192 results about "Aerosol inhalation" patented technology

The utility model provides an aerosol inhalation device, and relates to the technical field of aerosol inhalation devices, the aerosol inhalation device comprises an atomizer, through the arrangement of an anti-blocking device, during treatment, a sliding rod and a plurality of dredging rods can be pulled outwards to slide out of a first sliding hole and a spray hole respectively, and after the dredging rods are completely pulled out of the spray hole, the atomization inhalation device can be used for atomization. The clamping block is loosened, one end of the protective cover can be clamped into the inner wall of the clamping hole block under the reset action of the spring, the opened protective cover is limited and fixed, protection on the spraying hole is relieved, atomization treatment is facilitated, and the spraying hole can be blocked through similar and reverse operation. The dust and impurities in the air are prevented from entering the spray hole to cause blockage and influence the use of the atomizer, if the spray hole is blocked accidentally, the protective cover and the dredging rod are pulled and inserted back and forth, the blocked spray hole can be dredged, the dredged dust can enter the interior of the atomizer, and the interior of the atomizer can be cleaned when the interior of the atomizer is cleaned.

The invention provides a cough and asthma relieving compound medicine for nebulization treatment of a respiratory system as well as preparation and application of the cough and asthma relieving compound medicine. The cough and asthma relieving compound medicine takes various traditional Chinese medicinal materials such as ginkgo and ephedra as main raw materials, and further comprises compound bacteria, an osmotic pressure regulator and a cosolvent. The compound bacteria are prepared from cordyceps sinensis, bamboo fungus and pine olive in a specific mass ratio, the osmotic pressure regulator is prepared from glucose and glycerol in a specific ratio, and the cosolvent has multiple selectable components. The preparation method comprises a plurality of steps and unique processes including medicinal material extraction, salifying modification, ultrasonic extraction and the like. Clinical tests show that compared with a control group and a placebo group, the compound medicine disclosed by the invention can remarkably improve lung function related indexes of patients and reduce the level of inflammatory factors, and a visual simulation scoring method also proves that the compound medicine can effectively relieve symptoms of cough and asthma. The medicine can be used for preparing aerosol inhalation medicines for treating various respiratory diseases such as bronchial asthma and chronic obstructive pulmonary diseases, and has a good application prospect.

The invention belongs to the field of biological medicine, and particularly relates to an inhalable small molecule compound lung targeting delivery system and application thereof in radiation-induced lung injury protection. The invention develops a probiotic-drug symbiotic delivery system based on lactobacillus rhamnosus on the basis of finding that a small molecular compound with a molecular structure as shown in a formula (I) has excellent SOD and CAT enzyme activity and can prevent radiation-induced lung injury caused by radiotherapy for the first time. Wherein the small molecule compound is loaded on the surface of lactobacillus rhamnosus and is directly delivered to the alveolar cavity through aerosol inhalation, so that the targeting property and bioavailability of the small molecule compound at the RILI part can be enhanced. # imgabs0 # (I)

The invention relates to the technical field of biological medicine, in particular to a composite drug-loaded nano preparation and a preparation method thereof. The composite drug-loaded nano-preparation comprises a drug-loaded nano-liposome, and a biological enzyme and a myofibroblast targeting ligand which are loaded on the surface of the drug-loaded nano-liposome, the drug-loaded nano-liposome is a nano-liposome in which an anti-fibrosis drug is encapsulated; the mass ratio of the drug-loaded nano-liposome to the biological enzyme to the myofibroblast targeting ligand is (6-15): (0.5-4): (0-3). According to the invention, a composite drug-loaded nano preparation for pulmonary drug delivery in an aerosol inhalation manner is constructed, and the myofibroblast targeting ligand and the biological enzyme are jointly modified on the surface of the drug-loaded nano liposome; and the composite nano preparation (CLG-CS-FAP-NIN) which has myofibroblast targeting and can degrade excessive collagen in an extracellular matrix is prepared and is used for treating the pulmonary fibrosis.

