85 results about "Drug crystals" patented technology

Drug delivery balloons have densely packed crystals of small particle size of the drug thereon. An amorphous drug coating is applied to a balloon surface and annealed to provide the crystals. The balloon surface is nucleated to induce formation of drug crystals in the annealing step to provide the crystals in high density with small size.

The present disclosure is directed toward composite materials comprising high aspect ratio habits of drug crystals which can be partially or fully extending into a substrate, and additionally, can be projecting from a substrate at an angle of about 20° to about 90°. The present disclosure is directed toward medical devices, such as medical balloons, comprising said composite and methods of using and making the same. The described composite can be used for the local treatment of vascular disease. The present disclosure is also directed toward paclitaxel crystals with a hollow acicular habit.

The invention provides a water-soluble prodrug of tamibarotene, and a preparation method and applications thereof and belongs to the technical fields of organic compound synthesis and medical applications. The water-soluble prodrug of tamibarotene has favorable water solubility and suitable drug crystal form, and therefore, is suitable to be used as a raw material for medical preparations and especially suitable for preparing injections. Particularly, the invention provides medical acceptable salts of tamibarotene DMEA ester, which have the general formula (I), wherein HA is HCl, H2SO4, HNO3,H3PO4, HOAc, paratoluenesulfonic acid, maleic acid, succinic acid, citric acid or L(+)-tartaric acid.

A micro and nano-particulate drug comprising a drug substance and a surfactant in which the drug and surfactant form a eutectic mixture. The matrix formed between the drug substance and the surfactant has a melting point less than the decomposition temperature of the drug substance and thus provides the advantages of reduced irritation due to the melting process without the prior art problem of decomposition of the drug substance. In one embodiment, crystals are formed while the mixture is cooled at room temperature under high shear conditions. In a second embodiment, a flowable material may be formed which also contains the drug and that may be incorporated into a pharmaceutical delivery system is also disclosed. Methods of preparing the micro and nano-particulate drug crystals and non-crystalline substance are also contemplated in the inventive subject matter.

A nail and/or skin patch for preventing or treating mycoses is provided that is able to maintain a drug concentration in the nails and/or skin horny layer at a high concentration for a long period of time without adding a dissolving agent that prevents precipitation of drug crystals or permeation enhancer that promotes penetration of drug into the nails and/or skin, retains superior adhesion even when adhered for a long period of time and has causes little skin irritation.

A nail and/or skin patch for preventing or treating mycoses, which contains an antimycotic, having an octanol/water partition coefficient in the form of a logKo/w value of 4 or more, in a dissolved state in an acrylic-based pressure-sensitive adhesive layer or silicone-based pressure-sensitive adhesive layer.

The invention relates to a mesotrione oil suspension agent composition. The composition is characterized in that, the composition comprises, by mass: 8-15% of mesotrione, 10-20% of an emulsifying dispersant, 1-3% of a suspension stabilizer, 1-5% of water, 0.1-0.2% of an organosilicon defoaming agent, and balance of a green and environment-friendly solvent. The green and environment-friendly solvent mainly comprises a mixture of dimethyl carbonate and at least one of jatropha pine nut oil and castor oil. According to the mesotrione oil suspension agent provided by the invention, non-edible plant oil with wide source and the non-toxic green solvent are adopted as suspension carriers, such that the composition is green and environment-friendly, and has a characteristic of high safety to plants. Also, a crystal transition inhibiting agent is added, such that mesotrione original drug crystal transition and decomposition can be effectively inhibited.

The invention relates to an amorphous crystal form of a latest-generation cardiotonic agent valsartan ((2R, 4S)-5-biphenyl-4-group-5-(3-carboxyl-propionyl-amino)-2-methyl-ethyl valerate) trisodium and a preparation method of the cardiotonic agent.

The invention provides a self-assembling light-emitting conductive nano medicinal crystal and ultra-thin film, and the preparing process, wherein non-resilient electronic tunneling interaction is employed for self-assembling oxidation resistant enzyme oxygen free radical antagonist, beta-receptor agonist, P2 receptor agonist, benzene alkylamines calcium antagonist monomer, and bibasic, ternary and quaternary compound.

