The invention discloses a
stomach space-occupying hydrogel tablet as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out cross-linking reaction on a hydrophilic
polysaccharide compound and / or a derivative thereof and a water-
soluble polymer to prepare hydrogel; crushing to obtain gel base material particles; and mixing the gel base material particles with an
adhesive,
sodium alginate,
calcium chloride and
ethanol, granulating, and tabletting. The gastric space-occupying hydrogel tablet provided by the invention takes a hydrophilic
polysaccharide compound and / or a derivative thereof and a water-
soluble polymer as cores, a three-dimensional
network structure gel is formed through a cross-linking reaction, the three-dimensional
network structure gel and other functional combinations are mixed, crushed and tableted to prepare the tablet, a core
functional system of the gastric space-occupying hydrogel tablet is composed of a hydrophilic cross-linked gel base material and an
adhesive, and the core
functional system of the gastric space-occupying hydrogel tablet is composed of the hydrophilic cross-linked gel base material and the
adhesive. The components can be singly selected or compounded for use according to performance requirements, so that collaborative optimization of
mechanical strength, space occupying effect and
biocompatibility is realized.