Preparation method of material with nitric oxide (NO) catalytic activity

Abstract

The invention discloses a preparation method of a material with nitric oxide (NO) catalytic activity. The preparation method is implemented through the steps that a selenium-containing compound with nitric oxide catalytic activity, a sulfur-containing compound, a soluble copper salt, a compound with an o-phenol structure, a flavonoid compound, and a flavonol compound or a flavanone compound are mixed in a buffer solution and then polymerized. The material with NO catalytic activity not only can be applied to the surface modification of materials which are different in material, geometrical shape and topological structure, and also can be used as a filling material for a controlled release system. Double selenium bonds, double sulfur bonds, copper ions and phenolic hydroxyl groups, which are contained in the prepared material with nitric oxide (NO) catalytic activity, have an excellent free radical removal function; the selenium bonds, the sulfur bonds and the chelate copper ions, which are contained in the material, also have a reduced glutathione (GSH) response function; in addition, the copper ions containing in the material also have an antibacterial function; and the material, besides being used for catalyzing NO release, also can be applied to all related fields of free radical removal and GSH response function.

Description

technical field [0001] The invention relates to a technology for preparing materials with nitric oxide catalytic activity. Background technique [0002] Nobel Prize winners Murad and Ignarro discovered more than 30 years ago that the cell signaling factor NO is a key factor in maintaining the balance of the cardiovascular system. NO is mainly produced by endothelial cells through the action of nitric oxide synthase secreted by endothelial cells and arginine. The sustained release of NO is an important factor in maintaining cardiovascular homeostasis and regulating vasodilation. In addition, the researchers also found that NO has many important biological effects, such as: inhibition of platelet activation, smooth muscle proliferation and leukocyte activation. It also has important biological functions in immune response, anticancer, antibacterial and atherosclerotic treatment. It is worth mentioning that the study found that NO also plays an important role in the mobilizat...

AI Technical Summary

Problems solved by technology

However, there are many shortcomings in the application of NO catalytically active materials reported so far, such as: (1) The catalytically active materials with GPx are usually grafted on the surface, and the amount of grafting is limited, resulting in the amount of NO catalytically released Small, it is difficult to apply to the environment where large doses of NO are required; (2) Since the synthesized NO catalytic active material has no strong binding site with the material substrate, its stability is poor, and it is difficult to maintain long-term NO catalytic release