The invention provides a synthesis method of a novel inhalable liposome and an application of the novel inhalable liposome in ARDS (arterial thrombosis syndrome) treatment, and the synthesis method comprises the following steps: firstly, mixing DSPE-PEG2K-TK-NHS and tocilizumab (TCZ: Tocilizumab) to form a lead compound DSPE-PEG2K-TK-TCZ; the preparation method comprises the following steps: dissolving DPPC, cholesterol, DSPE-TK-PEG2k and FG4592 in 5mL of chloroform, carrying out reduced pressure evaporation in a sample bottle to form a film, and adding 3mL of deionized water to prepare Lip-coated RF; and then stirring and incubating the DSPE-PEG2K-TK-TCZ and the Lip (at) RF, so as to form the Lip (at) RFT. As a functional nano-material with ultra-small size, good biocompatibility, excellent ROS removal capability and ROS responsive drug release, the nano-material is used for treating ARDS. The invention has the advantages that: the Lip-coated RFT relieves lung oxidative stress, inflammatory response, protein permeability and histological severity in the LPS-induced mouse ALI model. Therefore, Lip at RFT can be used as a new way for treating ARDS. Aerosol inhalation of Lip-coated RFT can effectively improve the severity of ARDS.

The invention relates to the technical field of immunotherapy, in particular to a regulatory protein recombinant vaccine and application thereof in pulmonary fibrosis treatment. The vaccine contains polypeptide of amphiregulin antigen epitopes, and the amino acid sequence of the vaccine is shown as SEQ ID No. 1. A research result shows that the recombinant vaccine can effectively induce generation of a specific antibody aiming at the AREG protein in a mouse body, so that secretion of the AREG protein and activation of downstream receptors of the AREG protein in the pulmonary fibrosis process are inhibited. By reducing collagen deposition in lung tissue and reducing tissue structure damage, the recombinant vaccine significantly reduces gene expression of fibrosis-related protein, recovers lung functions of pulmonary fibrosis model mice, and inhibits further development of diseases. In addition, the recombinant vaccine can be administered in an aerosol inhalation mode, and has broad-spectrum, efficient and long-term stable expression and good safety. The invention provides a brand-new targeted therapy means for clinical prevention and treatment of pulmonary fibrosis, and shows a wide application prospect.

A handheld time-delay inhalation atomizing cup, comprising a base component; an electrical control component and an air pump are mounted in said base component; an atomizer is mounted at one end of said base component; an atomizing cup, detachably mounted on said base component, which internally forms an atomizing storage cavity for storing the smoke produced by the atomizer; the smoke produced by the atomizer are sent into the atomizing storage cavity via said air pump for storage. The invention adopts an integrated portable design and is characterized in splitting atomization and inhalation, top air intake and replaceable adapters, which enhances the convenience and flexibility of use; it not only simplifies the operation process, but also significantly improves the user's inhalation experience by integrating the aerosol inhalation function, more suitable for the modern fast-paced lifestyle.

The invention discloses pediatric pneumonia aerosol inhalation treatment equipment and a using method, and relates to the technical field of pediatric pneumonia aerosol inhalation treatment.The pediatric pneumonia aerosol inhalation treatment equipment comprises an equipment main body mechanism, the equipment main body mechanism comprises an atomization equipment main body, and the upper surface of the atomization equipment main body is fixedly communicated with a liquid medicine containing cylinder; the paediatric pneumonia aerosol inhalation treatment equipment comprises an atomization equipment main body, the output end of the atomization equipment main body is fixedly communicated with an inhalation mask, and the front side of the atomization equipment main body is provided with an elastic flow control mechanism. The installation tightness of the equipment and the face of the child patient is adjusted, the problem that the face of the child patient is squeezed and injured due to the fact that an elastic band is too tight is solved, the problem that the face of the child patient falls off due to the fact that the elastic band is too loose and the child patient is active is solved, and the comfort and use convenience of the equipment are improved. The device can be conveniently used for aerosol inhalation treatment of a child patient.

The invention discloses an ultrasonic-assisted self-assembled resveratrol nanocrystal as well as a preparation method and application thereof, and belongs to the technical field of anti-pneumonia drugs. According to the resveratrol nanocrystal prepared by the method, the particle size is 181.5 + / -2.27 nm, the PDI is 0.08 + / -0.07, the potential is-12.6 + / -0.85 mV, and the resveratrol nanocrystal has reliable stability under the condition that a stabilizer is not used and can be maintained for at least one week; compared with free resveratrol, the crystal form of the resveratrol nanocrystal is changed, and the problems of resveratrol solubility (saturation solubility is increased by 35.1 times compared with free resveratrol), in-vitro uptake (in-vitro uptake is increased by 3.5 times compared with free resveratrol) and lung retention can be solved. Meanwhile, the resveratrol nanocrystal shows anti-inflammatory, antioxidant and antiviral activities superior to those of free resveratrol, and comprehensively shows that the resveratrol nanocrystal has safety and effectiveness in the field of aerosol inhalation treatment of RSV pneumonia.

