31 results about "Hormone drug" patented technology

The invention provides application of tea extracellular vesicles in preparation of drugs for relieving or treating allergic respiratory diseases, and belongs to the technical field of extracellular vesicles. The invention provides application of tea extracellular vesicles in preparation of drugs for relieving or treating allergic respiratory diseases. The tea extracellular vesicles are proved to be capable of remarkably improving related symptoms of allergic respiratory diseases including allergic rhinitis, have good anti-inflammatory and immunoregulation effects, and have the application potential of being used as natural active ingredients for preparing drugs or nasal delivery preparations for treating the allergic respiratory diseases. Compared with existing hormone drugs, the tea extracellular vesicles have the advantages of being natural in source, high in safety, low in side effect and the like; moreover, the extracellular vesicles have nanoscale particle sizes, good mucous membrane permeability and bioavailability, can improve the curative effect, and are suitable for long-term intervention.

Disclosed is a class of antibody-hormone drug conjugates having novel structures, or pharmaceutically acceptable salts thereof. Specifically, provided are an antibody-drug conjugate having the general structural formula Ab-(L-D)n or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the conjugate, and a use thereof in the treatment of autoimmune diseases.

The invention discloses a chitosan composite temperature-sensitive gel microsphere for vaginal administration and a preparation method thereof, and relates to the technical field of biological medicines.The preparation method comprises the steps that high-purity chitosan and a temperature-sensitive polymer are mixed, then a cross-linking agent is dropwise added in a gradient mode to form pre-gel, after medicine is ultrasonically embedded, spraying or micro-fluidic forming is conducted, and the chitosan composite temperature-sensitive gel microsphere is obtained; carrying out surface modification and freeze drying by using a stabilizing aid to obtain microspheres; the system is composed of a chitosan matrix, a poly N-isopropylacrylamide temperature-sensitive polymer, a sodium tripolyphosphate cross-linking agent, an antifungal / antiviral / hormone drug and a hydroxypropyl methyl cellulose stabilizing aid, the particle size of microspheres is 50-300 [mu] m, the microspheres are rapidly gelatinized at 37 DEG C, the half-life period of the drug is longer than 8 h, the adhesive force is improved by 30% or above, and the residence time is prolonged to 12 h or above. According to the invention, by constructing a temperature-sensitive interpenetrating network structure and performing surface functional modification, body temperature triggered in-situ gelation, long-acting slow release and strong adhesion synergism are realized, and the local treatment effect and patient compliance are remarkably improved.

A system for predicting the dosage of exogenous FSH administered to a subject in a COS cycle, comprising: a data acquisition module used for acquiring the age, basic AMH, basic FSH or ΔINHB, and basic AFC data of the subject; and an exogenous FSH drug dosage calculation module used for: performing first calculation on the acquired data so as to calculate predicted NROs of the subject; performing second calculation on the acquired data so as to calculate the ratio of the predicted NROs of the subject to the dosage of the exogenous FSH drug administered to the subject; and calculating the dosage of the administered exogenous FSH drug on the basis of the predicted NROs obtained by the first calculation and the ratio. In the system, the predicted NROs are first calculated, then predicted ovarian sensitivity, i.e., the ratio of the predicted NROs to the dosage of the exogenous FSH drug, is calculated, and then the dosage of the administered exogenous FSH drug is obtained, so that the dosage of the exogenous FSH drug can be predicted when there is only one unknown variable, i.e., the dosage of the exogenous FSH drug, in the predicted ovarian sensitivity outcome variables.

The invention relates to the technical field of traditional Chinese medicine extraction and preparation, in particular to a traditional Chinese medicine compound extract for repairing oral mucosa, an extraction method of the traditional Chinese medicine compound extract, an oral mucosa repairing preparation and a preparation method of the oral mucosa repairing preparation. The traditional Chinese medicine compound extract is prepared from 4.8% of radix scutellariae, 4.3% of cortex phellodendri, 4.0% of radix notoginseng, 4.5% of rhizoma coptidis, 4.4% of indigo naturalis, 4.3% of nacre mother of pearl, 25.0% of radix arnebiae seu lithospermi, 4.3% of fructus cnidii, 35.6% of aloe, 4.3% of cortex magnoliae officinalis, 4.3% of dandelion, 0.1% of borneol and 0.1% of camphor, natural Chinese herbal medicine ingredients are adopted, side effects of chemical drugs are reduced, adverse reactions possibly caused by long-term use of hormone drugs are avoided, the traditional Chinese medicine compound extract is suitable for long-term use, and the traditional Chinese medicine compound extract is free of toxic and side effects. The heavy metal content is strictly controlled to ensure that the product safety reaches the standard required by the drug administration department.

