48 results about "Hormone drug" patented technology

The invention belongs to the technical field of biological medicines, and particularly relates to a pyruvate preparation for treating asthma and a preparation method of the pyruvate preparation. The pyruvate preparation is prepared from the following components in parts by weight: 10 to 12 parts of pyruvate, 10 to 12 parts of sodium chloride, 0.5 to 1 part of citric acid and 500 parts of water for injection. The pH value of the pyruvate preparation is 6 to 7. The pyruvate preparation is used for daily management of asthma patients, the purpose of inhibiting asthma is achieved by controlling increase of the number of inflammatory cells such as eosinophilic granulocytes and reducing inflammatory reaction, the effect of the pyruvate preparation is close to that of similar hormone medicine dexamethasone, and the effect of the pyruvate preparation is improved while the treatment purpose is achieved. The dependence and side effects of patients on hormone drugs are reduced.

The invention is applicable to the technical field of medicine, and provides application of MgAl-LDH in preparation of a medicine for treating joint inflammation, LDH / RH-Gel for joint cavity injection is prepared by taking MgAl-LDH (magnesium aluminum hydrotalcite) as a carrier and carrying RH with anti-inflammatory and cartilage repair activity and combining with temperature-sensitive gel (Gel) by utilizing the advantages of joint cavity injection administration. The preparation is good in biological safety, the solubility of the RH is remarkably improved, and the residence time of the RH in an articular cavity is prolonged; the inflammatory response and cartilage loss are remarkably reduced, the disease progress is delayed, and the OA is effectively treated. The scheme is also suitable for delivery of joint inflammation treatment drugs such as non-steroidal anti-inflammatory drugs, hormone drugs, biological factors and monoclonal antibodies. And the MgAl-LDH can also form a composite carrier with other gels. The traditional Chinese medicine composition is expected to be used for treating arthritis diseases such as rheumatism, rheumatoid arthritis, osteoarthritis and synovitis.

The invention provides application of tea extracellular vesicles in preparation of drugs for relieving or treating allergic respiratory diseases, and belongs to the technical field of extracellular vesicles. The invention provides application of tea extracellular vesicles in preparation of drugs for relieving or treating allergic respiratory diseases. The tea extracellular vesicles are proved to be capable of remarkably improving related symptoms of allergic respiratory diseases including allergic rhinitis, have good anti-inflammatory and immunoregulation effects, and have the application potential of being used as natural active ingredients for preparing drugs or nasal delivery preparations for treating the allergic respiratory diseases. Compared with existing hormone drugs, the tea extracellular vesicles have the advantages of being natural in source, high in safety, low in side effect and the like; moreover, the extracellular vesicles have nanoscale particle sizes, good mucous membrane permeability and bioavailability, can improve the curative effect, and are suitable for long-term intervention.

Disclosed is a class of antibody-hormone drug conjugates having novel structures, or pharmaceutically acceptable salts thereof. Specifically, provided are an antibody-drug conjugate having the general structural formula Ab-(L-D)n or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the conjugate, and a use thereof in the treatment of autoimmune diseases.

The invention discloses a chitosan composite temperature-sensitive gel microsphere for vaginal administration and a preparation method thereof, and relates to the technical field of biological medicines.The preparation method comprises the steps that high-purity chitosan and a temperature-sensitive polymer are mixed, then a cross-linking agent is dropwise added in a gradient mode to form pre-gel, after medicine is ultrasonically embedded, spraying or micro-fluidic forming is conducted, and the chitosan composite temperature-sensitive gel microsphere is obtained; carrying out surface modification and freeze drying by using a stabilizing aid to obtain microspheres; the system is composed of a chitosan matrix, a poly N-isopropylacrylamide temperature-sensitive polymer, a sodium tripolyphosphate cross-linking agent, an antifungal / antiviral / hormone drug and a hydroxypropyl methyl cellulose stabilizing aid, the particle size of microspheres is 50-300 [mu] m, the microspheres are rapidly gelatinized at 37 DEG C, the half-life period of the drug is longer than 8 h, the adhesive force is improved by 30% or above, and the residence time is prolonged to 12 h or above. According to the invention, by constructing a temperature-sensitive interpenetrating network structure and performing surface functional modification, body temperature triggered in-situ gelation, long-acting slow release and strong adhesion synergism are realized, and the local treatment effect and patient compliance are remarkably improved.

