78results about How to "Improve anticoagulation" patented technology

The invention discloses a preparation method of chitosan-polyurethane ionic compound elastomeric material, which comprises the following steps: polyisocyanates reacts with polymer polylol and then reacts with diol or diamine, organic solvent and ionization reagent are added in the reactants to react with water for generating anionic waterborne polyurethane and further performs the ionic recombination reaction with cationic chitosan water solution to obtain the microemulsion or latex of chitosan-polyurethane ion composite, and finally the microemulsion or latex of chitosan-polyurethane ion composite is dried and solidified to obtain the chitosan-polyurethane ionic compoundelastomeric material. The chitosan-polyurethane ionic compoundelastomeric material has the advantages of good mechanical property, easy processing, good oil-water resistance property, good cohesive property with parent metal, controllable performance, good biocompatibility, biodegradable property, high biological activity, good blood contact property, good bacteriostatic property, good antibacterial property, and the like, can be applied in fields of mechanical industry, building industry, sport, medical treatment, and the like, and especially has wider purpose in aspects of life science research, medical materials and medical appliances.

The invention relates to medical applications and preparation methods of Pleurotus ferulae Lanzi polysaccharide and composites thereof. The preparation methods of the invention comprise the following steps of extracting, removing protein and purifying, wherein the step of removing protein adopts the following methods of: (1) a solvent extraction method; (2) an ion exchange resin method; (3) an enzyme method; and (4) a gel chromatography; and the step of purifying adopts the following methods of: (1) the solvent extraction method; (2) an ethanol precipitation method; (3) a liquid-liquid counter-current distribution chromatography; and (4) the gel chromatography.

A ginger extract mainly containing the volatile oil of ginger and gingerol for preparing medicines to treat heart failure, myocardial ischemia, atherosclerosis, etc is prepared from the dried ginger through pulverizing, supercritical CO2 fluid extracting and separation.

The invention discloses a preparation method of a material with nitric oxide (NO) catalytic activity. The preparation method is implemented through the steps that a selenium-containing compound with nitric oxide catalytic activity, a sulfur-containing compound, a soluble copper salt, a compound with an o-phenol structure, a flavonoid compound, and a flavonol compound or a flavanone compound are mixed in a buffer solution and then polymerized. The material with NO catalytic activity not only can be applied to the surface modification of materials which are different in material, geometrical shape and topological structure, and also can be used as a filling material for a controlled release system. Double selenium bonds, double sulfur bonds, copper ions and phenolic hydroxyl groups, which are contained in the prepared material with nitric oxide (NO) catalytic activity, have an excellent free radical removal function; the selenium bonds, the sulfur bonds and the chelate copper ions, which are contained in the material, also have a reduced glutathione (GSH) response function; in addition, the copper ions containing in the material also have an antibacterial function; and the material, besides being used for catalyzing NO release, also can be applied to all related fields of free radical removal and GSH response function.

The invention relates to a medicinal mixture for treating cardiovascular diseases, which comprises (by weight portions) ginger extract 100 and dried orange peel extract 1-100 mainly containing ginger volatile oil, gingerol and dried orange peel volatile oil.

The invention discloses a bioprosthetic valve with anticoagulation and anti-calcification functions and a preparation method thereof. The method comprises the following steps: carrying out cross-linking treatment on a biological valve by adopting glutaraldehyde, and carrying out modification treatment by adopting hydrophilic molecules or hydrophobic molecules after cross-linking; or performing modification treatment on the biological valve by hydrophilic molecules or hydrophobic molecules, and then carrying out crosslinking treatment by glutaraldehyde; or performing at least one time of modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules, then performing cross-linking treatment by glutaraldehyde, and finally performing at least one timeof modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules. The biological valve prepared by the preparation method disclosed by the invention not only has good mechanical properties, but also has excellent anticoagulation and anti-calcification effects.

The invention discloses a preparation method of a surface coating of intravascular stents or cardiac valves with excellent biocompatibility, which includes the steps: A. the preparation of a coating solvent: heparin is dissolved in deionized water, the pH value thereof is adjusted to 7 to 8 and then an endothelial cell growth factor is added to form a heparin/growth factor solution; collagens are dissolved in acetum to form a collagen solution; B. dip-coating: the intravascular stents or the cardiac valves are immersed in the heparin/growth factor solution and a layer of heparin/growth factor is dipped and coated on the surface of the intravascular stents or the cardiac valves, and then the intravascular stents or the cardiac valves are taken out for being cleaned by the deionized water and being dried by nitrogen gas; and the intravascular stents or the cardiac valves are immersed in the collagen solution, coated with a layer of collagen, and taken out for being cleaned by the deionized water and being dried by nitrogen gas; the steps of dip-coating by the use of the heparin/growth factor and the collagen are repeated in sequence for 1 time to 60 times; finally the step of dip-coating by the use of the heparin/growth factor is carried out again to obtain the surface coating with excellent biocompatibility of the intravascular stents or the cardiac valves. The intravascular stents or the cardiac valves prepared have excellent biocompatibility and low preparation cost.