The invention discloses a system and a method for detecting the level of cortisol in urine and application, and relates to the technical field of detection of the level of cortisol in urine. The detection system comprises a 24h urocortisol related data and urocortisol correlation analysis module. Wherein the 24-hour urocortisol related data and urocortisol correlation analysis module is based on a monitored 24-hour urocortisol level value after a patient takes hydrocortisone acetate, a 24-hour urocortisol related data level value before and 1 hour after the patient takes hydrocortisone acetate at 8 o'clock in the morning, and a 24-hour urocortisol related data level value before and 1 hour after the patient takes hydrocortisone acetate at 4 o'clock in the afternoon; and performing multivariate linear correlation analysis to obtain a linear relation. The urine cortisol level is calculated according to the linear relational expression, the treatment effect of hormone drugs, especially hydrocortisone acetate, on hypopituitary function can be accurately monitored, and the phenomenon that in the prior art, all urine within 24 h is collected and then cortisol detection is conducted, so that the result is not accurate is avoided.

This invention belongs to the field of biomedicine, specifically relating to siRNA that inhibits AR gene expression, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are at least partially anticomplementary to form a double-stranded region, and the sense strand or antisense strand consists of 19-25 nucleotides with blunt ends of complementary nucleotide sequences; or the antisense strand consists of 27 nucleotide sequences with overhangs. The siRNA of this invention can maintain long-term efficacy with a single dose, exhibiting good compliance in patients with chronic diseases such as androgenetic alopecia. Furthermore, it has lower off-target toxicity and fewer side effects compared to small molecule chemical drugs and hormone drugs.

The present application relates to the technical field of skin care products, and discloses a composition with the effect of soothing sensitive skin, which is composed of the following components in mass percentage: plant extract 10-12%, skin repair factor 2-3%, jasmine hydrolat 10%, humectant 6-7%, and the balance being water. The composition with the effect of soothing sensitive skin has significant soothing effect, which is close to the soothing effect of common hormone ointments on the market. The composition can significantly reduce inflammatory factors, has good anti-inflammatory effect, simultaneously repairs damaged skin, enhances the moisturizing function, and enhances the skin barrier through the moisturizing and repairing effect. The composition has the effect of resisting anaphylaxis by reducing the content of trypsin and inhibiting the allergic reaction of mast cells. Human patch test and fish embryo development toxicity test prove that the composition with the effect of soothing sensitive skin has no skin adverse reactions and no development toxicity, is mild, safe and non-irritating, and is suitable for preparing skin care products for adults and infants.

The application discloses a preparation method of estradiol-17beta-alkyl acid ester and belongs to the technical field of preparation and processing of steroid hormone drugs. The method uses estradiol as raw material, dissolves the raw material in an organic solvent, adds alkyl acid, and then adds a catalyst and a dehydrating agent to generate a mixture of 3, 17beta-dialkyl acid ester and 17beta-alkyl acid ester, and then adds a hydrolysis reagent to generate 17beta-alkyl acid ester. The method uses a new dehydrating agent and a specific catalyst to solve the problems of high temperature, low yield, expensive and toxic reagents in the estradiol 17beta-hydroxyl esterification process of the traditional process, and the process conditions are more moderate, the purity and yield of the prepared product are higher, the reagents are more green and environmentally friendly, and the method is more in line with the industrial development trend of green chemistry.

