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271results about How to "Immunomodulatory" patented technology

Cationic angelica polysaccharide nanoparticle gene delivery system and preparation method thereof

The invention discloses a cationic angelica polysaccharide nanoparticle gene delivery system. The system is a gene delivery system of angelica polysaccharide combined DNA (Deoxyribonucleic Acid) plasmids modified by amine compounds, wherein molecular weight distribution of angelica polysaccharides is 30 to 50KD and 80 to 100KD; the mass ratio of the cationic angelica polysaccharide to the DNA plasmids is (1-200):1; and the particle diameter of the cationic angelica polysaccharide-DNA plasmid nancomposite is 21 to 77nm. The system has the characteristics that: 1, the angelica polysaccharide has various biological activities such as immune regulation activity, anti-aging activity, anticoagulation activity and the like, is safe and biologically degradable, does not have immunogenicity and isprepared with a simple, economic and convenient process; and 2, all the three cationic angelica polysaccharides have good DNA plasmid combination effect and gene delivery expression effect. Positive charges carried by primary amine, secondary amine and tertiary amine groups combined with saccharide chains can be effectively combined with the DNA plasmids with negative charges through an electrostatic effect, so that the plasmids are protected from being degraded by various enzymes inside and outside cells.
Owner:JIANGSU UNIV

Foraging feed of special compound feed for breeding stichopus japonicus and preparation method of foraging feed

The invention relates to a foraging feed of a special compound feed for breeding stichopus japonicus and a preparation method of the foraging feed. The technical problems of poor disease control, high cost and the like in conventional breeding of the stichopus japonicus are solved. The foraging feed is prepared through the following steps of adding mixed microbe fluid to the following raw materials in parts by weight of 7-13 parts of soybean meal, 6-9 parts of sweet potato residues, 5-8 parts of corn steep liquor, 5-10 parts of sea mud, 3-5 parts of bran, 8-10 parts of soybean protein concentrate, 5-8 parts of yeast protein, 6-10 parts of wheat flour, 3-6 parts of shrimp powder, 3-5 parts of spirulina powder, 5-10 parts of sea spinach powder, 0.5-1.6 parts of sodium alginate, 0.5-1 part of bentonite, 4-8 parts of betaine, 0.5-4 parts of immune polysaccharide, 0.3-0.5 part of taurine, 0.5-2 parts of honeysuckle flowers, 1-3 parts of radix astragali, 0.5-1 part of gypsum, 0.8-2 parts of haws, 1-3 parts of licorice roots, 1-3 parts of activated carbon, 0.5-1.0 part of calcium propionate, 3-5 parts of complex vitamins, 0.5 part of complex enzymes and the like, and performing fermentation. The foraging feed is prepared through the following steps of mixing the raw materials, performing crushing, performing screening, performing fermentation, performing drying and the like. The foraging feed of the special compound feed is widely applied to breeding of the stichopus japonicus.
Owner:WEIHAI GOLD FEED
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