86 results about "Saturation solubility" patented technology

The invention relates to a method for hydrotreatment of continuous liquid-phase wax oil. Wax oil raw oil, an effluent from a reactor and hydrogen are mixed in mixers to form a mixture, hydrogen can be dissolved in hydrocarbon oil in a form of bubbles by virtue of hydrogen distributors arranged inside the mixers, the amount of hydrogen is higher than the saturated solubility of liquid or the total hydrogen consumption, a plurality of bed layers are arranged in the reactor, the mixers are arranged among the bed layers, the mixture and fresh hydrogen or a mixture of hydrogen and partial reaction products are mixed again, a partial effluent from the reactor is partially circulated and a partial effluent is subjected to cooling, separating and fractional distillation to obtain the product. By the method, the problems that reaction process is difficult to process due to the limitation on the solubility of hydrogen in the hydrocarbon oil and the chemical hydrogen consumption is relatively high are solved and the adaptability of raw oil is expanded and furthermore, under the condition of relatively low circulation ratio, low-sulfur refined wax oil can be produced to provide high-quality feedstock for catalytic cracking.

The pharmaceutical preparation for transdermal administration contains solvent ingredients, such as water and ethanol and / or propanol, and drospirenone. The drospirenone is contained in the preparation in an amount that is not above its saturation solubility in an initial state prior to application to skin. However after application to the skin the amount of drospirenone exceeds its saturation solubility due to escape or discharge of the solvent ingredients from the preparation. Preferably the saturation solubility is exceeded by at least a factor of five during application to the skin. The pharmaceutical preparation can also contain an estrogen, such as ethinyl estradiol. It can be in the form of a semi-solid or liquid preparation that is contained in a reservoir-type transdermal patch. A transdermal patch for contraception containing the pharmaceutical preparation including drospirenone and ethinyl estradiol is also disclosed.

The invention relates to a test method and a test device for obtaining saturated solubility and diffusion coefficients of a solid solute in a liquid phase simultaneously. According to solute mass conservation law and Archimedes law in the process of dissolution, a physical model in the process of dissolving the solid solute is established and mathematical description of the physical model is determined so as to establish an experiment characterization method and a measurement device. In the test method and the test device, the saturated solubility and the diffusion coefficients of the solid solute in the liquid phase at a certain temperature and under certain pressure are calculated from the measured real-time dissolved amount through a specific inversion model (physical and mathematical model). The test device has the advantages of simple operation, short measuring time and capability of measuring large quantity of data; and the solubility and the diffusion coefficients are obtained simultaneously, and the measured data can be verified mutually, so the measuring accuracy is improved and the data consistency is ensured well.

It is an object of the present invention to provide a method for producing microparticles, which can produce monodispersed microparticles, causes no clogging with a product due to self-dischargeability, requires no great pressure, and is excellent in productivity, wherein a fluid in which at least one kind of microparticle materials is dissolved is introduced between two processing surfaces arranged to be opposite to each other to be able to approach to and separate from each other, at least one of which rotates relative to the other, to be formed into a thin film fluid, and the thin film fluid is cooled or heated (warmed) to allow saturation solubility to change, thereby separating microparticles.

The invention provides a sensor for measuring the content of hydrogen in a metal melt and a measuring method. The sensor structurally comprises a solid-state proton conductor element, a reference electrode, a quasi-to-be-detected electrode, a reference substance, a communicating pipe and an insulating ceramic adhesive. The measuring method comprises the following steps: (1) inserting a sensor and a corrosion-resistant electrode into a metal melt, ensuring that a solid-state proton conductor element is completely immersed into the metal melt and a quasi-to-be-detected electrode and the metal melt are in direct contact, wherein the contact surface is a to-be-detected electrode; (2) connecting a potentiometer, a reference electrode conductor or a metal gas-guide pipe and a corrosion-resistant electrode and measuring the potential difference between a reference electrode and the to-be-detected electrode; (3) calculating the hydrogen content S of the metal melt according to the measured potential difference, the temperature of the metal melt, and the saturated solubility of hydrogen in the metal melt. According to the sensor, the proton conductor element can be in direct contact with the metal melt, the atmosphere of balance between the reference substance and hydrogen in the metal melt can be quickly built, the measurement speed is higher, the measurement result is more accurate and the sensor is simpler by simplification.