The present application belongs to the field of musk deer breeding, and discloses a kind of musk deer feed and its feeding method in breeding, aiming at solving the problem of few kinds of musk deer feed in the market, and the problem of short musk deer producing time, harmful components in musk etc. caused by unbalanced nutrition and excessive addition of hormone drugs. The present application is composed of agaric, fish meal, silkworm chrysalis, yeast, soybean meal, peanut meal, corn, salt and compound vitamin. The musk deer feed is prepared by mixing agaric, fish meal and silkworm chrysalis with yeast, and then the musk deer is fed by increasing the amount of feed day by day. The musk deer feed provided by the present application changes under the action of microorganisms, so that the raw materials can play a synergistic effect. After the musk deer feeds on the feed for several months before producing musk, the musk deer becomes stronger, more active, secretes more male hormones, has stronger sexual ability and stronger musk secreting ability, so that the musk producing amount is increased.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an oral growth hormone pharmaceutical composition and a preparation method thereof. The composition comprises at least one growth hormone with an effective dose, at least one absorption enhancer, at least one pH regulator and at least one excipient. The pharmaceutical composition disclosed by the invention effectively promotes the absorption of the oral growth hormone drug, and further improves the bioavailability of the growth hormone drug.

The application discloses an extracellular matrix fusion protein and a preparation method and application thereof, relates to the technical field of recombinant proteins, and aims to solve the technical problem that the existing protein cosmetic products on the market have relatively single functions and are difficult to meet application requirements. The extracellular matrix fusion protein has a nucleotide sequence as shown in SEQ ID No. 7. The extracellular matrix fusion protein with the nucleotide sequence as shown in SEQ ID No. 7 can significantly promote cell adhesion and proliferation, promote cell migration, and act on the dermis layer through the skin, and significantly promote collagen secretion, and since the recombinant protein belongs to a biological protein, has the advantages of easy decomposition and no residue, and has a more broad application prospect compared with ordinary chemical cosmetic products and hormone drugs.

The invention discloses an oral probiotic fermented composition, a preparation method and application of the oral probiotic fermented composition in oral products, and relates to the technical field of daily cosmetics, the composition comprises the following components: rhizoma bletillae extract, mother pearl shell powder and borneol, the mass ratio of the rhizoma bletillae extract to the mother pearl shell powder to the borneol is (5-10): (89.5-94.7): (0.3-0.5), and the mass ratio of the rhizoma bletillae extract to the mother pearl shell powder to the borneol is (5-10): (89.5-94.7): (0.3-0.5). The composition completely adopts natural plant extracts and natural pearls, all the components are closely matched and have a synergistic effect, the composition shows excellent effects in the aspects of inflammation resistance, hemostasis and the like, and compared with traditional chemical and hormone drugs, the composition has no irritation to human gingiva, can serve as a key soothing component, and can be used for relieving the gingiva of a human body and relieving the gingiva of the human body. The composition is widely applied to oral care product formulas, meets the relieving requirement of gingival problems, is simple and convenient in preparation process, greatly reduces the production cost, and can still keep stable quality and excellent effects under the condition of ensuring large-scale production.

The invention relates to the field of traditional Chinese medicines, in particular to a preparation method and application of a nephritis medicine. According to the invention, the extract A (volatile oil), the extract B (ethanol extract) and the extract C (aqueous extract) are mixed according to a specific ratio (such as 4: 6 or 5: 5), so that a multi-component synergistic effect is exerted, and the anti-inflammatory, anti-oxidation and renal function protection effects are remarkably enhanced. Based on natural components of a traditional Chinese medicine compound and an optimized extraction process, side effects of common immunosuppressants or hormone drugs in western medicines are avoided, and safer treatment choices are provided.

The present invention relates to the technical field of extraction and preparation of traditional Chinese medicines, and in particular to a traditional Chinese medicine compound extract for oral mucosa repair, an extraction method thereof, an oral mucosa repair preparation and a preparation method thereof. The traditional Chinese medicine compound extract consists of the following components by weight: 4.8% scutellaria baicalensis, 4.3% phellodendron amurense, 4.0% notoginseng, 4.5% coptis chinensis, 4.4% indigo naturalis, 4.3% mother-of-pearl, 25.0% lithospermum officinale, 4.3% cnidium monnieri, 35.6% aloe vera, 4.3% magnolia bark, 4.3% dandelion, 0.1% borneol and 0.1% camphor. The present invention adopts natural traditional Chinese medicine ingredients, reduces the side effects of chemical drugs, avoids the adverse reactions that may be caused by long-term use of hormone drugs, is suitable for long-term use, and ensures that the product safety meets the standards required by drug supervision departments by strictly controlling the heavy metal content.

