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6-APA is the chemical compound (+)-6-aminopenicillanic acid. Use. 6-APA is the core of penicillins. It is obtained from the fermentation brew of the Penicillium mold and used as the main starting block for the preparation of numerous semisynthetic penicillins. History. In 1958, Beecham scientists in the UK discovered the ...
Synthesis of β-lactam penicillin antibiotics with peptide structure
The invention relates to the synthesis of novel penicillin β-lactam antibiotics with synthetic peptide structures containing C-C and C-N multiple bonds, and the synthesis of their pharmaceutically acceptable salts, via four-component reactions using 6-aminopenicillanic acid (6-APA) as the aldehyde, amine, isonitrile, and carboxylic acid, or 6-aminopenicillanic acid (6-APA) as the aldehyde carboxylic acid and amine.
Owner:T C ERCIYES UNIVERSITESI