The invention provides a method for smelting high-nitrogen steel by a vacuum induction positive-pressure furnace, belonging to the technical field of smelting of high-nitrogen steel. The method comprises the steps: preparing a smelting material, clearing a crucible, loading a smelting raw material meeting the requirement of smelting a grade of steel; vacuumizing a smelting chamber of the vacuum induction furnace, and starting power transmission to heat a furnace material when the vacuum degree is less than 15Pa, wherein a power is 40 Kw; gradually increasing the power, and after a weld pool occurs, controlling the power to avoid splashing; completely smelting the furnace material, and reducing the power to perform refining to remove O, N, H and the like; starting a nitrogen making machine to introduce nitrogen, and adjusting a pressure in the furnace until reaching a required pressure value so that the saturation solubility of nitrogen is increased; adding the smelting raw material of increasing the partial pressure and a nitrogen-increasing alloy so as to increase the alloy yield; adding a final deoxidizing agent, controlling the temperature of molten steel, and pouring in an electrifying manner. The method is suitable for smelting the grade of steel requiring that the content of nitrogen is more than a defined numerical value or control range, and is capable of achieving the purposes of accuracy in component control, and high and stable nitrogen yield. The method has the advantages that the nitrogen yield reaches above 99 percent, particularly smelting high-nitrogen steel with nitrogen content up to 2 percent comes true, the components are accurate, and the cost is lower; the method is suitable for largely smelting special steel and steel for medical apparatuses and instruments with nitrogen content of 0.4-1.4 percent.

An object of the invention is to provide a transdermal absorption preparation capable of sustaining the blood morphine concentration at an effective level over at least 48 hours, etc. This transdermal absorption preparation comprises a medicinal composition for transdermal absorption in which an active ingredient selected from morphine and salts thereof is blended in such an amount as corresponding to the saturation solubility or more in an active ingredient-holding vehicle having fluidity at a temperature around the human skin surface temperature and at least a portion of the active ingredient is held in a crystalline form, characterized in that, in the case where a preparation obtained from the above-described medicinal composition for transdermal absorption is applied to the uninjured skin of the back of a white rabbit having been shaven with electrical clippers for 72 hours, the available amount of the active ingredient per single dose of the preparation is from 10 mg to 400 mg in terms of morphine base, and the plasma concentrations of the active ingredient 24 hours and 48 hours after the application of the preparation under the above-described conditions are each at least 40 ng / mL in terms of morphine base, and so on.

A filling liquid for distribution of an ink jet head of a thermal type, the filling liquid filling a nozzle flow path during distribution of the ink jet head, a hydrophilic region formed on a periphery of an ink discharge port having an opening area of from 100 to 350 μm2, the filling liquid including: an aqueous medium having at least a water-soluble organic compound and water as constituents; and a dye dissolved in the aqueous medium, a concentration of the dye in the filling liquid being 0.2 mass % or more and 1 mass % or less with respect to a total mass of the filling liquid and the concentration of the dye being equal to or less than saturation solubility with respect to the water-soluble organic compound, wherein the filling liquid has a surface tension of 25 mN / m or more and 34 mN / m or less.

This invention discloses a liver-protection and healthy wine and its preparation method, in which, the wine includes distilled spirit, puerarin, glycyrrhizic acid, resveratrol, paeoniflorin, march 7 total glycosides and salvia acid B, and the spirit includes mixtures of one or several kinds of healthy factors, which avoids harm of spirit to the liver.

The present invention discloses one kind of blood fat regulating health wine, which includes white liquor and puerarin, resveratrol, resveratrol glycoside and / or ursolic acid. Each 500 ml of the health wine contains at least 1 mg of the said health factors. The blood fat regulating health wine is mellow, stable and controllable in quality, and has the health function of preventing and treating atherosclerosis.

An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w / w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.