The invention discloses application of a solid-phase extraction nanofiber material to detection of hormone drugs in aquatic products, and relates to the technical field of drug detection. The specific preparation method comprises the following steps: firstly, preparing an activated solid-phase extraction column, and preparing 2D-MOF from a ligand, a metal source and alkali; then mixing a polymer with a solvent, or mixing the 2D-MOF, the polymer and the solvent to obtain an electrostatic spinning solution, performing electrostatic spinning on the electrostatic spinning solution to obtain an electrostatic spinning film, and drying to obtain nanofibers; the activated solid-phase extraction column is prepared from the nanofibers. The method comprises the following steps: enriching and purifying hormone drugs in an aquatic product sample extracting solution by using an activated solid-phase extraction column, and detecting 18 hormone drugs in an aquatic product based on ultra-high performance liquid chromatography-tandem mass spectrometry. The activated solid-phase extraction column has good enrichment and recovery effects on hormone drugs, and the detection method is accurate and sensitive.

The present disclosure relates to a multi-component intravaginal ring (IVR) for improved release of non-hormonal agents that can be used in a multi-purpose prophylactic technology (MPT) that simultaneously prevents accidental pregnancy and prevents or treats sexually transmitted infections (STIs) while optimizing vaginal health.

The invention relates to the technical field of medicine synthesis, and particularly discloses a synthesis process of an estrogen regulating medicine. A is used as a starting point of a reaction route, J is prepared through naphthalenone reduction and enol etherification, electron-rich biaryl construction, nitro reduction and benzyl deprotection, secondary amine construction, chiral resolution, acetylation and LAH strong reduction in sequence, all the reaction raw materials are low in price and easy to obtain, the process is stable and mild, the yield is high, and the method has high value for adjusting rapid and mild synthesis of estrogen drugs.

The invention relates to the technical field of drug delivery, in particular to a temperature control atomization combined inhalation type hormone drug release method which comprises the following steps: S1, setting a target temperature range and a target particle size range of liquid medicine; s2, when the temperature of the liquid medicine deviates from the target temperature range, the heating power is dynamically adjusted through a PID algorithm, so that the temperature of the liquid medicine is stabilized within the target temperature range; s3, the liquid medicine with the stable temperature is conveyed to a piezoelectric ceramic atomization piece, and initial aerosol is generated; acquiring current particle size distribution data; s5, if the current particle size distribution data does not conform to the target particle size range, adjusting atomization parameters of a piezoelectric ceramic atomization piece, and generating aerosol with the adaptive particle size; s6, controlling the aerosol with the adaptive particle size to be released to the respiratory tract of the patient. According to the invention, by constructing a temperature control closed loop, particle size feedback adjustment and inhalation synchronous release mechanism, accurate control and efficient delivery of hormone drugs in the aerosol inhalation process are realized.

The present application belongs to the technical field of biological medicine, and particularly relates to a pyruvate preparation for asthma treatment and a preparation method thereof. The pyruvate preparation comprises the following components in parts by weight: 10-12 parts of pyruvate, 10-12 parts of sodium chloride, 0.5-1 part of citric acid, and 500 parts of water for injection; and the pH of the pyruvate preparation is 6-7. The pyruvate preparation is used for daily management of asthma patients, can control the increase of inflammatory cells such as eosinophilic granulocyte, reduce inflammatory reaction, and thus achieve the purpose of inhibiting asthma. The effect of the pyruvate preparation is close to that of the same kind of hormone drug dexamethasone, and the pyruvate preparation can achieve the treatment purpose while reducing the dependence of patients on hormone drugs and side effects.

