8 results about "Saturation solubility" patented technology

The application discloses a kind of low-defect manganese-based prussian blue under solid-liquid dynamic balance fast preparation method, comprising the following steps: S1, sodium citrate is dissolved in deionized water, then add manganese acetate and ascorbic acid, form the solution A containing manganese complex;Wherein, the molar ratio of sodium citrate, manganese acetate and ascorbic acid is (4.5-5.5): 1:(0.3-0.4);S2, sodium ferrocyanide is added to deionized water, stirring is formed at a set temperature containing unsolved sodium ferrocyanide solid supersaturated suspension B;Wherein, the addition amount of sodium ferrocyanide is far more than its saturated solubility at the temperature, so that the system maintains solid-liquid two-phase equilibrium state;Crystalline integrity is higher: thanks to "whole process dynamic saturation" environment, the manganese-based prussian blue prepared by the application has more obvious monoclinic phase characteristics (corresponding XRD double peak is obvious, intensity is obvious, signal-to-noise ratio is good) compared with comparative document, lattice vacancy and coordination water content are significantly lower than comparative document scheme, and electronic conductivity is increased by nearly 50%.

Provided are a crystal form of a gonadotropin releasing hormone antagonist, a preparation method therefor, and use thereof. A crystal form C and a crystal form D have high purity, good illumination stability, high temperature stability, and high humidity stability, and have good solubility and low hygroscopicity; the saturation solubility of the crystal form C and the crystal form D is 101.75 μg / ml and 87.21 μg / ml, respectively; when the relative humidity is increased from 0 to 50% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 1.76% and 0.73%, respectively; and when the relative humidity is increased from 0 to 90% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 3.43% and 1.61%, respectively. Therefore, the control of a production condition is facilitated, the preparation process is simple, the quality is stable, and large-scale industrial production is easy.

The application discloses a multi-salt electrolyte system crystallization simulation method and device based on a solubility function model, a medium and a product, relates to the field of chemical thermodynamics and crystallization process simulation, and comprises the following steps: obtaining saturation solubility experimental data of target components under different experimental conditions; constructing a solubility function model of the target components based on the saturation solubility experimental data, and fitting solubility function model parameters of each electrolyte system; calculating the theoretical saturation solubility of the target components under the current conditions based on the solubility function model and the fitted solubility function model parameters, so as to determine whether the multi-salt electrolyte system is in a supersaturated state; and if the multi-salt electrolyte system is in a supersaturated state, calculating the crystallization amount of the target components based on material balance relations, and obtaining the mother liquor composition, the flow rate of the mother liquor stream and the flow rate of the solid product. The application can improve the accuracy and universality of the crystallization simulation of complex electrolyte systems.

The invention discloses a resveratrol crystal form X and a preparation method and application thereof, an X-ray powder diffraction pattern of the resveratrol crystal form X has characteristic peaks at 2 theta angles of 27.4 degrees, 31.8 degrees, 45.6 degrees and 56.5 degrees, and the 2 theta angle error range is + / -0.2 degrees; meanwhile, the invention discloses a preparation method and application in a medicine for treating pneumonia. According to the crystal form X provided by the invention, the saturation solubility of resveratrol is increased by 35.1 times (up to 1793.8 + / -36.8 mu g / mL); the tablet has good dissolution capacity in a slightly acidic inflammation environment; meanwhile, the compound has higher affinity to a protein receptor on a respiratory syncytial virus (RSV), shows a more excellent inhibition effect on the RSV in vitro and in vivo, and has better anti-inflammatory and antioxidant activity; meanwhile, the crystal form X of the resveratrol is more beneficial to cellular uptake, the uptake amount is 3.5 times of the original amount compared with common resveratrol, retention in the lung can be improved, aerosol inhalation for treating the RSV pneumonia has safety and effectiveness, and it is shown that the resveratrol can be used for preparing the medicine for treating the pneumonia, especially the RSV pneumonia.

The invention relates to the field of medicines, and discloses a pharmaceutical composition for treating obstructive sleep apnea as well as a preparation method and application thereof. The pharmaceutical composition comprises a ternary co-amorphous compound containing zinc ions, and raw materials of the ternary co-amorphous compound comprise suthiamethoxam, L-arginine, a divalent zinc ion donor and a surface stabilizer. Wherein zinc ions form a cross-linked network with the suthiamethoxam and the L-arginine through coordination, so that drug lattices are destroyed, and molecular movement is limited. According to the preparation method, a liquid-assisted high-energy mechanical ball milling process is adopted, a trace amount of coordination catalytic liquid is added to reduce a solid-phase reaction energy barrier, and efficient conversion from a crystalline state to an amorphous state is realized. Through the synergistic effect of multiple components, the saturation solubility and the dissolution rate of the suthiamethoxam are remarkably improved, meanwhile, the coordination crosslinking of zinc ions and the steric hindrance effect of the surface stabilizer are utilized, crystal transformation of an amorphous system is effectively inhibited, and the physical stability and oral bioavailability of the medicine are enhanced.

The invention provides a device and a method for preparing high-purity selenium dioxide, which can effectively remove impurities which have large difference in saturation solubility with selenium dioxide solid phase in liquid phases such as water, ethanol and the like, and realize preparation of high-purity selenium dioxide. According to the invention, a dissolution crystallization method and a similar zone melting mechanism for melting crystallization are unified and expanded to most dissolvable compounds. The device and the method provided by the invention have the advantages of high purity upper limit, low energy consumption, strong applicability and the like.

The sublimation film-forming composition of the present application contains a sublimation substance and a solvent having a saturated solubility of the sublimation substance of greater than 10 mass %.

The sublimable film formation composition of the present invention includes a sublimable substance and a solvent in which a saturation solubility of the sublimable substance is more than 10% by mass.