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The invention relates to the technical field of atomizers, in particular to efficient aerosol inhalation adjuvant therapy equipment which comprises a compression atomizer, a supporting table is arranged at the bottom of the compression atomizer, a sliding block is slidably connected to the upper surface of the supporting table, a limiting plate is fixedly connected to one side of the upper surface of the sliding block, and a fixing frame is fixedly connected to the other side of the upper surface of the sliding block. The fixing frame is rotationally connected with the barrier plate through a pin shaft, the barrier plate is fixedly connected with the fixing frame through a supporting spring, the compression atomizer communicates with the input end of the atomizing cup through a connecting pipe, the atomizing cup communicates with the mask through a telescopic guide pipe, and clamping assemblies are arranged on one side of the atomizing cup and one side of the mask correspondingly; the compression atomizer is finally limited and fixed through the limiting plate, so that the situation that the compression atomizer is dragged to move due to pulling of the connecting pipe can be avoided, and then collision damage of the compression atomizer is avoided; and through the arrangement of the clamping assembly, the connection between the atomizing cup and the mask is stable, the treatment effect is ensured, and the treatment progress is prevented from being delayed.

The invention discloses a method for detecting nitrosamine impurities in a levosalbutamol hydrochloride aerosol inhalation solution, which comprises the following steps: diluting the levosalbutamol hydrochloride aerosol inhalation solution to obtain a test solution; detecting the test solution by adopting an ultra-high performance liquid chromatography-mass spectrometry method; chromatographic conditions are as follows: a filler of a chromatographic column is octadecylsilane chemically bonded silica; the mobile phase A is a formic acid aqueous solution, the concentration of formic acid is 0.09-0.11%, and% is volume percent; the mobile phase B is acetonitrile; the nitrosamine impurity is N-nitroso-salbutamol. The detection method is high in selectivity and good in specificity, the limit of quantitation is as low as 1.2% of the limit, the limit of detection is as low as 0.4% of the limit, detection can be completed only in 10 minutes, the method is high in sensitivity, the content of trace nitrosamine impurity N-nitroso-salbutamol in a sample can be rapidly and accurately detected, and the analysis cost is effectively reduced.

Control device for aerosol inhalation device, includes operational amplifier including output terminal configured to generate voltage according to voltage applied to load configured to heat aerosol source and having correlation between temperature and electrical resistance value, control unit including input terminal and configured to perform processing based on voltage applied to the input terminal, and voltage dividing circuit configured to electrically connect the output terminal of the operational amplifier and the input terminal of the control unit. Power supply voltage of the operational amplifier is higher than power supply voltage of the control unit, and equals voltage applied to aerosol generation circuit including the load, and one of inverting input terminal and noninverting input terminal of the operational amplifier is electrically connected to the aerosol generation circuit.

The invention relates to the field of anesthesia atomization devices, in particular to anesthesia atomization inhalation equipment which comprises an anesthesia atomization mask, a rubber sealing layer is fixedly connected to the bottom end of the anesthesia atomization mask, a mounting valve is fixedly mounted on one side of the top end of the anesthesia atomization mask, and a support is fixedly connected to the side, close to the mounting valve, of the anesthesia atomization mask. The support is fixedly connected with a circular shaft, the circular shaft is provided with a plurality of limiting grooves arranged in an array mode, and the middle position of the circular shaft is rotationally connected with a support. Breathing of a patient is guided through the rotating three-color plate and sound with rhythm, the patient is guided from the two aspects of vision and hearing, and the patient is more comfortable to wear; according to the anesthetic atomization device, the optimal breathing rhythm, inspiration, breath holding and expiration of a patient can be effectively and rapidly found when the patient is subjected to anesthetic atomization, and aerosol particles obtained after anesthetic atomization can make more sufficient contact with the respiratory tract mucosa and be absorbed, so that the intra-pulmonary deposition rate of anesthetic medicine is increased, and the anesthetic atomization effect is improved.

