64 results about "Aerosol inhalation" patented technology

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

Control device for aerosol inhalation device, includes operational amplifier including output terminal configured to generate voltage according to voltage applied to load configured to heat aerosol source and having correlation between temperature and electrical resistance value, control unit including input terminal and configured to perform processing based on voltage applied to the input terminal, and voltage dividing circuit configured to electrically connect the output terminal of the operational amplifier and the input terminal of the control unit. Power supply voltage of the operational amplifier is higher than power supply voltage of the control unit, and equals voltage applied to aerosol generation circuit including the load, and one of inverting input terminal and noninverting input terminal of the operational amplifier is electrically connected to the aerosol generation circuit.

The invention discloses application of ceftriaxone sodium in preparation of a medicine for preventing and / or treating pulmonary nodules, and belongs to the technical field of tumor prevention and treatment, ceftriaxone sodium is converted into inhalable aerosol particles through an aerosol inhalation device, targeted delivery of the medicine to the lung can be achieved, systemic adverse reactions caused by systemic administration are remarkably reduced, and the curative effect of the medicine is improved. Therefore, the medicine has a treatment effect on pulmonary nodules. Experimental results in the early stage prove that ceftriaxone sodium with different concentrations is subjected to aerosol inhalation to intervene in a mouse pulmonary nodule model induced by uratan, and the ceftriaxone sodium has a good prevention and treatment effect. The research can provide new experimental basis and reference for development of lung nodule related prevention and treatment medicines, provides new technical ideas for prevention and treatment of other diseases, and has important academic value and potential of further development and research.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of being inhaled by atomization and a preparation method, a detection method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 300 to 700 parts of blumea oil, 400 to 700 parts of fructus perillae oil and 10 to 35 parts of menthol. The traditional Chinese medicine composition is high in delivery rate, total delivery amount, fine particle dosage and fine particle proportion, most of the traditional Chinese medicine composition can directly reach the lung, and the traditional Chinese medicine composition can be used for aerosol inhalation, is good in atomization effect, meets clinical use requirements and can be used for treating lung diseases.

The present invention relates to the technical field of heterocyclic compound drugs and their preparation and application, and specifically to a tropane alkaloid composition for the treatment of COPD and its application. The composition combines tropane alkaloids, mannose-6-phosphate and polylactic acid-glycolic acid copolymer, and is constructed into a nanocomposite by nanoparticle preparation technology for aerosol inhalation administration. The composition aims to solve the problems of low bioavailability and lack of targeting in conventional administration of tropane alkaloids. Targeted delivery is achieved by introducing mannose-6-phosphate into the surface of nanoparticles, promoting drug enrichment in the lungs, and using polylactic acid-glycolic acid copolymer to control drug release, thereby increasing local drug concentration and therapeutic efficacy in the lungs.

The application provides a kind of antibiotic-loaded nanoemulsion and its preparation method and application, it is related to the technical field of medical adjuvant, antibiotic is mixed with medicinal adjuvant soybean oil, dipalmitoyl phosphatidylcholine and cholesterol, and volatile organic solvent is used to dissolve and form oil phase;Deoxycholic acid sodium and tween are dissolved in sterile liquid to form water phase;Oil phase and water phase are mixed, and are treated by ultrasonic treatment, rotary evaporation treatment and high pressure homogenization treatment, to obtain antibiotic-loaded nanoemulsion.The application adjusts the type of inhalable medicinal adjuvant, the addition ratio of inhalable medicinal adjuvant, the ratio of oil phase and water phase, and the ultrasonic power and homogenization pressure and other factors, so that the prepared nanoemulsion can efficiently load antibiotic, and has good aerosol inhalation performance, better drug stability, the nanoemulsion can be retained in mouse lung tissue for a long time, and the lung drug delivery efficiency is significantly improved.