The invention belongs to the technical field of preparation of steroid hormone drugs, and particularly relates to a preparation method of an alpha epoxy steroid compound, which comprises the following steps: by taking a steroid compound I containing a carbon-carbon double bond as a raw material, adding an alkaline reagent, a catalyst and hydrogen peroxide in a solvent clarified state, carrying out epoxy synthesis reaction to obtain an alpha epoxy steroid compound II; wherein the catalyst refers to 3 ', 5'-dichloro-2, 2, 2-trifluoroacetophenone, and the catalyst refers to 3 ', 5'-dichloro-2, 2, 2-trifluoroacetophenone. The invention effectively solves the problems of many isomerization byproducts, low yield, long production period and high comprehensive production cost in the prior art, and provides the preparation method of the alpha epoxy steroid compound with high selectivity and obvious economic benefit, so that the process is more suitable for industrial mass production.

A system for predicting the dosage of exogenous FSH administered to a subject in a COS cycle, comprising: a data acquisition module used for acquiring the age, basic AMH, basic FSH or ΔINHB, and basic AFC data of the subject; and an exogenous FSH drug dosage calculation module used for: performing first calculation on the acquired data so as to calculate predicted NROs of the subject; performing second calculation on the acquired data so as to calculate the ratio of the predicted NROs of the subject to the dosage of the exogenous FSH drug administered to the subject; and calculating the dosage of the administered exogenous FSH drug on the basis of the predicted NROs obtained by the first calculation and the ratio. In the system, the predicted NROs are first calculated, then predicted ovarian sensitivity, i.e., the ratio of the predicted NROs to the dosage of the exogenous FSH drug, is calculated, and then the dosage of the administered exogenous FSH drug is obtained, so that the dosage of the exogenous FSH drug can be predicted when there is only one unknown variable, i.e., the dosage of the exogenous FSH drug, in the predicted ovarian sensitivity outcome variables.

The invention discloses a preparation method of a steroid methyl ketone compound, belongs to the technical field of preparation of steroid hormone drugs, and particularly relates to a preparation method for preparing a methyl ketone compound shown as a formula II from a steroid corticoid intermediate chloro compound shown as a formula I through zinc powder dechlorination reduction. The solvent is alcohol, and performing dechlorination reduction to obtain the compound shown in the formula II. The method disclosed by the invention is thorough in reduction, wide in substrate applicability and good in safety, can greatly improve the purity and yield of the product in the step, does not need to use a large amount of acid as a solvent, is beneficial to synthesis of downstream corticoid and safe index control operation, and is particularly suitable for a corticoid synthesis process and industrial production thereof.

The invention relates to the technical field of traditional Chinese medicine extraction and preparation, in particular to a traditional Chinese medicine compound extract for repairing oral mucosa, an extraction method of the traditional Chinese medicine compound extract, an oral mucosa repairing preparation and a preparation method of the oral mucosa repairing preparation. The traditional Chinese medicine compound extract is prepared from 4.8% of radix scutellariae, 4.3% of cortex phellodendri, 4.0% of radix notoginseng, 4.5% of rhizoma coptidis, 4.4% of indigo naturalis, 4.3% of nacre mother of pearl, 25.0% of radix arnebiae seu lithospermi, 4.3% of fructus cnidii, 35.6% of aloe, 4.3% of cortex magnoliae officinalis, 4.3% of dandelion, 0.1% of borneol and 0.1% of camphor, natural Chinese herbal medicine ingredients are adopted, side effects of chemical drugs are reduced, adverse reactions possibly caused by long-term use of hormone drugs are avoided, the traditional Chinese medicine compound extract is suitable for long-term use, and the traditional Chinese medicine compound extract is free of toxic and side effects. The heavy metal content is strictly controlled to ensure that the product safety reaches the standard required by the drug administration department.

