The invention belongs to the technical field of cleaning of marine biofouling and particularly relates to a cavitation cleaning device. A cavitation cleaning device for clearing biofouling on surfaces of marine ships and platforms comprises a water inlet adapter (5), a cavitation cleaning spray gun (6), a head cover (7), a stabilizing disc (8), a control unit (9), a pressure hull (10), a power unit (11), a depth sensor (12), a tail cover (13), a lifting oil bag (14), a two-way hydraulic pump (15), an oil storage barrel (16) and a battery pack (17). The cavitation cleaning device provided by the invention can be used for cleaning for a long time underwater without needing underwater manual operation, and the cleaning process of the cavitation cleaning device is finished by an operator on a deck through complete remote control of a control center according to a signal fed back by an underwater camcorder unit. Because underwater manual operation is avoided, underwater potential safety hazards of workers are eliminated; and diving suits and underwater acoustic communication equipment are not used, thereby greatly reducing the system cost.