29 results about "Aerosol inhalation" patented technology

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The invention discloses application of ceftriaxone sodium in preparation of a medicine for preventing and / or treating pulmonary nodules, and belongs to the technical field of tumor prevention and treatment, ceftriaxone sodium is converted into inhalable aerosol particles through an aerosol inhalation device, targeted delivery of the medicine to the lung can be achieved, systemic adverse reactions caused by systemic administration are remarkably reduced, and the curative effect of the medicine is improved. Therefore, the medicine has a treatment effect on pulmonary nodules. Experimental results in the early stage prove that ceftriaxone sodium with different concentrations is subjected to aerosol inhalation to intervene in a mouse pulmonary nodule model induced by uratan, and the ceftriaxone sodium has a good prevention and treatment effect. The research can provide new experimental basis and reference for development of lung nodule related prevention and treatment medicines, provides new technical ideas for prevention and treatment of other diseases, and has important academic value and potential of further development and research.

An Aerosol Inhalation Chamber

The application discloses an aerosol inhalation type LNP composition for treating lung diseases and a preparation method and application thereof. The composition comprises an aerosol stabilizer and a surface coupled Anti-CD3 antibody lipid nanoparticle, and the surface coupled Anti-CD3 antibody lipid nanoparticle internally loads a CAR-mRNA targeting FAP. The application improves the efficiency of LNP targeted binding to T cells by coupling CD3 antibodies to LNP, and the LNP can significantly improve the in-vivo reprogramming efficiency of mouse T cells by coupling CD3 antibodies. The application administers the antibody coupled LNP by aerosol inhalation, and compared with common intravenous injection, the lung lesion accumulation of the LNP is improved, so that the treatment effect of pulmonary fibrosis is effectively improved.

The invention relates to the technical field of pharmaceutical compositions, in particular to an atomization composition and application thereof. An aerosolized composition comprising: A) an MSC-derived active ingredient selected from any one or a combination of (i) MSC exosomes / extracellular vesicles, (ii) an MSC conditioned culture solution concentrate, (iii) an MSC lysate, (iv) an MSC-derived soluble factor, (v) an immobilized / embedded protected MSC or fragment thereof; b) ergothioneine (EGT) or a pharmaceutically acceptable salt thereof; and C) a pharmaceutically acceptable carrier / buffer system making it suitable for aerosol inhalation administration. The exosome is combined with ergothioneine, and the effectiveness of sleep improvement is remarkably improved through mechanism synergy of nerve regulation and cell protection; the introduction of the atomization drug delivery technology breaks through the limitation of the traditional therapy from multiple dimensions of non-invasiveness, accurate delivery, individualized treatment, accessibility and the like, so that wider crowds (including special crowds) can safely, conveniently and efficiently receive treatment.

This invention provides an aerosol suction cartridge equipped with a sealing member that ensures both heat stability and breathability. [Solution] An aerosol inhalation cartridge is characterized in that a sealing member 9, an aerosol forming substrate, a support member, and a mouthpiece are arranged and wrapped with an outer casing to form an elongated cylindrical shape, the sealing member is formed from a sheet-like member into a cylindrical shape including one or more of the following shapes: roll shape 9a, folded shape 9b, or random shape 9c, and has a length of 3.0 to 7.0 mm along the height direction, and the aerosol forming substrate is an elongated cylindrical shape containing a filler that generates an aerosol when heated by a rod-shaped heating member.

The invention relates to the technical field of chronic obstructive pulmonary disease treatment, and discloses a chronic obstructive pulmonary disease patient expectoration assisting and aerosol inhalation integrated device which comprises a main machine, a first connecting pipe is connected to the top of a double-end bent pipe in a penetrating mode, a second connecting pipe is connected to one side of the top of the double-end bent pipe in a penetrating mode, and a first catheter is connected to the top of the first connecting pipe in a penetrating mode. A first catheter is connected to the top of the first connecting pipe in a penetrating mode, a second catheter is connected to the top of the second connecting pipe in a penetrating mode, a connector is connected to one end of the first catheter in a penetrating mode, and a suction nozzle is fixedly arranged at one end of the connector. The operation of expectoration assistance and atomization treatment is respectively carried out through the pipeline of the same channel, meanwhile, the airflow trend and liquid flow of the two are not interfered with each other under the treatment condition of the same channel, different treatment pipelines do not need to be frequently replaced for treatment when a chronic obstructive pulmonary disease patient is treated, the risk of pulmonary infection of the patient is reduced, and the treatment efficiency is improved. The treatment effect is improved.