The invention discloses a system and a method for detecting the level of cortisol in urine and application, and relates to the technical field of detection of the level of cortisol in urine. The detection system comprises a 24h urocortisol related data and urocortisol correlation analysis module. Wherein the 24-hour urocortisol related data and urocortisol correlation analysis module is based on a monitored 24-hour urocortisol level value after a patient takes hydrocortisone acetate, a 24-hour urocortisol related data level value before and 1 hour after the patient takes hydrocortisone acetate at 8 o'clock in the morning, and a 24-hour urocortisol related data level value before and 1 hour after the patient takes hydrocortisone acetate at 4 o'clock in the afternoon; and performing multivariate linear correlation analysis to obtain a linear relation. The urine cortisol level is calculated according to the linear relational expression, the treatment effect of hormone drugs, especially hydrocortisone acetate, on hypopituitary function can be accurately monitored, and the phenomenon that in the prior art, all urine within 24 h is collected and then cortisol detection is conducted, so that the result is not accurate is avoided.

The present invention belongs to the field of biomedicine technology, and specifically relates to a composition containing pyruvate, a preparation method thereof and an application thereof. The composition comprises the following raw materials in parts by weight: 2-3 parts of pyruvate and 3-5 parts of modified tyrosine, and the structural formula of the modified tyrosine is:. The composition can significantly reduce the number of inflammatory cells in the bronchoalveolar lavage fluid of mice with acute lung injury, as well as the W / D ratio of lung tissue and MPO activity. At the same time, the composition is used in a relatively small amount, which can avoid side effects such as liver damage caused by long-term use of hormone drugs and reduce drug resistance. The preparation method provided by the present invention is simple and feasible, and provides a new synthetic idea for preparing drugs for treating acute lung injury.

Disclosed are a method and system for treating wastewater from the production of synthetic steroid hormone drugs. When polyaluminium chloride is used for coagulation, the method collects the coagulation stirring speed value and the coagulation temperature value through real-time monitoring, and introduces a data processing and analysis algorithm at the back end to perform a time series collaborative analysis of the coagulation stirring speed value and the coagulation temperature value, so as to perform adaptive control of coagulation parameters based on the correlation between the coagulation stirring speed and the temperature. In this way, the wastewater treatment effect can be improved.

This invention belongs to the field of biomedicine, specifically relating to siRNA that inhibits AR gene expression, comprising a sense strand and an antisense strand, wherein the sense strand and the antisense strand are at least partially anticomplementary to form a double-stranded region, and the sense strand or antisense strand consists of 19-25 nucleotides with blunt ends of complementary nucleotide sequences; or the antisense strand consists of 27 nucleotide sequences with overhangs. The siRNA of this invention can maintain long-term efficacy with a single dose, exhibiting good compliance in patients with chronic diseases such as androgenetic alopecia. Furthermore, it has lower off-target toxicity and fewer side effects compared to small molecule chemical drugs and hormone drugs.

The invention belongs to the technical field of biological medicines, and particularly relates to a pyruvate-containing composition as well as a preparation method and application thereof. The composition comprises the following raw materials in parts by weight: 2-3 parts of pyruvate and 3-5 parts of modified tyrosine, wherein the structural formula of the modified tyrosine is # imgabs0 #. The composition can obviously reduce the number of inflammatory cells in alveolar lavage fluid of mice with acute lung injury, the W / D ratio of lung tissue and MPO activity, meanwhile, the dosage of the composition is relatively small, the side effects such as liver function injury caused by long-term use of hormone drugs can be avoided, and the drug resistance of the drugs is relieved. The preparation method provided by the invention is simple and feasible, and a new synthesis thought is provided for preparing the medicine for treating the acute lung injury.

The present application relates to the technical field of skin care products, and discloses a composition with the effect of soothing sensitive skin, which is composed of the following components in mass percentage: plant extract 10-12%, skin repair factor 2-3%, jasmine hydrolat 10%, humectant 6-7%, and the balance being water. The composition with the effect of soothing sensitive skin has significant soothing effect, which is close to the soothing effect of common hormone ointments on the market. The composition can significantly reduce inflammatory factors, has good anti-inflammatory effect, simultaneously repairs damaged skin, enhances the moisturizing function, and enhances the skin barrier through the moisturizing and repairing effect. The composition has the effect of resisting anaphylaxis by reducing the content of trypsin and inhibiting the allergic reaction of mast cells. Human patch test and fish embryo development toxicity test prove that the composition with the effect of soothing sensitive skin has no skin adverse reactions and no development toxicity, is mild, safe and non-irritating, and is suitable for preparing skin care products for adults and infants.

