360results about How to "Reduce lesions" patented technology

The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cGMP-dependent phosphodiesterase. The gastrointestinal disorder may be classified as either irritable bowel syndrome, constipation, or excessive acidity etc. The gastrointestinal disease may be classified as either inflammatory bowel disease or other GI condition including Crohn's disease and ulcerative colitis, and cancer.

Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating lupus, a fibrotic condition, or inflammatory myopathies and other conditions (e.g., skin conditions).

Described herein are novel soluble chimeric fusion proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including domain 4 of KDR. The claimed chimeric fusion proteins antagonize the endothelial cell proliferative and angiogenic activity of VEGF and are useful in the treatment of neovascularization-related disease.

An oral care composition includes an effective amount of a basic amino acid in free or salt form; and an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits.

The subject invention provides a composition comprising a mixture of polypeptides in the form of a tannate salt wherein each polypeptide is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine and L-Lysine, methods of preparation and uses thereof.

The present invention provides novel methods and materials including for treating acne and including methods comprising administering to a subject a composition comprising a therapeutically effective amount of XMP.629 or a pharmaceutically acceptable salt or derivative thereof.

The invention discloses an application of MSC (mesenchymal stem cell) exosomes in preparation of a pharmaceutic preparation for treating PF (pulmonary fibrosis). The MSC exosomes are adopted to treat PF of a mouse, the survival rate of the mouse can be remarkably increased, the PF pulmonary lesions caused by BLM (bleomycin) are relieved, the mouse lung tissue pathological score is reduced, and accordingly, the MSC exosomes have wide application prospect in the aspect of preparation of the pharmaceutic preparation for treating PF.

The current invention refers to the procedure to obtain compositions rich in omega 3 fatty acids with content in phytanic acid below 90 μg per gram of oil. The current invention also refers to the obtaining of compositions rich in DHA with a content in phytanic acid below 90 μg per gram of oil, more specifically between 650-950 mg / g, that is, between 65% and 95% of DHA in weight and values of PhA below 90 μg, preferably below 5 μg per gram of the oil forming the composition. The compositions obtained are used in the field of food supplements, nutritional products and pharmaceutical products due to their prophylactic action and therapeutic effect.

This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 0.01 nanoseconds at the full-width-at-half-maximum. This treatment may at least prevent growth of the lesion.

The invention relates to a method for planting saffron crocus in a Tibet region and belongs to the technical field of natural medicine plantation. The method comprises the steps of field seed ball breeding and indoor cultivation flower picking. The field seed ball breeding comprises the sub-steps of selection of seed corms, plantation preparation, plantation, field management, harvesting of the seed corms and storage of the seed corms. The indoor cultivation flower picking comprises the sub-steps of loading into flat baskets, shelving, cultivation management, and harvesting and processing of the saffron crocus. The saffron crocus is planted in a large field in the Tibet region by using the plantation method, sunlight is sufficient, the plantation time of the seed corms in the land is long, flowers are picked in the land, and the cost is reduced; by virtue of the selection and the cooperation of various plantation parameters according to the technical scheme, filaments of the produced saffron crocus are long, the appearance is good, and the yield is high; the content of saffron crocus essence and saffron crocus bitter principle is greatly higher than that of the saffron crocus produced in the prior art, the medicinal value is high, and pesticide residues are eliminated; moreover, seed balls are large, low in lesion and low in degeneration.

The skin care composition is a cream or lotion that moisturizes the skin, relieving dryness, itchiness, and eczema. The skin care composition contains moisturizers and a plurality of natural oils containing essential fatty acids, the natural oils being selected from the group consisting of borage oil, omega-3 oil, emu oil, evening primrose oil, safflower oil, hemp seed oil, flaxseed oil, and rosehip oil. The moisturizers include olive oil and glycerin. In addition, the skin care composition contains an anti-inflammatory agent, preferably aloe vera juice and aloe extract, and emulsifiers, stabilizers, emollients for softening the skin, and water. The skin care composition may also contain a fragrance and a preservative. Optionally, the skin care composition may contain menthol crystal.

