniline, N-hydroxymethyl acrylamide and a cosolvent in deionized water, and adjusting the pH value to obtain a homopolymerization solution; cooling the homopolymerization solution, introducing nitrogen, adding an initiator, introducing nitrogen again, carrying out a polymerization reaction, and after the reaction is completed, carrying out heating and heat preservation, and carrying out an aging reaction, so as to obtain a polyacrylamide rubber block; and cutting, granulating, drying, crushing and screening the polyacrylamide gel block to obtain the self-thickening polyacrylamide. The self-thickening polyacrylamide disclosed by the invention contains hydroxyl-N-allylaniline and N-hydroxymethyl acrylamide monomers, gel is generated along with time extension under the oil reservoir condition, the profile control effect is improved, and the problems of phase separation and chromatographic effect caused by migration velocity difference of a conventional gel system are avoided.

The invention discloses an artificial blood vessel and a preparation method thereof, and the preparation method comprises the following steps: uniformly mixing an erythrocyte ghost suspension and melanin nanoparticles to obtain a mixed solution; carrying out ultrasonic treatment and extrusion on the mixed solution to obtain a melanin nano-vesicle solution; carrying out electrostatic spinning on the polycaprolactone solution to obtain a polycaprolactone electrostatic spinning blood vessel; soaking the polycaprolactone electrostatic spinning blood vessel in an ethylenediamine solution, and then washing the polycaprolactone electrostatic spinning blood vessel with a phosphate buffer solution; then soaking in a 4-morpholine ethanesulfonic acid solution; finally, carrying out heparinization in a 4-morpholine ethanesulfonic acid solution containing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, N-hydroxysuccinimide and heparin; and incubating the heparin-modified polycaprolactone electrostatic spinning blood vessel in the melanin nano-vesicle solution to obtain the artificial blood vessel. The melanin nano-vesicles are modified, so that the anticoagulation performance of erythrocyte membranes is reserved, and meanwhile, the scavenging capacity of melanin nano-particles on reactive oxygen free radicals is reserved.

The invention relates to a composition with whitening and skin tendering effects, essence lotion and a preparation method and application of the essence lotion, in the composition with the whitening and skin tendering effects, the weight ratio of achillea millefolium extract to hydroxyethyl piperazine ethanesulfonic acid to ormosia henryi bark extract is (0.1-1): (0.5-8): (0.05-0.5). The essence lotion is prepared from the following components in percentage by weight: 0.75 to 6 percent of composition with skin whitening and tendering effects, 3 to 8 percent of emollient, 0.5 to 2 percent of emulsifier, 0.01 to 1 percent of filler, 0.5 to 2 percent of thickener, 0.8 to 1.5 percent of preservative, 0.02 to 0.2 percent of daily essence, 0.1 to 10 percent of skin conditioner, 0.1 to 10 percent of humectant and the balance of deionized water. The main components have a synergistic effect, can effectively regulate and control the information network effect of endothelin and reduce the differentiation, proliferation and the like of melanocytes in the first step of melanin generation by inhibiting the activity of tyrosinase, can promote cell autophagy and effectively metabolize melanin and lipofuscin generated in the skin, and achieves the effects of whitening, whitening, whitening and the like. The skin tendering effect is realized.

The invention belongs to the technical field of development of nintedanib preparations, and particularly relates to a nintedanib suspension preparation, a preparation method thereof and application of the nintedanib suspension preparation in treatment of pulmonary fibrosis. The preparation method comprises the following steps: dissolving a phospholipid material in an organic solvent at 50-70 DEG C, and preserving heat to obtain a solution A; dissolving inorganic salt in water for injection, and preserving heat to obtain a solution B; dissolving the ethanesulfonic acid nintedanib in the water for injection to obtain a solution C; dissolving an osmotic pressure regulator in the water for injection to obtain a solution D; mixing the solution A and the solution B by using microfluidics to obtain a suspension E; filtering through a tangential flow membrane to remove the organic solvent in the suspension E, adding the solution C, keeping the temperature for a period of time, adding the solution D as required, and uniformly mixing; and filtering the suspension with a sterilization filter to obtain the nintedanib suspension preparation. The liposome suspension prepared from the nintedanib prepared by the invention is stable in physical state and excellent in slow release effect, is suitable for low-dose inhalation administration in the lung, and is beneficial to improving the treatment effect and reducing side effects.

