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Preparation method of heart and brain intravascular stent

A cardiovascular and cerebrovascular, high-temperature melting technology, applied in the field of medical applications, can solve problems such as impaired vascular function and poor corrosion resistance, and achieve the effects of eliminating vascular sclerosis, excellent corrosion resistance, and low elastic modulus

Inactive Publication Date: 2016-06-15
刘国远 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the above problems, the present invention provides a method for preparing cardiovascular and cerebrovascular stents. The cardiovascular and cerebrovascular stents prepared by the preparation method can solve the problems of relative displacement between vascular stents and blood vessels and poor corrosion resistance in existing vascular stents. And damage the vascular function, easily damage the cells to cause vascular sclerosis and other problems, and the strength is moderate, the processing plasticity is good, the mechanical strength and volume can meet the clinical requirements, and the surface treatment of the stent can be used as a drug. Carrier, capable of targeted and sustained release of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method for cardiovascular and cerebrovascular stents, comprising the following steps:

[0033](1) equipped with raw materials, the percentage by weight of the alloy composition in the cardiovascular and cerebrovascular stent is 1.5% of zirconium, 2% of molybdenum, 3.5% of niobium, and the rest are magnesium and titanium, wherein the weight ratio of magnesium and titanium is 2:1;

[0034] (2) Adjust the temperature in the high-temperature melting furnace to 1900°C. When the temperature rises to 800°C, add alloy components in the above-mentioned weight ratio except magnesium into the high-temperature melting furnace, melt at 1900°C for 1.5h, and surface scum removal; keep the heating rate at 80°C / min, then increase the temperature in the high-temperature melting furnace to 2200°C, and then smelt at this temperature for 3 hours; cool down the high-temperature melting furnace to a temperature of 720°C, and then add the above The weight ratio of magnesium is sm...

Embodiment 2

[0049] A preparation method for cardiovascular and cerebrovascular stents, comprising the following steps:

[0050] (1) equipped with raw materials, the percentage by weight of the alloy composition in the cardiovascular and cerebrovascular stent is 2.5% of zirconium, 1% of molybdenum, 4.5% of niobium, and the rest are magnesium and titanium, wherein the weight ratio of magnesium and titanium is 2:1;

[0051] (2) Adjust the temperature in the high-temperature melting furnace to 1700°C. When the temperature rises to 800°C, add alloy components of the above-mentioned weight ratio except magnesium into the high-temperature melting furnace, melt at 1700°C for 2.5 hours, and surface scum removal; keep the heating rate at 60°C / min, then increase the temperature in the high-temperature melting furnace to 2500°C, and then smelt at this temperature for 2 hours; cool down the high-temperature melting furnace to a temperature of 750°C, and then add the above The weight ratio of magnesium...

Embodiment 3

[0066] A preparation method for cardiovascular and cerebrovascular stents, comprising the following steps:

[0067] (1) equipped with raw materials, the percentage by weight of the alloy composition in the cardiovascular and cerebrovascular stent is 2% zirconium, 1.5% molybdenum, 4% niobium, and the rest are magnesium and titanium, wherein the weight ratio of magnesium and titanium is 2: 1;

[0068](2) Adjust the temperature in the high-temperature melting furnace to 1800°C. When the temperature rises to 800°C, add alloy components of the above-mentioned weight ratio except magnesium into the high-temperature melting furnace, melt at 1800°C for 2 hours, and remove the surface Scum removal; keep the heating rate at 70°C / min, then increase the temperature in the high-temperature melting furnace to 2350°C, and then smelt at this temperature for 2.5 hours; cool down the high-temperature melting furnace to a temperature of 740°C, and then add the above The weight ratio of magnesium...

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Abstract

The invention relates to a preparation method of a heart and brain intravascular stent.The heart and brain intravascular stent prepared through the preparation method can solve the problems that in existing intravascular stents, relative displacement occurs between the intravascular stents and vessels, corrosion resistance is poor, vascular functions are deteriorated, and cells are damaged easily to cause vascular sclerosis; the heart and brain intravascular stent is moderate in strength and good in processing plasticity, mechanical strength and the volume can meet the clinic requirements, the surface of the stent is treated, and accordingly the stent can serve as a medicine carrier and position slow-release medicine in a targeted mode.Meanwhile, the preparation method is relatively low in cost, high in manufacturing precision and high in formation efficiency.

Description

technical field [0001] The invention belongs to the field of medical applications, and relates to a method for processing and manufacturing an alloy stent used in the field of intravascular interventional therapy, in particular, to a method for preparing a cardiovascular and cerebrovascular stent. Background technique [0002] At present, common cardiovascular and cerebrovascular diseases mainly include arterial stenosis and aneurysm. If these diseases are not treated in time, they may lead to blood vessel blockage and tumor rupture, which will seriously endanger human life. At present, stent intervention is one of the main methods to treat cardiovascular diseases. The research on the interaction between intervention materials and human tissues has attracted more and more attention. The so-called human tissues refer to blood vessels, bones, organs and body fluids. Vascular stents widely used clinically mainly include bare metal stents and drug-eluting stents. [0003] An id...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/12C22C23/00C23C18/12B23P15/00
CPCA61L31/022A61L31/12A61L2300/20A61L2300/252A61L2300/406A61L2300/41A61L2300/42A61L2430/22B23P15/00C22C23/00C23C18/1216C23C18/1241
Inventor 刘国远
Owner 刘国远
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