The invention discloses a dasatinib tablet, which comprises dasatinib and pharmaceutically-acceptable medicinal auxiliary materials, and is characterized in that: the dasatinib is an anhydride of which the particle size D(0.1) is equal to 3.0-10 mum, D(0.5) is equal to 15-60 mum and D(0.9) is equal to 100-150 mum. A qualified dasatinib tablet is prepared by taking the dasatinib anhydride as a raw material, so that the problems of over-high dissolution rate of a tablet prepared from the anhydride, untoward reactions caused by initial burst release of a medicament, reduction in the acting time, easy occurrence of unqualified dissolution rate and the like, which are caused by relatively high water saturation solubility of the dasatinib anhydride, are solved, and the industrial batch production requirements of low cost, simple process and qualification on a dasatinib raw material and a preparation can be met.

An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w / w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.

The invention relates to a method for preparing coccidium-resistant suspension containing Diclazuril and maduramicin ammonium. A user can take the suspension with water; and diluted stock solution can be uniformly dispersed in water and keep the stable suspension state, and has the characteristics of convenient administration, waste reduction, dosage guarantee, high dissolution rate of medicaments, high saturated solubility of the medicaments, long detention time of the medicaments in vivo, high bioavailability, no blockage of drinkers and the like. The coccidium-resistant suspension containing the Diclazuril and the maduramicin ammonium can fully exert the medical effect when treating chicken coccidiosis.

Provided are a kit and a laminate which are capable of suppressing residues derived from a temporary adhesive in manufacture of a semiconductor. The kit for manufacturing a semiconductor device includes a composition which contains a solvent A; a composition which contains a solvent B; and a composition which contains a solvent C, in which the kit is used when a temporary adhesive layer is formed on a first substrate using a temporary adhesive composition containing a temporary adhesive and the solvent A, at least some of an excessive amount of the temporary adhesive on the first substrate is washed using the composition containing the solvent B, a laminate is manufactured by bonding the first substrate and a second substrate through the temporary adhesive layer, one of the first substrate and the second substrate is peeled off from the laminate at a temperature of lower than 40° C., and then the temporary adhesive remaining on at least one of the first substrate or the second substrate is washed using the composition containing the solvent C, and the solvent A, the solvent B, and the solvent C respectively satisfy a predetermined vapor pressure and a predetermined saturated solubility.

The invention provides a composition containing refrigeration oil and refrigerant and application thereof. The refrigeration oil and the refrigerant in the composition fulfill the following requirements: on the basis of the gross mass of the composition, when the weight content of the refrigeration oil equals to or is smaller than 50% of the gross mass and the temperature is between minus 50 DEG C to 80 DEG C, the saturated solubility of the refrigeration oil in the refrigerant is 5% to 30% of the total mass; the kinematic viscosity of the refrigeration oil at 40 DEG C is 5 to 60 mm<2> / s. The composition provided by the embodiment of the invention enables the refrigeration oil to be appropriately dissolved with the refrigerant, so that the reliability and the system performance of the compressor can be effectively improved.

Disclosed is a low-cost and resource-saving cleaning method wherein high cleaning effects are obtained by high-pressure jet cleaning or two-fluid cleaning using a gas-dissolved water. In the high-pressure jet cleaning method or the two-fluid cleaning method, a cleaning liquid or a mixed fluid of the cleaning liquid and a gas is jetted from a cleaning fluid jetting nozzle toward a subject to be cleaned, and the subject is cleaned. The cleaning liquid introduced into the cleaning fluid jetting nozzle contains the dissolved gas in a quantity equal to or more than the saturation solubility at the liquid temperature of the cleaning liquid.

