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Cellulose acetate/polyethylene glycol blood dialysis membrane and preparation method thereof

A cellulose acetate and polyethylene glycol technology, applied in spinning solution preparation, fiber treatment, semi-permeable membrane separation, etc., can solve problems such as troublesome use, poor compaction, and reduced passage rate of small molecular substances, and achieve excellent Biocompatibility, the effect of improving the retention rate

Inactive Publication Date: 2015-09-16
SUZHOU BEC BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cellulose acetate is a kind of porous membrane material, which can meet the requirements for the permeability of urea and water, but its compactness is poor. When used under high pressure, the pore size of the membrane leading to the dialysis material will become smaller, which is difficult for small molecules in the blood. The passage rate of the substance is reduced and, therefore, can also cause problems with its use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A cellulose acetate / polyethylene glycol hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 2.5 μm, the pore diameter is 3.2 μm, and the wall thickness is 65 μm;

[0023] The dialysis membrane was prepared from the following components in mass parts: 35 parts of cellulose acetate, 12 parts of polyethylene glycol, 8 parts of polymethyl methacrylate, 6 parts of polycaprolactone, 12 parts of tetrahydrofuran and 15 parts of acetone share.

[0024] A preparation method of cellulose acetate / polyethylene glycol hemodialysis membrane, the preparation steps are as follows:

[0025] (1) Preparation of spinning solution: Add cellulose acetate, polyethylene glycol, polymethyl methacrylate and polycaprolactone to a mixed solution of acetone and tetrahydrofuran, heat and dissolve in a water bath at 37°C to obtain a spinning solution ;

[0026] (2) Electrospinning: Electrospinning the spinning solution to prepare cellulose ace...

Embodiment 2

[0030] A cellulose acetate / polyethylene glycol hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 2.5 μm, the pore diameter is 3.2 μm, and the wall thickness is 65 μm;

[0031] The dialysis membrane was prepared from the following components in mass parts: 45 parts of cellulose acetate, 18 parts of polyethylene glycol, 16 parts of polymethyl methacrylate, 16 parts of polycaprolactone, 20 parts of tetrahydrofuran and 25 parts of acetone share.

[0032] A preparation method of cellulose acetate / polyethylene glycol hemodialysis membrane, the preparation steps are as follows:

[0033] (1) Preparation of spinning solution: Add cellulose acetate, polyethylene glycol, polymethyl methacrylate and polycaprolactone to a mixed solution of acetone and tetrahydrofuran, heat and dissolve in a water bath at 37°C to obtain a spinning solution ;

[0034] (2) Electrospinning: Electrospinning the spinning solution to prepare cellulose a...

Embodiment 3

[0038] A cellulose acetate / polyethylene glycol hemodialysis membrane, the dialysis membrane is a hollow fiber membrane, the diameter of the hollow fiber is 2.5 μm, the pore diameter is 3.2 μm, and the wall thickness is 65 μm;

[0039] The dialysis membrane was prepared from the following components in mass parts: 38 parts of cellulose acetate, 14 parts of polyethylene glycol, 11 parts of polymethyl methacrylate, 9 parts of polycaprolactone, 15 parts of tetrahydrofuran and 18 parts of acetone share.

[0040] A preparation method of cellulose acetate / polyethylene glycol hemodialysis membrane, the preparation steps are as follows:

[0041] (1) Preparation of spinning solution: Add cellulose acetate, polyethylene glycol, polymethyl methacrylate and polycaprolactone to a mixed solution of acetone and tetrahydrofuran, heat and dissolve in a water bath at 37°C to obtain a spinning solution ;

[0042] (2) Electrospinning: Electrospinning the spinning solution to prepare cellulose ac...

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Abstract

The invention discloses a cellulose acetate / polyethylene glycol blood dialysis membrane and a preparation method thereof, and relates to the field of biological materials. The dialysis membrane is a hollow fiber membrane, wherein hollow fiber has a diameter of 0.8 to 4.5 [mu]m, a pore size of 1.4 to 4.8 [mu]m and a wall thickness of 55 to 90 [mu]m. The dialysis membrane is prepared from the following components: cellulose acetate, polyethylene glycol, polymethyl methacrylate, polycaprolactone, tetrahydrofuran and acetone. The preparation method for the cellulose acetate / polyethylene glycol blood dialysis membrane comprises the following preparation steps: (1) preparation of a spinning solution; and (2) electrostatic spinning. The cellulose acetate / polyethylene glycol blood dialysis membrane provided by the invention has excellent biocompatibility and certain anticoagulant and surface adsorptive effects, can improve retention rate of macromolecular protein and is an ideal dialysis membrane material.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a cellulose acetate / polyethylene glycol hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and retain excess water in the body, and at the same time replenish the substances needed in the body, and maintain electrolytes and purpose of acid-base balance. [0003] There are two kinds of existing hemodialysis membrane materials: one is cellulose acetate membrane material; the other is synthetic material, including materials such as polysulfone, polyacrylonitrile, polymethylmethacrylate and polyethersulfone. [0004] Cellulose acetate is a kind of porous membrane material, which can meet the requirements for the permeability of ...

Claims

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Application Information

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IPC IPC(8): B01D71/52B01D67/00B01D69/08A61M1/18D01D1/02D01D5/00D04H1/728
Inventor 李苏杨李文遐徐勤霞
Owner SUZHOU BEC BIOLOGICAL TECH
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