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Chinese medicine red sage-astragalus root prepn for treating liver fibrosis and liver cirrhosis and its prepn process

A technology of liver fibrosis and traditional Chinese medicine preparations, which is applied in the direction of medical formulas, medical preparations containing active ingredients, pill delivery, etc. It can solve the problems of low content of effective drug ingredients, poor patient compliance, and large dosage of patients, and achieve curative effect Significant, many active ingredients, enhanced qi effect

Active Publication Date: 2007-06-06
CHENGDU HUASUN GRP INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug can reduce the collagen deposition in the liver and inhibit the fat storage cells, thereby blocking the development of liver cirrhosis to a certain extent. However, the prescriptions of the above-mentioned Chinese patent medicines have many flavors, even as many as 16 flavors, and most of them contain precious medicinal materials. And the production process is complex and expensive; at the same time, due to the large number of flavors of the raw materials and the low content of effective drug ingredients, the curative effect needs to be improved; and the patient takes a large amount, usually 3-4 times a day, 4 tablets or 4 tablets each time Above, the patient's medication compliance is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The components of the medicine for treating liver fibrosis and liver cirrhosis in this example and their weight proportions are: 75 parts of total astragalus polysaccharides, 10 parts of total astragalus saponins, 10.5 parts of total phenolic acids of salvia miltiorrhiza, and 4.5 parts of total tanshinones. Its dosage form is capsule. It can be prepared by the following steps:

[0044] (1) Extract astragalus polysaccharide and astragalus saponin from Astragalus

[0045] a. Water extraction: Take the astragalus cut into pieces, add water and decoct 3 times, 2 hours each time, filter, combine the filtrate, concentrate to 3 times the amount of crude drug, centrifuge at high speed, and concentrate the centrifugate to relative density under reduced pressure 1.1;

[0046] b. Alcohol precipitation: add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, filter, and recover the ethanol from the filtrate until it has no alcohol smell, and obtain the filtr...

Embodiment 2

[0056] The components of the medicine for treating liver fibrosis and liver cirrhosis in this example and their weight percentages are: 50 parts of total astragalus polysaccharides, 3 parts of total astragalus saponins, 20 parts of total phenolic acids of salvia miltiorrhiza, and 10 parts of total tanshinone. Its dosage form is a tablet. It can be prepared by the following steps:

[0057] (1) Extract astragalus polysaccharide and astragalus saponin from Astragalus

[0058] a. Water extraction: take the astragalus cut into pieces, add water and decoct 3 times, 1 hour each time, filter, combine the filtrate, concentrate to 1.5 times the amount of crude drug, centrifuge at high speed, and concentrate the centrifugate to relative density under reduced pressure 1.1;

[0059] b. Alcohol precipitation: Add ethanol to make the alcohol content reach 50%, let it stand for 20 hours, filter, and recover the ethanol from the filtrate until it has no alcohol smell, and obtain the filtrate...

Embodiment 3

[0069] The components of the medicine for treating liver fibrosis and liver cirrhosis in this example and their weight percentages are: 80 parts of total astragalus polysaccharides, 20 parts of total astragalus saponins, 5 parts of total phenolic acids of salvia miltiorrhiza, and 2 parts of total tanshinone. Its dosage form is granules. It can be prepared by the following steps:

[0070] (1) Extract astragalus polysaccharide and astragalus saponin from Astragalus

[0071] a. Water extraction: Take the astragalus cut into pieces, add water and decoct 3 times, 3 hours each time, filter, combine the filtrate, concentrate to 4 times the amount of crude drug, centrifuge at high speed, and concentrate the centrifugate to relative density under reduced pressure 1.4;

[0072] b. Alcohol precipitation: Add ethanol to make the alcohol content reach 70%, let it stand for 28 hours, filter, and recover the ethanol from the filtrate until it has no alcohol smell, and obtain the filtrate o...

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PUM

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Abstract

The present invention is one kind of Chinese medicine preparation for treating liver fibrosis and liver cirrhosis. The Chinese medicine preparation consists of astragalus total polysaccharide, astragalus total saponin, total salvianolic acid and total tanshinone. The Chinese medicine preparation has low cost, great number of effective components, high effective component content, determined curative effect, small dosage and high compliance.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine preparation for treating liver fibrosis and liver cirrhosis and a preparation method thereof. Background technique [0002] The drugs used clinically to treat liver fibrosis at home and abroad mainly include colchicine and glucocorticoids. Although these drugs have the effect of anti-hepatic fibrosis to a certain extent, their clinical application is limited due to factors such as high toxicity and side effects and high price. In addition, the study and use of malotilate and hydroxylase inhibitors were all terminated due to clinical findings of severe side effects. Other drugs for treating hepatic fibrosis, such as r-interferon, unsaturated lecithin, prostaglandin, etc., are mostly still in the stage of clinical research and experimental research. Therefore, there is still no ideal drug and treatment method for Western medicine anti-hepatic fibrosis treatment. [0003] The research on the treat...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/16A61K9/20A61K9/48A61P1/16A61K31/715A61K31/7048A61K31/343
Inventor 刘惠莲万方郑士杰曹科赵卫青张珣扶海倪念春
Owner CHENGDU HUASUN GRP INC LTD
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