The invention discloses a household aerosol inhalation device for treating pulmonary tuberculosis, and relates to the technical field of medical instruments. The device comprises an atomization assembly, an oxygen supply assembly and a breathing assembly. An atomization main body and a control panel integrated with a vital sign monitoring module are arranged in the atomization assembly; the oxygen supply assembly is detachably arranged on the side wall of the atomization assembly and used for providing and adjusting oxygen. The breathing assembly is simultaneously connected with the atomization pipeline and the oxygen supply pipeline through a connecting seat, and a one-way valve and an inward-concave structure are arranged in the connecting seat and used for guiding inhaled mixed gas and guiding exhaled gas to enter a treatment tank at the bottom end of the mask to be treated. According to the invention, the synchronization of atomization administration and continuous oxygen supply is realized, the bacteria-containing aerosol is filtered from the source through the treatment tank, and the vital sign monitoring function is combined, so that the problems that oxygen therapy needs to be interrupted, the cross infection risk is high and the state of a patient cannot be monitored in real time in traditional treatment are effectively solved, and the safety and effectiveness of treatment are remarkably improved.

This invention provides an aerosol suction cartridge equipped with a sealing member that ensures both heat stability and breathability. [Solution] An aerosol inhalation cartridge is characterized in that a sealing member 9, an aerosol forming substrate, a support member, and a mouthpiece are arranged and wrapped with an outer casing to form an elongated cylindrical shape, the sealing member is formed from a sheet-like member into a cylindrical shape including one or more of the following shapes: roll shape 9a, folded shape 9b, or random shape 9c, and has a length of 3.0 to 7.0 mm along the height direction, and the aerosol forming substrate is an elongated cylindrical shape containing a filler that generates an aerosol when heated by a rod-shaped heating member.

The invention relates to the technical field of molecular biology and biological medicine, in particular to a siTGF-beta1 / siGAS6 co-delivery system capable of being used for aerosol inhalation synergistic treatment of idiopathic pulmonary fibrosis. Specific siTGF-beta1 is designed aiming at mRNA (messenger ribonucleic acid) of a transforming growth factor TGF-beta1, and the siTGF-beta1, siGAS6 capable of effectively inhibiting GAS6 gene expression and a mannan-polypeptide conjugate carrier are further compounded to form a mannan-polypeptide conjugate co-delivery system of the siTGF-beta1 and the siGAS6, namely a mannan-polypeptide / siTGF-beta1 / siGAS6 co-delivery system. The system can be used for preparing a medicine for treating idiopathic pulmonary fibrosis, especially for preparing a medicine capable of being inhaled by atomization. The idiopathic pulmonary fibrosis can be synergistically treated in an aerosol inhalation mode. According to the technical scheme, lung macrophages can be efficiently targeted, and a synergistic treatment effect is generated to realize efficient treatment on idiopathic pulmonary fibrosis.

The utility model discloses an aerosol inhalation device for sheep treatment, and relates to the technical field of veterinary treatment. Comprising an atomization mask, an atomization mechanism used for treating sheep is arranged on the atomization mask, the atomization mechanism comprises a locking assembly, the locking assembly comprises a connecting protective sleeve arranged at the right end of the atomization mask, and a connecting ring is arranged at the right end of the connecting protective sleeve. A second rubber ring and a first rubber ring are attached to the neck, friction between the second rubber ring and the first rubber ring is reduced, the sheep is protected, then a rope is tensioned for locking, complex fixing steps are not needed, the mounting efficiency is improved, the atomization mask is arranged on the head area of the sheep in a sleeving mode, it is ensured that the atomization mask directly covers the mouth and nose of the sheep, and the labor intensity of workers is relieved. Atomized medicine can directly and efficiently enter the respiratory tract, loss of the medicine in air is reduced, and the utilization rate and the treatment effect of the medicine are improved.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for determining related substances of a carbocisteine aerosol inhalation solution. The method adopts a high performance liquid chromatography method, and the chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a filler; carrying out gradient elution by taking phosphate and an ion pair buffer solution as a mobile phase A and methanol as a mobile phase B; the flow rate is 0.6 ml / min to 1.0 ml / min; the column temperature is 30-40 DEG C; the detection wavelength is 200 nm to 230 nm; the sample injection volume is 10-30 [mu] l. The method can be used for detecting the related substances of the carbocisteine aerosol inhalation solution, can detect the related substances including an impurity A, an impurity C, an impurity D, an impurity E, an impurity G and the like, and also has relatively strong detection capability on the related substances of the raw materials. The determination method provided by the invention has the advantages of stable system, durability, high efficiency, simplicity and convenience in operation and easiness in reproduction.