The invention discloses application of ceftriaxone sodium in preparation of a medicine for preventing and / or treating pulmonary nodules, and belongs to the technical field of tumor prevention and treatment, ceftriaxone sodium is converted into inhalable aerosol particles through an aerosol inhalation device, targeted delivery of the medicine to the lung can be achieved, systemic adverse reactions caused by systemic administration are remarkably reduced, and the curative effect of the medicine is improved. Therefore, the medicine has a treatment effect on pulmonary nodules. Experimental results in the early stage prove that ceftriaxone sodium with different concentrations is subjected to aerosol inhalation to intervene in a mouse pulmonary nodule model induced by uratan, and the ceftriaxone sodium has a good prevention and treatment effect. The research can provide new experimental basis and reference for development of lung nodule related prevention and treatment medicines, provides new technical ideas for prevention and treatment of other diseases, and has important academic value and potential of further development and research.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of being inhaled by atomization and a preparation method, a detection method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 300 to 700 parts of blumea oil, 400 to 700 parts of fructus perillae oil and 10 to 35 parts of menthol. The traditional Chinese medicine composition is high in delivery rate, total delivery amount, fine particle dosage and fine particle proportion, most of the traditional Chinese medicine composition can directly reach the lung, and the traditional Chinese medicine composition can be used for aerosol inhalation, is good in atomization effect, meets clinical use requirements and can be used for treating lung diseases.

The invention discloses a high-water-solubility paclitaxel compound chemically modified by diaconitic acid molecules as well as a synthesis method and application of the paclitaxel compound chemically modified by the diaconitic acid molecules. The paclitaxel compound comprises paclitaxel and two aconitic acid molecules which are covalently bonded through ester bonds; the water-soluble paclitaxel compound is simple and convenient in preparation method and suitable for industrial production, paclitaxel drug molecules have amphiphilic properties, namely hydrophilicity and lipophilicity after being structurally modified by the method, the water solubility and the permeability are improved, the possibility of developing various oral and aerosol inhalation drug preparations is provided, and the compound is high in water solubility at normal temperature, low in cost and suitable for industrial production. According to the present invention, the prepared paclitaxel compound has characteristics of no foam generation during dissolution, more than 8 mg / ml, no need of any co-solvent, compound toxicity lower than the original drug paclitaxel, and ester bond accelerated hydrolysis fracture under the weak acid condition of the in vivo tumor tissue, such that the compound has advantages of certain tumor tissue targeting, good bioavailability and good anti-tumor effect.

The invention discloses an exosome atomized preparation as well as a preparation method and application thereof, and belongs to the technical field of exosome technology and respiratory disease treatment. The problems that antibiotics and anti-inflammatory drugs adopted in the prior art have the defects of drug resistance, large side effects and the like in lung inflammation are solved. The exosome is derived from stem cells which are subjected to gp96 pretreatment and overexpress gp96 antigen information, the gp96 activates antigen presenting cells, the delivery efficiency of immunomodulatory factors (such as IL-10 and TGF-beta) carried by the exosome is enhanced, proinflammatory factors (such as TNF-alpha and IL-6) are inhibited, and in combination with the administration mode of an atomized preparation, through aerosol inhalation, the exosome can be used for preparing the immunomodulatory factor immunomodulatory agent. The exosome can directly reach a lung lesion area, so that the local drug concentration is improved, and the systemic side effects are reduced.

The invention belongs to the technical field of drug detection, and discloses a method for detecting edetate disodium in a levosalbutamol hydrochloride aerosol inhalation solution, which comprises the following steps: detecting a test solution of a to-be-detected sample by high performance liquid chromatography, with a mobile phase being a mixed solution of a borax solution and acetonitrile, the mass ratio of sodium tetraborate to water to acetonitrile in the mobile phase is (6-9): 100: (100-120). The content of edetate disodium in each batch of samples is detected, so that the safety and effectiveness of the levosalbutamol hydrochloride aerosol inhalation solution are guaranteed.

The present invention relates to the technical field of heterocyclic compound drugs and their preparation and application, and specifically to a tropane alkaloid composition for the treatment of COPD and its application. The composition combines tropane alkaloids, mannose-6-phosphate and polylactic acid-glycolic acid copolymer, and is constructed into a nanocomposite by nanoparticle preparation technology for aerosol inhalation administration. The composition aims to solve the problems of low bioavailability and lack of targeting in conventional administration of tropane alkaloids. Targeted delivery is achieved by introducing mannose-6-phosphate into the surface of nanoparticles, promoting drug enrichment in the lungs, and using polylactic acid-glycolic acid copolymer to control drug release, thereby increasing local drug concentration and therapeutic efficacy in the lungs.

