9 results about "Hormone drug" patented technology

This invention belongs to the field of biomedicine, specifically relating to siRNA that inhibits AR gene expression, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are at least partially anticomplementary to form a double-stranded region, and the sense strand or antisense strand consists of 19-25 nucleotides with blunt ends of complementary nucleotide sequences; or the antisense strand consists of 27 nucleotide sequences with overhangs. The siRNA of this invention can maintain long-term efficacy with a single dose, exhibiting good compliance in patients with chronic diseases such as androgenetic alopecia. Furthermore, it has lower off-target toxicity and fewer side effects compared to small molecule chemical drugs and hormone drugs.

The present application belongs to the field of musk deer breeding, and discloses a kind of musk deer feed and its feeding method in breeding, aiming at solving the problem of few kinds of musk deer feed in the market, and the problem of short musk deer producing time, harmful components in musk etc. caused by unbalanced nutrition and excessive addition of hormone drugs. The present application is composed of agaric, fish meal, silkworm chrysalis, yeast, soybean meal, peanut meal, corn, salt and compound vitamin. The musk deer feed is prepared by mixing agaric, fish meal and silkworm chrysalis with yeast, and then the musk deer is fed by increasing the amount of feed day by day. The musk deer feed provided by the present application changes under the action of microorganisms, so that the raw materials can play a synergistic effect. After the musk deer feeds on the feed for several months before producing musk, the musk deer becomes stronger, more active, secretes more male hormones, has stronger sexual ability and stronger musk secreting ability, so that the musk producing amount is increased.

The invention relates to the field of traditional Chinese medicines, in particular to a preparation method and application of a nephritis medicine. According to the invention, the extract A (volatile oil), the extract B (ethanol extract) and the extract C (aqueous extract) are mixed according to a specific ratio (such as 4: 6 or 5: 5), so that a multi-component synergistic effect is exerted, and the anti-inflammatory, anti-oxidation and renal function protection effects are remarkably enhanced. Based on natural components of a traditional Chinese medicine compound and an optimized extraction process, side effects of common immunosuppressants or hormone drugs in western medicines are avoided, and safer treatment choices are provided.

The present application belongs to the technical field of biological medicine, and particularly relates to a pyruvate preparation for asthma treatment and a preparation method thereof. The pyruvate preparation comprises the following components in parts by weight: 10-12 parts of pyruvate, 10-12 parts of sodium chloride, 0.5-1 part of citric acid, and 500 parts of water for injection; and the pH of the pyruvate preparation is 6-7. The pyruvate preparation is used for daily management of asthma patients, can control the increase of inflammatory cells such as eosinophilic granulocyte, reduce inflammatory reaction, and thus achieve the purpose of inhibiting asthma. The effect of the pyruvate preparation is close to that of the same kind of hormone drug dexamethasone, and the pyruvate preparation can achieve the treatment purpose while reducing the dependence of patients on hormone drugs and side effects.

The present application provides a kind of lentinan and its preparation method and application, lentinan preparation method includes: preparation method includes: after crushing lentinan raw material, auxiliary extraction is carried out by adding composite enzyme, decoction 3-5h, filter to obtain lentinan intermediate, then add alpha-glucosidase and beta-glucosidase to obtain reaction liquid, stir to 40-45 ℃, dry to obtain lentinan.The lentinan prepared by the lentinan preparation method of the present application has high activity and meets the quality requirements of lentinan characteristic atlas, the method does not remove protein and alcohol precipitation, can be mass-produced and reduces production cost.The lentinan is modified by using composite enzyme assisted extraction and alpha-glucosidase and beta-glucosidase, which improves the extraction efficiency, and the lentinan obtained has higher activity than ordinary lentinan, which can be used for the treatment of skin disease in pigs, reduces the use amount of hormone drugs, and reduces the drug residue in the body of pig.

The present invention belongs to the technical field of preparation of steroid hormone drugs, and specifically relates to a preparation method for α epoxy steroid compounds. The method comprises: using a steroid compound I containing a carbon-carbon double bond as a starting material, and adding a basic reagent, a catalyst and hydrogen peroxide into a solvent under the state of complete dissolution of the starting material in the solvent, and carrying out an epoxide synthesis reaction to obtain an α epoxy steroid compound II, wherein the catalyst refers to 3',5'-dichloro-2,2,2-trifluoroacetophenone. The present invention effectively solves the problems in the prior art such as excessive isomeric by-products, low yield, long production period and high overall production costs, and provides the preparation method for the α epoxy steroid compounds with high selectivity and significant economic benefits, so that the process is more suitable for the requirement of industrial mass production.

The application discloses an active composition for treating atopic dermatitis and application thereof, and belongs to the technical field of biological medicine. The application uses a specific proportion of (+)-catechin hydrate, epicatechin, chlorogenic acid and coniferyl alcohol as active ingredients, so as to play a synergistic effect of multi-target and multi-pathway, and achieve the effect of treating atopic dermatitis. In addition, the composition of the carrier is optimized, the stability, skin permeability and slow-release performance of the active ingredients are improved, the transdermal penetration and target site accumulation of the active ingredients are enhanced, the local drug concentration and the persistence of the curative effect are improved, the active ingredients have better bioactivity under low temperature, various local external dosage forms such as gels, creams, dressings and sprays can be prepared according to the clinical needs, the application is flexible, the adverse reactions caused by long-term use of traditional hormone drugs or chemical synthetic drugs can be avoided, and the application has a good industrial transformation prospect.

The application discloses a traditional Chinese medicine capsule of Herba Epimedii and Radix Morindae Officinalis and a preparation method thereof, relates to the technical field of traditional Chinese medicine preparations, and overcomes the defects of single-component preparation target, large side effect of hormone-containing drugs and unreasonable traditional compound prescription, etc.

The application discloses a kind of solid phase extraction nanofiber material detection hormone drugs in aquatic products, and relates to drug detection technical field.The specific preparation method includes: first, an activated solid phase extraction column is prepared, and 2D-MOF is prepared using ligand, metal source and alkali;Then polymer and solvent, or 2D-MOF, polymer and solvent are mixed to obtain electrospinning solution, electrospinning solution is electrospun to obtain electrospinning film, and drying is nanofiber;Activated solid phase extraction column is made using nanofiber.Hormone drugs in the extract of aquatic product sample are enriched and purified using activated solid phase extraction column, and 18 kinds of hormone drugs in aquatic products are detected based on ultra-high performance liquid chromatography-tandem mass spectrometry.The activated solid phase extraction column of the application has good enrichment recovery effect on hormone drugs, and the detection method is accurate and sensitive.