The invention discloses an aerosol inhalation device and method based on a flexible strain sensor, solves the problems that an aerosol inhalation device in the prior art has certain lag in detecting airflow at the mouth and the nose, and the synchronization function is easy to lose efficacy, and has the advantages of realizing a breathing synchronous atomization function, avoiding the lag and misjudgment of the airflow, improving the accuracy and the reliability of the aerosol inhalation device. According to the specific scheme, the aerosol inhalation device based on the flexible strain sensor comprises a respiration monitoring vest and a working main machine, the working main machine comprises an atomization assembly and is provided with an atomizing opening for spraying atomized liquid medicine, the respiration monitoring vest is provided with the strain sensor, and the strain sensor is arranged on the working main machine. The strain sensor generates an analog quantity signal in a linear relation with thoracic motion amplitude and sends the generated analog quantity signal to the controller, the controller judges whether a patient is in an inspiration or expiration state according to the thoracic motion signal, and the controller is connected with the atomization assembly so that atomization can be conducted when the patient inspires and stops atomization when the patient expires.

The utility model discloses micro aerosol inhalation device monitoring equipment which is installed between an atomizer and a breathing tail pipe and comprises an equipment body and an upper computer, the equipment body is in communication connection with the upper computer, the equipment body comprises a connecting pipe, a shell and a monitoring device, the connecting pipe transversely penetrates through the shell, the monitoring device is arranged in the shell, and the upper computer is connected with the monitoring device. The monitoring device is in communication connection with the upper computer. The shell comprises a base, side plates and an upper shell, a monitoring device is arranged on the base, the side plates are arranged at the two ends of the base, a through hole is formed in each side plate, the connecting pipe penetrates through the through holes to be fixedly connected with the side plates, a plurality of communicating pipes are arranged on the connecting pipe, the communicating pipes are connected with the monitoring device, and the upper shell is detachably connected with the base. The flow sensor and the pressure sensor are matched with each other, the flow and the pressure of medicine are detected in real time, and the device is small in overall size, low in manufacturing cost, suitable for different inhalation devices and high in monitoring accuracy.

An Aerosol Inhalation Chamber

The invention belongs to the technical field of targeted drugs, and particularly relates to a 293T exosome for targeted delivery of pirfenidone through a membrane-loaded FAP and a preparation method and application thereof.The exosome secreted by 293T cells serves as a natural nano-carrier, an FAP antibody with fibroblast targeting performance is modified on the exosome membrane surface through a copper-free click chemical method, and the exosome membrane surface is modified through a copper-free click chemical method; an anti-fibrosis drug PFD is efficiently loaded into the exosome by adopting an ultrasonic method, so that an engineered exosome system (293Texo antiFAP + PFD) with targeted recognition and drug delivery functions is constructed. The system is delivered to the lung in an aerosol inhalation mode, accurate enrichment and stable release of PFD at the pulmonary fibrosis focus can be achieved, and therefore lung tissue structure damage and collagen deposition are effectively relieved, and the anti-fibrosis curative effect is remarkably improved. According to the technology, the problems of low drug delivery efficiency, large side effect, poor targeting property and the like in traditional treatment are solved, and a safe, efficient and accurate treatment strategy is provided for pulmonary fibrosis.

This aerosol inhalation device comprises: a housing having an opening; an accommodation part for accommodating a consumable material that is to be heated therein; and a lid part. The lid part is movable between a first position at which the opening is covered and a second position at which the opening is opened so that the consumable material can be inserted. The lid part is configured so as to receive, at the second position, a biasing force for moving toward the first position. The biasing force includes a magnetic force.

The application discloses an aerosol inhalation type LNP composition for treating lung diseases and a preparation method and application thereof. The composition comprises an aerosol stabilizer and a surface coupled Anti-CD3 antibody lipid nanoparticle, and the surface coupled Anti-CD3 antibody lipid nanoparticle internally loads a CAR-mRNA targeting FAP. The application improves the efficiency of LNP targeted binding to T cells by coupling CD3 antibodies to LNP, and the LNP can significantly improve the in-vivo reprogramming efficiency of mouse T cells by coupling CD3 antibodies. The application administers the antibody coupled LNP by aerosol inhalation, and compared with common intravenous injection, the lung lesion accumulation of the LNP is improved, so that the treatment effect of pulmonary fibrosis is effectively improved.

