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A way to alleviate PM 2.5 Platycodon grandiflorum polysaccharides that cause respiratory diseases and their applications
Owner:TIANJIN UNIV OF SCI & TECH
A recombinant lactococcus microcapsule, its preparation method and application
ActiveCN121287651BHas antioxidant functionAbility to express antioxidant enzymesPeptide/protein ingredientsAntipyreticStaphylococcus lactisBowels diseases
This invention relates to a recombinant *Lactococcus lactis* microcapsule, its preparation method, and its applications, belonging to the field of genetic engineering. To address the technical problems of low safety, high side effects, unstable efficacy, and insufficient targeting in existing methods for treating or alleviating inflammatory bowel disease (IBD), this invention provides a recombinant *Lactococcus lactis* microcapsule. By integrating a fusion gene encoding catalase and superoxide dismutase, a recombinant *Lactococcus lactis* with antioxidant function is constructed. The recombinant *Lactococcus lactis* is then coated with a mucosa-adhesive chitosan and sodium alginate composite nanomaterial to obtain a microcapsule with antioxidant enzyme expression capabilities and a nano-protective coating. The recombinant *Lactococcus lactis* microcapsule provided by this invention can enhance the activity and bioavailability of orally delivered substances under the harsh acidic environment and complex physiological barriers of the gastrointestinal tract, providing a new strategy and experimental evidence for the clinical prevention and treatment of IBD.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY