140 results about "Ketene" patented technology

This invention relates to the field of chemical synthesis technology, specifically disclosing a high-temperature pyrolysis reaction system and its application. The high-temperature pyrolysis reaction system of this invention employs a two-stage reactor design and is filled with a differentiated catalyst. Combined with acetone as an intermediate feedstock between the two stages, it improves the feedstock conversion rate and the selectivity of the target product. The biomimetic integral catalyst solves the problems of poor mass transfer, high pressure resistance, and backmixing caused by traditional packing materials, achieving precise control of the pyrolysis time and inhibiting secondary polymerization and reverse reactions of the product at high temperatures. Through synergistic optimization of reactor configuration, catalyst structure, and separation technology, the entire system effectively suppresses carbon deposition, achieving efficient preparation of dimethyl ketene. This invention forms an integrated high-temperature pyrolysis reaction system from pyrolysis reactor design, catalyst structure design, and improved separation technology, and applies it to the pyrolysis of isobutyric anhydride to produce dimethyl ketene, achieving high feedstock conversion rate and high selectivity of the target product.

The application discloses a kind of composite super-hydrophobic paper based on alkyl ketene dimer and metal polyphenol network and preparation method thereof, belong to functional paper-based material field.The method is first immersed in 0.25%~5% alkyl ketene dimer emulsion in cellulose paper, is dried at 90~110 DEG C and is cured 48-96h to prepare modified paper;Then, the pH is 8.0-9.0 of tris-hydroxymethyl aminomethane hydrochloride buffer solution, hydrochloric acid dopamine is dissolved in the buffer solution to form dopamine solution, and the concentration is 0.25~20mg / mL of metal ion solution;Finally, the modified paper is immersed in dopamine solution and metal ion solution in turn, and is dried to obtain composite super-hydrophobic paper.The obtained composite super-hydrophobic paper uses cellulose paper-based material as substrate, and hydrophobic layer and metal polyphenol network layer are formed on the surface in turn, the composite paper has super-hydrophobic performance, water barrier performance and photo-thermal response performance, the preparation process is simple, and is suitable for waterproof packaging, self-cleaning surface, anti-icing and deicing and photo-thermal antibacterial and other fields.

This invention relates to the field of enzyme engineering technology, and in particular to a highly efficient lactone hydrolase mutant for degrading zearalenone and its applications. This lactone hydrolase mutant uses the lactone hydrolase gene from Monosporascus sp. GIB2 as a template, and performs a site-directed mutation at amino acid position 134 to obtain L134A, L134V, L134I, and L134M mutants. Under optimal conditions of pH 9.0 and 60℃, these single-point mutants can efficiently degrade zearalenone (ZEN) within 3 minutes. The enzyme activity for degrading zearalenone is significantly improved compared to the original enzyme, with degradation activities increasing by 1.22 (L134A), 1.25 (L134V), 1.17 (L134I), and 1.14 (L134M), respectively, demonstrating significant applications and economic value in the feed industry.

The application discloses a preparation and by-product recycling process of acesulfame potassium, and belongs to the technical field of food additive production and processing. Amino sulfonic acid is added into N-butyl pyridine hydrogen sulfate ionic liquid and triethylamine in batches to obtain a homogeneous mixed solution; secondly, the mixed solution and diketene are introduced into a micro-channel reactor to perform a condensation reaction; and the discharge liquid is introduced into a polystyrene sulfonic acid resin loaded SO3 fixed bed reactor to perform a cyclization reaction; subsequently, the cyclization product is subjected to hydrolysis, decolorization, potassium salt crystallization and drying to obtain the acesulfame potassium product; and the crystallization mother liquor is separated through a nanofiltration membrane, and the intercepted liquid is an ionic liquid and triethylamine mixture, which is directly reused. The application inhibits the self-polymerization of diketene through the micro-channel reactor, replaces concentrated sulfuric acid with solid acid to avoid waste acid pollution, and realizes efficient recycling of by-products by combining nanofiltration membrane separation and catalytic depolymerization technology, and has the characteristics of green environmental protection and economic efficiency.