The invention discloses a resveratrol crystal form X and a preparation method and application thereof, an X-ray powder diffraction pattern of the resveratrol crystal form X has characteristic peaks at 2 theta angles of 27.4 degrees, 31.8 degrees, 45.6 degrees and 56.5 degrees, and the 2 theta angle error range is + / -0.2 degrees; meanwhile, the invention discloses a preparation method and application in a medicine for treating pneumonia. According to the crystal form X provided by the invention, the saturation solubility of resveratrol is increased by 35.1 times (up to 1793.8 + / -36.8 mu g / mL); the tablet has good dissolution capacity in a slightly acidic inflammation environment; meanwhile, the compound has higher affinity to a protein receptor on a respiratory syncytial virus (RSV), shows a more excellent inhibition effect on the RSV in vitro and in vivo, and has better anti-inflammatory and antioxidant activity; meanwhile, the crystal form X of the resveratrol is more beneficial to cellular uptake, the uptake amount is 3.5 times of the original amount compared with common resveratrol, retention in the lung can be improved, aerosol inhalation for treating the RSV pneumonia has safety and effectiveness, and it is shown that the resveratrol can be used for preparing the medicine for treating the pneumonia, especially the RSV pneumonia.

The invention relates to the technical field of pharmaceutical compositions, in particular to an atomization composition and application thereof. An aerosolized composition comprising: A) an MSC-derived active ingredient selected from any one or a combination of (i) MSC exosomes / extracellular vesicles, (ii) an MSC conditioned culture solution concentrate, (iii) an MSC lysate, (iv) an MSC-derived soluble factor, (v) an immobilized / embedded protected MSC or fragment thereof; b) ergothioneine (EGT) or a pharmaceutically acceptable salt thereof; and C) a pharmaceutically acceptable carrier / buffer system making it suitable for aerosol inhalation administration. The exosome is combined with ergothioneine, and the effectiveness of sleep improvement is remarkably improved through mechanism synergy of nerve regulation and cell protection; the introduction of the atomization drug delivery technology breaks through the limitation of the traditional therapy from multiple dimensions of non-invasiveness, accurate delivery, individualized treatment, accessibility and the like, so that wider crowds (including special crowds) can safely, conveniently and efficiently receive treatment.

This invention provides an aerosol suction cartridge equipped with a sealing member that ensures both heat stability and breathability. [Solution] An aerosol inhalation cartridge is characterized in that a sealing member 9, an aerosol forming substrate, a support member, and a mouthpiece are arranged and wrapped with an outer casing to form an elongated cylindrical shape, the sealing member is formed from a sheet-like member into a cylindrical shape including one or more of the following shapes: roll shape 9a, folded shape 9b, or random shape 9c, and has a length of 3.0 to 7.0 mm along the height direction, and the aerosol forming substrate is an elongated cylindrical shape containing a filler that generates an aerosol when heated by a rod-shaped heating member.

The invention discloses an atomization inhalation device capable of preventing cross infection. The atomization inhalation device comprises a base, an atomization concentration bin, a plurality of injection pieces, a breathing tube and a filtering piece. The atomization concentration bin is of a hollow structure and is provided with a partition structure located in the middle, and the partition structure is provided with a through hole. The multiple injection pieces are arranged in the circumferential direction of the barrel and communicate with an upper cavity of the atomization concentration bin; an ingress pipe is arranged at the lower part of the cylinder to guide the breathing tube to be inserted, and an air guide hole is formed in the side wall of the breathing tube and is aligned with the conduction hole; a sealing structure is arranged between the breathing tube and the ingress tube; the filter part is arranged on the rear side of the barrel, is hermetically connected with the breathing tube and is used for connecting the corrugated tube. Through the arrangement, the technical problem of high cross infection risk caused by backflow pollution and incapability of dismounting and replacing of a breathing tube in an existing aerosol inhalation device is solved.

