The invention relates to the technical field of weight-reducing products, and specially discloses a weight-reducing meal replacement composition and a preparation method thereof. The weight-reducing meal replacement composition is composed of the following ingredients: soybean protein isolate, casein, medium-chain triglyceride, psyllium husk powder, resistant dextrin, konjac powder, chia seeds, tender barley leaf powder, isomalto-oligosaccharide, inulin, fructo-oligosaccharides, compound minerals, compound vitamins, comprehensive fruit and vegetable powder, vitamin C, curcumin, white grape powder, matcha powder and a saussurea involucrate flower culture. The weight-reducing meal replacement composition is capable of regulating glucose and lipid metabolism as well as correcting disturbanceof glucose and lipid metabolism in obese people under the premise of providing adequate proteins, minerals and trace elements for the body; moreover, the weight-reducing meal replacement composition is also capable of achieving the effects of inhibiting sugar and fat absorption, reducing cholesterol and ensuring long-lasting satiety while relatively low calorie is provided.