The invention relates to a bisulfonate hydrophobic associated polymer oil-displacing agent with a cyclic structure and a preparation method thereof. The oil-displacing agent is formed by copolymerization of four monomers, namely acrylamide, sodium 2-allyl methylamino ethanesulfonate, diallyl disulfoethyl betaine and long-chain alkyl dimethyl (p-3-carboxyl acrylamide benzyl) ammonium chloride which is a hydrophobic monomer with a benzene ring structure. The preparation method comprises the following steps: firstly, adding distilled water, then sequentially adding acrylamide, 2-allyl methylamino sodium ethanesulfonate, diallyl disulfoethyl betaine and a hydrophobic monomer long-chain alkyl dimethyl (p-3-carboxyl acrylamide benzyl) ammonium chloride with a benzene ring structure, supplementing water, adjusting the total concentration, introducing N2 to remove oxygen, adding an initiator, and stirring to obtain the water-absorbent polymer. And reacting at a certain temperature to obtain the quadripolymer. The prepared oil-displacing agent has good water solubility, temperature resistance and shearing resistance, shows good salt resistance in saline water with the mineralization degree larger than or equal to 30000 mg / L, shows a good oil-displacing effect in heterogeneous rock cores, and can improve the crude oil recovery rate by 10% or above.

The invention provides synthesis of a T-2 toxin antigen and preparation and application of a monoclonal antibody. Relates to the technical field of biotoxin detection. The preparation method of the T-2 toxin antigen comprises the following steps: step 1, synthesizing an immunogen T-2-BSA by adopting a carbodiimide method, dissolving 2mg of T-2 adipic acid with 0.5 mL of dimethylformamide, and recording as a solution A; 5 mg of bovine serum albumin and 3 mg of EDC are dissolved with a 2-morpholine ethanesulfonic acid buffer solution with the pH being 5.5, and the solution is marked as a solution B; step 2, under the condition of stirring, dropwise adding the solution A into the solution B, stirring for 18 hours in a dark place at 4 DEG C, then dialyzing for 3 days by using a phosphate buffer solution, changing the solution once a day, centrifuging the dialysate for 10 minutes at 3,500 r / min, and discarding the precipitate; the adipic acid is coupled with the T-2 toxin through a chemical method, and the unique step enriches the structural characteristics of the hapten, so that the prepared T-2 toxin complete antigen is excellent in immune effect, can efficiently excite immune response of an organism, and shows high specificity and sensitivity.

The invention discloses a carbon dioxide adsorbent based on a silver metal organic framework and a production method thereof.The carbon dioxide adsorbent is obtained by compounding aminoethanesulfonic acid and the silver metal organic framework according to the mass ratio of 1: 1, and the production method comprises the steps that S1, a bimetal framework is synthesized; s2, preparing a silver metal organic framework; s3, amino ethanesulfonic acid modification; by compounding the aminoethanesulfonic acid and the silver metal organic framework, the distribution of metal silver in the organic framework can be optimized, and CO2 chemical adsorption is enhanced through double metal nodes and easy acidic sites; metal silver forms a silver metal framework through coordination, aminoethanesulfonic acid modifies the surface of a pore channel through a sulfonic acid group, physical adsorption and chemical adsorption on CO2 are enhanced, the obtained carbon dioxide adsorbent can be combined with the surface plasma resonance effect, light energy can be efficiently converted into heat energy under visible light, and therefore desorption energy consumption is reduced.

