Synthesis process of o-chloro-benzathine penicillin
A technology of o-benzyl penicillin and synthesis process, applied in directions such as organic chemistry, can solve the problems of complex production process, difficult implementation of technical process, low production efficiency, etc., achieves overcoming many processes, improves single-pass conversion rate and product productivity, improve work efficiency
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[0015] The o-chlorobenzathine penicillin synthesis technique of the present embodiment comprises the following steps:
[0016] (1) According to the ratio of organic solvent to water (1-3): 1, prepare an aqueous solution of organic solvent, add it to the condensation tank, turn on the stirring and jacket cooling water, and use 99-210 grams per liter of organic solvent Add 6-aminopenicillanic acid into the aqueous solution; when the temperature drops below 16°C, start to add 12% NaOH solution into the tank to keep the pH value at 8-9 to gradually dissolve 6-aminopenicillanic acid until;
[0017] (2) The molar ratio of 6-aminopenicillanic acid and o-chlorobenzisoxazole chloride is 1: (0.95-1.15) to weigh o-chlorobenzisoxazole chloride, when the above (1) step When the temperature of the sodium salt solution in the solution is cooled to below 10°C, start to add the weighed o-chlorobenzisoxazole chloride into the tank, then start to add the NaOH solution with a concentration of 13...
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