The application discloses a preparation method of estradiol-17beta-alkyl acid ester and belongs to the technical field of preparation and processing of steroid hormone drugs. The method uses estradiol as raw material, dissolves the raw material in an organic solvent, adds alkyl acid, and then adds a catalyst and a dehydrating agent to generate a mixture of 3, 17beta-dialkyl acid ester and 17beta-alkyl acid ester, and then adds a hydrolysis reagent to generate 17beta-alkyl acid ester. The method uses a new dehydrating agent and a specific catalyst to solve the problems of high temperature, low yield, expensive and toxic reagents in the estradiol 17beta-hydroxyl esterification process of the traditional process, and the process conditions are more moderate, the purity and yield of the prepared product are higher, the reagents are more green and environmentally friendly, and the method is more in line with the industrial development trend of green chemistry.

The present application belongs to the field of musk deer breeding, and discloses a kind of musk deer feed and its feeding method in breeding, aiming at solving the problem of few kinds of musk deer feed in the market, and the problem of short musk deer producing time, harmful components in musk etc. caused by unbalanced nutrition and excessive addition of hormone drugs. The present application is composed of agaric, fish meal, silkworm chrysalis, yeast, soybean meal, peanut meal, corn, salt and compound vitamin. The musk deer feed is prepared by mixing agaric, fish meal and silkworm chrysalis with yeast, and then the musk deer is fed by increasing the amount of feed day by day. The musk deer feed provided by the present application changes under the action of microorganisms, so that the raw materials can play a synergistic effect. After the musk deer feeds on the feed for several months before producing musk, the musk deer becomes stronger, more active, secretes more male hormones, has stronger sexual ability and stronger musk secreting ability, so that the musk producing amount is increased.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an oral growth hormone pharmaceutical composition and a preparation method thereof. The composition comprises at least one growth hormone with an effective dose, at least one absorption enhancer, at least one pH regulator and at least one excipient. The pharmaceutical composition disclosed by the invention effectively promotes the absorption of the oral growth hormone drug, and further improves the bioavailability of the growth hormone drug.

The application discloses an extracellular matrix fusion protein and a preparation method and application thereof, relates to the technical field of recombinant proteins, and aims to solve the technical problem that the existing protein cosmetic products on the market have relatively single functions and are difficult to meet application requirements. The extracellular matrix fusion protein has a nucleotide sequence as shown in SEQ ID No. 7. The extracellular matrix fusion protein with the nucleotide sequence as shown in SEQ ID No. 7 can significantly promote cell adhesion and proliferation, promote cell migration, and act on the dermis layer through the skin, and significantly promote collagen secretion, and since the recombinant protein belongs to a biological protein, has the advantages of easy decomposition and no residue, and has a more broad application prospect compared with ordinary chemical cosmetic products and hormone drugs.

The invention discloses an oral probiotic fermented composition, a preparation method and application of the oral probiotic fermented composition in oral products, and relates to the technical field of daily cosmetics, the composition comprises the following components: rhizoma bletillae extract, mother pearl shell powder and borneol, the mass ratio of the rhizoma bletillae extract to the mother pearl shell powder to the borneol is (5-10): (89.5-94.7): (0.3-0.5), and the mass ratio of the rhizoma bletillae extract to the mother pearl shell powder to the borneol is (5-10): (89.5-94.7): (0.3-0.5). The composition completely adopts natural plant extracts and natural pearls, all the components are closely matched and have a synergistic effect, the composition shows excellent effects in the aspects of inflammation resistance, hemostasis and the like, and compared with traditional chemical and hormone drugs, the composition has no irritation to human gingiva, can serve as a key soothing component, and can be used for relieving the gingiva of a human body and relieving the gingiva of the human body. The composition is widely applied to oral care product formulas, meets the relieving requirement of gingival problems, is simple and convenient in preparation process, greatly reduces the production cost, and can still keep stable quality and excellent effects under the condition of ensuring large-scale production.

