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Compound inhalation preparation containing penicillin antibiotic

A penicillin and antibiotic technology, applied in antibacterial drugs, aerosol delivery, respiratory diseases, etc., can solve the problem of not finding the use of antibacterial drugs

Inactive Publication Date: 2014-12-17
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no antibacterial drugs, especially penicillin antibiotics, have been used in the treatment of asthma and chronic obstructive pneumonia caused by non-microbial infections

Method used

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  • Compound inhalation preparation containing penicillin antibiotic
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  • Compound inhalation preparation containing penicillin antibiotic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]According to the following table, active ingredient 1 was micronized with a flow energy mill. See the table below for the particle size of D90. Anhydrous lactose 8g was micronized with a flow energy mill to an average particle size of 36 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0039]

Embodiment 2

[0041] According to the following table, active ingredient 1 was micronized with a flow energy mill. The D90 particle size is shown in the table below. Anhydrous lactose 8g was micronized with a flow energy mill to an average particle size of 40 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0042]

Embodiment 3

[0044] According to the table below, active ingredient 1 was micronized with a flow energy mill. See the table below for the particle size of D90. Anhydrous lactose 8g was micronized with a flow energy mill to an average particle size of 42 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0045]

[0046] The preparation of aerosol, the active ingredient used is the weight of 1000 dosage units, HFA-134a is 1,1,1,2-tetrafluoroethane, HFA-227 is 1,1,1,2,3,3, 3-Heptafluoropropane.

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Abstract

The invention relates to a compound inhalation preparation containing penicillin antibiotic and applications thereof. The preparation in an inhalation dosage form is capable of treating pulmonary bacterial infection with less dosage and has a certain curative effect on asthma and chronic obstructive pneumonia. The preparation is made into an dry powder inhalation dosage form, after a long period of preservation, the content of allergic matters namely penicilloic acid and penicillenic acid is not increased, so that the happening rate of allergy is largely reduced, when the preparation is used to treat asthma caused by non-microbial infection and chronic obstructive pneumonia.

Description

Technical field: [0001] The present invention relates to inhalation preparations and uses containing penicillin antibiotics. Background technique: [0002] Penicillin antibiotics are a class of antibiotics containing a β-lactam structure, which are divided into semi-synthetic penicillins and natural penicillins. Natural penicillin is extracted from Penicillium culture fluid, containing G, K, X, F and dihydro-F and so on. Semi-synthetic penicillin is obtained by adding different groups to the side chain of the intermediate 6-aminopenicillanic acid (6-APA). [0003] The main route of administration of penicillin antibiotics is oral or injection, and can also be used to treat diseases caused by lung bacterial infections through atomized inhalation, but this kind of atomized inhalation has obvious disadvantages. Time, while penicillin antibiotics are placed in water for a long time, which will increase the appearance of allergic substances penicilloic acid and penicillonic aci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/431A61K31/43A61K9/72A61K9/12A61P11/06A61P11/00A61P31/04
Inventor 孙亮赵琳
Owner TIANJIN JINYAO GRP
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