The invention relates to the technical field of chronic obstructive pulmonary disease treatment, and discloses a chronic obstructive pulmonary disease patient expectoration assisting and aerosol inhalation integrated device which comprises a main machine, a first connecting pipe is connected to the top of a double-end bent pipe in a penetrating mode, a second connecting pipe is connected to one side of the top of the double-end bent pipe in a penetrating mode, and a first catheter is connected to the top of the first connecting pipe in a penetrating mode. A first catheter is connected to the top of the first connecting pipe in a penetrating mode, a second catheter is connected to the top of the second connecting pipe in a penetrating mode, a connector is connected to one end of the first catheter in a penetrating mode, and a suction nozzle is fixedly arranged at one end of the connector. The operation of expectoration assistance and atomization treatment is respectively carried out through the pipeline of the same channel, meanwhile, the airflow trend and liquid flow of the two are not interfered with each other under the treatment condition of the same channel, different treatment pipelines do not need to be frequently replaced for treatment when a chronic obstructive pulmonary disease patient is treated, the risk of pulmonary infection of the patient is reduced, and the treatment efficiency is improved. The treatment effect is improved.

The utility model relates to a mist storage tank, which belongs to the field of medicine inhalers and comprises a main tank body for storing aerosol and an inhalation mask mounted on the main tank body. The main tank body is colorless and transparent, the top of the main tank body is provided with an air inlet joint for mounting the inhalation mask, and the main tank body is provided with an air inlet pipe which is positioned on the lower side of the air inlet joint and is communicated with the air inlet joint and an inner cavity of the main tank body; an indicating ball is arranged in the air inlet pipe, and a limiting structure for limiting the indicating ball from falling off is arranged at the bottom of the air inlet pipe; a medicine inlet is formed in the bottom of the main tank body. The aerosol storage tank has the advantage that the observation effect on the inhalation amount of aerosol when a patient uses the aerosol storage tank is improved.

The present invention relates to a pharmaceutical composition for enhancing respiratory mucosal immunity and provides a method for preparing the pharmaceutical composition. The composition is based on two novel hexapeptide small molecules, peptide I and peptide II, and is further prepared into an aerosol inhalation preparation. Inhalation administration can effectively increase lysozyme activity and S-IgA content in the saliva of model animals, effectively improving the mucosal immunity of model animals. It has a preventive effect on respiratory tract infections and chronic diseases.

The invention relates to the field of medical instruments, and discloses an oxygen-driven oxygen therapy and salt therapy integrated equipment control method and system, the system comprises an oxygen generation branch and a salt aerosol branch, the salt aerosol branch takes oxygen output by the oxygen generation branch as a driving gas source, and the oxygen generation branch is connected with the salt aerosol branch. The method comprises the following specific steps: acquiring a salt aerosol concentration parameter at an output end of the salt aerosol integrated equipment in a current state, an oxygen production branch output oxygen flow parameter, a salt aerosol branch output flow, a salt aerosol concentration parameter and a salt aerosol branch working parameter; obtaining an adjustment target parameter; and adjusting the oxygen flow output by the oxygen generation branch and / or the salt aerosol concentration output by the salt aerosol branch according to the target parameters. By means of the salt aerosol inhalation treatment device, high-concentration oxygen can be provided for a patient while salt aerosol inhalation treatment is conducted on the patient, and when the oxygen flow is adjusted, the output concentration of the salt aerosol can be automatically adjusted, output of the salt aerosol can be rapidly stabilized, and stable treatment is provided for the patient.

The invention discloses a household aerosol inhalation device for treating pulmonary tuberculosis, and relates to the technical field of medical instruments. The device comprises an atomization assembly, an oxygen supply assembly and a breathing assembly. An atomization main body and a control panel integrated with a vital sign monitoring module are arranged in the atomization assembly; the oxygen supply assembly is detachably arranged on the side wall of the atomization assembly and used for providing and adjusting oxygen. The breathing assembly is simultaneously connected with the atomization pipeline and the oxygen supply pipeline through a connecting seat, and a one-way valve and an inward-concave structure are arranged in the connecting seat and used for guiding inhaled mixed gas and guiding exhaled gas to enter a treatment tank at the bottom end of the mask to be treated. According to the invention, the synchronization of atomization administration and continuous oxygen supply is realized, the bacteria-containing aerosol is filtered from the source through the treatment tank, and the vital sign monitoring function is combined, so that the problems that oxygen therapy needs to be interrupted, the cross infection risk is high and the state of a patient cannot be monitored in real time in traditional treatment are effectively solved, and the safety and effectiveness of treatment are remarkably improved.