The invention relates to the technical field of ink, and discloses environment-friendly water-based gravure ink for automotive upholstery and a preparation method thereof.The preparation method comprises the steps that 2-[3-(2-(methacryloyloxy) ethyl) ureido] ethanesulfonic acid and chitosan are subjected to a graft polymerization reaction to obtain modified chitosan, the modified chitosan, pigment, a dispersing agent and the like are added into water-based acrylic resin, and the environment-friendly water-based gravure ink is prepared. The environment-friendly water-based gravure ink for the automobile interior trim parts is obtained. The modified chitosan contains a large amount of hydrophilic sulfonate groups, has excellent dispersibility in the water-based acrylic resin, is grafted with polyacrylate molecular chains, has better compatibility with the acrylic resin, and is beneficial to improving the tensile strength and mechanical properties of the ink adhesive film. The modified chitosan contains a large amount of ureido groups and can form hydrogen bond interaction force with polyurethane, polycarbonate and the like, so that the cohesiveness and adhesive force between the ink and plastic matrixes such as polyurethane, polycarbonate and the like are improved.

The invention discloses whitening essence and a preparation method thereof, and belongs to the field of skin care products. The five-phase mixture comprises hydroquinone, tretinoin, fluocinonide, glabridin and vitamin C derivatives; the phase A is prepared from water, PCA sodium, butanediol, sodium hyaluronate and 1, 2-hexanediol; the phase B is prepared from ascorbyl glucoside, arginine, a skin conditioner, chlorphenesin, hydroxyethyl piperazine ethanesulfonic acid, alpha-arbutin, nicotinamide, dipotassium glycyrrhizinate and a skin conditioning and relieving agent; a phase C: 1, 3-propylene glycol and a preservative; a phase D: PEG-40 hydrogenated castor oil and rose oil; and a phase E: water, 1, 2-pentanediol, a peppermint leaf extract and glutathione. Compared with the existing whitening essence in the market, the whitening essence prepared by the invention can be applied to different skin types, and can be absorbed by different skin types when acting on different skin types, so that the whitening essence prepared by the invention can be used for whitening different skin types when being applied to users with different skin types, and the whitening essence can be used for whitening different skin types. The whitening and moisturizing effects are good.

The invention relates to the technical field of all-vanadium redox flow batteries, and particularly discloses a composition for promoting continuous production of a vanadium electrolyte and application of the composition. The invention discloses a composition for promoting continuous production of a vanadium electrolyte, which is characterized by specifically comprising the following components in parts by weight: 32-42 parts of concentrated sulfuric acid, 0.8-1.2 parts of a sulfonic acid compound, 0.05-0.15 part of sodium sulfate and 60-66 parts of water, the sulfonic acid compound is selected from any one or more of methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, sulfamic acid and p-toluenesulfonic acid. When the composition provided by the invention is used in continuous production of the vanadium electrolyte, the use amount of concentrated sulfuric acid is reduced, vanadium pentoxide can be effectively activated, and the reaction rate is increased; and the produced vanadium electrolyte has excellent electrochemical performance.

The invention relates to a perovskite solar cell based on 2-(diethanolamine) ethanesulfonic acid modification and a preparation method and application thereof. The perovskite solar cell sequentially comprises a conductive substrate, a tin dioxide electron transport layer, a 2-(diethanolamine) ethanesulfonic acid (EBS) interface passivation layer, a perovskite light absorption layer, a hole transport layer and a metal electrode layer from bottom to top. Compared with the prior art, the EBS interface passivation layer is constructed between the stannic oxide electron transport layer and the perovskite light absorption layer, so that the dual passivation effect is achieved; the oxygen vacancy defect is passivated through tight combination of a hydroxyl group and the stannic oxide layer; the sulfonic acid group is combined with the perovskite layer to passivate Pb and I ion defects, so that the conductivity of the electron transport layer is improved, energy level matching is promoted, the loss caused by non-radiative recombination is reduced, the residual stress of the perovskite layer is released, and the overall performance of the device is improved.

