200 results about "Steroid Compound" patented technology

Disclosed are a steroid compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a use thereof. The compound has SREBP pathway inhibitory activity, and can be used for preventing and / or treating diseases such as obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, and skin injury.

The invention relates to a steroid compound and a pharmaceutical composition containing the steroid compound. The steroid compound has a structure as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the structure as shown in the formula (I). The compound or the composition provided by the invention can be used for preparing medicines for preventing, treating, treating or relieving eye diseases of patients. # imgabs0 #

The present invention relates to a steroid compound and a conjugate thereof, and specifically relates to a compound and a conjugate thereof, or a tautomer, a mesomer, a racemate, an enantiomer and a diastereoisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof; and a method for preparing the compound and the conjugate thereof and the use thereof.

The invention discloses a steroid compound as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a prodrug, or a pharmaceutically acceptable salt or ester thereof. The invention also discloses application of the steroid compound in preparation of medicines for treating ophthalmic diseases. # imgabs0 #

The invention relates to a steroid compound with a structure as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite and a prodrug thereof, or a pharmaceutically acceptable salt or ester thereof, and application of the steroid compound in preparation of medicines for treating ophthalmic diseases. # imgabs0 #

The invention relates to a steroid compound and a pharmaceutical composition containing the steroid compound. The steroid compound has a structure as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the structure as shown in the formula (I). The compound or the composition provided by the invention can be used for preparing medicines for preventing, treating, treating or relieving eye diseases of patients. # imgabs0 #

The invention relates to a steroid compound and a pharmaceutical composition containing the steroid compound. The steroid compound has a structure as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the structure as shown in the formula (I). The compound or the composition provided by the invention can be used for preparing medicines for preventing, treating, treating or relieving eye diseases of patients. # imgabs0 #

The invention discloses a 3-ketosteroid-delta1-dehydrogenase mutant and application of the 3-ketosteroid-delta1-dehydrogenase mutant in catalyzing dehydrogenation of a steroid compound, the mutant with high catalytic activity is obtained through screening, and the solubility of a substrate is increased by adding a cosolvent Tween-80, so that the biological catalytic efficiency is improved. Under the optimal condition, the mutant disclosed by the invention can improve the feeding amount conversion rate of 15g / L of (16 alpha)-methyl androstane-4, 9-diene-3, 17-diketone to 99.9%.

The invention relates to a steroid compound and a composition containing the steroid compound. The compound or the composition can be used for preparing medicines for preventing, treating, treating or alleviating metabolic diseases of patients.

Disclosed in the present invention are steroid compounds, a preparation method therefor and the use thereof. Particularly disclosed are steroid compounds having a structure shown as formula (I), (II) or (III), etc., or pharmaceutically acceptable salts thereof. The compounds provided by the present invention have SREBP pathway inhibitory activity, and thus can be used for preventing and / or treating obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, skin injury and other diseases.

The composition comprising a ginseng-based extract selected from the group consisting of a ginseng extract, a red ginseng extract, and a black ginseng extract and a steroid compound as active ingredients according to the present invention has a broad virus inhibitory activity, and thus can be used for effectively preventing, improving, or treating infections caused by viruses or diseases caused by infections.

The invention relates to a steroid compound and a pharmaceutical composition containing the steroid compound. The steroid compound has a structure as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the structure as shown in the formula (I). The compound or the composition provided by the invention can be used for preparing medicines for preventing, treating, treating or relieving eye diseases of patients. # imgabs0 #

The invention belongs to the technical field of preparation of steroid hormone drugs, and particularly relates to a preparation method of an alpha epoxy steroid compound, which comprises the following steps: by taking a steroid compound I containing a carbon-carbon double bond as a raw material, adding an alkaline reagent, a catalyst and hydrogen peroxide in a solvent clarified state, carrying out epoxy synthesis reaction to obtain an alpha epoxy steroid compound II; wherein the catalyst refers to 3 ', 5'-dichloro-2, 2, 2-trifluoroacetophenone, and the catalyst refers to 3 ', 5'-dichloro-2, 2, 2-trifluoroacetophenone. The invention effectively solves the problems of many isomerization byproducts, low yield, long production period and high comprehensive production cost in the prior art, and provides the preparation method of the alpha epoxy steroid compound with high selectivity and obvious economic benefit, so that the process is more suitable for industrial mass production.