The invention discloses a generation equipment and generation method for non-electrolytic slightly-acidic hypochlorous acid water. The concentration of the slightly-acidic hypochlorous acid water can be lower than 200 ppm, especially be lower than 60 ppm; the pH value ranges from 6.20 to 6.80, the pH fluctuation range is controlled to be within plus or minus 0.05 at any value therebetween, and stable storage can be performed for 18 months. The generation equipment comprises at least one stage of purification device, a slightly-acidic hypochlorous acid water generation device, a control system and water supply ports. The purification device is used for purifying raw water from a raw water supply system. The slightly-acidic hypochlorous acid water generation device is located in the down stream of the purification device, and is provided with reaction devices, a water inlet and addition agent injection devices. The reaction devices are used for performing a quantum chemical reaction on addition agents and water from the purification device, and controlling H hydrated protons by stage to reach the stable saturated solubility of H ions, thereby processing into the slightly-acidic hypochlorous acid water with stable pH. The control system is electrically connected with the slightly-acidic hypochlorous acid water generation device, and is arranged to accurately control a whole generation process. The water outlets of the purification devices and the water outlet of the slightly-acidic hypochlorous acid water generation device are connected to the water supply ports through corresponding pipelines in a switchable way. The equipment can provide various functional water with different uses, and can switch water taking types according to user needs.

The invention discloses a nitrogen content control method for FB2 steel smelted by a vacuum induction furnace. The nitrogen content in steel is controlled by improving the nitrogen partial pressure, and the method comprises the following steps: step 1, charging; step 2, vacuumizing; step 3, filling with nitrogen; step 4, melting down; step 5, performing vacuum casting; and step 6, destroying the vacuum environment and adding a protective slag. The vacuum induction furnace is employed for smelting FB2 steel, the partial pressure of nitrogen in the vacuum induction furnace is improved by filling with nitrogen, the saturation solubility and the surface adsorption rate of steel in molten steel are improved, and the nitrogen content in molten steel is increased, and thus the target of controlling the nitrogen content is realized.

The invention relates to a nicarbazin and ethopabate nano mixed suspension agent and preparation method thereof, the nano mixed suspension agent of the invention can be administrated by drinking, and the stock solution after being diluted can be evenly dispersed in water and can be kept for stable suspension state, the nano mixed suspension agent has characteristics of convenient administration, reduced waste, ensured dose, increased dissolution velocity of the medicament, increased saturation dissolvability of the medicament, prolonged detention time of the medicament in vivo, improved bioavailability and no blocking of the drinking machine, so that the nicarbazin and ethopabate can sufficiently exert medicament effect when treating the chicken coccidiosis.

An object of the invention is to provide a transdermal absorption preparation capable of sustaining the blood morphine concentration at an effective level over at least 48 hours, etc. This transdermal absorption preparation comprises a medicinal composition for transdermal absorption in which an active ingredient selected from morphine and salts thereof is blended in such an amount as corresponding to the saturation solubility or more in an active ingredient-holding vehicle having fluidity at a temperature around the human skin surface temperature and at least a portion of the active ingredient is held in a crystalline form, characterized in that, in the case where a preparation obtained from the above-described medicinal composition for transdermal absorption is applied to the uninjured skin of the back of a white rabbit having been shaven with electrical clippers for 72 hours, the available amount of the active ingredient per single dose of the preparation is from 10 mg to 400 mg in terms of morphine base, and the plasma concentrations of the active ingredient 24 hours and 48 hours after the application of the preparation under the above-described conditions are each at least 40 ng / mL in terms of morphine base, and so on.

A method for producing ozone gas-dissolved water includes a process in which a mixed gas of an ozone gas and an oxygen gas and degassed water are supplied to an ozone-dissolving section and the mixed gas is dissolved in the degassed water. The amount of the mixed gas supplied to the ozone-dissolving section is controlled such that the sum of the dissolved oxygen gas concentration of the degassed water and the increment of the dissolved oxygen gas concentration calculated from the amount of the oxygen gas in the mixed gas and the amount of the degassed water on the assumption that ozone in the mixed gas entirely decomposes into oxygen is less than or equal to the saturated solubility of the oxygen gas under conditions using the obtained ozone gas-dissolved water.

