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Chinese medicinal compound for treating coronary heart diseases, preparation method and application thereof

A technology for coronary heart disease and traditional Chinese medicine, which is applied in the application field of preparation and treatment of coronary heart disease, can solve the problem that the symptoms of coronary ischemia cannot be fundamentally improved, the need for new changes in the incidence of coronary heart disease cannot be adapted, and there is little room for clinical syndrome differentiation and drug selection, etc. problems, to achieve the effect of improving arteriosclerosis of the vascular wall, strict medication, and less medication

Active Publication Date: 2010-11-10
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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Problems solved by technology

[0002] Cardiovascular disease has become one of the main diseases that endanger human health, and the number of deaths caused by cardiovascular disease is on the rise every year. Among them, coronary heart disease is a common disease in cardiovascular disease. Curing is the characteristic of the disease. At present, there are many drugs for coronary heart disease, especially chemical drugs, and coronary expansion drugs, such as nitroglycerin drugs, anticoagulant and anti-platelet aggregation drugs. These drugs have achieved relatively good results in clinical practice. Good curative effect can relieve the pain of patients, but most drugs can only temporarily improve the symptoms of coronary artery ischemia, the disease is prone to relapse, and long-term use, side effects are large, and can not fundamentally improve the symptoms of coronary artery ischemia
Traditional Chinese medicine has unique advantages in the treatment of coronary heart disease. It can not only effectively improve the symptoms of coronary artery ischemia, but also last for a long time, with little adverse reactions and little damage to the patient's organs. For example, Chinese invention patents 01108286.0, 200410018357.9, 03152897.X, 200310103981.4, 02114549.0 etc. have all disclosed the medicine for the treatment of coronary heart disease, but existing traditional Chinese medicine preparation partial beneficial air temperature yang is more, activates blood circulation, rarely has the traditional Chinese medicine preparation that invigorates heart kidney qi and yin concurrently activates serum heat, can't adapt to the new coronary heart disease morbidity of today. There is little room for clinical syndrome differentiation and drug selection due to changing needs

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  • Chinese medicinal compound for treating coronary heart diseases, preparation method and application thereof
  • Chinese medicinal compound for treating coronary heart diseases, preparation method and application thereof

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Effect test

Embodiment 1

[0026] 1. Composition of traditional Chinese medicine compound raw materials: 20 grams of Ophiopogon japonicus, 9 grams of Cornus officinalis, 10 grams of leeches, 15 grams of rhodiola rosea, 15 grams of ginkgo leaves, and 15 grams of Polygonum cuspidatum.

[0027] 2, the preparation method of the Chinese medicine compound preparation provided by the invention comprises the following steps:

[0028] (1) Proportionally take 20 grams of Ophiopogon japonicus, 8 grams of dogwood, 10 grams of leeches, 15 grams of rhodiola, 15 grams of ginkgo leaves, and 15 grams of Polygonum cuspidatum. , each time for 1.5 hours, the extracts were combined, concentrated, and the concentrated solution was obtained for subsequent use;

[0029] (2) Take the concentrated solution obtained in step (1), add ethanol to make the concentration of ethanol reach 80%, let it stand, precipitate, take the supernatant, concentrate, and obtain the alcohol precipitation concentrated solution (effective part), and s...

Embodiment 2

[0032] 1. Composition of traditional Chinese medicine compound raw materials: 60 grams of Ophiopogon japonicus, 15 grams of Cornus officinalis, 20 grams of leeches, 60 grams of rhodiola rosea, 60 grams of ginkgo leaves, and 60 grams of Polygonum cuspidatum.

[0033] 2, the preparation method of the Chinese medicine compound preparation provided by the invention comprises the following steps:

[0034](1) Take 60 grams of Ophiopogon japonicus, 15 grams of dogwood, 20 grams of leeches, 60 grams of rhodiola, 60 grams of ginkgo leaves, and 60 grams of Polygonum cuspidatum in proportion. , each time for 1.5 hours, the extracts were combined, concentrated, and the concentrated solution was obtained for subsequent use;

[0035] (2) Take the concentrated solution obtained in step (1), add ethanol to make the concentration of ethanol reach 80%, let it stand, precipitate, take the supernatant, concentrate, and obtain the alcohol precipitation concentrated solution (effective part), and s...

Embodiment 3

[0038] 1. Composition of traditional Chinese medicine compound raw materials: 50 grams of Ophiopogon japonicus, 12 grams of dogwood, 15 grams of leeches, 50 grams of rhodiola rosea, 50 grams of ginkgo leaves, and 50 grams of knotweed.

[0039] 2, the preparation method of the Chinese medicine compound preparation provided by the invention comprises the following steps:

[0040] (1) Take 50 grams of Ophiopogon japonicus, 10 grams of dogwood, 15 grams of leeches, 50 grams of rhodiola, 50 grams of ginkgo leaves, and 50 grams of Polygonum cuspidatum in proportion, and first use 8 times the amount of materials to extract twice with 50% ethanol , 2 hours each time, combine the extracts, concentrate, and obtain the concentrated solution for subsequent use;

[0041] (2) Take the concentrated solution obtained in step (1), add ethanol to make the concentration of ethanol reach 80%, let it stand, precipitate, take the supernatant, concentrate, and obtain the alcohol precipitation concen...

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Abstract

The invention discloses a Chinese medicinal compound for treating coronary heart diseases, a preparation method and application thereof. The Chinese medicinal compound consists of the following raw materials in part by weight: 6 to 60 parts of dwarf lilyturf tuber, 3 to 15 parts of common macrocarpium fruit, 3 to 20 parts of leech, 6 to 60 parts of rhodiola rosea, 6 to 60 parts of ginkgo leaf and 6 to 60 parts of giant knotweed rhizome. The Chinese medicinal compound provided by the invention is prepared in proportion by adopting the theory of syndrome differentiation and treatment according to the theory of the traditional Chinese medical science, pharmacological experimental results indicate that the Chinese medicinal compound provided by the invention has the excellent effects of nourishing heart and kidney, clearing heat and invigorating blood circulation and eliminating blood stasis and removing obstruction in channels, and the modern pharmacological study indicates that the Chinese medicinal compound has the strong effects of improving myocardial oxygen-carrying capacity, expanding the coronary artery, anticoagulating, resisting inflammation, reducing lipid and the like, so the Chinese medicinal compound can resist myocardial ischemia, relieve angina of the coronary heart diseases, resist arteriosclerosis and prevent thrombosis; and the Chinese medicinal compound provided by the invention has low adverse reactions and can be used for treating the coronary heart diseases.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to a compound traditional Chinese medicine which has the effect of treating coronary heart disease, and also relates to the application of the compound traditional Chinese medicine in preparing and treating coronary heart disease. Background technique [0002] Cardiovascular disease has become one of the main diseases that endanger human health, and the number of deaths caused by cardiovascular disease is on the rise every year. Among them, coronary heart disease is a common disease in cardiovascular disease. Curing is the characteristic of the disease. At present, there are many drugs for coronary heart disease, especially chemical drugs, and coronary expansion drugs, such as nitroglycerin drugs, anticoagulant and anti-platelet aggregation drugs. These drugs have achieved relatively good results in clinical practice. Good curative effect can relieve patients' pain, but mos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P9/10A61K35/62
Inventor 严冬钱玉良
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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