The invention provides a flurbiprofen cataplasm and a preparation method thereof. The cataplasm consists of a backing, a paste body and an anti-adhesion membrane, wherein the paste body is prepared from the following components: emulsion, a first tackifier, a humectant, a gel skeleton material, a cross-linking agent, a cross-linking regulator and a filler; the emulsion is obtained by mixing a component A and a component B; the component A is obtained by mixing flurbiprofen, a surfactant and a solvent; the component B is prepared from a pH regulator, a second tackifier and water; the surfactant is prepared from benzyl ether and span, or is prepared from Kolliphor HS 15 and span; and the gel skeleton material is selected from at least one of partially neutralized sodium polyacrylate, carbomer, polyacrylic acid, polyvinylpyrrolidone and polybutylene. The flurbiprofen cataplasm is good in percutaneous absorption and good in storage stability, and drug crystals cannot be separated out after long-term storage.

The invention relates to the technical field of medicine crystals, in particular to a sodium fusidate novel crystal form and a preparation method and application thereof. In an X-ray powder diffraction spectrogram of the novel crystal form, the sodium fusidate novel crystal form has characteristic peaks at the positions of 9.646 degrees, 10.882 degrees, 11.034 degrees, 13.840 degrees, 14.046 degrees, 16.577 degrees, 17.318 degrees, 17.687 degrees, 18.072 degrees, 19.868 degrees, 23.036 degrees, 25.489 degrees and 27.400 degrees as shown in 2 theta+/-0.2 degrees. The novel sodium fusidate crystal form prepared by the invention has the advantages of good fluidity, convenience in subpackage and preservation and the like, can be used for preparing a sodium fusidate injection, and is favorable for improving the medicine quality and the like.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a drug-loaded emulsion of a liquid crystal coated crystal drug and a preparation method thereof. The emulsion comprises a crystal drug and a liquid crystal emulsifier. A lamellar liquid crystal structure similar to a human skin cuticle structure exists in the drug-loaded emulsion of the liquid crystal coated crystal drug, and meanwhile, a crystal drug crystal structure also exists in the emulsion. The drug-loaded emulsion provided by the invention overcomes the defects of poor water solubility, low biofilm permeability of active components of traditional drugs, and has the advantages of high skin safety, multiple slow release characteristics, drug entrapment rate of nearly 100% and the like; and provides a new design idea for the development of an efficient drug-loaded emulsion preparation with higher retention rate of the active pharmaceutical ingredients, better preparation stability and more effective entrapment of the active pharmaceutical ingredients.

Provided are a method and device for forming a drug coating layer with which it is possible to suppress damage to elongated drug crystals on the surface of a balloon and to maintain a suitable shape for causing the drug crystals to act on a living body. A method for forming a drug coating layer (40) in which a plurality of elongated bodies (42), which are crystals of a water-insoluble drug havinga length axis, are formed on the surface of a balloon (30), wherein the method has: a step in which a coating solution that includes a water-insoluble drug, a water-soluble additive, an organic solvent, and water is supplied to the surface of the balloon (30), the organic solvent and the water are caused to evaporate, and each of an additive layer (41) which includes the water-soluble additive andprojecting crystals (48) the tips of which project from the additive layer (41) are formed; a step in which a surplus portion (49) of the projecting crystals (48) that projects from the additive layer (41) is cut out from a site surrounded by the additive layer (41), and the site surrounded by the additive layer (41) is formed into an elongated body (42); and a step in which the cut-out surplus portion (49) is removed from the drug coating layer (40).