The invention discloses a baicalin nanometer crystal which comprises a raw material and an auxiliary material, wherein the raw material is baicalin. The preparation method of the baicalin nanometer crystal comprises the following steps: (1) dispersing a stabilizing agent into water to obtain a system A; (2) dispersing the baicalin into a good solvent to obtain system B; (3) dispersing the system B into the system A under the action of high-speed shearing to obtain a nanometer suspension C; (4) after the nanometer suspension C is centrifugalized at high speed, discarding supernatant, adding a small amount of the system A, and dispersing again through the high-speed shearing to obtain a concentrated suspension D; (5) adding a protective agent to the nanometer suspension C obtained from the step (3) or the concentrated suspension D obtained from the step (4), and drying to obtain the baicalin solid-state nanometer crystal. The baicalin nanometer crystal disclosed by the invention can be used for overcoming the defect that the baicalin is difficult to dissolve in water; compared with a raw material drug, the prepared baicalin nanometer crystal is significantly enhanced in saturated solubility.

An inkjet recording method comprising: shooting to a recording medium an active-light-ray-curable inkjet ink including a photopolymerizable compound, a wax, a photopolymerization initiator, and a coloring material, and that undergoes reversible sol-gel phase transition relative to temperature; and curing the ink by irradiating an active light ray to the ink that has been shot to the recording medium, wherein the ink including a (meta) acrylate compound (B) having a molecular weight of 300-1500 and a C log P value within the range 4.0 to 7.0, the wax content being 1.0-10 percent by mass of the total mass of the ink, and the temperature of the recording medium at active light ray irradiation being set such that the saturation solubility of the wax with respect to the ink constitutes 0.5 percent by mass or less. According to this image-forming method, blooming is suppressed.

Provided is a long-life organic electroluminescent element that has a light-emitting layer formed with a wet film-forming method. The composition for the organic electroluminescent element contains two or more types of organic electroluminescent materials that contain a light-emitting material and a solvent, and satisfies formula (1): (EL material (S) is the organic electroluminescent element material with the lowest weight in the composition. EL material (N) is the organic electroluminescent element material with the greatest weight. The weight ratio is the weight ratio between the EL material (S) and the EL material (N). Saturation solubility is the saturation solubility of the pertinent material for the solvent in the composition at 20 DEG C and 1 atmosphere pressure).

The invention relates to construction of Tween 80-based biocompatible microemulsion and in vitro release and oxidation resistance study of carried apigenin. A pseudo-ternary phase diagram is adopted for constructing Tween80 / IPM / PEG400 / H2O biocompatible microemulsion, and partition is carried out by utilizing conductivity, so that structure of the microemulsion is changed from a bicontinuous phase(B.C.) to an O / W type. Further the O / W type microemulsion is selected as an apigenin carrier, saturation solubility experiments show that the constructed microemulsion obviously improves solubility ofthe apigenin, and compared with the solubility in water, the solubility is improved by 300 times when the microemulsion is taken as the carrier. In vitro release experiments show that the microemulsion has better slow-release effect on the apigenin, and a releasing process of the apigenin in the microemulsion accords with first-order kinetics and is under concentration diffusion control. A medicine still has better antioxidant activity in the microemulsion and has better clearing effect on ABTS<+>.. Release rate of the apigenin in the microemulsion, accumulated release rate and antioxidant activity can be regulated and controlled by changing a mass ratio of a surfactant to oil (S / O) and water content.

Disclosed is a low-cost and resource-saving cleaning method wherein high cleaning effects are obtained by high-pressure jet cleaning or two-fluid cleaning using a gas-dissolved water. In the high-pressure jet cleaning method or the two-fluid cleaning method, a cleaning liquid or a mixed fluid of the cleaning liquid and a gas is jetted from a cleaning fluid jetting nozzle toward a subject to be cleaned, and the subject is cleaned. The cleaning liquid introduced into the cleaning fluid jetting nozzle contains the dissolved gas in a quantity equal to or more than the saturation solubility at the liquid temperature of the cleaning liquid.

The blood sugar reducing health wine includes white liquor and puerarin, astragalus polysaccharide, jasminoidin and / or ursolic acid. Each 500 ml of the health wine contains at least 1 mg of the said health factors. The blood sugar reducing health wine is mellow, stable and controllable in quality, and has the health function of preventing and treating diabetes.