The application discloses a photothermal response antibacterial and anti-inflammatory hydrogel microneedle for treating atopic dermatitis and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method of the hydrogel microneedle comprises the following steps: dissolving a matrix material, a photoinitiator and a photothermal response polyimidazole salt rare earth metal complex drug into a solvent to obtain a needle tip layer premix solution; dissolving a water-soluble polymer backing material in a solvent to obtain a backing layer solution; injecting the needle tip layer premix solution into a needle tip cavity of a microneedle mold, and fully filling the needle tip cavity by performing first ultrasonic treatment and vacuum treatment; then adding the backing layer solution into the microneedle mold, and performing second ultrasonic treatment and vacuum treatment, and then performing ultraviolet light curing, demolding and the like to obtain the photothermal response antibacterial and anti-inflammatory hydrogel microneedle. The hydrogel microneedle can effectively kill bacteria at an atopic dermatitis infection site and inhibit inflammatory reactions, and provides a new means for non-hormone drug treatment of atopic dermatitis.

The present application provides a kind of lentinan and its preparation method and application, lentinan preparation method includes: preparation method includes: after crushing lentinan raw material, auxiliary extraction is carried out by adding composite enzyme, decoction 3-5h, filter to obtain lentinan intermediate, then add alpha-glucosidase and beta-glucosidase to obtain reaction liquid, stir to 40-45 ℃, dry to obtain lentinan.The lentinan prepared by the lentinan preparation method of the present application has high activity and meets the quality requirements of lentinan characteristic atlas, the method does not remove protein and alcohol precipitation, can be mass-produced and reduces production cost.The lentinan is modified by using composite enzyme assisted extraction and alpha-glucosidase and beta-glucosidase, which improves the extraction efficiency, and the lentinan obtained has higher activity than ordinary lentinan, which can be used for the treatment of skin disease in pigs, reduces the use amount of hormone drugs, and reduces the drug residue in the body of pig.

The present invention belongs to the technical field of preparation of steroid hormone drugs, and specifically relates to a preparation method for α epoxy steroid compounds. The method comprises: using a steroid compound I containing a carbon-carbon double bond as a starting material, and adding a basic reagent, a catalyst and hydrogen peroxide into a solvent under the state of complete dissolution of the starting material in the solvent, and carrying out an epoxide synthesis reaction to obtain an α epoxy steroid compound II, wherein the catalyst refers to 3',5'-dichloro-2,2,2-trifluoroacetophenone. The present invention effectively solves the problems in the prior art such as excessive isomeric by-products, low yield, long production period and high overall production costs, and provides the preparation method for the α epoxy steroid compounds with high selectivity and significant economic benefits, so that the process is more suitable for the requirement of industrial mass production.

The application discloses an active composition for treating atopic dermatitis and application thereof, and belongs to the technical field of biological medicine. The application uses a specific proportion of (+)-catechin hydrate, epicatechin, chlorogenic acid and coniferyl alcohol as active ingredients, so as to play a synergistic effect of multi-target and multi-pathway, and achieve the effect of treating atopic dermatitis. In addition, the composition of the carrier is optimized, the stability, skin permeability and slow-release performance of the active ingredients are improved, the transdermal penetration and target site accumulation of the active ingredients are enhanced, the local drug concentration and the persistence of the curative effect are improved, the active ingredients have better bioactivity under low temperature, various local external dosage forms such as gels, creams, dressings and sprays can be prepared according to the clinical needs, the application is flexible, the adverse reactions caused by long-term use of traditional hormone drugs or chemical synthetic drugs can be avoided, and the application has a good industrial transformation prospect.

The application discloses a traditional Chinese medicine capsule of Herba Epimedii and Radix Morindae Officinalis and a preparation method thereof, relates to the technical field of traditional Chinese medicine preparations, and overcomes the defects of single-component preparation target, large side effect of hormone-containing drugs and unreasonable traditional compound prescription, etc.

A system for predicting the dosage of exogenous FSH administered to a subject in a COS cycle, comprising: a data acquisition module used for acquiring the age, basic AMH, basic FSH or ΔINHB, and basic AFC data of the subject; and an exogenous FSH drug dosage calculation module used for: performing first calculation on the acquired data so as to calculate predicted NROs of the subject; performing second calculation on the acquired data so as to calculate the ratio of the predicted NROs of the subject to the dosage of the exogenous FSH drug administered to the subject; and calculating the dosage of the administered exogenous FSH drug on the basis of the predicted NROs obtained by the first calculation and the ratio. In the system, the predicted NROs are first calculated, then predicted ovarian sensitivity, i.e., the ratio of the predicted NROs to the dosage of the exogenous FSH drug, is calculated, and then the dosage of the administered exogenous FSH drug is obtained, so that the dosage of the exogenous FSH drug can be predicted when there is only one unknown variable, i.e., the dosage of the exogenous FSH drug, in the predicted ovarian sensitivity outcome variables.