The present disclosure provides for a method and a topical composition to treat facial angiofibromas in Tuberous Sclerosis by applying from about 0.25% to about 2% rapamycin to a small body surface area.

Described herein are novel soluble chimeric fusion proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including domain 4 of KDR. The claimed chimeric fusion proteins antagonize the endothelial cell proliferative and angiogenic activity of VEGF and are useful in the treatment of neovascularization-related disease.

Compositions and methods of use thereof for the treatment of psoriasis and related skin ailments are disclosed. The compositions include topical skin formulations of glucosamine in an emollient base such as moisturizing cream. In addition to glucosamine, the formulations may include keratolytic substances such as coal tar extract or salicylic acid. The formulations may also include glucosamine and antioxidant anti-inflammatory herbal extracts such as oleuropein and berberine in an emollient base.

The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.

The invention discloses Chinese ointment for treating pediatric diaper dermatitis. The Chinese ointment aims at disease causes of the pediatric diaper dermatitis, namely the pediatric dermatitis is caused by holding moisture and pyretic toxicity. The Chinese ointment is prepared by selecting the following medicaments having the effects of clearing heat and drying damp, purging pathogenic fire and cooling blood, and detoxicating and promoting eruption: parslane herb, golden thread, climbing groundsel herb, Chinese gall, Chinese mugwort leaf, common andrographis herb, amur corktree bark, Chinese angelica, rehmanniae praeparatum, plantain herb and honeysuckle flower by scientific compatibility. The Chinese ointment has the advantages of addressing both symptoms and root causes, and having good treatment effect.

A health-care food for preventing and treating atherosclerosis, hypercholesterolemia, hyperlipemia, hypertension, coronary heart disease, angina pectoris, tumor, etc, and balancing the functions of organs is prepared from 10 Chinese-medicinal materials including anemarrhena rhizome, ginger, wolfberry fruit, yam, etc.

The invention relates to staple food flour with balanced nutrition. The staple food flour is prepared from wheat flour, oat flour, potato flour, coix seed flour, millet flour, corn flour, sorghum flour, rice flour, glutinous rice flour, soy flour, mung bean flour, small red bean flour and navy bean flour. The production method comprises the following steps of a, respectively drying wheat, oat, unhusked rice, corn, sorghum, rice and glutinous rice, and grinding the dried wheat, the dried oat, the dried unhusked rice, the dried corn, the dried sorghum, the dried rice and the dried glutinous rice; b, respectively drying coix seeds, dried potatoes, soybeans, mung beans, small red beans and kidney beans, and performing superfine grinding; and c, pouring the powdery materials into a mixer, uniformly stirring the powdery materials so as to obtain mixtures, and loading the mixtures into bags so as to obtain finished products. The staple food flour with balanced nutrition, disclosed by the invention, is made by scientifically compounding 13 kinds of food materials in food grains, beans and potatoes, and is good in mouth feel; people can eat cereals every day in a balanced manner, nutrient components of the staple food flour can be sufficiently neutralized, a traditional habit that single wheat flour or single rice is eaten is changed, the constitutions and the immunity of people are enhanced, the purpose of increasing the physical health level of people is achieved, and the staple food flour disclosed by the invention can be used as staple food flour in daily life of people.

The invention discloses an intelligent litter-cleaning rail-type silkworm breeding device convenient to feed and relates to the technical field of silkworm breeding devices. The device comprises a shed body, a shed cover, a silkworm rack, an auxiliary rack and a pull rod; a first sliding rail and a second sliding rail which are matched with each other and correspond to each other in the position are arranged on a baseplate which is of a U-shaped structure and is arranged on the shed body; the shed cover, a heat preservation pad and a sunshade net are fixed to the opening end of the U-shaped structure of the shed body; a carbon dioxide sensor, a temperature and humidity sensor, an automatic controller, a temperature and humidity adjustment pipe and a ventilation pipe are arranged in the shed body; the silkworm rack is arranged on the first sliding rail, and a silkworm bed and a litter disk are arranged on the silkworm rack; the auxiliary rack is arranged on a second sliding rail. According to the intelligent litter-cleaning rail-type silkworm breeding device, a combined structure of the portable silkworm rack and the auxiliary rack, the temperature and humidity sensor and the automatic controller are arranged in the shed body, the problems, of larger occupation space, difficult breeding and litter cleaning and complex temperature and humidity control of a silkworm chamber, of an existing silkworm rack are solved, the situation is avoided that the growth and development of silkworms are limited by the temperature, the growth speed of the silkworms is improved, and high-yield breeding is achieved.