An aerosol inhalation device comprises a housing and a cap. The housing has a first end and a second end, the second end having a slidable cover. The cap is configured such that, in a state in which the cap is attached to the second end of the housing, a second force applied to the cap in a first direction will remove the cap from the second end. The cover is configured such that, in a state in which the cap is attached to the second end, a third force is applied to the cover in the first direction as a result of the second force being applied to the cap in the first direction. The third force is less than the first force.

A method of connecting a user to an extended reality environment for an aerosol inhalation session includes: determining a state of an aerosol generating device; and facilitating connection of the user to the extended reality environment based on the determined state. There is also provided an aerosol generating device. There is also provided an electronic communication device.

The invention discloses a method for controlling breathing self-adaptive training in the atomization process and a related device, and relates to the technical field of breathing control. The method comprises the steps that after atomization is started, a user role is recognized; configuring a breathing training mode for the user based on the user role, wherein the breathing training mode comprises breathing duration and breathing matching parameters under the breathing duration; reminding a user to perform respiratory training operation based on the respiratory training mode; identifying expiration parameters output by the user under the breathing training operation; judging whether respiratory training reaches the standard or not based on the expiration parameters; if it is judged that the respiratory training reaches the standard, the respiratory training process is ended. According to the invention, the respiratory rhythm of children can be more effectively regularized, and the medicine dissipation is reduced, so that the aerosol inhalation treatment effect is effectively improved.

The utility model belongs to the technical field of aerosol generation, and discloses an aerosol generation device and an aerosol generation system. The flow guide structure in the aerosol generating device comprises a first airflow chamber and a second airflow chamber which extend side by side and are isolated from each other, the sectional area of the first airflow chamber is smaller than that of the second airflow chamber, and a filtering substance is arranged in the second airflow chamber; the atomizer is used for atomizing the liquid substrate to generate first aerosol; the receiving cavity is communicated with the second airflow chamber and is used for accommodating at least one part of an aerosol generating product, so that second aerosol generated by the aerosol generating product is guided into the second airflow chamber; wherein the first airflow chamber is used for allowing first aerosol to pass through, the second airflow chamber is used for allowing second aerosol to pass through, and the first aerosol and the second aerosol passing through the filtering substance are mixed for inhalation. By means of the aerosol inhalation device, the taste of inhalable aerosol can be enriched, inhalation hierarchy is improved, and high safety can be further guaranteed.

The invention belongs to the technical field of biological medicine, and discloses a zanthoxylum nitidum-sourced external vesicle, a preparation method and an application in preparation of a medicine for preventing and treating acute lung injury, and the external vesicle with the particle size of 60-100 nm and a lipid bilayer structure is extracted and purified from the root of zanthoxylum nitidum for the first time. The external vesicle can be administered in modes of aerosol inhalation and the like, and shows an excellent curative effect in an acute lung injury model: lung tissue edema and inflammatory cell infiltration can be remarkably relieved, levels of key proinflammatory factors such as IL-6, TNF-alpha, IL-1beta and the like in serum are reduced, macrophages are promoted to be differentiated to an anti-inflammatory M2 type, and the curative effect is remarkable. The treatment effect is better than that of traditional dexamethasone, and the side effect is lower. The invention provides a brand-new, efficient and safe candidate drug and a natural nano treatment strategy for preventing and treating acute lung injury and ARDS.

An inhalation formulation for treating an IPF disease. The inhalation formulation is an aerosol inhalation liquid formulation, an inhalation aerosol, a dry powder inhaler or a soft mist inhaler. The inhalation formulation contains an active drug, and the active drug is any one of apremilast, ibudilast, roflumilast, crisaborole, and difamilast. A preparation process for the inhalation formulation is introduced into a conventional formulation. An active component in a conventional oral formulation is prone to being destroyed in the digestive tract, and has low bioavailability, a liver first pass effect, and a slow onset of action. An inhalation formulation capable of significantly alleviating IPF is prepared. Tests prove that the prepared inhalation formulation can effectively increase the bioavailability, and improve the clinical use effect.

