The invention discloses a central air-conditioning energy-saving control system and a control strategy thereof. The control system comprises a room load analysis module, an air volume control module, a chilled water flow control module, a cooling water flow control module, a cooling tower control module, an indoor temperature sensor group, a chilled water temperature sensor group, a cooling water temperature sensor group, an outdoor temperature/humidity sensor, a chilled water system terminal device, a cooling water system terminal device, an air system terminal device, connecting devices between various devices and a control cabinet for storing various data processing control modules. The control strategy directly directs regulation and control of the system according to room load change, involving calculating room load fluctuation according to room temperature change and converting the room load fluctuation into a real-time air volume regulating variable, a real-time chilled water flow regulating variable and a real-time cooling water flow adjusting variable. A water supply/return temperature distance control mode is a monitoring way for maintaining normal operation of the system. The system of the present invention is compact in structure, high in automation degree, high in intelligence degree, and stable and reliable in operation.