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Porous bioglass/chitosan/silk fibroin composite material and preparation method thereof

A technology of silk fibroin and bioglass, applied in the field of biomedicine, can solve the problems of low mechanical properties and achieve the effects of strong mechanical strength, excellent biological properties and ensuring biocompatibility

Inactive Publication Date: 2015-01-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a natural polymer material, chitosan not only has good biocompatibility, but also has antibacterial and sterilizing effects. However, it has the disadvantage of low mechanical properties and is difficult to use alone as a bone tissue healing material.

Method used

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  • Porous bioglass/chitosan/silk fibroin composite material and preparation method thereof
  • Porous bioglass/chitosan/silk fibroin composite material and preparation method thereof
  • Porous bioglass/chitosan/silk fibroin composite material and preparation method thereof

Examples

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Embodiment 1

[0042] A porous bioglass / chitosan / silk fibroin composite material, comprising a silk fibroin scaffold, the surface of the silk fibroin scaffold is compounded with chitosan, and the surface of the chitosan is compounded with honeycomb porous bioactive glass . The weight ratio of the silk fibroin support, chitosan and honeycomb porous bioactive glass is 1:0.2:0.15.

[0043] The present invention also provides a preparation method of the above-mentioned porous biological glass / chitosan / silk fibroin composite material, the specific steps are:

[0044] (1) Preparation of cellular porous bioactive glass:

[0045] Add 200ml of absolute ethanol to the beaker, under the action of ultrasound, add CaO22.5%, SiO 2 45%, P 2 o 5 10%, Na 2 O22.5% composition of biological glass powder, to which dropwise concentration of 0.5M dilute nitric acid solution, the pH value is adjusted to 7.0, to obtain biological glass slurry, adding polyvinyl alcohol (polyvinyl alcohol 05-95 (L ), alcoholysi...

Embodiment 2

[0053] A porous bioglass / chitosan / silk fibroin composite material, comprising a silk fibroin scaffold, the surface of the silk fibroin scaffold is compounded with chitosan, and the surface of the chitosan is compounded with honeycomb porous bioactive glass . The weight ratio of the silk fibroin support, chitosan and honeycomb porous bioactive glass is 1:0.08:0.15.

[0054] The present invention also provides a preparation method of the above-mentioned porous biological glass / chitosan / silk fibroin composite material, the specific steps are:

[0055] (1) Preparation of cellular porous bioactive glass:

[0056] Add 200ml of absolute ethanol to the beaker, under the action of ultrasound, add CaO22.5%, SiO 2 45%, P 2 o 5 10%, Na 2 O2 2.5% composition of biological glass powder, wherein the nitric acid solution of 0.5M is added dropwise to adjust the pH value to 7.0, to obtain the biological glass slurry, add polyvinyl alcohol (polyvinyl alcohol 05-95 (L), The degree of alcoho...

Embodiment 3

[0060] A porous bioglass / chitosan / silk fibroin composite material, comprising a silk fibroin scaffold, the surface of the silk fibroin scaffold is compounded with chitosan, and the surface of the chitosan is compounded with honeycomb porous bioactive glass . The weight ratio of the silk fibroin support, chitosan and honeycomb porous bioactive glass is 1:0.1:0.15.

[0061] The present invention also provides a preparation method of the above-mentioned porous biological glass / chitosan / silk fibroin composite material, the specific steps are:

[0062] (1) Preparation of cellular porous bioactive glass:

[0063] Add 200ml of absolute ethanol to the beaker, under the action of ultrasound, add CaO22.5%, SiO 2 45%, P 2 o 5 10%, Na 2 The biological glass powder of O2 2.5% composition, to which concentration is added dropwise the nitric acid solution of 0.5M, makes pH value adjust to 7.0, obtains biological glass slurry, adds (polyvinyl alcohol 05-95 (L), alcoholysis Degree 94.0-9...

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Abstract

The invention provides a porous bioglass / chitosan / silk fibroin composite material and its preparation method. The porous bioglass / chitosan / silk fibroin composite material is characterized in that a silk fibroin scaffold is included; chitosan is combined on the surface of the silk fibroin scaffold; and porous bioglass is combined on the surface of chitosan. The silk fibroin scaffold is used as a substrate and is combined with chitosan and bioglass particulate. Overall biocompatibility and degradation property of the material are guaranteed, and the material has a certain mechanical strength. In addition, each component can give play to its own functions separately, so as to make up performance deficiency of a single material. Thus, the material becomes an excellent tissue engineering material which has good biocompatibility and degradability, has effects of antibiosis and growth-promotion and has a certain mechanical strength.

Description

technical field [0001] The invention relates to a honeycomb porous bioglass material in the field of biomedicine and a preparation technology for a biocomposite material thereof. It specifically includes the preparation of a honeycomb porous nano-biological glass and the preparation of a porous biological glass / chitosan / silk fibroin composite material. Background technique [0002] The chemical composition of bioglass is similar to that of human bone, and it has good biocompatibility and degradability. After implantation in the human body, it can effectively promote tissue differentiation and bone healing. Therefore, the preparation of bioglass and its compounding with other materials have become a hot spot in recent years. Most of the recently synthesized bioglasses are mesoporous bioglasses: Chinese patent CN1887361A uses a sol-gel method to prepare a mesoporous bioglass fiber material with a pore size of 1-30nm. Chinese patent CN101314039A discloses a method for synthe...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/22A61L27/20A61L27/10A61L27/54
Inventor 光善仪安央赵冬梅徐洪耀
Owner DONGHUA UNIV
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