136 results about "Cephalosporin Antibiotic" patented technology

The present invention relates to a method for the preparation of cephalosporin antibiotic of the formula (II), which comprises hydrolyzing and halogenating the ester of formula (III) by photochemical irradiation in one pot using a halogenating agent in the absence or presence of a solvent, to produce compound of formula (I), activating the 4-halogeno-2-substitutedimino-3-oxo-butyric acid of formula (I) using conventional activation agents gives compound of formula (IV), condensing the activated compound of the formula (IV) with 7-amino cephem derivative of the formula (V) to produce a compound of formula (VI), and cyclizing the compound of formula (VI) with thiourea to give cephalosporin compounds of the formula (II).

The invention relates to an enzyme-linked immune detection method for quantitatively detecting the content of spore antibiotic in animal food and belongs to the immune analysis field. The method comprises the steps of adopting the polyclonal antibody of the spore antibiotic with a group-specific antibody as a detection reagent; preparing an enzyme-linked immune detection kit; by using cephalexin as a standard, measurating the concentration of different spore class antibiotics and the relative value of the cephalexin standard through an experiment; and providing the measurated correction factors. The multi-residue detection of the enzyme-linked immune detection kit is expected to be realized. The method has the advantages of simple pretreatment, high sensitivity, high accuracy, etc.

The invention belongs to the field of cephalosporin antibiotic medicaments, and in particular relates to a method for synthesizing 7-phenylacetylamino-3-chloromethyl cephalosporin alkyl acid p-methoxybenzyl ester (GCLE). The technical proposal is that the method comprises the following steps: reacting penicillin sulfoxide ester with ammonium benzene sulfinate and 2-mercaptobenzothiazole in dichloromethane, and steaming out a solvent at normal pressure to generate aza-cyclobutanone thiosulfinate intermediate; adding dichloromethane to the intermediate after cooling, stirring and introducing saturated brine ice for cooling, adding trichloro isocyanic acid for reaction so as to generate an allylic chlorination product of the aza-cyclobutanone thiosulfinate; and reducing the pressure and drying the allylic chlorination product by distillation, adding dimethyl formamide to the product, stirring and introducing saturated brine ice for cooling, adding ammonia for reaction, adding water and dichloromethane to the mixture, mixing and stirring the mixture, standing for layering, transferring a dichloromethane layer at the bottom layer to another reactor, and steaming out the solvent at the normal pressure to obtain a dry product which is the GCLE. The method has the advantages of mild reaction condition, few reaction steps, simple operation, short production cycle, and improved production efficiency.

A novel process is disclosed for the preparation of Cefepime, a cephalosporin antibiotic, using novel new intermediates of the general Formula, where X represents Bromine or Chlorine atom This process comprises the step of cyclizing the bromo or chloro intermediate with thiourea to produce Cefepime of high purity. A process to prepare bromo or chloro intermediate comprising the acylation of 7-Amino-3-[(1-methyl-1-pyrrolidinium) methyl]-3-cephem-4-carboxylate with 4-halo-2-methoxyimino-3-oxobutyric acid halide is also described.

A process for the preparation of cefdinir of the formula (I) the said process comprising the steps of: i) condensing 7-amino-3-cephem-4-carboxylic acid of the formula (XII) wherein R1 is as defined above with compound of the formula (XIII) in the presence of a tertiary amine and an organic solvent, followed by treatment with a base to produce a salt of compound formula (XIV), wherein M+ is a counter ion and ii) hydrolyzing the compound of the formula (XIV) using an acid in the presence of a solvent to produce cefdinir of formula (I).

The invention discloses a method for removing bacterial endotoxins in cephalosporin antibiotics by utilizing macroporous adsorption resins, comprising the following steps: firstly filtering the cephalosporin antibiotics solution containing the bacterial endotoxins and removing solid insoluble matters; then utilizing the pretreated macroporous adsorption resins to carry out static adsorption or dynamic adsorption on the cephalosporin antibiotics solution; and finally crystallizing, drying and grinding the solution after adsorption treatment, thus obtaining the product with bacterial endotoxins in accordance with the quality standard. The method has the advantages of high bacterial endotoxins removal rate, good selectivity, easy desorption, repeated use, low fluid resistance and easy magnification.

The invention relates to an inhalation preparation containing cephalosporin antibiotic and applications thereof. The cephalosporin antibiotic is made into an inhalation dosage form, and thus the preparation can treat pulmonary bacterial infection with less dosage and has a certain curative effect on asthma and chronic obstructive pneumonia.

An improved one-pot process for the preparation of Ceftiofur of the formula (I) or its salt, without isolating intermediate compound

The invention provides a medicament for treating lower respiratory tract infection and a preparation method thereof, aiming at solving problems of poor effect on some pathogenic bacteria, difficult control of non-bacterial infection, high price and the like for preventing lower respiratory tract infection by using cephalosporin antibiotics in the prior art; the medicament comprises the following components by weight: 10-30 parts of fritillaria thun-bergli, 20-40 parts of almond, 10-15 parts of loquat leaves, 15-30 parts of white mulberry root bark, 6-10 parts of radix stemonae, 10-30 parts of rhizoma phragmitis, 10-15 parts of radix bupleuri, 6-10 parts of pinellia ternate, 10-15 parts of scutellaria, 30-60 parts of radix astragali, 10-15 parts of platycodon grandiflorum, 30-60 parts of gypsum, 10-15 parts of radix ophiopogonis, 20-40 parts of licorice, and 10-15 parts of citrus peel. The medicament of the invention adopts Chinese herbal medicine as main components, and has the advantages of no drug tolerance, easy control of non-bacterial infection, and low cost.