An oral care composition includes an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits.

The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.

The invention relates to a non-fusion implantation device between dynamic spinous processes, belonging to the technical field of spinal column surgical medical instruments and aiming to provide an implant combined type or signal type device for treating or remitting diseases related to a spinal column. The implantation device is embedded between two spinous processes and comprises a center body, two limited wings and a locking device, wherein the center body is a flexible body, is integrally in a U shape and comprises three parts, i.e. an upper part, a middle part and a lower part, and the upper part and the lower part of the center body are provided with areas which are implanted between the spinous processes and contact with the spinous processes; the limited wings extend from the center body to the spinous processes; and the locking device is used for fixing the limited wings and the spinous processes. The non-fusion implantation device provides the dynamic fixing of anteflexion, retroflexion, left rotation and right rotation without generating adjacent segment degeneration acceleration or novel syndromes and can be widely suitable for treating and remitting the diseases related to the spinal column or osteoporosis diseases.

The invention relates to a traditional Chinese medicine composition for preventing and treating the coccidiosis of poultry. The traditional Chinese medicine composition respectively comprises the following components: a radix dichroae extract, a radix bupleuri extract, a cytromium rhizome extract, a torilis anthriscus extract, a kuhseng extract, a Korean pulsatilla extract, a bigfruit elm extract, a sweet wormwood extract, a rangooncreeper fruit extract, a Japanese pagodatree extract, an astragalus root extract, a herba ecliptae extract, a isatis leaf extract, an angelica extract, a radix platycodi extract, a rehmannia root extract, a weeping forsythia extract, a purslane extract, a heba euphorbiae humifusae extract and a plantain extract. The invention has lower cost, convenient use, no toxic or side effect and no medicine residue and is the traditional Chinese medicine composition for preventing and treating the coccidiosis of the poultry, which conforms to the requirement of a safe animal remedy and guarantees the safety of an animal source food.

The invention provides pH-sensitive coated slow-release phosphate fertilizer and a preparation method thereof. The pH-sensitive coated slow-release phosphate fertilizer is prepared by uniformly spraying a coating layer having pH sensibility on surfaces of phosphate fertilizer-phosphate solubilizing microbial inoculum mixture particles. Crops lack of phosphor secretes a large amount of organic acid so that a pH value around the roots is reduced, and aiming at solving the above mechanism, the pH-sensitive coated slow-release phosphate fertilizer can greatly swell according to pH value decreasing so that a large amount of phosphor is released. The pH-sensitive coated slow-release phosphate fertilizer can control release of phosphor according to different phosphor requirement amounts of crops in different growth stages, can timely supply an appropriate amount of phosphor for plants and solves the problem of mismatching of a fertilizer release amount of the existing slow-release fertilizer and crop growth requirements in different stages.

Disclosed herein are compositions for the treatment of a disease in an animal including yeast extract of Saccharomyces cerevisiae, Bacillus licheniformis or Bacillus subtilis spores, and a carrier. Also included are animal feed compositions including the composition for the prevention, control and / or treatment of a disease in an animal and an animal's food / feed. The compositions are useful to prevent, control, and treat diseases such as necrotic enteritis in poultry when used in combination with an anticoccidal ionophore or coccidiosis vaccine.

We achieved the present invention on the basis of the finding that an excellent therapeutic effect against pancreatic cancer can be obtained by administering an IL-6 inhibitor and an antimetabolite to pancreatic cancer patients. We also found that metastatic lesions from human pancreatic cancer can be reduced and ascites can be eliminated.