105 results about "Aerosol inhalation" patented technology

The utility model provides an aerosol inhalation device, and relates to the technical field of aerosol inhalation devices, the aerosol inhalation device comprises an atomizer, through the arrangement of an anti-blocking device, during treatment, a sliding rod and a plurality of dredging rods can be pulled outwards to slide out of a first sliding hole and a spray hole respectively, and after the dredging rods are completely pulled out of the spray hole, the atomization inhalation device can be used for atomization. The clamping block is loosened, one end of the protective cover can be clamped into the inner wall of the clamping hole block under the reset action of the spring, the opened protective cover is limited and fixed, protection on the spraying hole is relieved, atomization treatment is facilitated, and the spraying hole can be blocked through similar and reverse operation. The dust and impurities in the air are prevented from entering the spray hole to cause blockage and influence the use of the atomizer, if the spray hole is blocked accidentally, the protective cover and the dredging rod are pulled and inserted back and forth, the blocked spray hole can be dredged, the dredged dust can enter the interior of the atomizer, and the interior of the atomizer can be cleaned when the interior of the atomizer is cleaned.

The invention belongs to the field of biological medicine, and particularly relates to an inhalable small molecule compound lung targeting delivery system and application thereof in radiation-induced lung injury protection. The invention develops a probiotic-drug symbiotic delivery system based on lactobacillus rhamnosus on the basis of finding that a small molecular compound with a molecular structure as shown in a formula (I) has excellent SOD and CAT enzyme activity and can prevent radiation-induced lung injury caused by radiotherapy for the first time. Wherein the small molecule compound is loaded on the surface of lactobacillus rhamnosus and is directly delivered to the alveolar cavity through aerosol inhalation, so that the targeting property and bioavailability of the small molecule compound at the RILI part can be enhanced. # imgabs0 # (I)

A handheld time-delay inhalation atomizing cup, comprising a base component; an electrical control component and an air pump are mounted in said base component; an atomizer is mounted at one end of said base component; an atomizing cup, detachably mounted on said base component, which internally forms an atomizing storage cavity for storing the smoke produced by the atomizer; the smoke produced by the atomizer are sent into the atomizing storage cavity via said air pump for storage. The invention adopts an integrated portable design and is characterized in splitting atomization and inhalation, top air intake and replaceable adapters, which enhances the convenience and flexibility of use; it not only simplifies the operation process, but also significantly improves the user's inhalation experience by integrating the aerosol inhalation function, more suitable for the modern fast-paced lifestyle.

The present application relates to the technical field of biological medicine, and discloses inhalable aptamer modified molybdenum disulfide nanoflower compound and application thereof.The compound comprises a molybdenum disulfide nanoflower core, a dendritic polylysine modification layer attached to the surface of the molybdenum disulfide nanoflower, doxorubicin loaded on the molybdenum disulfide nanoflower and / or the dendritic polylysine modification layer, and AS1411 aptamer combined on the outer surface of the dendritic polylysine modification layer by electrostatic assembly.The compound can be delivered to a lung lesion by atomization inhalation or aerosol inhalation, and undergoes responsive structural change under the action of hydrogen peroxide in a tumor microenvironment, generates active oxygen, and promotes the release of doxorubicin, so as to realize the synergistic antitumor effect of chemotherapy and chemical dynamic therapy.The compound has good colloidal stability, drug loading capacity, active targeting ability and lung local delivery potential, and can be used for preparing inhalation preparations or local administration preparations for treating lung cancer.

The invention relates to the technical field of atomizers, in particular to efficient aerosol inhalation adjuvant therapy equipment which comprises a compression atomizer, a supporting table is arranged at the bottom of the compression atomizer, a sliding block is slidably connected to the upper surface of the supporting table, a limiting plate is fixedly connected to one side of the upper surface of the sliding block, and a fixing frame is fixedly connected to the other side of the upper surface of the sliding block. The fixing frame is rotationally connected with the barrier plate through a pin shaft, the barrier plate is fixedly connected with the fixing frame through a supporting spring, the compression atomizer communicates with the input end of the atomizing cup through a connecting pipe, the atomizing cup communicates with the mask through a telescopic guide pipe, and clamping assemblies are arranged on one side of the atomizing cup and one side of the mask correspondingly; the compression atomizer is finally limited and fixed through the limiting plate, so that the situation that the compression atomizer is dragged to move due to pulling of the connecting pipe can be avoided, and then collision damage of the compression atomizer is avoided; and through the arrangement of the clamping assembly, the connection between the atomizing cup and the mask is stable, the treatment effect is ensured, and the treatment progress is prevented from being delayed.