The utility model relates to a single-balloon catheter with medicine injection and plugging compression functions and injection equipment, and is applied to the field of medical instruments. The device comprises a first pipe fitting, a balloon and a second pipe fitting, and the first pipe fitting comprises a first through hole; the balloon is communicated with the first pipe fitting and can stretch out and draw back in the radial direction to be matched with a pipe cavity for plugging the esophagus; the second pipe fitting penetrates through the first pipe fitting, the second pipe fitting comprises an administration channel and a second through hole, and the second through hole can be communicated with the first through hole and the administration channel; in the closed state, the first through hole and the second through hole do not coincide in the radial direction; in a working state, the first through hole and the second through hole are at least partially overlapped in the radial direction. After the single-balloon catheter is inserted into a corresponding position, the balloon expands to block the catheter cavity and fix the catheter to a diseased region, so that hormone medicine can be fully mixed and soaked with a wound surface above the balloon, the perfusion effect can be kept for a long time, and the clinical curative effect is improved.

The invention relates to the field of traditional Chinese medicines, in particular to a preparation method and application of a nephritis medicine. According to the invention, the extract A (volatile oil), the extract B (ethanol extract) and the extract C (aqueous extract) are mixed according to a specific ratio (such as 4: 6 or 5: 5), so that a multi-component synergistic effect is exerted, and the anti-inflammatory, anti-oxidation and renal function protection effects are remarkably enhanced. Based on natural components of a traditional Chinese medicine compound and an optimized extraction process, side effects of common immunosuppressants or hormone drugs in western medicines are avoided, and safer treatment choices are provided.

The invention belongs to the technical field of steroid compound preparation, and particularly relates to a method for preparing a steroid intermediate by microbial fermentation of sterol. According to the method for preparing the steroid intermediate through microbial fermentation of sterol, sterol serves as a carbon source, mycobacteria serves as a fermentation strain, polyglycerol fatty acid ester is added in the initial stage of fermentation to serve as a fermentation aid, hydroxytyrosol or sodium dehydroacetate is added in the middle stage of fermentation to serve as a fermentation aid, and AD, ADD, 1, 3-butanediol and 1, 3-butanediol are prepared through fermentation culture. The invention relates to four steroid intermediates, namely 4-HBC and 4-HBC. Compared with conventional auxiliary-free fermentation culture, the preparation method has the advantages that the yield of a steroid intermediate can be remarkably increased, and the yield of the intermediate can reach 160 mg / L or above. Therefore, a novel preparation strategy can be provided for synthesis of the steroid intermediates, more raw materials can be provided for synthesis of hormone drugs, and meanwhile, the preparation method has important significance in promoting development and application of the steroid intermediates.

The present invention relates to the technical field of extraction and preparation of traditional Chinese medicines, and in particular to a traditional Chinese medicine compound extract for oral mucosa repair, an extraction method thereof, an oral mucosa repair preparation and a preparation method thereof. The traditional Chinese medicine compound extract consists of the following components by weight: 4.8% scutellaria baicalensis, 4.3% phellodendron amurense, 4.0% notoginseng, 4.5% coptis chinensis, 4.4% indigo naturalis, 4.3% mother-of-pearl, 25.0% lithospermum officinale, 4.3% cnidium monnieri, 35.6% aloe vera, 4.3% magnolia bark, 4.3% dandelion, 0.1% borneol and 0.1% camphor. The present invention adopts natural traditional Chinese medicine ingredients, reduces the side effects of chemical drugs, avoids the adverse reactions that may be caused by long-term use of hormone drugs, is suitable for long-term use, and ensures that the product safety meets the standards required by drug supervision departments by strictly controlling the heavy metal content.