The present application provides a kind of application of the steroid compound in preparation prevention or treatment skin pigmentation related condition or anti-aging related product, the steroid compound is as shown in formula I, and has treatment, lightening and / or alleviating effect on senile plaques, freckles, chloasma and the like caused by pigmentation on the skin of mammal.(I).

The invention discloses a steroid compound, which has the following structural formula I: # imgabs0. The steroid compound can retard the pulmonary fibrosis progress by inhibiting fibroblast proliferation, regulating the generation and degradation of extracellular matrix and inhibiting inflammation.

The application discloses a kind of steroid compounds and preparation method and purposes, and the structure of the steroid compound is as shown in formula I, wherein the definition of each substituent group is described in the specification and claims.The steroid compound of the application is a steroid compound with excellent AR antagonistic and AR degradation activity dual function, with good drug properties, good safety characteristics, and can be used for the treatment of diseases related to AR signal pathway.

The application of a steroid compound in the preparation of a medicine for preventing and / or treating floaters. The steroid compound can have a good treatment, alleviation and prevention effect on floaters, can greatly alleviate and / or cure floaters, and improve visual clarity.

The invention belongs to the technical field of anti-tumor drugs, and particularly relates to a flexible drug-loaded cell microparticle capable of efficiently targeting tumors and a preparation method of the flexible drug-loaded cell microparticle. Comprising tumor cell-derived drug-loaded microparticles coated with chemotherapeutic drugs, and a flexible regulator modified on the surfaces of the tumor cell-derived drug-loaded microparticles, the flexible regulator comprises a saponin compound and / or a steroid compound, and can regulate and control the hardness of the tumor cell-derived drug-loaded microparticles. The tumor cell-derived drug-loaded microparticles are modified, so that the enrichment and deep penetration of the drug-loaded microparticles in tumor tissues can be remarkably improved, and the efficient targeted delivery of the tumor tissues is realized. Meanwhile, efficient uptake of tumor stem cells to the medicine is promoted, targeted killing is achieved, the tumor stem cells are effectively removed, and tumor growth is remarkably inhibited. In addition, circulating tumor cells can be efficiently targeted, accurate delivery of tumor metastasis is achieved, and tumor metastasis is remarkably inhibited by inhibiting migration and invasion of tumor cells and reducing formation of lung metastasis.

The embodiment of the invention provides an oxadiazole-steroid compound, a pharmaceutical composition and application. The oxadiazole-steroid compound is a compound with a structure as shown in a formula I or pharmaceutically acceptable salt of the compound or a mixture of the compound and the pharmaceutically acceptable salt. The oxadiazole-steroid compound provided by the embodiment of the invention can effectively activate a metabolic regulation target FXR, and has excellent potential for preventing or treating MAFLD and related complications thereof. Meanwhile, the compound has no excitation effect on an MRGPRX4 receptor possibly causing pruritus while maintaining the FXR excitation activity, and a safer choice is provided for treatment of related diseases. Therefore, the oxadiazole-steroid compound has a more remarkable application prospect in preparation of the medicine for treating the metabolism-related fatty liver disease.

The present invention provides a method for dehalogenating 9-halogenated steroid compounds and its application, which relates to the technical field of chemical synthesis. The method for dehalogenating 9-halogenated steroid compounds includes the following steps: Compound I reacts with a thiofatty acid salt to obtain the 9-dehalogenated product Compound II of the 9-halogenated steroid compound. The method for dehalogenating 9-halogenated steroid compounds provided by the present invention reacts Compound I with a thiofatty acid salt to obtain the 9-dehalogenated product Compound II of the 9-halogenated steroid compound. Toxic reagents such as zinc powder, chromium granules or tri-n-butyltin, which are highly toxic and cause serious environmental pollution, are not used in the reaction. It is green and environmentally friendly, the synthesis process is simple and easy to operate, and the production applicability is improved.

The invention belongs to the technical field of biology, and relates to a method for producing a steroid compound by utilizing saccharomyces cerevisiae. The method comprises the following steps: replacing a YPL062w gene of the saccharomyces cerevisiae with an expression cassette of a PptHMGR gene, replacing a DPP1 gene of the saccharomyces cerevisiae with an expression cassette of ERG10, ERG13 and tHMG1 genes, replacing an LPP1 gene of the saccharomyces cerevisiae with an expression cassette of ERG12, ERG8, ERG19 and IDI1 genes, replacing an ROX1 gene of the saccharomyces cerevisiae with an expression cassette of ERG20, ERG9 and ERG1 genes, and replacing an ARO10 gene of the saccharomyces cerevisiae with an expression cassette of ERG11, ERG2 and ERG3 genes. An expression cassette of ERG1, DrDHCR7, GgDHCR24 and LEU2 genes is inserted into a delta DNA multi-copy site, and a first recombinant strain capable of synthesizing cholesterol is obtained; introducing a coding gene of an enzyme required for synthesizing a target steroid compound by taking cholesterol as a precursor into the genome of the first recombinant strain to obtain a second recombinant strain; and culturing the second recombinant strain and extracting the target steroid compound. The method has a wide application prospect in steroid compound production.

