Inhalation preparation containing cephalosporin antibiotic

A technology of antibiotics and cephalosporins, which is applied in the direction of antibacterial drugs, aerosol delivery, respiratory diseases, etc., and can solve the problems of not finding the use of antibacterial drugs

Inactive Publication Date: 2014-12-17
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, no antibacterial drugs, especially cephalosporins, have been used in the treatment of asthma and chronic obstructive pneumonia caused by non-microbial infections

Method used

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  • Inhalation preparation containing cephalosporin antibiotic
  • Inhalation preparation containing cephalosporin antibiotic
  • Inhalation preparation containing cephalosporin antibiotic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] According to the following table, active ingredient 1 was micronized with a flow energy mill. See the table below for the particle size of D90. Anhydrous lactose 8g was micronized with a flow energy mill to an average particle size of 36 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0043] Example number

Embodiment 2

[0045] According to the following table, active ingredient 1 was micronized with a flow energy mill. The D90 particle size is shown in the table below. Anhydrous lactose 8g was micronized with a flow energy mill to an average particle size of 40 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0046] Example number

Embodiment 3

[0048] According to the table below, active ingredient 1 was micronized with a flow energy mill. See the table below for the particle size of D90. Anhydrous lactose 8g was micronized with a flow energy mill to an average particle size of 42 μm. Packed in 1000 size 3 capsules, the active ingredients in each capsule are shown in the table below.

[0049] Example number

[0050] The preparation of aerosol, the active ingredient used is the weight of 1000 dosage units, HFA-134a is 1,1,1,2-tetrafluoroethane, HFA-227 is 1,1,1,2,3,3, 3-Heptafluoropropane.

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Abstract

The invention relates to an inhalation preparation containing cephalosporin antibiotic and applications thereof. The cephalosporin antibiotic is made into an inhalation dosage form, and thus the preparation can treat pulmonary bacterial infection with less dosage and has a certain curative effect on asthma and chronic obstructive pneumonia.

Description

Technical field: [0001] The present invention relates to the inhalation preparation and application containing cephalosporin antibiotics. Background technique: [0002] Cephalosporin antibiotics are semi-synthetic antibiotics containing cephems in their molecules, belonging to β-lactam antibiotics, which can be synthesized from 7-aminocephalosporanic acid (7-ACA), 7-aminodesacetoxycephalosporanic acid (7 -ADCA) and 7-amino-7-methoxycephalosporanic acid and other structures are prepared by chemical modification. [0003] Cephalosporin antibiotics have been widely used clinically because of their strong antibacterial effect, resistance to β-lactamase, high clinical efficacy, low toxicity, and less allergic reactions than penicillins. However, as the scope of application of cephalosporins becomes wider and wider, more and more cases of allergic reactions are caused. Allergic reactions bring great harm to patients, ranging from drug eruption to anaphylactic shock and even endan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/12A61K9/14A61K31/546A61K31/545A61P11/06A61P11/00A61P31/04
Inventor 孙亮赵琳
Owner TIANJIN JINYAO GRP
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