Control device for aerosol inhalation device, includes operational amplifier including output terminal configured to generate voltage according to voltage applied to load configured to heat aerosol source and having correlation between temperature and electrical resistance value, control unit including input terminal and configured to perform processing based on voltage applied to the input terminal, and voltage dividing circuit configured to electrically connect the output terminal of the operational amplifier and the input terminal of the control unit. Power supply voltage of the operational amplifier is higher than power supply voltage of the control unit, and equals voltage applied to aerosol generation circuit including the load, and one of inverting input terminal and noninverting input terminal of the operational amplifier is electrically connected to the aerosol generation circuit.

The invention discloses application of ceftriaxone sodium in preparation of a medicine for preventing and / or treating pulmonary nodules, and belongs to the technical field of tumor prevention and treatment, ceftriaxone sodium is converted into inhalable aerosol particles through an aerosol inhalation device, targeted delivery of the medicine to the lung can be achieved, systemic adverse reactions caused by systemic administration are remarkably reduced, and the curative effect of the medicine is improved. Therefore, the medicine has a treatment effect on pulmonary nodules. Experimental results in the early stage prove that ceftriaxone sodium with different concentrations is subjected to aerosol inhalation to intervene in a mouse pulmonary nodule model induced by uratan, and the ceftriaxone sodium has a good prevention and treatment effect. The research can provide new experimental basis and reference for development of lung nodule related prevention and treatment medicines, provides new technical ideas for prevention and treatment of other diseases, and has important academic value and potential of further development and research.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition capable of being inhaled by atomization and a preparation method, a detection method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 300 to 700 parts of blumea oil, 400 to 700 parts of fructus perillae oil and 10 to 35 parts of menthol. The traditional Chinese medicine composition is high in delivery rate, total delivery amount, fine particle dosage and fine particle proportion, most of the traditional Chinese medicine composition can directly reach the lung, and the traditional Chinese medicine composition can be used for aerosol inhalation, is good in atomization effect, meets clinical use requirements and can be used for treating lung diseases.

The invention discloses an exosome atomized preparation as well as a preparation method and application thereof, and belongs to the technical field of exosome technology and respiratory disease treatment. The problems that antibiotics and anti-inflammatory drugs adopted in the prior art have the defects of drug resistance, large side effects and the like in lung inflammation are solved. The exosome is derived from stem cells which are subjected to gp96 pretreatment and overexpress gp96 antigen information, the gp96 activates antigen presenting cells, the delivery efficiency of immunomodulatory factors (such as IL-10 and TGF-beta) carried by the exosome is enhanced, proinflammatory factors (such as TNF-alpha and IL-6) are inhibited, and in combination with the administration mode of an atomized preparation, through aerosol inhalation, the exosome can be used for preparing the immunomodulatory factor immunomodulatory agent. The exosome can directly reach a lung lesion area, so that the local drug concentration is improved, and the systemic side effects are reduced.

The present invention relates to the technical field of heterocyclic compound drugs and their preparation and application, and specifically to a tropane alkaloid composition for the treatment of COPD and its application. The composition combines tropane alkaloids, mannose-6-phosphate and polylactic acid-glycolic acid copolymer, and is constructed into a nanocomposite by nanoparticle preparation technology for aerosol inhalation administration. The composition aims to solve the problems of low bioavailability and lack of targeting in conventional administration of tropane alkaloids. Targeted delivery is achieved by introducing mannose-6-phosphate into the surface of nanoparticles, promoting drug enrichment in the lungs, and using polylactic acid-glycolic acid copolymer to control drug release, thereby increasing local drug concentration and therapeutic efficacy in the lungs.