The invention relates to the technical field of medical equipment, in particular to an aerosol inhalation device capable of accurately controlling dosage, which comprises an outer shell with an atomization cavity; an atomizing nozzle is inserted into the atomizing cavity; an atomization outlet is formed in the outer shell; an inner shell is further inserted into the atomizing cavity, a plurality of corrugated pipes distributed in the circumferential direction are arranged on the inner shell, and the atomizing cavity communicates with the atomizing outlet through the corrugated pipes; one end of the inner shell is communicated with the atomization outlet through a one-way valve, and the other end is communicated with the outside through a damping channel; the inner shell is further sleeved with a plurality of annular air bags, the annular air bags are arranged at intervals in the pipe length direction of the corrugated pipe and alternately located on the inner side and the outer side of the corrugated pipe, and the annular air bags communicate with the inner shell. Therefore, on one hand, the inspiration channel and the expiration channel of the patient are arranged to be located in different channels, impact on the atomized medicine during expiration is reduced, and on the other hand, when the patient rapidly breathes, the corrugated pipe is deformed into an S shape, and excessive inhalation of the atomized medicine in a short time is avoided.

An Aerosol Inhalation Chamber

To provide an aerosol generation device that suppresses liquid shortage during suction regardless of a user's usage.SOLUTION: The circuit unit of the aerosol generation device is provided with a control unit that controls the supply of power to the load that heats the aerosol source. When the interval between the inhalations of the aerosol is shorter than the first period, the controller controls the amount of power supplied to the load to generate the aerosol to be smaller than the reference value. The first period is determined to suppress occurrence of liquid depletion during inhalation of the aerosol.SELECTED DRAWING: Figure 3

The utility model discloses a lung administration aerosol inhalation device for pediatrics, which belongs to the field of atomization devices and is characterized in that when an atomization bottle inclines, an impact ball in a hollow follow-up bottle on the side surface of the atomization bottle inclines through gravity, and finally, an arc-shaped impact sheet on the side surface of the impact ball impacts the inner side wall of the hollow follow-up bottle; the alarm device gives an alarm in time through the controller, it is ensured that medicine in the atomization bottle can be output in a correct mode, and it is ensured that the size and concentration of atomized particles are stable.

The invention discloses a ginsenoside aerosol inhalation solution as well as a preparation method and application thereof, and belongs to the technical field of medicines. The ginsenoside solution for aerosol inhalation is prepared from the following raw materials in parts by weight: 0.1 to 3 parts of ginsenoside Re, 1 to 8 parts of hydroxypropyl-beta-cyclodextrin, 0.1 to 3.5 parts of sodium chloride, 1 to 5 parts of polyethylene glycol, 0.05 to 0.15 part of ascorbic acid, 0.1 to 0.8 part of chitosan and a pH (Potential of Hydrogen) regulator. Experiments prove that the ginsenoside aerosol inhalation solution prepared from the raw materials is high in atomization efficiency, high in bioavailability and good in stability, has a balanced slow-release effect and is small in side effect.

The invention relates to the cross technical field of traditional Chinese medicine engineering and physical therapy, in particular to a tobacco type aerosol inhalation method based on plant herbal fermentation, and aims to solve the problems of low utilization rate of effective components, poor safety and poor physical therapy effect in the existing moxibustion and herbal atomization technology. The method sequentially comprises three core steps of plant herbal raw material pretreatment, plant herbal microbial fermentation and smoke type atomization and inhalation, wherein in the pretreatment stage, genuine herbal raw materials containing Qichun wormwood, radix salviae miltiorrhizae and the like are subjected to cleaning, vacuum freeze drying and 100-200-nanometer-level superfine grinding; the utilization rate of raw materials is increased through nano-crushing, the activity of components is enhanced through microbial fermentation, retention of effective components is ensured through dual-mode atomization, harmful substances generated by traditional combustion are avoided, the scalding risk is eliminated, atomized particles penetrate into the deep part of the respiratory tract, and precise physiotherapy is achieved for throat discomfort, nasal obstruction and other scenes. The device can be widely applied to the fields of daily physiotherapy, respiratory tract health care and traditional Chinese medicine health preservation.