The invention discloses application of a solid-phase extraction nanofiber material to detection of hormone drugs in aquatic products, and relates to the technical field of drug detection. The specific preparation method comprises the following steps: firstly, preparing an activated solid-phase extraction column, and preparing 2D-MOF from a ligand, a metal source and alkali; then mixing a polymer with a solvent, or mixing the 2D-MOF, the polymer and the solvent to obtain an electrostatic spinning solution, performing electrostatic spinning on the electrostatic spinning solution to obtain an electrostatic spinning film, and drying to obtain nanofibers; the activated solid-phase extraction column is prepared from the nanofibers. The method comprises the following steps: enriching and purifying hormone drugs in an aquatic product sample extracting solution by using an activated solid-phase extraction column, and detecting 18 hormone drugs in an aquatic product based on ultra-high performance liquid chromatography-tandem mass spectrometry. The activated solid-phase extraction column has good enrichment and recovery effects on hormone drugs, and the detection method is accurate and sensitive.

The invention belongs to the technical field of preparation of steroid hormone drugs, and particularly relates to a preparation method of tetrahydroprogesterone, which comprises the following steps: dispersing a new 3-carboxylate intermediate compound in a mixed solvent, firstly adding alkali, reacting at a first suitable reaction temperature for a certain time, then adding inorganic acid at a second suitable temperature, and continuing reacting to obtain the tetrahydroprogesterone. And after the hydrolysis reaction is finished, carrying out post-treatment to obtain the target compound tetrahydroprogesterone. The invention effectively solves the problem of overhigh content of compound impurity 17 alpha-epimer in the prior art, and provides the preparation method of tetrahydroprogesterone with high productivity, low cost and wide commercial application prospect.

The present disclosure relates to a multi-component intravaginal ring (IVR) for improved release of non-hormonal agents that can be used in a multi-purpose prophylactic technology (MPT) that simultaneously prevents accidental pregnancy and prevents or treats sexually transmitted infections (STIs) while optimizing vaginal health.

The invention discloses a method for synchronously measuring multiple residual environmental hormones in solid waste, which comprises the following steps: carrying out first extraction operation based on multiple vortex treatments on a solid waste sample based on a first extracting agent and a salting-out agent to obtain a liquid to be purified; performing second centrifugal operation based on vortex treatment on the to-be-purified liquid based on the purifying agent; a centrifugal treatment product is purified and filtered, and a to-be-detected solution is obtained; setting chromatographic conditions, mass spectrum conditions and a mobile phase for determination, and performing HPLC-MS / MS determination on the liquid to be determined to obtain content data of 40 glucocorticoids, 27 sex hormones and 4 beta-receptor hormones in the solid waste sample; according to the present invention, the QuEChERS technology can be adopted to pre-treat the solid waste sample, the 71 environmental hormone drug residues can be simultaneously determined through the HPLC-MS / MS technology, and the method has advantages of high sensitivity, simple operation, accuracy, reliability and good reproducibility.

The invention relates to the technical field of medicine synthesis, and particularly discloses a synthesis process of an estrogen regulating medicine. A is used as a starting point of a reaction route, J is prepared through naphthalenone reduction and enol etherification, electron-rich biaryl construction, nitro reduction and benzyl deprotection, secondary amine construction, chiral resolution, acetylation and LAH strong reduction in sequence, all the reaction raw materials are low in price and easy to obtain, the process is stable and mild, the yield is high, and the method has high value for adjusting rapid and mild synthesis of estrogen drugs.

The invention belongs to the field of separation and extraction of Chinese medicinal materials, in particular to the invention, application and preparation of a new drug of gypenosanol B for antagonizing the side effects of radiotherapy, chemotherapy and glucocorticoid drugs. The existing drugs represented by glucocorticoid drugs show anti-inflammatory, anti-shock, anti-viral and immunosuppressive therapeutic effects in many diseases, but at the same time, the side effects caused to patients are also very large, mainly the problem that long-term use of glucocorticoids causes adrenal atrophy, sugar and salt metabolism disorders and damage to the heart, liver, lungs and kidneys. The following scheme is proposed, and the preparation method thereof comprises the following steps: S1, taking 20kg of gypenosanol total saponins, dissolving them in methanol, mixing them with 40kg of silica gel, and evaporating the solvent; S2, applying a 100kg dry silica gel chromatography column, and eluting them with a chloroform-methanol gradient. The drug of gypenosanol B extracted by the invention is used for antagonizing the side effects of glucocorticoid drugs and the side effects caused by radiotherapy and chemotherapy, and has a definite therapeutic effect and is safe and non-toxic.