The utility model discloses an electronic atomization device, which comprises a power supply device and a vapor fog generation device, and is characterized in that the power supply device comprises a first shell provided with a suction nozzle and a containing cavity communicated with the suction nozzle; the power supply assembly is mounted in the first shell; the host electrode is electrically connected with the power supply assembly and is exposed on the cavity wall, facing the suction nozzle, of the accommodating cavity; the steam fog generating device comprises a second shell rotationally installed in the containing cavity, the second shell is provided with a first end and a second end which are opposite, the end face of the first end is provided with a first fog discharging opening, and the end face of the second end is provided with a second fog discharging opening. The first vapor fog generator is arranged at the second end part and is provided with a first electrode assembly exposed on the end surface of the second end part; and the second vapor fog generator is arranged at the first end part and is provided with a second electrode assembly exposed on the end surface of the first end part. The electronic atomization device disclosed by the utility model can meet the requirement of a user for sucking steam fog with different tastes.

The application provides a kind of antibiotic-loaded nanoemulsion and its preparation method and application, it is related to the technical field of medical adjuvant, antibiotic is mixed with medicinal adjuvant soybean oil, dipalmitoyl phosphatidylcholine and cholesterol, and volatile organic solvent is used to dissolve and form oil phase;Deoxycholic acid sodium and tween are dissolved in sterile liquid to form water phase;Oil phase and water phase are mixed, and are treated by ultrasonic treatment, rotary evaporation treatment and high pressure homogenization treatment, to obtain antibiotic-loaded nanoemulsion.The application adjusts the type of inhalable medicinal adjuvant, the addition ratio of inhalable medicinal adjuvant, the ratio of oil phase and water phase, and the ultrasonic power and homogenization pressure and other factors, so that the prepared nanoemulsion can efficiently load antibiotic, and has good aerosol inhalation performance, better drug stability, the nanoemulsion can be retained in mouse lung tissue for a long time, and the lung drug delivery efficiency is significantly improved.

The invention discloses an aerosol inhalation device and method based on a flexible strain sensor, solves the problems that an aerosol inhalation device in the prior art has certain lag in detecting airflow at the mouth and the nose, and the synchronization function is easy to lose efficacy, and has the advantages of realizing a breathing synchronous atomization function, avoiding the lag and misjudgment of the airflow, improving the accuracy and the reliability of the aerosol inhalation device. According to the specific scheme, the aerosol inhalation device based on the flexible strain sensor comprises a respiration monitoring vest and a working main machine, the working main machine comprises an atomization assembly and is provided with an atomizing opening for spraying atomized liquid medicine, the respiration monitoring vest is provided with the strain sensor, and the strain sensor is arranged on the working main machine. The strain sensor generates an analog quantity signal in a linear relation with thoracic motion amplitude and sends the generated analog quantity signal to the controller, the controller judges whether a patient is in an inspiration or expiration state according to the thoracic motion signal, and the controller is connected with the atomization assembly so that atomization can be conducted when the patient inspires and stops atomization when the patient expires.

The invention relates to the technical field of heterocyclic compound drugs and preparation and application thereof, in particular to a tropane alkaloid prodrug composition for treating COPD (chronic obstructive pulmonary disease) and application of the tropane alkaloid prodrug composition. According to the composition, scopane alkaloid, mannose-6-phosphoric acid and a polylactic acid-glycolic acid copolymer are combined, and the prodrug nano composition is constructed through a nanoparticle preparation technology and is used for aerosol inhalation administration. The prodrug composition aims to solve the problems of low bioavailability and lack of targeting in conventional administration of scopolamine alkaloids. Mannose-6-phosphoric acid is introduced into the surfaces of nanoparticles to achieve targeted delivery, enrichment of drugs in the lung is promoted, drug release is controlled through a polylactic acid-glycolic acid copolymer, and the local drug concentration and treatment efficacy of the lung are improved.

The utility model relates to the field of anaesthesia machines, and discloses an anaesthesia machine threaded tube for aerosol inhalation, the anaesthesia machine threaded tube comprises a connector and two fixing rings, the bottom end of the connector is communicated with an exhalation tube and an inhalation tube, the exhalation tube and the inhalation tube are symmetrically distributed with the connector as the axis, and fixing ropes are fixedly mounted at the bottom ends of the fixing rings. The surface of the fixing rope is rotationally connected with a plurality of supporting frames, the supporting frames are distributed in a circumferential array mode with the center of the fixing rope as the axis, and the tops of the two fixing rings and the bottom end of the connector are installed in a threaded mode; the fixing ring is mounted at the bottom end of the connector, the fixing rope is fixedly connected to the bottom end of the connector, the multiple supporting frames are rotatably mounted on the surface of the fixing rope, and the surfaces of the supporting frames are clamped to the inner walls of the exhalation pipe and the suction pipe, so that the inner walls of the exhalation pipe and the suction pipe are supported by means of the supporting frames; and the situation that the exhalation tube and the inhalation tube are extruded by external force to affect breathing of a patient is effectively prevented.