The invention discloses a nebulization inhalation device special for humidifying the airway of a critical patient in the neurosurgery department, and relates to the technical field of medical nebulization equipment, the nebulization inhalation device comprises a liquid storage tank, the top of the liquid storage tank is provided with a multi-stage nebulization mechanism, and the top of the liquid storage tank is provided with a driving mechanism; the driving mechanism comprises a driving box fixedly connected to the upper surface of the liquid storage tank, the multi-stage atomization mechanism comprises a first-stage atomization box and a conveying pump which are fixedly connected to the upper surface of the driving box, and a rotating shaft rod is rotationally arranged in the first-stage atomization box. The multi-stage atomization mechanism is arranged and comprises the first-stage atomization box and the second-stage atomization box, preliminary atomization and further refining of medicine are achieved, the atomization efficiency and effect are improved, the purpose of precise humidification is achieved, the airway mucous membrane humidity is maintained, sputum scab formation is prevented, atomized particles are finer and more uniform, and the atomization effect is better. The airway humidifying device is more suitable for airway humidifying requirements of neurosurgical critical patients. The device is suitable for a tracheotomy or intubation patient, and the nursing workload is reduced.

The invention discloses a portable lung cancer atomization respiratory therapy device, which relates to the technical field of atomization devices, and comprises an atomizer and an air outlet assembly, a handle is fixed to the upper side of the atomizer, a rubber sleeve is fixed to the surface of the handle, two corresponding arc-shaped clamping pieces are fixed to the right side of the atomizer, a filtering assembly is installed in an air inlet formed in the front side of the atomizer, a moving assembly is installed at the front end of the filtering assembly, and an extrusion assembly is installed at the rear end of the moving assembly. The rear end of the extrusion assembly is located in the filtering assembly. The air outlet assembly comprises an air outlet pipe, a fixing ring, a rotating ring, a torsion spring, a connecting plate and an arc-shaped clamping rod, the air outlet pipe is fixed in an air inlet formed in the right side of the atomizer, rapid anti-falling connection of an air guide hose can be achieved, and air inlet filtering cotton can be evenly extruded to improve the filtering effect.

The present application provides a high-stability low-irritation fudosteine aerosol inhalation preparation without EDTA, which is composed of fudosteine, a pH regulator and water, the concentration of fudosteine in the preparation is 20-140 mg / mL, the pH is 3.5-4.0, and the pH regulator is an organic carboxylic acid. In addition, the present application also provides the use of the above-mentioned fudosteine aerosol inhalation preparation in the preparation of respiratory tract mucus dissolving agents. By adjusting the type of pH regulator, the fudosteine aerosol inhalation solution preparation not only effectively reduces the adverse reactions caused by the auxiliary material components, improves the drug safety, but also ensures that the fudosteine aerosol inhalation solution preparation has good preparation stability.

The invention provides a lipid nanoparticle composition for nucleic acid drug delivery and a preparation method and application thereof. The composition prepared by mixing the steroid-cationic lipid compound, the auxiliary phospholipid and the polyethylene glycol modified phospholipid has better stability and transfection efficiency. When the lipid nanoparticles are used for delivering nucleic acid, such as mRNA, nucleic acid drugs can be efficiently and stably delivered to target cells or organs, and meanwhile, the LNP can be used for aerosol inhalation administration of mRNA and can also be used for development of lyophilized preparations of mRNA. High specific antibody response can be caused in an experimental animal body, and the compound has better safety.

This application relates to the field of aerosol generation technology, and provides a heating component and an aerosol generating device. The heating component includes a support assembly, a light-emitting element, and a heat exchanger. The support assembly has a connected receiving cavity and an airflow channel, the receiving cavity being used to contain the aerosol matrix. At least a portion of the light-emitting element is disposed within the airflow channel, and the light-emitting element is used to emit light, which is used to radiate and heat the aerosol matrix. The heat exchanger is disposed within the airflow channel and surrounds the light-emitting element, the light-emitting element being used to heat the heat exchanger, and the heat exchanger being used to exchange heat with the airflow entering the airflow channel to generate a hot airflow that heats the aerosol matrix. The heating component provided in this application improves the heating uniformity of the aerosol matrix by combining light radiation heating and hot airflow heating, effectively reducing the risk of local overheating and the generation of impurities, thereby significantly improving the taste during aerosol inhalation.