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Preparation method and application of polylactic acid-glycolic acid copolymer coated by manganese dioxide layer

A technology of manganese dioxide sheet and manganese dioxide layer, applied in the field of medicine, can solve the problems of poor application effect, high toxicity, poor biocompatibility, etc., and achieve the effects of inhibiting proliferation, small toxic and side effects, and low production cost

Active Publication Date: 2016-08-31
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a preparation method and application of polylactic acid-glycolic acid copolymer coated with manganese dioxide sheet, which can effectively solve the biological problem of existing antitumor drugs. Poor compatibility, high toxicity and poor application effect

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  • Preparation method and application of polylactic acid-glycolic acid copolymer coated by manganese dioxide layer

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Embodiment 1

[0022] A preparation method of polylactic acid-glycolic acid copolymer coated with manganese dioxide sheet, characterized in that 100-200 mg of 2-(N-morpholine)ethanesulfonic acid-water is weighed and added to 200-400 mg poly In the lactic acid-glycolic acid nanoparticles, ultrasonically dissolve them for 5 minutes at a power of 40-100W and a temperature of 25°C, then add potassium permanganate solution with a concentration of 5.0M and a volume of 3.0-5.0mL, and react for 30 minutes. The polylactic acid-glycolic acid copolymer coated with manganese dioxide sheet was obtained.

Embodiment 2

[0024] A preparation method of polylactic acid-glycolic acid copolymer coated with manganese dioxide sheet, characterized in that, 135 mg of 2-(N-morpholine) ethanesulfonic acid-water is weighed and added to 230 mg of polylactic acid-glycolic acid Nanoparticles were dissolved by ultrasonication for 5 minutes at a power of 40W and a temperature of 25°C, and then a potassium permanganate solution with a concentration of 5.0M and a volume of 3.6mL was added and reacted for 30 minutes to obtain a coated manganese dioxide sheet poly(lactic-co-glycolic acid) copolymer.

Embodiment 3

[0026] A preparation method of polylactic acid-glycolic acid copolymer coated with manganese dioxide sheet, characterized in that 153 mg of 2-(N-morpholine) ethanesulfonic acid-water is weighed and added to 280 mg of polylactic acid-glycolic acid In the nanoparticles, ultrasonically dissolve them for 5 minutes at a power of 60W and a temperature of 25°C, then add potassium permanganate solution with a concentration of 5.0M and a volume of 4.0mL, and react for 30 minutes to obtain a coated manganese dioxide sheet poly(lactic-co-glycolic acid) copolymer.

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Abstract

The purpose of the invention is to provide a preparation method and an application of polylactic acid-glycolic acid copolymer coated by manganese dioxide layer, so as to solve the problem that the existing antineoplastic drugs are of poor biocompatibility, great toxicity and bad application effect. The preparation method comprises steps of weighing 100-200mg of 2-(N-morpholine) ethanesulfonic acid-water, adding it into 200-400mg of polylactic acid-glycolic acid nanometer particles, dissolving by ultrasonic wave for 5min under conditions of power of 40-100W and temperature of 25 degrees centigrade, then adding 3.0-5.0mL of potassium permanganate solution whose concentration is 5.0M, reacting for 30min, thereby obtaining the polylactic acid-glycolic acid copolymer coated by manganese dioxide layer. The preparation method of polylactic acid-glycolic acid copolymer coated by manganese dioxide layer has simple process, low production cost, high output and small toxicity and side effects; the polylactic acid-glycolic acid copolymer coated by manganese dioxide layer has a good inhibition effect to the amplification of tumor cells, and has good economical and social benefits.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method and application of a polylactic acid-glycolic acid copolymer coated with a manganese dioxide sheet. Background technique [0002] Hyperthermia (Photo-thermal Therapy, PTT) is to change the growth environment of tumor cells by heating, so as to make tumor cells degenerate and necrosis, so as to achieve the purpose of treatment. Gold nanomaterials, such as gold nanorods, gold nanoshells, gold nanocages, gold nanostars, etc., can produce a good heating effect under radio frequency irradiation. [0003] Gold nanorods have the characteristics of good biocompatibility, easy synthesis and easy modification. In addition, due to the high permeability and retention (EPR) effect of solid tumor tissues, gold nanorods are easy to stay in the tumor site. It provides a good premise to carry out applications in the field of biomedicine. Radio frequency (RF) can induce heat generati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L67/04A61K41/00A61K47/34A61K49/12A61K49/00A61K49/18A61P35/00
CPCA61K41/0052A61K47/34A61K49/0019A61K49/0093A61K49/126A61K49/1824C08J3/12C08J2367/04
Inventor 王蕾张振中张云李懂郝永伟张冰祥牛梦亚孟德辉郑翠霞赵红娟胡玉洁张红岭
Owner ZHENGZHOU UNIV
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