The invention provides a preparation method of a sulfated silk fibroin material. The method comprises the steps of: a, preparing an azo salt stock solution; b, dropping ice-bath cooled sodium nitrite aqueous solution to a mixed solution in the step a, and carrying out ice-bath uniformly to obtain the azo salt stock solution; and c, dissolving silk fibroin in a citrate buffer solution to obtain a silk fibroin solution, adding the azo salt stock solution, maintaining the pH of the citrate buffer solution within 7.5-10, carrying out ice-bath reaction, and dialyzing, freezing and drying to obtain the sulfated silk fibroin. The product prepared by the invention is not only a material with good anticoagulant performance, but also has less immunogenicity, so that the material is a bioactive material which can improve conglutination, diffusion and proliferation capacity of the silk fibroin, cells and growth factors. Types of biomaterials are enriched, and grounds for tissue engineering application such as vessels, ligaments and bones are provided.

The invention discloses a preparation method of novel anticoagulant stents coating capable of capturing endothelial progenitor cells, which comprises the following steps: performing hydroxylation processing on surface of a material, then dissolving dopamine in a Tris-base(pH is 8.5, 2mg/ml) solution, then depositing a layer or multilayer dopamine membrane at temperature of 37 DEG C on the surface of the material, then adjusting reaction condition according to pH and EDC/NHS concentration, and performing covalent grafting on a mixture of CD133+(0.8-3.2ug/ml) and Fucoidan(50-400ug/ml) at temperature of 37 DEG C to obtain a target product. The preparation method has the advantages of simple operation, mild reaction condition, high efficiency and low cost. A target coating has strong antithrombotic performance, anticoagulation and inhibition of endometrial hyperplasia of smooth muscle due to effect of low molecular weight Fucoidan, can rapidly capture the endothelial progenitor cells of peripheral blood so as to induce the endothelial progenitor cells to differentiate for obtaining endothelial cells, and then a complete endothelial cells layer is formed, and the novel anticoagulant stents coating has excellent anticoagulation performance and biological compatibility.

The invention discloses a modified polymer film as well as a preparation method and application thereof, and particularly relates to the field of modified polymer films. The preparation method comprises the following steps: dropwise adding a sulfanilic acid diazonium salt solution into Na<+> intercalated MXene, and after reaction, centrifuging, filtering, washing, ultrasonically treating and freeze-drying to obtain sulfonated MXene powder; immersing a polymer film in a GA/polyethyleneimine (PEI) mixed solution containing trihydroxymethyl aminomethane and metal salt, and reacting to obtain a GAcoating modified polymer film; and depositing the sulfonated MXene powder on the GA coating modified polymer film, and repeating the operations to obtain the single-layer or multi-layer GA/MXene modified polymer film. According to the invention, two methods, namely vacuum assisted suction filtration and layer-by-layer self-assembling, are combined, and the method has the characteristics of uniform film coating, controllable film thickness, better stability, low energy consumption and easiness in operation. In addition, the prepared modified polymer film has the functions of efficiently removing medium and small molecular toxins and having good oxidation resistance and protein adsorption resistance.

The invention discloses a method for preparing sulfated glycogen based on oysters or scallops. The method comprises the following steps of: 1, taking oysters or scallops, carrying out freeze drying on the oysters or scallops till the water content reaches 0-10 percent by mass, stirring and crushing the oysters or scallops subjected to freeze drying into powder, and adding water to the powder to prepare slurry; or taking fresh oysters or scallops, directly adding water to the fresh oysters or scallops, and homogenating to obtain slurry, wherein the mass of solid matters in the slurry accounts for 0.1-5 percent of the total mass; 2, obtaining oyster glycogen or scallop glycogen by using the slurry; 3, preparing a sulfate reagent; and 4, carrying out sulfated modification on the oyster glycogen or scallop glycogen by using the sulfated reagent. The method disclosed by the invention has the characteristics of high yield, low cost and outstanding product activity stability, wherein the yield can reach about 20 percent; and in addition, the prepared sulfate glycogen has very remarkable capabilities of improving the immunity, resisting viruses and resisting blood coagulation.

