Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents

A compound, C2-C6 technology, applied in the field of therapeutic agents for inflammatory diseases, can solve problems such as not mentioned
CN101636386AInactive Publication Date: 2010-01-27ASTELLAS PHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ASTELLAS PHARMA INC
Publication Date
2010-01-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a novel compound or a salt thereof, which is useful as a CRTH2 antagonist, especially as a medicament for disorder that participates eosinophil, for example, allergic disorder such as asthma, allergic rhinitis, allergic dermatitis, conjunctival inflammation, hives, eosinophilic bronchitis, food allergy, inflammation of the nasal sinuses, multiple sclerosis, angiitis, or chronic obstructive pulmonary disease (COPD) and the like.
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Description

technical field

[0001] The present application relates to novel compounds and medicaments containing the compounds as active ingredients, more particularly, the present application relates to therapeutic agents for inflammatory diseases. Background technique

[0002] Mast cells, known as conductive cells in allergic inflammation, can be activated by various stimuli including antigens and produce various inflammatory mediators.

[0003] Prostaglandin D 2 (PGD 2 ) is an important prostaglandin compound produced by activated mast cells. Some reports indicate that antigen challenge is in the airways of asthmatic patients (New England Journal of Medicine, 1986, 315(13), pp.800-804), in the nasal mucosa of allergic rhinitis patients or in the skin of allergic dermatitis patients (Journal of Immunology, 1991, 146 (2), pp.671-676) induce a large amount of PGD 2 .

[0004] Fujitani et al. reported that overexpression of PGD synthase in transgenic mice (where PGD 2 Increased pro...

Claims

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