This invention provides an aerosol suction cartridge equipped with a sealing member that ensures both heat stability and breathability. [Solution] An aerosol inhalation cartridge is characterized in that a sealing member 9, an aerosol forming substrate, a support member, and a mouthpiece are arranged and wrapped with an outer casing to form an elongated cylindrical shape, the sealing member is formed from a sheet-like member into a cylindrical shape including one or more of the following shapes: roll shape 9a, folded shape 9b, or random shape 9c, and has a length of 3.0 to 7.0 mm along the height direction, and the aerosol forming substrate is an elongated cylindrical shape containing a filler that generates an aerosol when heated by a rod-shaped heating member.

The invention discloses a novel biological medicine based on porphyrin derivatives and lipids and a preparation process of the novel biological medicine, and relates to the technical field of preparation of bioactive medicines. The medicine comprises protein containing natural porphyrin and derivatives thereof, and lipid containing natural or improved active ingredients, the substances are in a composition form of a mixture or a single substance and form liposomes or emulsions in a proper manner. According to the biological medicine, lipidosome or emulsion is used as a carrier, active ingredients such as porphyrin FS and hydrophobic febutadine a can be effectively transferred to a target position, the medicine transfer system can improve the stability and bioavailability of the medicine in a body, and the biological medicine is suitable for various administration routes such as oral cavity spraying, aerosol inhalation or solution inhalation and the like and has a wide application prospect. More flexible treatment selection is provided, the device is suitable for disease treatment needing local action, and the device is activated under irradiation of light with specific wavelength, so that the drug effect can be enhanced through control of an external light source.

The invention discloses a traditional Chinese medicine sleep-aiding atomized liquid and a preparation method thereof, the traditional Chinese medicine sleep-aiding atomized liquid comprises the following traditional Chinese medicine raw materials: cortex albiziae, angelica sinensis, frankincense, valerian root, spina date seed, lily, radix rehmanniae recen and liquorice, all the raw materials basically have the effects of calming and soothing the nerves, and especially, the cortex albiziae can regulate the nervous system function of a human body, and can regulate the sleep-aiding function of the human body; according to the traditional Chinese medicine sleep-aiding atomized liquid, the sleep center of the brain is affected, the excitement degree of the nervous system is improved, people can fall asleep more easily and keep a deep sleep state, good sleep can improve the body immunity, compared with a traditional sleeping medicine, the traditional Chinese medicine does not contain any chemical component or additive, no toxic or side effect is caused to the human body, and by means of the atomization technology, the traditional Chinese medicine sleep-aiding atomized liquid is prepared. Active ingredients are delivered to the lung in an aerosol inhalation mode to enter blood circulation, the active ingredients are prevented from being decomposed by gastric acid, and the first-pass effect of the liver is avoided, so that a human body can fall asleep more quickly and safely and enter deep sleep.

The invention discloses a solution for aerosol inhalation of a CK2 inhibitor CX4945 as well as a preparation method and application of the solution. The solution for aerosol inhalation, provided by the invention, is prepared from 10 to 20mg of CX4945, 10 to 20mg of an osmotic pressure regulator, a pH regulator and water for injection according to a single dose of 2mL. The CK2 inhibitor and the aerosol inhalation solution thereof provided by the invention can significantly inhibit neutrophil from generating NETs and the pro-inflammatory effect of the NETs, and can inhibit respiratory tract inflammations including chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), asthma and cystic fiber. The aerosol inhalation solution directly acts on the lung by being inhaled from the mouth and the nose, so that the metabolic process of the liver and the kidney to the medicine is reduced, the liver and kidney injury to patients is remarkably reduced, and the aerosol inhalation solution is particularly convenient for children, the old and severe patients to take.