Derivatives of Sabinene (1-isopropyl-4-methylenebicyclo[3.1.0]hexane, CAS No. 3387-41-5), as well as their synthesis and use in organoleptic applications, are described herein. The Sabinene derivatives include a compound having a general Formula (I), wherein --- is a single or a double bond; wherein if --- is a single bond, then Y is selected from the group consisting of CH2R1, CH=C(R2)R3, and (CH2)xCHR3R4; and OR5; wherein if --- is a double bond, then Y is O, N-OMe, or N-OEt; R is selected from the group consisting of H, C(O)-R6, and CH(R6)-OR5; R1 is selected from the group consisting of 1,3-dioxepan, 5-methyl-1,3-dioxolan-4-one, (CH=CH)x(CH2)nOH, (CH=CH)x(CH2)nCHO, CH(CH3)CO2Et, and CH(CH3)OH; R2 = H or Me; R3 is selected from the group consisting of CHO, CO2Et, (CH2)nOH, (CH2)nCHO, (CH2)nCN, and (CH2)nCO2Bu; and R4 is CHO or CH2OH; or R3 and R4 in combination form a dihydropyran, a tetrahydropyran, a tetrahydropyranol, a tetrahydropyranone, a dimethylcyclohexenone, or a dimethylcyclohexenol; R5 is selected from the group consisting of CH(CH3), CH(CH2CH3), C(CH3)CH3, and C(CH3)CH2CH3; R6 is selected from the group consisting of OMe and Me; x is an integer selected from 0 or 1; and n is an integer selected from 2 to 7; with the proviso that when --- is a double bond and Y is O, then R and R6 are not H.

A composite material comprising an adhesive film comprising a polar polymer bonding layer of ethylene methyl acrylate and ketene vinyl acrylate, and a bonding resin of polyethylene, polypropylene, ethyl vinyl acetate, acrylate, or combinations thereof; a metal substrate adhered to the bonding resin; and a polymer layer adhered to the polar polymer bonding layer, the polymer layer comprising polyvinyl chloride.

The present disclosure relates to solid state forms of (7R,14R)-1-(difluoromethoxy)-11-(4-(dimethylphosphoryl)-3-fluorophenyl)-10-fluoro-6-(methyl-d3)-6,7-dihydro-7,14-methanobenzo[f]benzo[4,5]imidazo[1,2-a][1,4]diazocin-5(14H)-one and salts thereof. Such solid state forms are useful in preparation of pharmaceutical compositions and dosage forms for the treatment of disease.

The application belongs to the technical field of medicine synthesis, and particularly relates to a 5H-dibenzo[a,d]cycloheptatriene-5-ketone intermediate compound and a method for preparing 5H-dibenzo[a,d]cycloheptatriene-5-ketone. The method uses SM-1 as a starting material, reacts with ethanethiol first, and then is coupled with SM-2 to obtain the intermediate compound I-2, and the compound I-2 can be reacted for one step under the action of a catalyst to obtain 5H-dibenzo[a,d]cycloheptatriene-5-ketone. The preparation method solves the problems of complex operation and high toxicity in the prior art, is simple to operate, the obtained product has high yield and purity, the reaction period is short, and is suitable for industrial production.

The present invention discloses a composition of an unbleached natural brown copier paper without using any bleaching chemicals or dyes comprising of pulp extracted from waste paper material of corrugated cartons, starch, and fillers. It further includes AKD (Alkyl Ketene Dimer) and enzymes. The waste paper material includes the percentage of 30% to 60% old Indian corrugated cartons (OCC), 20% to 70% old imported corrugated cartons (OCC) and 20% to 50% white record / sorted office paper (SOP).

