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Biological heart valve with anticoagulation and anti-calcification properties and preparation method thereof

A biological valve and anti-coagulation technology, which is applied in the field of medical materials and medical device preparation, can solve the problem of blood coagulation in interventional biological valves, and achieve the effect of meeting clinical needs, excellent anti-coagulation and anti-calcification effects, and improving structural stability

Pending Publication Date: 2020-08-25
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the present invention provides a biological valve with both anticoagulant and anticalcification properties, especially a pulmonary valve and its preparation method, aiming to solve the problems of blood coagulation and calcification of existing interventional biological valves, While ensuring the mechanical properties of biological valve materials, improve the anti-coagulation and anti-calcification effects of valve materials, and prolong the service life of valves

Method used

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  • Biological heart valve with anticoagulation and anti-calcification properties and preparation method thereof
  • Biological heart valve with anticoagulation and anti-calcification properties and preparation method thereof
  • Biological heart valve with anticoagulation and anti-calcification properties and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] A method for preparing a biological valve with both anticoagulant and anticalcification properties, the specific process is:

[0031] (1) After cleaning the porcine pericardial valve with deionized water, at 4°C, soak it in an aqueous solution of 5% hirudin and 1% condensing agent for 2 days;

[0032] (2) Soak in 5% glutaraldehyde solution at 4°C for 7 days;

[0033] (3) Soak in 3% aminoheparin aqueous solution at 4°C for 2 days to obtain the target biological valve material.

[0034] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is 34N under the uniaxial tensile test (1*5cm sample size).

[0035] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross-linked valve.

[0036] The subcutaneous implantation experiment in rats found that the anti-calcification effect of the b...

Embodiment 2

[0038] A method for preparing a biological valve with both anticoagulant and anticalcification properties, the specific process is:

[0039] (1) After the bovine pericardial valve is cleaned with deionized water, soak it in an aqueous solution of 3% taurine and 5% condensing agent at 4°C for 2 days;

[0040] (2) Soak in 5% glutaraldehyde solution at 4°C for 7 days;

[0041] (3) Soak in 5% chitosan heparin aqueous solution at 4°C for 2 days to obtain the target biological valve material.

[0042]The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0043] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional glutaraldehyde cross-linked valve.

[0044] The subcutaneous implantation experiment in rats found that, compared with the tra...

Embodiment 3

[0046] A method for preparing a biological valve with both anticoagulant and anticalcification properties, the specific process is:

[0047] (1) After cleaning the porcine pericardial valve with deionized water, soak it in a 5% glutaraldehyde solution for 7 days at 4°C;

[0048] (2) at 4°C, soak for 5 days in an aqueous solution of 20% Tris ethanesulfonic acid and 5% condensing agent;

[0049] (3) Soak in ethylenediamine-grafted polyglycidyl methacrylate-polyacrylamide-2-methylpropanesulfonic acid aqueous solution with a concentration of 3% at 4°C for 5 days to obtain the target biological valve material.

[0050] The tensile fracture stress of the anti-calcification biological heart valve prepared in this implementation is greater than 30N under the uniaxial tensile test (1*5cm sample size).

[0051] The platelet adhesion experiment found that the biovalve prepared in this implementation has significantly improved anticoagulant performance compared with the traditional gluta...

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Abstract

The invention discloses a biological heart valve with anticoagulation and anti-calcification properties and a preparation method thereof. The method comprises the specific steps that glutaraldehyde isadopted to conduct cross-linking treatment on the biological heart valve, and functional molecules containing amino groups are adopted to conduct functional modification treatment on the biological heart valve at least once before and / or after cross-linking treatment, and the functional molecules are fixed on the biological heart valve in a chemical grafting manner to obtain the biological heartvalve with anticoagulation and anti-calcification functions. The biological heart valve prepared by the invention not only has good mechanical properties, but also has excellent anticoagulation and anti-calcification effects.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical materials and medical devices, and in particular relates to a biological valve with anticoagulant and anticalcification properties and a preparation method thereof. Background technique [0002] Heart valve disease is a kind of cardiovascular disease, which is one of the important causes of high morbidity and mortality of cardiovascular disease. Traditional valve replacement surgery needs to be performed through thoracotomy, but because extracorporeal circulation is required for thoracotomy, the operation risk is high, and the recovery time of the patient is long. Some elderly patients and patients who are not suitable for thoracotomy cannot tolerate this type of surgery. In recent years, with the development of minimally invasive interventional technology, transcatheter interventional heart valve replacement technology has brought hope to patients. Interventional heart valve repla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50A61F2/24A61L33/10A61L33/04A61L33/12A61L33/06
CPCA61F2/24A61L27/3625A61L27/3687A61L27/50A61L33/0011A61L33/0076A61L2400/18A61L2430/20
Inventor 王云兵李高参杨立
Owner SICHUAN UNIV
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