3results about How to "Resistant" patented technology

A method for preparing a multi-component polyimide resin includes the steps of first preparing polyimide acid (PAA) and then preparing the multi-component polyimide resin. The multi-component polyimide resin employs a unique molecular structure design, which endows the material with excellent heat resistance. It exhibits superior heat resistance, maintaining structural stability and performance unchanged at high temperatures, which is particularly important for temperature-sensitive fields such as aerospace and electronic packaging.

This invention relates to a human chronic myeloid leukemia (CML) accelerated phase cell line, its applications, preparation methods, and reagent kits. The cell line, named Human CML Accelerated Phase Cell YYXY-M10, was deposited at the China Center for Type Culture Collection (CCTCC) on October 12, 2024, with accession number CCTCC NO: C2024346. The cells were isolated from bone marrow or peripheral blood samples of patients with CML accelerated phase. Without the addition of any cell growth factors, the cells can achieve stable in vitro proliferation and continuous passage, exhibiting stable in vitro morphology. They can form tumors in immunodeficient animals and are resistant to third-generation tyrosine kinase inhibitors. This invention can be used to study the pathogenesis of CML, the progression from accelerated phase to blast crisis, and drug resistance mechanisms. It has broad application prospects and practical value in basic research on human CML, drug screening and evaluation, and clinical medication guidance.

The invention discloses preparation and application of a drug-resistant organ model based on interaction of tumor cells and nerve cells, and the preparation method comprises the following steps: mixing tumor cells, PC12 induced and differentiated nerve cells and matrigel, using biocompatible fluorine oil as a continuous phase, preparing microspheres through a microfluidic microdroplet wrapping technology, curing, and culturing to obtain the drug-resistant organ model based on interaction of tumor cells and nerve cells. And obtaining the tumor drug-resistant organ. The organoid has drug resistance to platinum drugs such as cis-platinum, can simulate the drug resistance process mediated by interaction of in-vivo tumors and nerve cells, is used for tumor drug resistance mechanism research, drug resistance reversal drug screening and preclinical drug resistance detection, is easy and convenient to operate and good in uniformity, and has important biological medicine application value.