The utility model relates to a water-containing triethylamine automatic water separation device for AKD (alkyl ketene dimer) production. The water-containing triethylamine automatic water separation device comprises a condenser and an automatic water separation tank, the condenser comprises a shell pass inlet, a shell pass outlet I, a shell pass outlet II, a tube pass inlet and a tube pass outlet, the automatic water separation tank comprises a tank body, a layering pore plate and an overflow partition plate are fixedly installed on the bottom wall of the tank body, and an oil passing gap is reserved between the top end of the overflow partition plate and the top wall of the tank body. The interior of the tank body is divided into a pretreatment area, a water drainage area and an oil drainage area, and the water drainage area is located between the pretreatment area and the oil drainage area; the layering pore plate is arranged in the tank body, so that a liquid phase body uniformly enters the drainage area and is layered in the drainage area, a liquid phase positioned on the upper layer of a liquid surface overflows into the oil drainage area through the overflow partition plate and is discharged out of the tank body through the oil phase discharge pipeline, and a liquid phase positioned on the lower layer is discharged out of the tank body through the water phase discharge pipeline, and tedious manual dehydration operation is not needed in the period; the production process is obviously simplified, and the production efficiency is improved.

The invention discloses a zingiberenone A-containing composition with repairing and anti-wrinkle effects and a preparation process of the zingiberenone A-containing composition. The composition is prepared from the following components in percentage by weight: 0.0015 percent to 2 percent of zingiberenone A, 30 percent to 40 percent of glycerol, 30 percent to 40 percent of propylene glycol, 10 percent to 20 percent of polysorbate-80 and 10 percent to 20 percent of PEG-60 hydrogenated castor oil. The preparation process comprises the following steps: mixing the components, heating in a water bath at 40-50 DEG C, and ultrasonically stirring until the components are completely dissolved. Through specific auxiliary material compounding and process, the technical bottleneck of poor water solubility of zingiberenone A is overcome, so that zingiberenone A can be stably applied to cosmetics. Human body efficacy evaluation proves that the composition containing 0.0015% of zingiberenone A has remarkable anti-wrinkle, firming, moisturizing and soothing effects; the composition containing 0.015% of the composition has significant skin barrier repairing, moisturizing and soothing effects, and is mild and non-irritant. According to the invention, stabilization and efficacy verification of zingiberenone A in cosmetics are realized for the first time.

The application relates to the technical field of organic synthesis, and discloses a method for synthesizing 4-benzyl-5-hydroxy-1-phenyl-1-en-3-ketone compounds. In the application, silane is used as a reducing agent, organic phosphine is used as a ligand, a dibenzylideneacetone compound (I) and an aldehyde compound (II) are subjected to a conjugate reduction / aldol addition series reaction under the catalysis of Cu to obtain a 4-benzyl-5-hydroxy-1-phenyl-1-en-3-ketone compound (III). The method carries out two-step series reactions in the same reaction container, does not need to separate reaction intermediates, reduces the operation process of separation and purification, and is simple in operation. The reaction condition is mild, and the reaction can be carried out at normal temperature. The copper catalyst is a non-noble metal catalyst, and has the advantages of wide source and low price.

The invention discloses a diaryl pentane compound as well as a pharmaceutical composition, a preparation method and application thereof, and relates to the technical field of medicines. The preparation method comprises the following steps: reacting vanillin and acetone serving as starting raw materials to generate an (E)-4-(4-hydroxy-3-methoxyphenyl)-3-butene-2-one intermediate, carrying out condensation reaction on the intermediate and a benzaldehyde derivative under an alkaline condition to obtain a conjugated diaryl pentane derivative, and finally, carrying out palladium-carbon catalytic hydrogenation reaction to obtain the 4-(4-hydroxy-3-methoxyphenyl)-3-butene-2-ketone derivative. The target diaryl pentane derivative can be prepared; 3-(4-hydroxy-3-methoxyphenyl) propionic acid and a benzylamine derivative are used as raw materials, the amide diaryl pentane analogue is prepared through an amide condensation reaction, the synthesis process is simple and convenient, and the steps are simple. The diaryl pentane compound prepared by the invention has remarkable alpha-glucosidase inhibitory activity, can effectively reduce the blood sugar level of mice orally taking cane sugar and starch, and has wide application prospects in blood sugar reducing medicines, weight losing medicines and health-care foods with a blood sugar reducing function.