The invention belongs to the technical field of aerosol inhalation, and particularly relates to a sivelestat sodium aerosol inhalation composition, a medicine component and application of the sivelestat sodium aerosol inhalation composition. The prepared sivelestat sodium aerosol inhalation composition is composed of sivelestat sodium or tetrahydrate of sivelestat sodium and a phosphate buffer, other auxiliary materials such as a surfactant, an excipient and an osmotic pressure regulator are not added any more, the requirement of the inhalation composition for osmotic pressure can be met, good stability is achieved, and the preparation method is simple and convenient to operate. And meanwhile, the irritation or toxicity to respiratory mucosa and cilia caused by auxiliary material factors can be reduced. According to the medicine assembly, the solution containing the sivelestat sodium composition and the net type atomizer with specific parameters are used in cooperation, the good lung injury treatment effect is achieved, and meanwhile the medicine assembly has the advantages of being small in residual liquid medicine amount and high in total delivery amount.

The utility model discloses a tracheotomy cannula convenient for aerosol inhalation. The tracheotomy cannula comprises a cannula body and an injection joint connected with the cannula body, the injection connector is detachably connected with the sleeve body through an integrated detachable structure or a detachable structure comprising a clamping sleeve, a gasket, a sealing ring and the like. The casing pipe body is of a bent double-layer structure with two through ends and comprises a casing pipe outer wall and a casing pipe inner wall, and a hollow structure is arranged between the casing pipe outer wall and the casing pipe inner wall; the two ends of the cannula body are a suction end inserted into the trachea and a guide-out end exposed out of the body respectively, the suction end of the cannula body can be inserted into the trachea of a patient performing tracheostomy operation, and the guide-out end can guide generated liquid out of the body; and one or more air injection holes are formed in the inner wall of the sleeve at the suction end.

The utility model discloses an electronic atomization device, which comprises a power supply device and a vapor fog generation device, and is characterized in that the power supply device comprises a first shell provided with a suction nozzle and a containing cavity communicated with the suction nozzle; the power supply assembly is mounted in the first shell; the host electrode is electrically connected with the power supply assembly and is exposed on the cavity wall, facing the suction nozzle, of the accommodating cavity; the steam fog generating device comprises a second shell rotationally installed in the containing cavity, the second shell is provided with a first end and a second end which are opposite, the end face of the first end is provided with a first fog discharging opening, and the end face of the second end is provided with a second fog discharging opening. The first vapor fog generator is arranged at the second end part and is provided with a first electrode assembly exposed on the end surface of the second end part; and the second vapor fog generator is arranged at the first end part and is provided with a second electrode assembly exposed on the end surface of the first end part. The electronic atomization device disclosed by the utility model can meet the requirement of a user for sucking steam fog with different tastes.

The application provides a kind of antibiotic-loaded nanoemulsion and its preparation method and application, it is related to the technical field of medical adjuvant, antibiotic is mixed with medicinal adjuvant soybean oil, dipalmitoyl phosphatidylcholine and cholesterol, and volatile organic solvent is used to dissolve and form oil phase;Deoxycholic acid sodium and tween are dissolved in sterile liquid to form water phase;Oil phase and water phase are mixed, and are treated by ultrasonic treatment, rotary evaporation treatment and high pressure homogenization treatment, to obtain antibiotic-loaded nanoemulsion.The application adjusts the type of inhalable medicinal adjuvant, the addition ratio of inhalable medicinal adjuvant, the ratio of oil phase and water phase, and the ultrasonic power and homogenization pressure and other factors, so that the prepared nanoemulsion can efficiently load antibiotic, and has good aerosol inhalation performance, better drug stability, the nanoemulsion can be retained in mouse lung tissue for a long time, and the lung drug delivery efficiency is significantly improved.

The invention discloses an aerosol inhalation device and method based on a flexible strain sensor, solves the problems that an aerosol inhalation device in the prior art has certain lag in detecting airflow at the mouth and the nose, and the synchronization function is easy to lose efficacy, and has the advantages of realizing a breathing synchronous atomization function, avoiding the lag and misjudgment of the airflow, improving the accuracy and the reliability of the aerosol inhalation device. According to the specific scheme, the aerosol inhalation device based on the flexible strain sensor comprises a respiration monitoring vest and a working main machine, the working main machine comprises an atomization assembly and is provided with an atomizing opening for spraying atomized liquid medicine, the respiration monitoring vest is provided with the strain sensor, and the strain sensor is arranged on the working main machine. The strain sensor generates an analog quantity signal in a linear relation with thoracic motion amplitude and sends the generated analog quantity signal to the controller, the controller judges whether a patient is in an inspiration or expiration state according to the thoracic motion signal, and the controller is connected with the atomization assembly so that atomization can be conducted when the patient inspires and stops atomization when the patient expires.

