Anti-coagulant polyester hemodialysis membrane and preparation method thereof

A technology of hemodialysis and anticoagulation, applied in semipermeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of non-dialysis membrane materials, poor retention rate of middle molecules and bovine albumin, etc., and achieve anticoagulation Good blood effect, improve anticoagulant phenomenon, high biocompatibility effect

Active Publication Date: 2015-03-25
南昌千麦医学检验实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It can be seen that the anticoagulant hemodialysis membrane first introduces epoxy groups to polylactic acid, and then activates diamines to make it hydrophilic to a certain extent, and induces heparin on its surface to make it possess Certain anticoagulant performance is an effective modification method. Although it has certain anticoagulant performance, the polylactic acid-based dialysis membrane does not perform well in the retention rate of middle molecules and bovine albumin. , is not an ideal dialysis membrane material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A polyester anticoagulant hemodialysis membrane, the dialysis membrane is a hollow fiber membrane prepared by using phospholipidized polyester polymer as the main membrane material, and adding a small amount of chitosan nanoparticles, including the following components in parts by mass : 25 parts of polyethylene terephthalate, 12 parts of glyceryl phosphate, 10 parts of tetrahydrofuran, 3 parts of trimethylamine, 2 parts of chitosan nanoparticles and 22 parts of dimethylacetamide.

[0022] According to the preparation method provided by the present invention, the polyester anticoagulant hemodialysis membrane is prepared, and the dry-wet method is adopted. The preparation steps are as follows:

[0023] (1) Put polyester and phospholipid into THF and stir evenly, add catalyst, react in water bath for 15 hours, part of polyester and phospholipid react to obtain phospholipidized polyester polymer;

[0024] (2) Prepare the spinning solution, put the above mixture into the sp...

Embodiment 2

[0030] A polyester anticoagulant hemodialysis membrane, the dialysis membrane is a hollow fiber membrane prepared by using phospholipidized polyester polymer as the main membrane material, and adding a small amount of chitosan nanoparticles, including the following components in parts by mass : 33 parts of polybutylene terephthalate, 15 parts of glyceryl phosphate, 15 parts of tetrahydrofuran, 4 parts of trimethylamine, 4 parts of chitosan nanoparticles and 30 parts of dimethylacetamide.

[0031] According to the preparation method provided by the present invention, the polyester anticoagulant hemodialysis membrane is prepared, and the dry-wet method is adopted. The preparation steps are as follows:

[0032] (1) Put polyester and phospholipid into THF and stir evenly, add catalyst, react in water bath for 15 hours, part of polyester and phospholipid react to obtain phospholipidized polyester polymer;

[0033] (2) Prepare the spinning solution, put the above mixture into the sp...

Embodiment 3

[0039] A polyester anticoagulant hemodialysis membrane, the dialysis membrane is a hollow fiber membrane prepared by using phospholipidized polyester polymer as the main membrane material, and adding a small amount of chitosan nanoparticles, including the following components in parts by mass : 39 parts of polyarylate, 16 parts of glycerol phosphate, 22 parts of tetrahydrofuran, 5 parts of trimethylamine, 6 parts of chitosan nanoparticles and 36 parts of dimethylacetamide.

[0040] According to the preparation method provided by the present invention, the polyester anticoagulant hemodialysis membrane is prepared, and the dry-wet method is adopted. The preparation steps are as follows:

[0041] (1) Put the polyester and phospholipid into tetrahydrofuran and stir evenly, add a catalyst, and react in a water bath for 18 hours. Part of the polyester and phospholipid react to obtain a phospholipidized polyester polymer;

[0042](2) Prepare the spinning solution, put the above mixtu...

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Abstract

The invention relates to an anti-coagulant polyester hemodialysis membrane and a preparation method of the anti-coagulant polyester hemodialysis membrane, belonging to the field of biological materials. The hemodialysis membrane is a hollow fiber membrane which is mainly made of a phosphatidylcholine polyester polymer and is added with a small amount of chitosan nanoparticles, the mean inner diameter is 132-280mum, and the wall thickness is 38-68mum; the hemodialysis membrane is prepared from the following components in part by weight: 25-45 parts of polyester, 12-20 parts of phospholipid, 10-30 parts of tetrahydrofuran, 3-7 parts of catalyst, 2-10 parts of chitosan nanoparticle and 22-48 parts of solvent. The preparation method of the anti-coagulant polyester hemodialysis membrane adopts a dry-wet method preparation process. The anti-coagulant polyester hemodialysis membrane provided by the invention has the characteristics of small inner diameter, moderate wall thickness and good film forming effect, can be well formed, and has strong pressure resistance, pore diameter reduction or pore closing can be prevented even if the hemodialysis membrane is used for a long time, and reduction of the dialytic efficiency is prevented.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a polyester anticoagulant hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] Hemodialysis membrane uses the principle of semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and retain excess water in the body, and at the same time replenish the substances needed in the body, and maintain electrolytes and purpose of acid-base balance. [0003] Because the dialysis membrane is in direct contact with the blood of the human body, it is easy to have a biological or chemical reaction with various components in the blood, causing a dialysis reaction. The common reactions include two types, one is allergy or blood coagulation caused by the dialysis membrane material, and the other is The first is the complement activation effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/38B01D69/08B01D69/02B01D67/00
Inventor 喻国贞张帆全春兰
Owner 南昌千麦医学检验实验室有限公司
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