The invention discloses a method for synthesizing jasmine lactone through photocatalytic reaction, and belongs to the field of fine chemicals. The synthesis method comprises the following steps: taking (E)-1, 6-octadiene-3-ketone-2 and iodoacetic acid as raw materials, carrying out photocatalytic reaction to obtain (E)-5-oxo-8-decenoic acid, then reacting with sodium borohydride to obtain (E)-5-hydroxy-8-decenoic acid, and carrying out esterification reaction on a crude product under the catalysis of acid without separation to obtain jasmonlactone. The method for obtaining the jasmine lactone has the advantages of easiness in synthesis of raw materials, mild reaction conditions, low cost and few steps, shows the superiority and simplicity of the synthesis method, and provides a simple way for preparation of the compounds.

The application belongs to the field of organic synthesis and provides a synthesis method of tulikene ketone. The application adopts the design of solid acid-metal trapping catalyst A1-P and TEMPO solid resin catalyst B1-R synergistic catalysis, realizes the cyclization and condensation reaction of citral through the Brønsted acid site constructed by porous silica supported aminopropyl silane and phosphoric acid, combines the selective oxidation reaction of chloromethylated crosslinked polystyrene resin supported TEMPO, and realizes the preparation of beta-tulikene ketone through the double bond migration, dehydration and short path rectification under reduced pressure. The product area percentage is not less than 98.5%, the E configuration content is not less than 92%, the colority is not higher than 40 APHA, and the total heavy metal content is not higher than 5 ppm. The application solves the problems of poor mechanical stability of the catalyst fixed bed, low E configuration selectivity, high colority and heavy metal residue in the traditional process, is suitable for the preparation of food essence and daily chemical essence, and has wide application value.

Disclosed are novel phenalene-l-one photosensitizers capable of generating singlet oxygen, compositions comprising at least one novel phenalene-l-one photosensitizer, and uses of the novel phenalene-l-one photosensitizers. The compositions are bleaching compositions, comprising at least one phenalene-l-one photosensitizer, at least one persulfate, at least one alkalizing agent and at least one peroxide source. (Formula I)

The present invention pertains to the field of sizing agents. The present invention relates to an AKD-PEI conjugate and the composition and a preparation thereof. The AKD-PEI conjugate, which comprises a moiety derived from polyethyleneimine (PEI) and a moiety derived from an alkyl ketene dimer (AKD) covalently linked to each other, has improved stability and unexpected multifunctionality, involves simple preparation and low viscosity, and is beneficial for industrial application.

The present invention relates to a method for preparing an essentially cellulose-based microfluidic device. More particularly, said method is an additive method consisting specifically in encapsulating a microfluidic strip in a hydrophobizing mixture comprising microfibrillated cellulose and at least one hydrophobizing agent, preferably selected from alkyl ketene dimers (AKD), alkenylsuccinic acid anhydrides, rosin resins, silicones and mixtures thereof, preferably alkyl ketene dimers. The invention also relates to an essentially cellulose-based microfluidic device.

The invention belongs to the field of medicinal chemistry, and discloses a 3-(2, 4-dihydroxyphenyl)-2H-chromene-2-ketone derivative and application thereof. According to the present invention, 3-(2, 4-dihydroxyphenyl)-2H-chromene-2-ketone is adopted as a lead compound to carry out corresponding structure optimization so as to obtain a series of 3-(2, 4-dihydroxyphenyl)-2H-chromene-2-ketone PDE2 inhibitor derivatives, and the general formula of the 3-(2, 4-dihydroxyphenyl)-2H-chromene-2-ketone PDE2 inhibitor derivatives is shown in the specification. The compounds show excellent inhibitory activity on PDE2, have significant application prospects for treating central nervous system diseases, have potential curative effects on improving memory deficit, improving learning and cognition functions, relieving dyskinesia and the like, can be used as key active ingredients, are used for researching and developing special pharmaceutical preparations for inhibiting PDE2 activity, and have broad application prospects. And a new way is expected to be opened up for the treatment of central nervous system diseases.