The invention provides an aerosol inhalation device applied to pediatric respiratory system diseases, and belongs to the technical field of pediatric respiratory tract adjuvant therapy. The device comprises a base, the top of the base is fixedly connected with a tank body, and one side of the tank body is fixedly provided with an adjusting mechanism. By arranging the stirring mechanism, during use, after a treatment medicament is added into the tank body, the stirring mechanism is inserted by means of an adjusting mechanism, then a first motor is started to drive a first gear and a second gear to rotate, and the first gear drives an auger to rotate in the forward direction and pushes a liquid medicine to flow in the forward direction and roll upwards and synchronously drives the second gear; the second gear and the inner gear ring are in transmission connection, rotate in the same direction and are opposite to the first gear, so that the spiral stirring blade is driven to rotate reversely, the auger and the spiral stirring blade are both opposite and are arranged in a twisted spiral shape, the liquid medicine is promoted to violently roll over and be mixed up and down, different medicaments can be efficiently and uniformly stirred, and the treatment effect is practically improved.

The utility model discloses micro aerosol inhalation device monitoring equipment which is installed between an atomizer and a breathing tail pipe and comprises an equipment body and an upper computer, the equipment body is in communication connection with the upper computer, the equipment body comprises a connecting pipe, a shell and a monitoring device, the connecting pipe transversely penetrates through the shell, the monitoring device is arranged in the shell, and the upper computer is connected with the monitoring device. The monitoring device is in communication connection with the upper computer. The shell comprises a base, side plates and an upper shell, a monitoring device is arranged on the base, the side plates are arranged at the two ends of the base, a through hole is formed in each side plate, the connecting pipe penetrates through the through holes to be fixedly connected with the side plates, a plurality of communicating pipes are arranged on the connecting pipe, the communicating pipes are connected with the monitoring device, and the upper shell is detachably connected with the base. The flow sensor and the pressure sensor are matched with each other, the flow and the pressure of medicine are detected in real time, and the device is small in overall size, low in manufacturing cost, suitable for different inhalation devices and high in monitoring accuracy.

An Aerosol Inhalation Chamber

The invention belongs to the technical field of targeted drugs, and particularly relates to a 293T exosome for targeted delivery of pirfenidone through a membrane-loaded FAP and a preparation method and application thereof.The exosome secreted by 293T cells serves as a natural nano-carrier, an FAP antibody with fibroblast targeting performance is modified on the exosome membrane surface through a copper-free click chemical method, and the exosome membrane surface is modified through a copper-free click chemical method; an anti-fibrosis drug PFD is efficiently loaded into the exosome by adopting an ultrasonic method, so that an engineered exosome system (293Texo antiFAP + PFD) with targeted recognition and drug delivery functions is constructed. The system is delivered to the lung in an aerosol inhalation mode, accurate enrichment and stable release of PFD at the pulmonary fibrosis focus can be achieved, and therefore lung tissue structure damage and collagen deposition are effectively relieved, and the anti-fibrosis curative effect is remarkably improved. According to the technology, the problems of low drug delivery efficiency, large side effect, poor targeting property and the like in traditional treatment are solved, and a safe, efficient and accurate treatment strategy is provided for pulmonary fibrosis.

This aerosol inhalation device comprises: a housing having an opening; an accommodation part for accommodating a consumable material that is to be heated therein; and a lid part. The lid part is movable between a first position at which the opening is covered and a second position at which the opening is opened so that the consumable material can be inserted. The lid part is configured so as to receive, at the second position, a biasing force for moving toward the first position. The biasing force includes a magnetic force.

