The invention discloses a high-performance shaft-end O-shaped rubber sealing ring. The high-performance shaft-end O-shaped rubber sealing ring is prepared from the following raw materials in parts by weight: 30-45 parts of tetra-propylene fluorine rubber, 15-25 parts of acrylonitrile-butadiene rubber, 20-40 parts of polyether urethane rubber, 20-40 parts of isoprene rubber, 2-5 parts of 1,1-di-(tert-butylperoxy)-3,3,5-trimethylcyclohexane, 0.5-1.5 parts of 1,2-polybutadiene, 1-1.8 parts of trimethylolpropane triacrylate, 45-55 parts of modified nano-montmorillonite, 20-40 parts of white carbon black, 5-15 parts of polytetrafluoroethylene fiber, 5-15 parts of carbon fiber, 5-15 parts of nano-kaolin, 5-10 parts of calcined clay, 10-20 parts of nano-calcium carbonate, 0.8-2.8 parts of isopropyl tri(dioctylpyrophosphate)titanate, 0.5-2 parts of triphenyl phosphate, 0.5-2 parts of dibutyl phthalate, 0.5-2 parts of microcrystalline wax and 1-1.8 parts of anti-aging agent.