The invention discloses a preparation method of water-soluble Sargassum fusiforme polysaccharides. The method comprises the following steps: ultrasonic extraction of the polysaccharides, deproteinization, and alcohol precipitation and drying; and the ultrasonic extraction step of the polysaccharides comprises: adding a NaCl solution and active polypeptides to Sargassum fusiforme meal, uniformly mixing the NaCl solution, the active polypeptides and the Sargassum fusiforme meal, carrying out suction filtration, centrifuging the obtained suction filtration liquid, and taking the obtained supernatant to obtain crude protein liquid. The method adopting the ultrasonic extraction of the Sargassum fusiforme and breaking cells by using the active peptides, the low salt solution, a swelling technology and an ultrasonic technology has the advantages of great shortening of the extraction time, good extraction effect, high content of proteins in the crude protein liquid and facilitation of the yield and the activity of the polysaccharides; and the water-soluble Sargassum fusiforme polysaccharides obtained by the extraction method have excellent anti-oxidation, anticoagulation, anti-inflammation, anticancer, antitumor and immune regulation functions and other biological functions.

The invention relates to an external patch for treating children anorexia and a preparation method thereof, and relates to a medicine for treating children anorexia and a preparation method thereof, raw materials of which comprise radix pseudostellariae, radix codonopsitis, the rhizome of large-headed atractylodes, Tuckahoe, hawthorn, lotus seed, gordon euryale seed, dried orange peel, prepared RHIZOMA PINELLIZE without adju-vant, ebony, cassia seed, hoantchy root, dried immature fruit of citron orange and ledebouriella seseloides and are made into external patch for treating the children anorexia through a special process. The patch is used outside the body, so the external patch is safe and convenient, first pass effect of the medicine on liver and gall, stimulation of stomach and burden of kidney can be prevented, and the herbs which both can be eaten and used as medicine and has soft drug effect are selected, so the external patch is free from irritating the skin, can warm the stomach and is suitable for the anorexia children patients.

The invention discloses a sea cucumber enzyme and a preparation method thereof, wherein the preparation method of the sea cucumber enzyme comprises the following steps: firstly, respectively preparingsea cucumber autolysis slurry, donkey-hide gelatin slurry, spirulina slurry and a gordon euryale seed saccharification liquid, then mixing and adding water for fermentation to obtain a sea cucumber fermentation liquid, finally adding isomaltulose, xylitol, malto-oligosaccharide and xanthan gum, performing high-pressure homogenization and then sterilizing to obtain the sea cucumber enzyme. The seacucumber enzyme is high in nutritional values, easy to digest and absorb, natural and coordinated in taste, and also has the efficacies of enhancing immunity, moisturizing the lung and tonifying thespleen, strengthening the brain and soothing the mind, lowering the blood lipid, and having anti-cancer and anticoagulation properties.

The invention discloses a method for preparing a black fungus and pantotrichum hypoglycemic composition, relates to the method for extracting a pantotrichum extract and auricularian and the method for preparing the hypoglycemic composition, and solves the problems of low extraction efficiency, low activity, and complex production process of the traditional method for extracting a pantotrichum active constituent and auricularian, and poor effect of regulating blood sugar level of a single natural active constituent. The pantotrichum is the traditional well-known and valuable medicinal herb, contains a plurality of physiological activators and has the unique effect and the special position in Chinese medicine and Chinese medicinal herbs. The auricularian has the physiological function of improving the body immunity, resisting the tumor, lowering the blood fat, regulating the blood sugar level, resisting bacterium, resisting coagulation, resisting radiation and the like. In the method, the fresh pantotrichum and the fresh black fungus are selected; and the pantotrichum extract and the auricularian power are obtained by the modern processes of vacuum freeze-drying, ultrasonic wave assist extracting and the like; and the black fungus and pantotrichum hypoglycemic composition is prepared by scientifically and reasonably compounding the pantotrichum extract and the auricularian power in proportion. The black fungus and pantotrichum hypoglycemic composition prepared by the invention has no side effect on the human body, has the effects of regulating the blood sugar level, improving the body immunity, lowering the blood flat, building up the body and the like, and can be taken as an aided drug for regulating the blood sugar level, a nutrition supplement, a nutritional additive, a health food and the like.

The present invention is one kind of Chinese medicine preparation for treating liver fibrosis and liver cirrhosis. The Chinese medicine preparation consists of astragalus total polysaccharide, astragalus total saponin, total salvianolic acid and total tanshinone. The Chinese medicine preparation has low cost, great number of effective components, high effective component content, determined curative effect, small dosage and high compliance.

