Ipratropium bromide aerosol composition without propellant and preparation method thereof
A technology of ipratropium bromide and composition, applied in the field of preparation of the medicine
A technology of ipratropium bromide and composition, applied in the field of preparation of the medicine
CN110302185APending Publication Date: 2019-10-08TIANJIN JINYAO GRP
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0029] Prescription of pharmaceutical preparation of 100ml:
[0030]
[0031] Preparation method: Mix ipratropium bromide monohydrate or ipratropium bromide, bacteriostatic agent, edetate disodium and water to dissolve completely, and adjust the pH value with hydrochloric acid.
Embodiment 2
[0033] Prescription of pharmaceutical preparation of 100ml:
[0034]
[0035]
Embodiment 1
[0038] Prescription of pharmaceutical preparation of 100ml:
[0039]
[0040] The preparation method is the same as in Example 1.
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The invention relates to a drug ipratropium bromide for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis and the like, the drug is the inhalable aerosol without a propellant, and the invention also relates to a preparation method of the drug.
Description
Technical field: [0001] The present invention relates to the drug ipratropium bromide for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis, etc. The drug is an inhalable aerosol without propellant, and the present invention also relates to a preparation method of the drug . Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be achieved. At present, the drugs for the t...
Claims
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Patent Timeline
08 Oct 2019
Publication
CN110302185A
- IPC
- A61K9/72; A61K31/46; A61K47/18; A61P11/00; A61P11/06
- CPC
- A61K9/0078; A61K9/12; A61K31/46; A61K47/183; A61P11/00; A61P11/06
- Inventors
- 张杰; 孙亮