The application discloses an aerosol inhalation type LNP composition for treating lung diseases and a preparation method and application thereof. The composition comprises an aerosol stabilizer and a surface coupled Anti-CD3 antibody lipid nanoparticle, and the surface coupled Anti-CD3 antibody lipid nanoparticle internally loads a CAR-mRNA targeting FAP. The application improves the efficiency of LNP targeted binding to T cells by coupling CD3 antibodies to LNP, and the LNP can significantly improve the in-vivo reprogramming efficiency of mouse T cells by coupling CD3 antibodies. The application administers the antibody coupled LNP by aerosol inhalation, and compared with common intravenous injection, the lung lesion accumulation of the LNP is improved, so that the treatment effect of pulmonary fibrosis is effectively improved.

The invention discloses a resveratrol crystal form X and a preparation method and application thereof, an X-ray powder diffraction pattern of the resveratrol crystal form X has characteristic peaks at 2 theta angles of 27.4 degrees, 31.8 degrees, 45.6 degrees and 56.5 degrees, and the 2 theta angle error range is + / -0.2 degrees; meanwhile, the invention discloses a preparation method and application in a medicine for treating pneumonia. According to the crystal form X provided by the invention, the saturation solubility of resveratrol is increased by 35.1 times (up to 1793.8 + / -36.8 mu g / mL); the tablet has good dissolution capacity in a slightly acidic inflammation environment; meanwhile, the compound has higher affinity to a protein receptor on a respiratory syncytial virus (RSV), shows a more excellent inhibition effect on the RSV in vitro and in vivo, and has better anti-inflammatory and antioxidant activity; meanwhile, the crystal form X of the resveratrol is more beneficial to cellular uptake, the uptake amount is 3.5 times of the original amount compared with common resveratrol, retention in the lung can be improved, aerosol inhalation for treating the RSV pneumonia has safety and effectiveness, and it is shown that the resveratrol can be used for preparing the medicine for treating the pneumonia, especially the RSV pneumonia.

This aerosol inhalation device has a housing and a cover. The housing has a first end and a second end, and has a slidable lid part at the second end. The cover is configured such that the cover is removed from the second end when a second force is applied to the cover in a first direction in a state where the cover is attached to the second end of the housing. The lid part is configured such that, a third force is applied to the lid part in the first direction when the second force is applied to the cover in the first direction in a state where the cover is attached to the second end. The third force is smaller than a first force.

The invention relates to the technical field of pharmaceutical compositions, in particular to an atomization composition and application thereof. An aerosolized composition comprising: A) an MSC-derived active ingredient selected from any one or a combination of (i) MSC exosomes / extracellular vesicles, (ii) an MSC conditioned culture solution concentrate, (iii) an MSC lysate, (iv) an MSC-derived soluble factor, (v) an immobilized / embedded protected MSC or fragment thereof; b) ergothioneine (EGT) or a pharmaceutically acceptable salt thereof; and C) a pharmaceutically acceptable carrier / buffer system making it suitable for aerosol inhalation administration. The exosome is combined with ergothioneine, and the effectiveness of sleep improvement is remarkably improved through mechanism synergy of nerve regulation and cell protection; the introduction of the atomization drug delivery technology breaks through the limitation of the traditional therapy from multiple dimensions of non-invasiveness, accurate delivery, individualized treatment, accessibility and the like, so that wider crowds (including special crowds) can safely, conveniently and efficiently receive treatment.

This invention provides an aerosol suction cartridge equipped with a sealing member that ensures both heat stability and breathability. [Solution] An aerosol inhalation cartridge is characterized in that a sealing member 9, an aerosol forming substrate, a support member, and a mouthpiece are arranged and wrapped with an outer casing to form an elongated cylindrical shape, the sealing member is formed from a sheet-like member into a cylindrical shape including one or more of the following shapes: roll shape 9a, folded shape 9b, or random shape 9c, and has a length of 3.0 to 7.0 mm along the height direction, and the aerosol forming substrate is an elongated cylindrical shape containing a filler that generates an aerosol when heated by a rod-shaped heating member.