The invention provides an oral thylakoid product for resisting organ failure and aging, which is prepared by the following steps: extracting thylakoid from plants including spinach, arabidopsis thaliana, lettuce, cabbage, green algae or wheat seedlings, redissolving the thylakoid into a buffer salt solution A, and carrying out ultrasonic treatment for 10-20 minutes under the ultrasonic power of 200-500W to prepare a suspension; adjusting the concentration of the suspension to 0.5-2 mg / ml, and obtaining a nano capsule-like body with the particle size of 200-500 nm by using a microfluidic technology; the buffer salt solution A is prepared from 10 to 100 mmol / L of 4-hydroxyethyl piperazine ethanesulfonic acid (HEPES), 1 to 2 mmol / L of ethylenediamine tetraacetic acid (EDTA) disodium, 0.5 to 4 mmol / L of magnesium chloride (MgCl2), 1 to 10 mmol / L of ascorbic acid and 100 to 500 mmol / L of sapoeda sodium (SNAC), and the pH value of the buffer salt solution A is adjusted to 7.5 to 8.0; and the concentration of the capsule in the buffer salt solution A is 100-400 mg / mL. According to the product, self QPRT enzyme of the thylakoid is used for efficiently catalyzing de novo synthesis of NAD + of whole body tissues and organs, so that multiple physiological processes such as energy synthesis enhancement, oxidative stress reduction and inflammatory reaction relief are finally realized, organ failure is efficiently reversed, and organ aging is relieved.

The invention provides a preparation method of a nano-gold star material, which comprises the following steps: stirring and heating a chloroauric acid solution, adding a sodium citrate solution, continuously stirring and heating, when the color of the solution is changed from colorless to dark red, adjusting the rotating speed to 600rpm, turning off a heating device, cooling at room temperature, filtering the reacted solution by using a water-based filter membrane, and drying to obtain the nano-gold star material. Removing impurities to obtain a gold seed solution; characterizing the gold seed solution and the gold seed particles; the preparation method comprises the following steps: adding a 4-hydroxyethyl piperazine ethanesulfonic acid solution, a gold seed solution, a hydroxylamine solution and a magnetic rotor into deionized water, dropwise adding a 22.5 mM chloroauric acid solution, adjusting the rotating speed to 700rpm, and reacting for 15 minutes at room temperature to obtain the nano gold star material. The prepared nano gold star material is uniform, stable, adjustable in particle size and high in dispersity, the material is in a three-dimensional multi-branch shape, and the diameter of the material is adjustable within 50-200 nm.

The invention belongs to the technical field of daily-use chemistry, and particularly relates to a keratin regulating composition containing mandelic acid and having skin smoothing and brightening effects and application of the keratin regulating composition. The composition provided by the invention comprises mandelic acid, lactobionic acid, hydroxyethyl piperazine ethanesulfonic acid, lactobacillus / soybean milk fermentation product filtrate and lactobacillus fermentation lysate. According to the application, mandelic acid, lactobionic acid, hydroxyethyl piperazine ethanesulfonic acid, lactobacillus / soybean milk fermentation product filtrate and lactobacillus fermentation lysate are compounded, so that the activity of KLK family proteases, especially kallikrein 5 (KLK5), can be obviously promoted, the decomposition of desmosome between keratinocytes is promoted, epidermal cells lose cohesion and finally naturally fall off, and the effect of promoting the activity of KLK family proteases is achieved. The cutin exfoliation promoting effect is achieved, so that the problems of skin darkness, roughness, pore blockage, acne and the like are solved, the glossiness and fineness of the skin are improved, and healthy and bright skin is achieved.

The invention relates to a polymer-coated silicon-carbon negative electrode material, a preparation method thereof and a lithium ion battery. The polymer-coated silicon-carbon negative electrode material sequentially comprises a silicon-carbon base material, a carbon coating layer and a polymer coating layer from inside to outside, wherein the polymer coating layer comprises the following materials in percentage by mass: 50-98% of a high-adhesion material, 1-20% of a conductive material and 1-30% of an auxiliary material. The high-adhesion material comprises the following materials in percentage by mass: 60-95% of an acrylic monomer, 1-30% of a monomer A and 1-30% of a monomer B. The monomer A is prepared from at least one of vinyl acetate, acrylonitrile, styrene, 2-acrylamide-2-phenyl ethanesulfonic acid, hydroxyethyl methylacrylate, sodium lignosulphonate, acrylamide and N-vinyl pyrrolidone; the preparation method effectively solves the problems of volume expansion and short cycle life of a traditional silicon-carbon negative electrode material in application, and has relatively high practical value and potential market application prospect.