The invention belongs to the field of biological medicine, and particularly relates to a sodium pyruvate aerosol inhalation preparation and a preparation method thereof. The aerosol inhalation preparation is prepared from the following raw materials in parts by weight: 0.04 to 0.09 part of baicalin-berbamine / sodium pyruvate clathrate compound freeze-dried powder and 100 parts of normal saline, the preparation process of the baicalin-berbamine comprises the following steps: reacting berbamine with 4-chlorphenyl glycidyl ether to obtain an intermediate A, mixing the intermediate A with a baicalin solution, reacting in the presence of a catalyst, and purifying after the reaction is completed to obtain the baicalin-berbamine. The sodium pyruvate aerosol inhalation preparation can effectively relieve asthma symptoms, and has excellent antibacterial activity, stability and biological activity.

The invention belongs to the field of biological medicine, and particularly relates to a sodium pyruvate aerosol inhalation preparation and a preparation method and application thereof. The aerosol inhalation preparation comprises the following components: sodium pyruvate, modified glycyrrhizic acid, a pH regulator and water for injection, the concentration of the sodium pyruvate is 50-120 mg / mL, the concentration of the modified glycyrrhizic acid is 5-40 mg / mL, and the pH value of the preparation is 6.5-7. By adding the modified glycyrrhizic acid, the stability and bioavailability of the sodium pyruvate can be effectively improved. In addition, sodium pyruvate and modified glycyrrhizic acid in the aerosol inhalation preparation take effect synergistically, and the pulmonary fibrosis process of patients with chronic obstructive pulmonary diseases can be effectively delayed.

The invention relates to the technical field of heterocyclic compound drugs and preparation and application thereof, in particular to a tropane alkaloid prodrug composition for treating COPD (chronic obstructive pulmonary disease) and application of the tropane alkaloid prodrug composition. According to the composition, scopane alkaloid, mannose-6-phosphoric acid and a polylactic acid-glycolic acid copolymer are combined, and the prodrug nano composition is constructed through a nanoparticle preparation technology and is used for aerosol inhalation administration. The prodrug composition aims to solve the problems of low bioavailability and lack of targeting in conventional administration of scopolamine alkaloids. Mannose-6-phosphoric acid is introduced into the surfaces of nanoparticles to achieve targeted delivery, enrichment of drugs in the lung is promoted, drug release is controlled through a polylactic acid-glycolic acid copolymer, and the local drug concentration and treatment efficacy of the lung are improved.

The utility model relates to the field of anaesthesia machines, and discloses an anaesthesia machine threaded tube for aerosol inhalation, the anaesthesia machine threaded tube comprises a connector and two fixing rings, the bottom end of the connector is communicated with an exhalation tube and an inhalation tube, the exhalation tube and the inhalation tube are symmetrically distributed with the connector as the axis, and fixing ropes are fixedly mounted at the bottom ends of the fixing rings. The surface of the fixing rope is rotationally connected with a plurality of supporting frames, the supporting frames are distributed in a circumferential array mode with the center of the fixing rope as the axis, and the tops of the two fixing rings and the bottom end of the connector are installed in a threaded mode; the fixing ring is mounted at the bottom end of the connector, the fixing rope is fixedly connected to the bottom end of the connector, the multiple supporting frames are rotatably mounted on the surface of the fixing rope, and the surfaces of the supporting frames are clamped to the inner walls of the exhalation pipe and the suction pipe, so that the inner walls of the exhalation pipe and the suction pipe are supported by means of the supporting frames; and the situation that the exhalation tube and the inhalation tube are extruded by external force to affect breathing of a patient is effectively prevented.

The invention provides an aerosol inhalation device applied to pediatric respiratory system diseases, and belongs to the technical field of pediatric respiratory tract adjuvant therapy. The device comprises a base, the top of the base is fixedly connected with a tank body, and one side of the tank body is fixedly provided with an adjusting mechanism. By arranging the stirring mechanism, during use, after a treatment medicament is added into the tank body, the stirring mechanism is inserted by means of an adjusting mechanism, then a first motor is started to drive a first gear and a second gear to rotate, and the first gear drives an auger to rotate in the forward direction and pushes a liquid medicine to flow in the forward direction and roll upwards and synchronously drives the second gear; the second gear and the inner gear ring are in transmission connection, rotate in the same direction and are opposite to the first gear, so that the spiral stirring blade is driven to rotate reversely, the auger and the spiral stirring blade are both opposite and are arranged in a twisted spiral shape, the liquid medicine is promoted to violently roll over and be mixed up and down, different medicaments can be efficiently and uniformly stirred, and the treatment effect is practically improved.