Anticoagulation, antibacterial, anti-adhesion, anti-anti-inflammation and lubricating copolymer coating material for surface of silicon rubber material and preparation method thereof

A coating material and anti-coagulation technology, applied in anti-coagulation treatment, coating, pharmaceutical formulations, etc., can solve the problems of patients with poor use feeling, bacterial infection, tissue adhesion, etc., and achieve wide application, mild reaction conditions, high density effect

Active Publication Date: 2019-09-06
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The copolymer coating material of the present invention solves a series of problems such as bacterial infection, tissue adhesion, inflammatory reaction caused by medical silicone rubber implant / intervention in the human body, and poor use feeling of patients due to the large friction coefficient.

Method used

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  • Anticoagulation, antibacterial, anti-adhesion, anti-anti-inflammation and lubricating copolymer coating material for surface of silicon rubber material and preparation method thereof
  • Anticoagulation, antibacterial, anti-adhesion, anti-anti-inflammation and lubricating copolymer coating material for surface of silicon rubber material and preparation method thereof
  • Anticoagulation, antibacterial, anti-adhesion, anti-anti-inflammation and lubricating copolymer coating material for surface of silicon rubber material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) The preparation method of anticoagulant, antibacterial, anti-adhesion, anti-inflammatory, lubricating copolymer coating material is:

[0039] Under argon protection, (4.95mmol) sulfonium ammonium zwitterionic monomer (n=1, m=12, R: methacrylic acid type) and (0.05mmol) succinimide active ester monomer (R 1 : methacrylic acid type) and (0.025mmol) azobisisobutyronitrile AIBN were dissolved in trifluoroethanol with a molar ratio of 99:1:0.5, mixed uniformly and reacted at 30°C for 48h, and the reaction solution was settled by methanol Finally, a white polymer is obtained, and the polymer is vacuum-dried at room temperature to obtain a zwitterion / active ester copolymer.

[0040]

[0041] (2) the preparation method of antibacterial, anti-adhesion, anti-inflammatory, lubricating silicone rubber material is:

[0042] The silicone rubber after the plasma treatment is in the solution of the prepared aminosilane coupling agent (methanol (v%): water (v%): acetic acid (v%)...

Embodiment 2

[0045] As prepared in Example 1, the difference is that the molar ratio of the sulfonium ammonium zwitterionic monomer to the active ester monomer in this example is 1:99.

Embodiment 3

[0047] (1) The preparation method of anticoagulant, antibacterial, anti-adhesion, anti-inflammatory, lubricating copolymer coating material is:

[0048] Under argon protection, (10.71mmol) ammonium phosphate zwitterionic monomer (n=8, m=1, R: methacrylamide type) and (0.56mmol) succinimide active ester monomer (R 1 : acrylic acid type) was dissolved in trifluoroethanol with a molar ratio of 95:5, and then 2-cyano-2-propylbenzodisulfide and azobisisobutyronitrile (AIBN) were added to the reaction system (each substance The molar ratio is the total amount of monomers: 2-cyano-2-propylbenzodisulfide: azobisisobutyronitrile = 100:1:0.5), after uniform mixing, react at 60°C for 12h, and the reaction solution is passed through The white polymer is obtained after methanol precipitation, and the polymer is vacuum-dried at room temperature to prepare a zwitterion / active ester copolymer.

[0049]

[0050] (2) The preparation method of anticoagulant, antibacterial, anti-adhesion, ant...

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Abstract

The invention provides an anticoagulation, antibacterial, anti-adhesion, anti-anti-inflammation and lubricating copolymer coating material for the surface of a silicon rubber material and a preparation method thereof. The material is a high molecular copolymer formed by polyelectrolyte and active ester; the polyelectrolyte is a zwitter-ion polyelectrolyte which is generated by polymerizing phosphate ammonium or carboxyl ammonia or sulphur ammonia zwitter-ion monomers. The monomers and active ester monomers of the prepared polyelectrolyte are directly mixed and polymerized, or a homopolymer ofone of the two monomers is prepared at first, the homopolymer is adopted as a chain transfer agent, and the other monomer is adopted as a polymer monomer to obtain the copolymer. The prepared copolymer coating can be bonded on the surface of silicon rubber through the single coating technology to form the stable polymer coating; the number and density of microorganisms and bacteria attached to thesurface of the modified silicon rubber material are remarkably decreased, and the anticoagulation, antibacterial, anti-adhesion and anti-anti-inflammation performance can be remarkably improved; thesurface of the silicon rubber is high in hydrophilicity, the friction coefficient is remarkably lowered, and the lubricating performance can be obviously enhanced.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an anticoagulant, antibacterial, anti-adhesion, anti-inflammatory and lubricating copolymer coating material on the surface of a silicone rubber material and a preparation method thereof. [0002] technical background [0003] Silicone rubber materials are widely used in biomedical fields due to their low toxicity, physiological inertness, and good biocompatibility and physical and mechanical properties. However, as an implant / interventional medical device material, when silicone rubber is in contact with tissues or body fluids, due to the inherent biological inertia of its surface and the lack of effective anticoagulant, antibacterial, and anti-adhesion capabilities, it will cause microbial contamination on the surface of the material. Serious problems such as blood coagulation, bacterial infection, and inflammatory reactions occur (Acta Biomater., 2017, 50:20-40; ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/38C08F220/36C08F230/02C08F293/00C08F220/60C08F212/14A61L31/10A61L31/14A61L33/06A61L33/00
CPCA61L31/10A61L31/14A61L33/0005A61L33/068A61L2400/10A61L2400/18C08F212/14C08F220/38C08F220/60C08F230/02C08F293/00C08F220/387C08F220/603C08F220/36C08L33/14C08L43/02C08L53/00
Inventor 沈健刘平生彭婉陈浩霖董亚宁曹琳
Owner NANJING NORMAL UNIVERSITY
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