Biological valve with anticoagulation and anti-calcification functions and preparation method thereof

A biological valve and anticoagulation technology, applied in the field of medical materials and medical device preparation, can solve problems such as coagulation of interventional pulmonary valve, improve long-term anticoagulation and anticalcification performance, eliminate immunogenicity, reduce coagulation and calcification Effect

Inactive Publication Date: 2020-07-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a biovalve with anticoagulant and anticalcification functions and a preparation method thereof, aiming at solving the problems of coagulation and calcification of existing intervening pulmonary valves, while ensuring the biovalve material mechanical Improve the anti-coagulation and anti-calcification effect of the valve material at the same time, prolong the service life of the valve

Method used

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  • Biological valve with anticoagulation and anti-calcification functions and preparation method thereof
  • Biological valve with anticoagulation and anti-calcification functions and preparation method thereof
  • Biological valve with anticoagulation and anti-calcification functions and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] A method for preparing a biological valve with anticoagulant and anticalcification functions, the specific process is:

[0034] (1) After cleaning the porcine pericardial valve with deionized water, soak it in an aqueous solution of 0.5% glucosamine and 1% condensing agent at 4°C for 2 days;

[0035] (2) Soak in 1% glutaraldehyde solution at 4°C for 7 days;

[0036] (3) Soak in 3% taurine aqueous solution at 4° C. for 2 days to obtain the target biological valve material.

[0037] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is 36N under the uniaxial tensile test (1*5cm sample size).

[0038] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross-linked valve.

[0039] The experiment of subcutaneous implantation in rats found that the anti-calcification effect of the bi...

Embodiment 2

[0041] A method for preparing a biological valve with anticoagulant and anticalcification functions, the specific process is:

[0042] (1) After the bovine pericardial valve is cleaned with deionized water, soak it in an ethanol aqueous solution of 1% perfluorooctanoic acid-2-aminoethyl ester and 3% condensing agent at 4°C for 2 days;

[0043] (2) Soak in 5% glutaraldehyde solution at 4°C for 7 days;

[0044] (3) Soak in 1% perfluorobutylamine ethanol aqueous solution at 4° C. for 2 days to obtain the target biological valve material.

[0045] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0046] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross-linked valve.

[0047]The subcutaneous implantation exp...

Embodiment 3

[0049] A method for preparing a biological valve with anticoagulant and anticalcification functions, the specific process is:

[0050] (1) After cleaning the porcine pericardial valve with deionized water, soak it in a glutaraldehyde solution with a concentration of 3% for 7 days at 4°C;

[0051] (2) at 4°C, soak for 5 days in an aqueous ethanol solution with a concentration of 2% (2-aminoethyl)-perfluorooctylamide and a concentration of 5% condensing agent;

[0052] (3) Soak in 3% perfluorooctylamine ethanol aqueous solution at 4°C for 5 days to obtain the target biological valve material.

[0053] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0054] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross...

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Abstract

The invention discloses a bioprosthetic valve with anticoagulation and anti-calcification functions and a preparation method thereof. The method comprises the following steps: carrying out cross-linking treatment on a biological valve by adopting glutaraldehyde, and carrying out modification treatment by adopting hydrophilic molecules or hydrophobic molecules after cross-linking; or performing modification treatment on the biological valve by hydrophilic molecules or hydrophobic molecules, and then carrying out crosslinking treatment by glutaraldehyde; or performing at least one time of modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules, then performing cross-linking treatment by glutaraldehyde, and finally performing at least one timeof modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules. The biological valve prepared by the preparation method disclosed by the invention not only has good mechanical properties, but also has excellent anticoagulation and anti-calcification effects.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical materials and medical devices, and in particular relates to a biological valve with anticoagulant and anticalcification functions and a preparation method thereof. Background technique [0002] Pulmonary valve disease is mainly caused by pulmonary regurgitation and pulmonary stenosis. Traditional surgical thoracotomy is easily complicated by severe pulmonary regurgitation, which leads to right ventricular cavity enlargement and arrhythmia. Further treatment requires another thoracotomy, but the second (or more) operation is not only difficult, but also has a higher risk and mortality. In recent years, with the development of minimally invasive interventional technology, transcatheter interventional heart valve replacement technology has brought hope to patients. Interventional heart valve replacement surgery does not require thoracotomy, low surgical risk, and short recovery time. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/34A61L27/36A61L27/50
CPCA61L27/28A61L27/34A61L27/3625A61L27/3687A61L27/50A61L2400/18A61L2430/20A61L2430/40C08L77/04
Inventor 王云兵李高参杨立
Owner SICHUAN UNIV
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