The invention provides a drug crystal library based on a block chain and a construction method thereof, and the drug crystal library comprises that a first layer is a crystal source data layer and isused for acquiring crystal information and storing drug crystal original data, and the security and privacy are guaranteed by a data holder; the second layer is a crystal representation layer, is usedfor crystal information chaining, stores crystal information documents generated according to corresponding standards, and ensures unique identification of one crystal form; and the third layer is acrystal index layer, is used for querying crystal related information, is realized through blockchain nodes, and stores shared document index information and query information. The method is suitablefor construction of a drug molecular crystal library, drug molecular crystal form information is managed by using a block chain, functions of adding, searching, comparing and the like of drug molecular crystal forms are realized in combination with software, and the purposes of protecting, authorizing and the like of the molecular crystal forms are achieved.

The invention relates to a method for preparing acicular acetaminophen crystal by a time domain shaped femtosecond laser, and belongs to the field of preparation of pharmaceutical crystal materials. The method comprises the following steps: (1) preparing a supersaturated solution of acetaminophen by using a heating device; (2) using a femtosecond laser irradiation method to enable the acetaminophen supersaturated solution to be ionized to generate cavitation bubbles and generate acicular acetaminophen crystal as the bubbles rupture; and (3) drying filtered acicular acetaminophen crystal by using a heating device. The method for preparing the acicular paracetamol crystal provided by the invention is carried out under normal temperature and normal pressure without any addition in the production, the manufacturing time is short, the ratio of the acetaminophen crystal is high, and the size is controllable.

The invention belongs to the field of medical preparation, and more specifically discloses a preparation method of tedizolid phosphate composition tablets. The preparation method comprise following steps: tedizolid phosphate, pregelatinized starch, sucrose, tyrosine, polacrilin potassium, and sodium lauryl sulfate are added into a 5% polyvinylpyrrolidone K30 solution, and wet granulation sodium lauryl sulfate is adopted so as to obtain the tedizolid phosphate composition tablets. The stability of the tedizolid phosphate composition tablets is improved obviously via screening on the accessory ingredients and controlling on the amount; and drug crystal transformation technical problem in wet granulation is solved via screening on the kind and the amount of a binding agent. It is found via experiments that, compared with the prior art, the preparation method possesses following advantages: the curative effect is better, the adverse reaction is reduced, and antimicrobial activity on MRSA is increased obviously.

The invention relates to non-steroidal anti-inflammatory drug ultra-fine powder and a preparation method thereof. A non-steroidal anti-inflammatory drug has the functions of resisting inflammations and rheumatism, relieving pain, bringing down a fever and resisting blood coagulation and is widely used for alleviating osteoarthritis, rheumatoid arthritis, various fevers and various painful symptoms in clinic. The method for preparing the non-steroidal anti-inflammatory drug ultra-fine powder comprises the steps that non-steroidal anti-inflammatory drug crystals are rapidly obtained by exerting ultrasonic waves with the frequency ranging from 10 kHz to 500 kHz, the power ranging from 1 mW to 5000 W and the sound intensity ranging from 0.1 mW/cm<2> to 500 w/cm<2> into a homogeneous solution containing the non-steroidal anti-inflammatory drug, and then the non-steroidal anti-inflammatory drug ultra-fine powder is directly obtained after normal operations such as solid collection, washing and drying are conducted. The non-steroidal anti-inflammatory drug ultra-fine powder is free of substrate materials and has the advantages that the drug-loading rate is high, the dissolution velocity is high, higher bioavailability is easy to achieve, and the stability and the safety are achieved, so that the requirements for improving the bioavailability of the drug, decreasing the drug dosage and reducing adverse reactions are met, and a wide application prospect in clinic is achieved.

The invention provides a medicine balloon catheter as well as a preparation method and application thereof. The medicine balloon catheter comprises a balloon catheter as well as a medicine coating and a phospholipid excipient layer which are sequentially coated on the outer surface of the balloon catheter. The phospholipid excipient layer effectively balances the bonding force among the drug coating, the balloon catheter and the blood vessel wall, drug loss in the conveying process can be reduced, the drug utilization rate can be increased, and the release rate of the drug at the diseased region and the immediate absorption rate of the blood vessel to the drug can be increased; in addition, drug crystals in the drug coating are more uniform in size, and the stability of the drug balloon catheter is higher.