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Paeonol niosome emulsifiable paste for external use and preparation method thereof

A technology of paeonol and capsule cream, applied in skin diseases, capsule delivery, ointment delivery, etc., can solve the problems of dermatitis and eczema without specific treatment

Active Publication Date: 2016-07-13
HEFEI LIFEON PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently there is no effective treatment for dermatitis eczema

Method used

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  • Paeonol niosome emulsifiable paste for external use and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 paeonol vesicular emulsifiable cream, it consists of:

[0018] Paeonol 20mg, Span6080mg, cholesterol 20mg, dicetyl phosphate 20mg, water for injection 60mL, absolute ethanol 5mL, emulsification time 3h. The vesicle encapsulation rate of paeonol nonionic surfactant obtained by this method was 46.66%, and the drug loading was 6.67%;

[0019] Weigh 5g of glyceryl monostearate, 100g of stearyl alcohol, and 100g of white petrolatum, mix and heat to 80°C to melt into an oil phase; in addition, weigh 20g of Tween-80, 0.5g of disodium hydrogen phosphate, 0.5g of citric acid, Propylene glycol 100g, ethyl p-hydroxybenzoate 3g, purified water, mix and dissolve, heat to 80°C as the water phase, slowly add the water phase to the oil phase, the stirring speed is 800r / min, the emulsification temperature is 80°C, emulsification After 20 minutes, when it cools to 45°C, add paeonol vesicle suspension at the same temperature, continue to stir until the temperature drops to 2...

Embodiment 2

[0020] Embodiment 2 paeonol vesicular emulsifiable cream, it consists of:

[0021] Paeonol 25mg, Span6080mg, cholesterol 20mg, dicetyl phosphate 10mg, water for injection 100mL, absolute ethanol 5mL, emulsification time 2h, the vesicle encapsulation rate of paeonol nonionic surfactant obtained by this method is 46.90% , drug loading 8.69%;

[0022] Weigh 5g of glyceryl monostearate, 120g of stearyl alcohol, and 100g of white petrolatum, mix and heat to 80°C to melt into an oil phase; in addition, weigh 20g of Tween-8020g, 0.5g of disodium hydrogen phosphate, 0.5g of citric acid, Propylene glycol 100g, ethyl p-hydroxybenzoate 3g, purified water, mix and dissolve, heat to 80°C as the water phase, slowly add the water phase to the oil phase, the stirring speed is 800r / min, the emulsification temperature is 60°C, emulsification After 20 minutes, when it cools to 45°C, add paeonol vesicle suspension at the same temperature, continue to stir until the temperature drops to 25°C, tes...

Embodiment 3

[0023] Embodiment 3 Paeonol nonionic surfactant vesicles, which consist of:

[0024] Paeonol 25mg, Span6090mg, cholesterol 30mg, dicetyl phosphate 10mg, water for injection 60mL, absolute ethanol 8mL, emulsification time 3h, the encapsulation rate of paeonol nonionic surfactant vesicle obtained by this method is 63.26 %, drug loading 10.2%;

[0025] Weigh 5g of glyceryl monostearate, 120g of stearyl alcohol, and 100g of white petrolatum, mix and heat to 70°C to melt into an oil phase; in addition, weigh 20g of Tween-8020g, 0.5g of disodium hydrogen phosphate, 0.5g of citric acid, Propylene glycol 100g, ethyl p-hydroxybenzoate 3g, purified water, mix and dissolve, heat to 70°C as the water phase, slowly add the water phase to the oil phase, the stirring speed is 800r / min, the emulsification temperature is 60°C, emulsification After 20 minutes, when it cools to 45°C, add paeonol vesicle suspension at the same temperature, continue to stir until the temperature drops to 25°C, te...

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Abstract

The invention relates to paeonol niosome emulsifiable paste. The paste is prepared by the following steps: paeonol, a nonionic surfactant, cholesterol and the like are used for preparing a niosome suspension by a self assembly mode; the suspension, paraffin, glyceryl monostearate, vaseline, propylene glycol, ethyl p-hydroxybenzoate and other auxiliary materials are used for preparing a niosome emulsion; the paste can be partially applied to skin, and can treat allergic dermatitis and eczema with skin whitening effects. The prepared niosomes have round forms, uniform particle size distribution, and high encapsulation efficiency. The paeonol niosome emulsifiable paste has good uniformity and stable properties, and in vitro rat and mouse skin experiment results prove that intracutaneous retention volume of medicaments is substantially increased with slow releasing effects. The partially applied position of the paeonol niosome emulsifiable paste has a high medicament utilization rate and substantial medicament reservoir slow releasing effects, and curative effects are improved.

Description

technical field [0001] The invention relates to a paeonol vesicle emulsion and a preparation method thereof, which can be used as local medicine for skin to treat various skin inflammations and eczema and has whitening effect. Background technique [0002] Paeonol (Pae for short), also known as paeonol, is mainly obtained from the dry root or whole plant of Cynanchumpaniculatum (Bunge) Kitagawa of the family Rumoaceae and the root bark of Paeoniasuffruticosa Andr and P.lactiflora Pall. The active ingredient extracted and separated from the plant is bitter and pungent. It is a small molecular phenolic compound in the form of white needle-like crystals. Its molecular weight is 166.18 and its molecular formula is C 9 h 10 o 3 , has anti-inflammatory, anti-allergic, antibacterial, sedative, hypnotic, analgesic and other pharmacological activities. Paeonol percutaneous administration is used for the treatment of eczema, allergic dermatitis and other diseases, which overcomes t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/06A61K31/12A61P17/00
Inventor 彭代银陈卫东何瑞曦黄天擎陈贺骏涛聂湘江
Owner HEFEI LIFEON PHARMA
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