10 results about "Teprenone" patented technology

The invention discloses a synthesis method of teprenone, which comprises the following steps: dissolving farnesyl acetone in a solvent, and reacting with a Grignard reagent at low temperature to obtain geranyl linalool; the method comprises the following steps: mixing geranyl linalool, alkyl acetoacetate and an organic aluminum catalyst, reacting under a heating condition, adding a dilute acid solution and an organic extraction solvent into the reacted mixed solution, extracting, separating an organic phase to obtain a teprenone crude product, and carrying out reduced pressure distillation purification to obtain teprenone, the yield and the purity of the teprenone in industrial production are improved.

The present application relates to the field of skin care products, and discloses a whitening and anti-aging composition for skin care products and application thereof, and an essence oil and a preparation method thereof. The whitening and anti-aging composition for skin care products contains an active substance combination and a compound essential oil and plant oil combination; the active substance combination contains glabridin, 4-butyl resorcinol, undecylenoyl phenylalanine, natural bisabalol, ascorbic acid tetraisopalmitate and teprenone; the compound essential oil and plant oil combination contains Damascus rose essential oil, magnolia essential oil, frankincense essential oil, Roman chamomile essential oil, carrot seed essential oil, passion fruit seed oil, red wolfberry seed oil, rose fruit oil and sea buckthorn fruit oil. The skin care product prepared from the whitening and anti-aging composition has a more moderate and efficient transdermal absorption rate, and has excellent anti-photoaging effect and whitening and freckle-removing effect.

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of teprenone. The invention aims to solve the technical problems that the existing teprenone synthesis route is complicated, the stereo configuration of a synthesis precursor is difficult to control and the like. According to the method, alpha-farnesene, beta-farnesene, farnesol and nerolidol which are sourced from microbial fermentation are used for preparing a farnesyl acetone crude product, and then high-purity all-trans (5E, 9E)-farnesyl acetone is obtained through rectification, or all-trans (5E, 9E)-farnesyl acetone is directly synthesized from beta-farnesene and farnesol. Therefore, commercial teprenone with qualified quality can be obtained through subsequent reaction.

The invention relates to the field of cosmetic preparations, in particular to cream containing teprenone and having a red-removing effect and a preparation method of the cream. The cream is prepared from the following raw materials in parts by weight: 50 to 80 parts of water, 6 to 15 parts of a polyhydric alcohol humectant, 3 to 6 parts of an emulsifier, 10 to 25 parts of an emollient, 0.1 to 0.4 part of carbomer, 0.1 to 0.4 part of a pH regulator, 0.8 to 1.5 parts of a preservative and 0.05 to 1 part of teprenone-citric acid monoester. Through esterification modification of hydroxyl or amino sites of teprenone, the stability and transdermal absorption capacity of teprenone in a cream system are improved, so that the soothing, repairing and red-removing effects are enhanced. The prepared cream is free of layering and peculiar smell after being stored at 40 DEG C for 3 months, has good appearance and application stability, and is suitable for daily nursing of sensitive or reddish skin.

The embodiment of the invention provides a composition for promoting cadherin expression, a skin care substance and application. The composition and the skin care substance can be used for promoting DSG1 expression. The composition with the function of promoting cadherin expression comprises teprenone, ceprenone, and ceprenone, and a compound represented by formula (1); wherein formula (1):

The invention belongs to the field of organic chemistry, and particularly relates to a preparation method of gamma, delta-unsaturated ketone by adopting a continuous flow process. According to the present invention, the existing Karol rearrangement reaction is improved, and the gamma, delta-unsaturated ketone preparation method using the continuous flow process is provided, and is successfully used in the synthesis of farnesyl acetone and teprenone. The preparation method disclosed by the invention can be safely, rapidly and continuously carried out at high temperature and high pressure, greatly improves the reaction efficiency, reduces unnecessary heat energy loss, and is green, environment-friendly, economical and more suitable for industrial production.

The application discloses a complex of ursodeoxycholic acid or obeticholic acid and teprenone and application of the complex in preparation of a medicine for preventing and treating liver fibrosis. The combination of ursodeoxycholic acid or obeticholic acid and teprenone can significantly reduce the levels and contents of glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminase (AST) and hydroxyproline (Hyp) in model mice, thereby the effect of ursodeoxycholic acid or obeticholic acid in treating liver fibrosis can be enhanced. Therefore, the complex of ursodeoxycholic acid or obeticholic acid and teprenone has a potential for preventing and treating liver fibrosis, which is superior to ursodeoxycholic acid or obeticholic acid single component.

Embodiments of the present disclosure disclose a use of a composition in the preparation of a retinoic acid X receptor gamma activator, the composition comprising phytol, teprenone, and silybin. Embodiments of the present disclosure also disclose a use of the composition in the preparation of an extracellular matrix metalloproteinase inhibitor and an interleukin-6 inhibitor at a specific ratio.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method and application of teprenone, and the synthesis method of the teprenone comprises the following steps: carrying out reduction reaction, halogenation reaction, Witting reaction and oxidation reaction on farnesyl acetone to obtain the teprenone. The synthetic route is simple, the experimental steps are few, and the prepared teprenone is high in yield and high in purity. Besides, the teprenone disclosed by the invention is mainly used in the field of skin care with cosmetic efficacy, and in a fibroblast model, the teprenone can significantly up-regulate the expression quantity of telomerase, TRF2, CDK2, CBX5 / HP1, SERTAD3 and ELAVL1 genes, and has an anti-aging effect.

This disclosure relates in general to methods for treating, stabilizing, or reducing the severity or slowing the progression of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), using an inhibitor of tumor progression site 2 (TPL2) kinase, and pharmaceutical compositions including TPL2 kinase inhibitors used in such methods.