The invention relates to a polymyxin B sulfate dry powder inhalation and application thereof, which can effectively solve the problem of medication for treating pneumonia and pulmonary infection caused by multi-drug-resistant gram-negative bacteria, the polymyxin B sulfate dry powder inhalation is prepared from polymyxin B sulfate, leucine and mannitol, and the preparation method comprises the following steps: dissolving polymyxin B sulfate, leucine and mannitol in ultrapure water according to a mass ratio, carrying out ultrasonic treatment to obtain a uniformly mixed medicine solution, and carrying out freeze drying to obtain the polymyxin B sulfate dry powder inhalation. The composition is simple, scientific and reasonable, the raw materials are rich, the preparation method is easy to operate, the product quality is good, the composition is administrated through aerosol inhalation, the composition is effectively used for treating pneumonia and pulmonary infection caused by multi-drug-resistant gram-negative bacteria, the composition is fast to absorb, the pulmonary drug concentration is high, the stability is good, and the composition is suitable for clinical application. The medicine is a great innovation in treatment of pneumonia and pulmonary infection caused by the multi-drug-resistant gram-negative bacteria, and has remarkable economic and social benefits.

The invention discloses an atomization inhalation device capable of preventing cross infection. The atomization inhalation device comprises a base, an atomization concentration bin, a plurality of injection pieces, a breathing tube and a filtering piece. The atomization concentration bin is of a hollow structure and is provided with a partition structure located in the middle, and the partition structure is provided with a through hole. The multiple injection pieces are arranged in the circumferential direction of the barrel and communicate with an upper cavity of the atomization concentration bin; an ingress pipe is arranged at the lower part of the cylinder to guide the breathing tube to be inserted, and an air guide hole is formed in the side wall of the breathing tube and is aligned with the conduction hole; a sealing structure is arranged between the breathing tube and the ingress tube; the filter part is arranged on the rear side of the barrel, is hermetically connected with the breathing tube and is used for connecting the corrugated tube. Through the arrangement, the technical problem of high cross infection risk caused by backflow pollution and incapability of dismounting and replacing of a breathing tube in an existing aerosol inhalation device is solved.

The invention relates to the technical field of chronic obstructive pulmonary disease treatment, and discloses a chronic obstructive pulmonary disease patient expectoration assisting and aerosol inhalation integrated device which comprises a main machine, a first connecting pipe is connected to the top of a double-end bent pipe in a penetrating mode, a second connecting pipe is connected to one side of the top of the double-end bent pipe in a penetrating mode, and a first catheter is connected to the top of the first connecting pipe in a penetrating mode. A first catheter is connected to the top of the first connecting pipe in a penetrating mode, a second catheter is connected to the top of the second connecting pipe in a penetrating mode, a connector is connected to one end of the first catheter in a penetrating mode, and a suction nozzle is fixedly arranged at one end of the connector. The operation of expectoration assistance and atomization treatment is respectively carried out through the pipeline of the same channel, meanwhile, the airflow trend and liquid flow of the two are not interfered with each other under the treatment condition of the same channel, different treatment pipelines do not need to be frequently replaced for treatment when a chronic obstructive pulmonary disease patient is treated, the risk of pulmonary infection of the patient is reduced, and the treatment efficiency is improved. The treatment effect is improved.

An electronic smoking device includes an elongate housing sleeve accommodating at least part of the following components: a battery as an electric power source powering an electrically activatable atomizer including an electric heater adapted to atomize a liquid supplied from a reservoir to provide an aerosol exiting from the atomizer; a puff detector adapted to indicate an aerosol inhaling puff; and control electronics connected to the puff detector and adapted to control the heater of the atomizer. At least part of the battery, the puff detector, the control electronics and / or the atomizer is mounted on an elongate insert permitting lateral access and fitting into the housing sleeve via one of the ends of the housing sleeve.

The utility model relates to a mist storage tank, which belongs to the field of medicine inhalers and comprises a main tank body for storing aerosol and an inhalation mask mounted on the main tank body. The main tank body is colorless and transparent, the top of the main tank body is provided with an air inlet joint for mounting the inhalation mask, and the main tank body is provided with an air inlet pipe which is positioned on the lower side of the air inlet joint and is communicated with the air inlet joint and an inner cavity of the main tank body; an indicating ball is arranged in the air inlet pipe, and a limiting structure for limiting the indicating ball from falling off is arranged at the bottom of the air inlet pipe; a medicine inlet is formed in the bottom of the main tank body. The aerosol storage tank has the advantage that the observation effect on the inhalation amount of aerosol when a patient uses the aerosol storage tank is improved.