Synthetic process for candesartan cilexetil
A technology for the synthesis of candesartan cilexetil, which is applied in the field of medicine, can solve problems such as difficult implementation of the process, low production efficiency, and complicated production process, so as to improve the single-pass conversion rate and product yield, and improve work efficiency , to overcome the effect of more processes
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[0011] The synthetic technique of the candesartan cilexetil of the present embodiment comprises the following steps:
[0012] (1) With ethyl 1-[(2'-cyano-1,1'-biphenyl-4-yl)methyl]-2-ethoxy-7-benzimidazolecarboxylate and azide Sodium chloride is used as a raw material, N,N-dimethylformamide is used as a solvent, MCl is used as a catalyst, and the reaction is carried out at 150° C. for 30 hours;
[0013] (2) Cool and depressurize to remove N,N-dimethylformamide, wash with toluene or xylene, and adjust the pH to 6 with 1N-HCl-;
[0014] (3) Solids are precipitated, filtered, and recrystallized from methanol to obtain candesartan cilexetil, wherein M is a metal or ammonium cation.
[0015] The synthesis process of candesartan cilexetil does not require further processing, the process is simple, the data is accurate and easy to measure, and the process flow is easy to implement.
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