The invention relates to a steroidal compound as well as a preparation method and application thereof. Specifically, the invention provides a compound shown as a general formula (I), a stereoisomer or pharmaceutically acceptable salt of the compound, a preparation method of the compound, a pharmaceutical composition containing the compound and application of the compound as a GABAa receptor modulator to treatment of CNS-related diseases.

The present application relates to a kind of steroid compound Aglatestate A, its preparation method and purposes, belong to medical field.The compound is extracted from the leaves of horse kidney fruit branch, preparation separation is simple.The present application has better inhibiting effect on the release of inflammatory factor of LPS-induced RAW264.7 cell, when in non-toxic concentration, the inhibiting effect of compound on the release of inflammatory factor NO of LPS-induced RAW264.7 cell is good, and the anti-inflammatory effect IC 50 =3.41±0.05 close to positive drug PDTC (NF-κB inhibitor / antioxidant), therefore, compound Aglatestate A has good development prospects of anti-inflammatory drug, and lay a solid foundation for the preparation of anti-inflammatory drug technology development.

The invention relates to the field of compounds, and discloses a steroidal compound with a structure of a general formula I, application and a preparation method thereof and a pharmaceutical composition containing the steroidal compound, the steroidal compound has a relatively strong positive regulation effect on a GABAA receptor, can be used for preparing oral medicines for resisting severe depression and postpartum depression, and has the characteristic of high efficiency.

The present application relates to the field of compounds, discloses a kind of steroid compound with general formula I structure and its purposes, preparation method and the pharmaceutical composition comprising the steroid compound, to GABA A Receptor has strong positive regulation, can be used for preparing oral anti-severe depression and postpartum depression drug, with the characteristics of high efficiency.

This invention belongs to the technical field of steroid compound preparation, specifically relating to a safe post-processing technology for 11α,17α-dihydroxyprogesterone fermentation broth, comprising four processing steps: 1) extraction; 2) saponification; 3) secondary dissolution for impurity removal; and 4) decolorization. This invention employs a four-step post-processing procedure of extraction-saponification-secondary dissolution for impurity removal-decolorization, which not only improves the yield and purity of 11α,17α-dihydroxyprogesterone, achieving a purity of over 99%, but also solves the problem of high-yield extraction of 11α,17α-dihydroxyprogesterone from fermentation broth. Furthermore, it makes the reaction conditions milder, the operation simpler, safer, and more reliable, making it more suitable for large-scale production.

The invention belongs to the technical field of phytochemistry and botanical pesticides, and relates to a C-23 spiro cholestane type steroid compound as well as a preparation method and application thereof. The C-23 spiro-cholestane type steroid compound disclosed by the invention has a remarkable inhibition effect on growth of grass, and can be used as an effective component of a plant source herbicide.

The application discloses a kind of steroidal compounds with anti-parkinson disease activity and its preparation method and application.The steroidal compound has the structure as shown in formula (I) or formula (II), or stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug of the structure shown in formula (I) or formula (II).The application is fermented by fungal co-cultivation to alternaria brassicae and penicillium granatum, and the expression of silent gene of strain is promoted by adopting co-cultivation and optimizing medium condition strategy, novel secondary metabolite is obtained, and new steroidal compound with treatment parkinson disease value and application prospect is extracted and separated from co-cultivation ferment, which provides great prospect for the research and development of parkinson disease treatment drugs.

The invention belongs to the technical field of bioengineering, and relates to a steroid C14 beta hydroxylase, an expression vector, an engineering bacterium and application thereof, the amino acid sequence of the hydroxylase is selected from a sequence shown in SEQ ID No.9 or a sequence modified on the basis of the sequence, or a sequence having at least 58% homology with the sequence. The hydroxylation of the steroid C14 beta is directly completed in one step, and the efficient and specific hydroxylation of the steroid compound C14 beta can be realized, so that the problem that the C14 beta hydroxylated steroid cannot be directly synthesized is solved.