To provide a liquid crystal alignment agent that can produce a liquid crystal element exhibiting good liquid crystal alignment properties, low charge accumulation, and rapid residual charge relaxation, as well as a liquid crystal alignment film with high strength. [Solution] A polymer (A) containing structural units derived from a monomer having a substructure represented by formula (1), and a group F which is at least one selected from the group consisting of polymerizable carbon-carbon unsaturated bond-containing groups, isocyanate groups, protected isocyanate groups, cyclic carbonate groups, groups having a ketene structure, groups having a meldrum acid structure, cyclic ether groups, cyclic thioether groups, oxazoline groups, protected hydroxyalkylamide groups, protected thiol groups, and protected secondary amino groups. 1 A liquid crystal alignment agent containing a compound (B) having a total of two or more of in one molecule and lacking an aromatic ring. In formula (1), Ar 1 and Ar 2 This is a divalent aromatic ring group, etc. 1 X is a hydrogen atom, etc. 1 is -O- etc. TIFF2026087169000033.tif20169

The invention relates to the field of organic chemistry and pharmacy and provides a novel compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate, a method for treating and preventing functional gastrointestinal disorders, which comprises administering an effective amount of compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxy benzoate 4-methyl-2H-chromen-2-on-7-yl sulphate to a patient in need thereof, a pharmaceutical composition based on compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate, a drug comprising compound [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate, and a finished dosage form comprising compound [L-(dimethylamino)-2-phenybutyl ]-3,4,5 -trimethoxybenzoate 4-methyl-2H-chromen-2-on-7-yl sulphate. The invention further relates to the use of compound [2-(dimethylamino) phenylbutyl]-3,4,5-trimethoxy benzoate 4-methyl-2H-chromen-2-on-7-yl sulphate for treating and preventing functional gastrointestinal disorders.

The invention provides a qualitative detection method for AKD and ASA sizing agents in a paper product. The method comprises the following steps: (1) treating a sample; (2) preparing a test sample; (3) preparing a comparison sample; and (4) carrying out thermal cracking-gas chromatography-mass spectrometry combined detection. According to the present invention, the AKD and the ASA in the paper product are qualitatively determined by using the thermal cracking-gas chromatography-mass spectrometry combined method through the research, the paper sample is directly placed in the pyrolysis instrument connected with the gas chromatograph, the cellulose is completely decomposed into the volatile substance at the high temperature, the reacted sizing agent and the unreacted sizing agent in the paper product are released, and the paper product is subjected to the thermal cracking-gas chromatography-mass spectrometry combined method, and whether the paper product contains the sizing agents such as AKD and ASA or not can be qualitatively analyzed according to test data of a gas chromatography-mass spectrometer. The technical scheme is simple, rapid and low in cost, and provides a reliable basis for paper identification and fiber source analysis.

The invention relates to the compound (2S,3S,4R,5R,6S,8R,9S,11R,15R)-3,5,15- triacetoxy-6(17)-epoxy-8-hydroxylathyrane-12E-en-14-one, also called (8R)-8-hydroxyepoxyboetirane A, as well as to a method for obtaining same and the use thereof to promote neuronal differentiation from neural precursors or neural stem cells in culture and in brain lesions. The invention also relates to the use of this compound to prepare a pharmaceutical composition that can be used to treat central nervous system lesions associated with neuron loss.

A laminated adhesive tape includes a substrate comprising two or more plies of thin, flexible material, the substrate having a first major surface and a second major surface opposite the first major surface. A polymeric laminating composition comprising a polymer and an alkyl ketene dimer binds the two or more plies and a pressure sensitive adhesive carried on the first major surface. In a further aspect, a method of making a laminated adhesive tape is provided.

The application discloses a preparation method of alpha-tuliketone, relates to organic synthesis technology utilization, and the preparation is that 4,8-dimethyl-3,7-nonadiene-2-ketone and triacetal are subjected to aldol condensation reaction under the action of acid-base bifunctional catalyst to generate alpha-tuliketone; the acid-base bifunctional catalyst is obtained by grafting organic base onto carboxylic acid functionalized mesoporous material.The acid-base bifunctional catalyst is simple in preparation, good in stability and reusable, is used for catalyzing the reaction of 4,8-dimethyl-3,7-nonadiene-2-ketone and triacetal, can directly generate target product alpha-tuliketone by one-pot method, is high in reaction activity, short in reaction period, simple in post-treatment, simplifies process, is high in yield, and the yield can reach more than 95%.