The application discloses a hydrogel for resisting post-glaucoma filtration surgery cicatrization reaction and a preparation method and application thereof, and ingredients of the hydrogel include 2-methacrylate hydroxyethyl and 2-((2-hydroxy-3-(methacryloxy)propyl)dimethylamino) acetate. The hydrogel has good optical performance, mechanical performance and biological antifouling performance. The hydrogel is used for glaucoma filtration surgery of rabbit eyes, can more effectively reduce intraocular pressure of the rabbit eyes and maintain filtration blebs, and significantly reduces the cicatrization reaction of scleral flaps of the rabbit eyes. The hydrogel can also be used as a drug carrier platform, loads anti-cicatrization drugs and hormone drugs, and provides a new strategy for clinical application of anti-cicatrization after glaucoma filtration surgery.

The application discloses a kind of solid phase extraction nanofiber material detection hormone drugs in aquatic products, and relates to drug detection technical field.The specific preparation method includes: first, an activated solid phase extraction column is prepared, and 2D-MOF is prepared using ligand, metal source and alkali;Then polymer and solvent, or 2D-MOF, polymer and solvent are mixed to obtain electrospinning solution, electrospinning solution is electrospun to obtain electrospinning film, and drying is nanofiber;Activated solid phase extraction column is made using nanofiber.Hormone drugs in the extract of aquatic product sample are enriched and purified using activated solid phase extraction column, and 18 kinds of hormone drugs in aquatic products are detected based on ultra-high performance liquid chromatography-tandem mass spectrometry.The activated solid phase extraction column of the application has good enrichment recovery effect on hormone drugs, and the detection method is accurate and sensitive.

The invention discloses an epimedium sagittatum seed embryo after-ripening method. The method comprises the following steps: disinfecting, washing and drying herba epimedii seeds; spraying fluridone onto the river sand, and treating for 24 hours; then putting the river sand into a roller, then putting the epimedium seeds into the roller, and carrying out rolling priming treatment for 24 hours; then gibberellin is used for treatment; the humidity state of the seeds in the roller is observed, and if the seeds are dry, the seeds and the river sand are poured out and treated with gibberellin with the same concentration; the seeds are longitudinally cut at regular intervals, the embryo completion condition is observed until white buds appear, namely endosperm grows out of germs, and embryo after-ripening is completed. According to the method, on the basis of a roller initiation technology, solid media, hormones and medicament treatment are combined, so that epimedium seed embryos are subjected to initiation dynamic treatment continuously in the embryo after-ripening process. According to the method, seed rotting can be overcome, the integrity of cell membranes of the seeds is guaranteed, and the albino seedling phenomenon caused by damage of the cell membranes is avoided. The seed utilization efficiency and the time efficiency are improved, and a foundation is laid for improving the seedling raising efficiency of the herba epimedii.

A system for predicting the dosage of exogenous FSH administered to a subject during a COS cycle, the system comprising: a data collection module for obtaining the age, basal AMH, basal FSH or ΔINHB, and basal AFC data of the subject; a first calculation is performed on the obtained data to calculate the predicted NRO of the subject; a second calculation is performed on the obtained data to calculate the ratio of the predicted NRO of the subject to the dosage of the exogenous FSH drug administered to the subject; and an exogenous FSH drug dosage calculation module for calculating the dosage of the exogenous FSH drug to be administered based on the predicted NRO calculated in the first calculation and this ratio. This system first calculates the predicted NRO, then calculates the predicted ovarian sensitivity, that is, the ratio of the predicted NRO to the dosage of the exogenous FSH drug, to obtain the dosage of the exogenous FSH drug to be administered. When the only unknown variable among the predicted ovarian sensitivity result variables is the dosage of the exogenous FSH drug, the dosage of the exogenous FSH drug can be predicted.