The invention relates to the technical field of molecular biology and biological medicine, in particular to a siTGF-beta1 / siGAS6 co-delivery system capable of being used for aerosol inhalation synergistic treatment of idiopathic pulmonary fibrosis. Specific siTGF-beta1 is designed aiming at mRNA (messenger ribonucleic acid) of a transforming growth factor TGF-beta1, and the siTGF-beta1, siGAS6 capable of effectively inhibiting GAS6 gene expression and a mannan-polypeptide conjugate carrier are further compounded to form a mannan-polypeptide conjugate co-delivery system of the siTGF-beta1 and the siGAS6, namely a mannan-polypeptide / siTGF-beta1 / siGAS6 co-delivery system. The system can be used for preparing a medicine for treating idiopathic pulmonary fibrosis, especially for preparing a medicine capable of being inhaled by atomization. The idiopathic pulmonary fibrosis can be synergistically treated in an aerosol inhalation mode. According to the technical scheme, lung macrophages can be efficiently targeted, and a synergistic treatment effect is generated to realize efficient treatment on idiopathic pulmonary fibrosis.

The invention provides a nuclear reactor pool decontamination robot and decontamination system, the nuclear reactor pool decontamination robot comprises a mobile platform, a first mechanical arm and a second mechanical arm, the mobile platform comprises a vehicle body and wheels, and the vehicle body is provided with a first camera; the first mechanical arm and the second mechanical arm are arranged on the vehicle body; a decontamination assembly is arranged at the tail end of the first mechanical arm and used for conducting decontamination flushing on the pool wall and the pool bottom of the nuclear reactor pool, and a decontamination brush head is arranged at the tail end of the second mechanical arm. The whole-course unmanned decontamination operation in the nuclear reactor water pool is realized, the decontamination operation can be automatically carried out according to a planned path, and the radioactive radiation and radioactive aerosol inhalation risks of manual operation are avoided.

The utility model discloses an aerosol inhalation device for sheep treatment, and relates to the technical field of veterinary treatment. Comprising an atomization mask, an atomization mechanism used for treating sheep is arranged on the atomization mask, the atomization mechanism comprises a locking assembly, the locking assembly comprises a connecting protective sleeve arranged at the right end of the atomization mask, and a connecting ring is arranged at the right end of the connecting protective sleeve. A second rubber ring and a first rubber ring are attached to the neck, friction between the second rubber ring and the first rubber ring is reduced, the sheep is protected, then a rope is tensioned for locking, complex fixing steps are not needed, the mounting efficiency is improved, the atomization mask is arranged on the head area of the sheep in a sleeving mode, it is ensured that the atomization mask directly covers the mouth and nose of the sheep, and the labor intensity of workers is relieved. Atomized medicine can directly and efficiently enter the respiratory tract, loss of the medicine in air is reduced, and the utilization rate and the treatment effect of the medicine are improved.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for determining related substances of a carbocisteine aerosol inhalation solution. The method adopts a high performance liquid chromatography method, and the chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a filler; carrying out gradient elution by taking phosphate and an ion pair buffer solution as a mobile phase A and methanol as a mobile phase B; the flow rate is 0.6 ml / min to 1.0 ml / min; the column temperature is 30-40 DEG C; the detection wavelength is 200 nm to 230 nm; the sample injection volume is 10-30 [mu] l. The method can be used for detecting the related substances of the carbocisteine aerosol inhalation solution, can detect the related substances including an impurity A, an impurity C, an impurity D, an impurity E, an impurity G and the like, and also has relatively strong detection capability on the related substances of the raw materials. The determination method provided by the invention has the advantages of stable system, durability, high efficiency, simplicity and convenience in operation and easiness in reproduction.

This aerosol inhalation device comprises: a housing; an accommodation part that has an opening and accommodates a consumable material so as to heat the same; a lid part that can move between a first position that completely covers the opening and a second position that uncovers the opening so as to allow the consumable material to be inserted therein; and a sealing member that is configured to seal the opening between the accommodation part and the lid part when the lid part is at the first position.