12 results about "Steroid Compound" patented technology

The present application provides a kind of application of the steroid compound in preparation prevention or treatment skin pigmentation related condition or anti-aging related product, the steroid compound is as shown in formula I, and has treatment, lightening and / or alleviating effect on senile plaques, freckles, chloasma and the like caused by pigmentation on the skin of mammal.(I).

The present invention provides an estetrol synthesis process, and relates to the technical field of steroid compound synthesis processes, and the method comprises the following steps: taking estrone as an initial raw material, firstly carrying out 3-site hydroxyl protection, and then carrying out an oxidative dehydrogenation reaction in the presence of a metal catalyst and in an oxygen atmosphere to prepare a key intermediate ketene, then 17-site carbonyl reduction, 17-site hydroxyl protection, 15, 16-site double bond dihydroxylation, 3-site protecting group removal and hydrolysis reaction are sequentially carried out, and finally the target product estetrol is obtained. The method adopts metal catalysis to directly oxidize to construct cycloenone, effectively avoids the problem of poor stability of partial intermediates in the prior art, has the advantages of simple process, short reaction steps, greenness, environmental protection and the like, and is suitable for industrial production.

Methods for stereoselectively crystallizing 3-keto-5β-cholanic acid (“3-KCA”) and 3-ketoursodeoxycholic acid (“3-KUDCA”) of extremely high purity, salts for carrying out such methods, particularly tert-butylamine and cyclohexylamine salts of 3-KCA, tert-butylamine salts of 3-KUDCA, and crystalline forms of these salts, as well as methods for preparing commercial steroid compounds from these purified materials.

The application discloses a 3-steroid ketone-delta 1-dehydrogenase mutant and application thereof in catalyzing dehydrogenation of a steroid compound, and the mutant with high catalytic activity is screened, and a cosolvent Tween-80 is added to increase solubility of a substrate and then improve biological catalytic efficiency.Under optimal conditions, the mutant can increase the conversion rate of (16alpha)-methyl androst-4,9-diene-3,17-dione 15g / L to 99.9%.

This invention belongs to the field of biotechnology, specifically relating to a C-containing... 16 A method for preparing β-O-acyl cardiac steroid compounds. This invention first prepares C... 16 β-hydroxylated cardiotonic steroid compounds, followed by a simple chemical derivatization step, can achieve C... 16 Efficient synthesis of β-O-acyl cardiotonic steroids. This invention also provides a newly discovered steroid C 16 β-hydroxylase and recombinant engineered strains expressing this enzyme, which can efficiently and selectively catalyze the C-hydroxylation of cardiotonic steroid compounds. 16 β-hydroxylation. The method of this invention is environmentally friendly, easy to operate, and cost-effective, demonstrating great potential for industrial application and cost competitiveness.

The present application relates to the field of steroid drugs and biotechnology, and relates to a novel steroid hydroxylase CYP68BE1 from Beauveria bassiana, a coding gene thereof and application. Specifically, the present application provides a novel steroid hydroxylase CYP68BE1 from Beauveria bassiana, a nucleic acid molecule coding the enzyme, a vector containing the nucleic acid molecule, and a recombinant bacterium containing the vector or having the nucleic acid molecule integrated therein. Through recombination of yeast bacteria or microsomal transformation of steroids, it is found that the CYP68BE1 enzyme can catalyze the hydroxylation reaction of C11α and / or C6β and / or C1β and / or C1α of steroid compounds. Among them, the transformation products include various steroid drug intermediates and / or steroid active compounds, and the present application has great application potential and economic value.

This invention discloses a steroidal compound with anti-lipotoxicity and antioxidant activity, its preparation method, and its applications. The steroidal compound is β-sitosterol-3-β-O-glucopyranoside-6′-O-palmitate, with the structural formula shown below. The steroidal compound BSBD of this invention exhibits significant anti-lipotoxicity and antioxidant activity in a HepG2 cell model induced by the combined effects of free fatty acids and hydrogen peroxide, showing great promise for application in the preparation of drugs for the prevention or treatment of non-alcoholic steatohepatitis.

The application discloses a preparation method of a steroid compound with the functions of inducing DNA damage of liver cancer cells and relieving neuroinflammation, and belongs to the technical field of drug synthesis. The technical solution of the application is characterized by the following: the molecular structure of the steroid compound is: or, wherein R is an aryl compound, an alkyl compound, a heterocyclic compound, or wherein X is an aryl compound. The application designs and synthesizes a novel steroid compound. The compound not only has the ability of inducing DNA damage and apoptosis of HepG2 cells, but also can effectively relieve the release of NO of microglial cells induced by LPS.

The present application provides a steroid compound for treating central nervous system diseases, having a 9β, 10α structure and having the following structural formula: which acts as a GABA modulator, prolongs the opening time of chloride ion channel activated by GABA, modulates the excitability of central nervous system (CNS), treats and prevents CNS related disorders; and the 9β, 10α steroid compound of the present application has a sedative effect and can be used as a sedative.

The application discloses a synthesis method of a renal fibrosis inhibitor from marine fungi and application of the renal fibrosis inhibitor in preparation of an anti-renal fibrosis drug, wherein the renal fibrosis inhibitor from marine fungi is a ergosterol-pyrone hybrid steroid compound with a structure as shown in formula I, and the method comprises the following steps: in a non-proton organic solvent, taking ergosterol and a pyrone derivative as substrates, performing one-step non-enzymatic coupling reaction in the presence of an acid promoter, and after the reaction is completed, performing separation and purification to obtain the renal fibrosis inhibitor from marine fungi, wherein the synthesis route is extremely simple, the yield is high, a production bottleneck is broken, and the obtained striasteroid B has significant inhibitory renal fibrosis activity and drug-making potential: I, wherein R is -CH3 or -CH2OH.

Disclosed in the present invention are a steroid compound, and a preparation method therefor and an application thereof. The steroid compound may have a structure as shown in formula XXI, etc. The compound of the present invention has SREBP pathway inhibitory activity, and can be used for preventing and / or treating diseases such as obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, and skin damage.