The utility model discloses a device for realizing anti-deposition material transfer of a solid-containing solution in AKD (Alkyl Ketene Dimer) production, which comprises a material storage container, a turbulent flow inner cylinder is arranged in the material storage container, the top of the turbulent flow inner cylinder is fixedly connected with the top of the material storage container, the bottom of the turbulent flow inner cylinder is suspended, and a plurality of turbulent flow holes are uniformly distributed on the cylinder wall of the turbulent flow inner cylinder; an ultrasonic vibration assembly; a bottom stirring assembly; a transfer pump; the turbulent flow inner barrel in the material storage container can change the flowing path and speed of a solid-containing solution, the turbulent flow effect is enhanced, solid particles are effectively prevented from depositing at the bottom of the container and the barrel wall, and meanwhile, the material storage container has the advantages of being simple in structure, convenient to operate and high in practicability. The ultrasonic vibrator on the outer side wall further inhibits particle deposition through ultrasonic vibration, the stirring assembly at the bottom ensures that the solution is uniform during discharging, and the mixing element efficiently divides, shears and mixes the solution in the rotating process, so that the solid-containing solution is always kept in a uniform state in the whole material transferring process.

The invention belongs to the field of medicinal chemistry, and particularly discloses a 7-hydroxy-3-(2-hydroxyphenyl)-2H-chromene-2-ketone PDE2 inhibitor and application of the 7-hydroxy-3-(2-hydroxyphenyl)-2H-chromene-2-ketone PDE2 inhibitor. According to the invention, 11 target compounds are designed and synthesized by optimizing the structure of a lead compound, a 7-site hydroxyl group is kept unchanged, and different C1-C6 alkoxy groups are introduced to a 4-site phenolic hydroxyl group of a 3-site benzene ring. In-vitro enzyme activity research results show that part of the synthesized compounds show good PDE2 inhibitory activity and have the potential of being developed into drugs for treating central nervous system related diseases (such as hypomnesis and thinking retardation).

The present application provides a kind of pharmaceutical composition with lipid-lowering effect, including luteolin, isorhamnetin, 9-hydroxy-4,7-megastigme-3-ketone, lotus leaf base, 3-O-feruloyl quinic acid, kaempferol-3-O-acacia disaccharide-7-O-glucoside, kaempferol-3-O-beta-D-acacia glycoside and ginsenoside Rg1.The composition of example 1 has lipid-lowering efficacy verified by golden hamster hyperlipidemia model and AML12, HepG2 cell fatty degeneration model, the regulation effect of the composition of example 1 on the key target points of AMPK signal pathway and NF-κB signal pathway is verified by using molecular pharmacology experiment, and the mechanism of the composition of example 1 in treating hyperlipidemia by regulating energy metabolism and anti-inflammatory mechanism is described.

The present disclosure directs to the technical field of epoxy resins, and particularly relates to an antichlor and a preparation method as well as an application thereof, for solving problems in existing chlorine removal methods that separation efficiency of an epoxy resin containing hydrolyzable chlorine is low, lots of energy needs to be consumed in the separation process, molecular distillation equipment is expensive and requirements on vacuum degree and material tightness are high. The antichlor is a polymer containing keto-carbonyl groups. The preparation method includes: adding a mixed solution of styrene and ketene into a reactor containing an organic solvent; adding an initiator, a coupling agent and an anti-gelling agent into the reactor under an atmosphere of shielding gas; controlling the styrene and ketene to perform a polymerization reaction under first preset reaction conditions; and removing the organic solvent after completion of the polymerization reaction, thereby obtaining the antichlor.

The application provides a synthesis method of high-purity high-myrcene, comprising the following steps: carrying out [2+2] cycloaddition reaction of 8-methyl-2,7-nonadiene-4-ketone and ethenone to obtain a beta-lactone intermediate, and carrying out retro-cycloaddition reaction of the beta-lactone intermediate to obtain high-purity high-myrcene product. The synthesis route of the application is novel and short, high-myrcene is prepared simply and efficiently by taking simple and easily obtained 8-methyl-2,7-nonadiene-4-ketone and ethenone as raw materials through two-step reaction of cycloaddition and ring-opening, the overall yield of the route is high, compared with the traditional process of Grignard addition-dehydration method, the content of the target isomer is significantly improved, and the development of high-myrcene downstream derivatives is facilitated.