The invention discloses an anticoagulation coating. An alcohol solution of a segmented copolymer with a regular structure and narrow molecular weight distribution is formed by gradually polymerizing a zwitterionic monomer and gamma-(methacrylic acyloxy) propyltrimethoxysilane (KH-570); the number-average molecular weight of the copolymer is 5,000-50,000; and the zwitterionic monomer can be an ammonium phosphate, ammonium carboxyl or ammonium sulphur zwitterionic monomer which contains methacrylic acyloxy, methacrylic acylamino or cinnamenyl. The anticoagulation macromolecular coating can be effectively bonded on the surface of a material, so that the anticoagulation performance of the material is improved. The invention further discloses a preparation method and a using method of the coating.

The invention discloses a method for sulfonating pectin, which comprises the step of sulfonating pectin or triethylamine pectin salt by using sulfur trioxide-pyridine complex in a dimethylsulfoxide (DMSO) environment so as to obtain sulfonated pectin polysaccharide. The method adopts the following two systems: a trioxide-pyridine complex-DMSO system, and a TBA-trioxide-pyridine complex-DMSO system. The method disclosed by the invention is simple in operation and good in sulfonating effect. The sulfonated pectin polysaccharide prepared by the method is small in degradation in the reaction process, small in side reaction, has good anticoagulation, anti-tumor and anti-virus actives and a wide application range.

The invention discloses mulberry cream capable of benefiting qi and nourishing blood and a preparation method of the mulberry cream, and relates to the technical field of processing of mulberries. Themulberry cream comprises the following raw materials in parts by weight: 12-18 parts of longan aril, 50-60 parts of mulberries, 20-26 parts of bighead atractylodes rhizomes, 15-20 parts of fresh licorice roots, 20-26 parts of rhizoma polygonati odorati, 14-20 parts of Chinese yams, 18-24 parts of red jujubes, and 22-28 parts of fiveleaf gynostemma herbs. The mulberry cream is prepared by cookingvarious natural vegetable materials, has the efficacy of invigorating spleen-stomach, replenishing qi, strengthening the spleen and the stomach, moistening dryness, nourishing blood and soothing the nerves, and is suitable for crowds suffering from insomnia, amnesia, polydipsia, constipation, deficiency of qi and blood and the like to drink, the rhizoma polygonati odorati and the fiveleaf gynostemma herbs are processed to modify taste of the mulberry cream, in the cooking process, massive honey or cane sugar does not need to be added for seasoning, the mulberry cream is appropriate in mouth feel, has a certain health-care treatment effect on crowds suffering from high blood pressure, high blood sugar and high blood lipid and suffering from deficient cold of the spleen and the stomach, andcan improve complexion, nourish the body, and promote salivation after being drunk for a long term. The effect of the mulberry cream is more notable than that of single mulberry cream, and the mulberry cream disclosed by the invention is free from discomfort and poor side effects.

The invention relates to a tremella fuciformis cookie. By adding tremella fuciformis polysaccharide and tremella fuciformis powder in a raw material formula and matching the tremella fuciformis polysaccharide and the tremella fuciformis powder reasonably, the synergy of the tremella fuciformis polysaccharide and the tremella fuciformis powder has the effects of improving body immunity, resisting tumors, resisting anabrosis, resisting blood coagulation, preventing cerebral thrombosis, lowering lipid, lowering blood glucose, promoting the body protein synthesis, slimming and the like, so that the finally obtained tremella fuciformis cookie is obvious in health care effect, is suitable for mid-aged population with relatively high blood glucose and blood lipid, has good taste and is rich in nutrition.

The invention discloses modified milk powder beneficial to cardiovascular health. The modified milk powder is prepared by taking dried skim milk, whey powder, whole milk powder, radices puerarire, folia mori and folia bambosae as raw materials, adding calcium, iron, zinc, selenium and other trace elements, and then adding siraitia grosvenorii powder and isomaltooligosaccharide or fructo-oligosaccharide for seasoning. According to the modified milk powder beneficial to cardiovascular health and a preparation method thereof, under the synergistic effect of the components, on one hand, the nutritional ingredients of people suffering from cardiovascular diseases are guaranteed, and on the other hand, the good effects of reducing blood fat, controlling blood sugar and reducing blood pressure can be achieved. Therefore, the modified milk powder not only is a healthy food for the people with the cardiovascular diseases, but also has a good health-care effect on ordinary people. The taste is very good, the faint bamboo leaf fragrance is realized, and the sweetness is relatively moderate.