The invention discloses an anti-oxidation, whitening and brightening composition as well as a preparation method and application thereof. The anti-oxidation, whitening and brightening composition is prepared from the following components in parts by weight: 2 to 6 parts of nicotinamide, 0.5 to 5 parts of tranexamic acid, 1 to 5 parts of nonapeptide-1 solution, 0.5 to 1 part of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 2 parts of pink red plum compound essence, 0.01 to 0.5 part of hydroxyethyl piperazine ethanesulfonic acid, 0.01 to 0.5 part of glabridin and 0.0001 to 0.2 part of glutathione. According to the invention, the composition prepared from nicotinamide, tranexamic acid, nonapeptide-1, tetrahydromethylpyrimidine carboxylic acid, pink-red plum composite essence, hydroxyethyl piperazine ethanesulfonic acid, glabridin and glutathione is prepared into the essence, and the clearance rate of the essence to ABTS free radicals reaches 58% or above, which shows that the essence has very good antioxidant ability; the cell tyrosinase activity inhibition rate of the composition under the concentration of 1.2% (v / v) reaches 51% or above, which shows that the composition has very good whitening and brightening effects.

The invention discloses a liquefying agent, application thereof and a nucleic acid detection system, the liquefying agent comprises strong base, acetylcysteine and 2-(N-morpholine) ethanesulfonic acid; in the liquefying agent, the concentration of the strong base is 0.2 mol / L to 1 mol / L; the concentration of the acetylcysteine is 3 to 300 mmol / L; the concentration of the 2-(N-morpholine) ethanesulfonic acid ranges from 2 mmol / L to 5 mmol / L. Through the synergistic effect of the strong base, the acetylcysteine and the 2-(N-morpholine) ethanesulfonic acid, the liquefaction time can be remarkably shortened, the viscous biological sample treatment efficiency and speed can be improved, and the viscous biological sample treated by the liquefier can be directly used for nucleic acid amplification; and the viscous biological sample treated by the liquefying agent can be stored for a long time, the accuracy and reliability of nucleic acid detection are ensured by long-time stability, and the credibility of a detection result is improved.

The application discloses an anticoagulant biomaterial for blood purification and a preparation method and application thereof, and comprises the following steps: providing an amphiphilic copolymer P(AA-MMA); blending polyethersulfone, P(AA-MMA) and a solvent, stirring at a set temperature to obtain a casting solution, and preparing a blending membrane from the casting solution; soaking the blending membrane in a 2-morpholine-4-yl ethanesulfonic acid buffer solution containing argatroban, 1-ethyl-(3-dimethylaminopropyl) carbonyl diimide and hydroxy succinimide, and reacting at room temperature to obtain an argatroban grafted blending membrane, namely the anticoagulant biomaterial. The method improves the hydrophilicity of the membrane, reduces the albumin adsorption of the membrane, reduces the adhesion of platelets on the membrane, prolongs the coagulation time APTT, PT and TT of the membrane, and is better in biocompatibility and enhanced in anticoagulation performance.

This invention provides a fluorescence-enhanced composite probe based on gold nanoclusters anchored on a zinc-based coordination polymer, its preparation method, and its application, belonging to the field of probe preparation technology. The method involves first mixing an aqueous solution of glutathione and an aqueous solution of tetrachlorohydrin to obtain a gold nanocluster solution; then adding adenine and water to a 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid buffer solution and stirring until homogeneous, followed by the addition of a zinc chloride solution to obtain a zinc-based coordination polymer; finally, the gold nanocluster solution and the zinc-based coordination polymer solution are mixed homogeneously to obtain the fluorescence-enhanced composite probe based on gold nanoclusters anchored on the zinc-based coordination polymer. The probe of this invention can rapidly and sensitively recognize adenosine triphosphate (ATP). It can also be used to construct fluorescent hydrogels by mixing this material with κ-carrageenan; the hydrogels exhibit a sensitive response to ATP and good self-healing ability.